Stress-activated cap’n’collar transcription factors in aging and human disease

p62 Accumulates and Enhances Aggregate Formation in Model Systems of Familial Amyotrophic Lateral Sclerosis

Gál, J., Ström, A., Kilty, R., Zhang, F., & Zhu, H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608787200 · Cited by 176

Increased expression of Nrf2/ARE-dependent anti-oxidant proteins in tamoxifen-resistant breast cancer cells

Kim, S. K., Yang, J. W., Kim, M. R., Roh, S. H., Kim, H. G., Lee, K. Y., Jeong, H. G., & Kang, K. W. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.05.011 · Cited by 174

Neuroprotective Effects of the Triterpenoid, CDDO Methyl Amide, a Potent Inducer of Nrf2-Mediated Transcription

Yang, L., Calingasan, N. Y., Thomas, B., Chaturvedi, R. K., Kiaei, M., Wille, E. J., Liby, K. T., Williams, C. R., Royce, D. B., Risingsong, R., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005757 · Cited by 173

Nuclear Oncoprotein Prothymosin α Is a Partner of Keap1: Implications for Expression of Oxidative Stress-Protecting Genes

Karapetian, R. N., Evstafieva, A. G., Abaeva, I. S., Chichkova, N. V., Filonov, G. S., Rubtsov, Y. P., Sukhacheva, E. A., Melnikov, S. V., Schneider, U., Wanker, E. E., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.3.1089-1099.2005 · Cited by 173

Dietary restriction in C. elegans: From rate-of-living effects to nutrient sensing pathways

Walker, G. A., Houthoofd, K., Vanfleteren, J. R., & Gems, D. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.014 · Cited by 172

Cadmium Induces Nuclear Export of Bach1, a Transcriptional Repressor of Heme Oxygenase-1 Gene

Suzuki, H., Tashiro, S., Sun, J., Doi, H., Satomi, S., & Igarashi, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306764200 · Cited by 171

Mice Lacking Transcription Factor NF-E2 Provide In Vivo Validation of the Proplatelet Model of Thrombocytopoiesis and Show a Platelet Production Defect That Is Intrinsic to Megakaryocytes

Lécine, P., Villeval, J., Vyas, P., Swencki, B., Xu, Y., & Shivdasani, R. A. (1998) · Blood · doi:10.1182/blood.v92.5.1608 · Cited by 170

Purification of the Human NF-E2 Complex: cDNA Cloning of the Hematopoietic Cell-Specific Subunit and Evidence for an Associated Partner

Ney, P. A., Andrews, N. C., Jane, S. M., Safer, B., Purucker, M., Weremowicz, S., Morton, C. C., Goff, S. C., Orkin, S. H., & Nienhuis, A. W. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.9.5604 · Cited by 168

NADPH Oxidase and ERK Signaling Regulates Hyperoxia-induced Nrf2-ARE Transcriptional Response in Pulmonary Epithelial Cells

Papaiahgari, S. R., Kleeberger, S. R., Cho, H., Kalvakolanu, D. V., & Reddy, S. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408275200 · Cited by 167

Role of the Nrf2-antioxidant system in cytotoxicity mediated by anticancer cisplatin: Implication to cancer cell resistance

Cho, J., Manandhar, S., Lee, H., Park, H.-M., & Kwak, M. (2007) · Cancer Letters · doi:10.1016/j.canlet.2007.10.022 · Cited by 167

Identification of polymorphic antioxidant response elements in the human genome

Wang, X., Tomso, D. J., Chorley, B. N., Cho, H., Cheung, V. G., Kleeberger, S. R., & Bell, D. A. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm066 · Cited by 164

Formation of a Monomeric DNA Binding Domain by Skn-1 bZIP and Homeodomain Elements

Blackwell, T. K., Bowerman, B. A., Priess, J. R., & Weintraub, H. M. (1994) · Science · doi:10.1126/science.7939715 · Cited by 162

Immunoreactivities of p62, an ubiqutin-binding protein, in the spinal anterior horn cells of patients with amyotrophic lateral sclerosis

Mizuno, Y., Amari, M., Takatama, M., Aizawa, H., Mihara, B., & Okamoto, K. (2006) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2006.05.060 · Cited by 158

Nrf1 Is Targeted to the Endoplasmic Reticulum Membrane by an N-terminal Transmembrane Domain

Wang, W., & Chan, J. Y. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602802200 · Cited by 158

Cancer chemoprevention: scientific promise, clinical uncertainty

Sporn, M. B., & Liby, K. T. (2005) · Nature Clinical Practice Oncology · doi:10.1038/ncponc0319 · Cited by 157

Nrf2 Possesses a Redox-sensitive Nuclear Exporting Signal in the Neh5 Transactivation Domain

Li, W., Yu, S., & Kong, A.-N. T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602746200 · Cited by 157

Small Maf Proteins in Mammalian Gene Control: Mere Dimerization Partners or Dynamic Transcriptional Regulators?

Blank, V. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.11.074 · Cited by 154

Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice

Li, J., Stein, T. D., & Johnson, J. A. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00209.2003 · Cited by 154

Sulforaphane improves cognitive function administered following traumatic brain injury

Dash, P. K., Zhao, J., Orsi, S. A., Zhang, M., & Moore, A. N. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.04.028 · Cited by 148

Positive or Negative MARE-Dependent Transcriptional Regulation Is Determined by the Abundance of Small Maf Proteins

Motohashi, H., Katsuoka, F., Shavit, J. A., Engel, J. D., & Yamamoto, M. P. (2000) · Cell · doi:10.1016/s0092-8674(00)00190-2 · Cited by 148

Identification of Nrf2-regulated genes induced by chemopreventive isothiocyanate PEITC by oligonucleotide microarray

Hu, R., Xu, C., Shen, G., Jain, M. R., Khor, T. O., Gopalkrishnan, A., Lin, W., Reddy, B. S., Chan, J. Y., & Kong, A. T. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.06.019 · Cited by 148

The coffee diterpene kahweol induces heme oxygenase‐1 via the PI3K and p38/Nrf2 pathway to protect human dopaminergic neurons from 6‐hydroxydopamine‐derived oxidative stress

Hwang, Y. P., & Jeong, H. G. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.06.045 · Cited by 146

Fibroblast Growth Factor-1 Induces Heme Oxygenase-1 via Nuclear FactorErythroid 2-related Factor 2 (Nrf2) in Spinal Cord Astrocytes

Vargas, M. R., Pehar, M., Cassina, P., Palma, L. M., Thompson, J. A., Beckman, J. S., & Barbeito, L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501920200 · Cited by 146

Glucocorticoid Receptor (GR)-Associated SMRT Binding to C/EBPβ TAD and Nrf2 Neh4/5: Role of SMRT Recruited to GR in GSTA2 Gene Repression

Ki, S. H., Cho, I. J., Choi, D. W., & Kim, S. G. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.10.4150-4165.2005 · Cited by 145

Translational Control of Nrf2 Protein in Activation of Antioxidant Response by Oxidants

Purdom, S., Sheveleva, E. V., Sun, H., & Chen, Q. M. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.035360 · Cited by 143

Subcellular localization and cytoplasmic complex status of endogenous Keap1

Watai, Y., Kobayashi, A., Nagase, H., Mizukami, M., McEvoy, J. D., Singer, J. D., Itoh, K., & Yamamoto, M. P. (2007) · Genes to Cells · doi:10.1111/j.1365-2443.2007.01118.x · Cited by 141

Identification of polymorphisms in the promoter region of the human NRF2 gene

Yamamoto, T., Yoh, K., Kobayashi, A., Ishii, Y., Kure, S., Kôyama, A., Sakamoto, T., Sekizawa, K., Motohashi, H., & Yamamoto, M. P. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.06.112 · Cited by 140

Nrf1 Is Critical for Redox Balance and Survival of Liver Cells during Development

Chen, L., Kwong, M., Lu, R., Ginzinger, D. G., Lee, C., Leung, L., & Chan, J. Y. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.13.4673-4686.2003 · Cited by 139

Antioxidant-induced Phosphorylation of Tyrosine 486 Leads to Rapid Nuclear Export of Bach1 That Allows Nrf2 to Bind to the Antioxidant Response Element and Activate Defensive Gene Expression

Kaspar, J. W., & Jaiswal, A. K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.040022 · Cited by 136

Bromocriptine activates NQO1 via Nrf2-PI3K/Akt signaling: Novel cytoprotective mechanism against oxidative damage

Lim, J. H., Kim, K., Kim, S. W., Hwang, O., & Choi, H. J. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.03.004 · Cited by 136

The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease

Cuadrado, A., Moreno-Murciano, P., & Pedraza‐Chaverrí, J. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/13543780802716501 · Cited by 135

Antioxidant and cytoprotective responses to redox stress

Mathers, J. E., Fraser, J. A., McMahon, M. J., Saunders, R. D. C., Hayes, J. D., & McLellan, L. I. (2004) · Biochemical Society Symposia · doi:10.1042/bss0710157 · Cited by 134

The Double-Edged Sword of Nrf2: Subversion of Redox Homeostasis during the Evolution of Cancer

Hayes, J. D., & McMahon, M. J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.004 · Cited by 134

Mitochondrial Superoxide Production and Nuclear Factor Erythroid 2-Related Factor 2 Activation in p75 Neurotrophin Receptor-Induced Motor Neuron Apoptosis

Pehar, M., Vargas, M. R., Robinson, K. M., Cassina, P., Díaz‐Amarilla, P., Hagen, T. M., Radí, R., Barbeito, L., & Beckman, J. S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0823-07.2007 · Cited by 133

Segmentally restricted, cephalic expression of a leucine zipper gene during Drosophila embryogenesis

Mohler, J., Vani, K., Leung, S., & Epstein, A. (1991) · Mechanisms of Development · doi:10.1016/0925-4773(91)90086-l · Cited by 129

Nrf2 Transcriptionally Activates the mafG Gene through an Antioxidant Response Element

Katsuoka, F., Motohashi, H., Engel, J. D., & Yamamoto, M. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411451200 · Cited by 129

Butylated hydroxyanisole regulates ARE‐mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells

Yuan, X., Xu, C., Pan, Z., Keum, Y., Kim, J. H., Shen, G., Yu, S., Oo, K. T., Ma, J., & Kong, A. T. (2006) · Molecular Carcinogenesis · doi:10.1002/mc.20234 · Cited by 128

NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation

Motohashi, H., Kimura, M., Fujita, R., Inoue, A., Pan, X., Takayama, M., Katsuoka, F., Aburatani, H., Bresnick, E. H., & Yamamoto, M. P. (2009) · Blood · doi:10.1182/blood-2009-05-223107 · Cited by 125

Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum

Zhang, Y., Crouch, D. H., Yamamoto, M. P., & Hayes, J. D. (2006) · Biochemical Journal · doi:10.1042/bj20060725 · Cited by 124

Isolation of cDNA encoding the human NF-E2 protein.

Chan, J. Y., Han, X. L., & Kan, Y. W. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11366 · Cited by 123

Induction of heme-oxygenase 1 requires the p38MAPK and PI3K pathways and suppresses apoptotic cell death following hypericin-mediated photodynamic therapy

Kocanova, S., Buytaert, E., Matroule, J., Piette, J. G., Gołąb, J., de Witte, P. A. M., & Agostinis, P. (2007) · APOPTOSIS · doi:10.1007/s10495-006-0016-x · Cited by 123

酵母での遺伝的選択によるNF-E2関連転写因子、Nrf1のクローニング

Chan, J. Y., X‐L, H., & W, K. Y. (1993) · Cited by 123

Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype

Devling, T. W. P., LINDSAY, C. D., McLellan, L. I., McMahon, M. J., & Hayes, J. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501475102 · Cited by 122

JunD activates transcription of the human ferritin H gene through an antioxidant response element during oxidative stress

Tsuji, Y. (2005) · Oncogene · doi:10.1038/sj.onc.1208901 · Cited by 121

Recent advances in the genetics of amyotrophic lateral sclerosis

Valdmanis, P. N., Daoud, H., Dion, P. A., & Rouleau, G. A. (2009) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-009-0030-9 · Cited by 121

Inhibition and Genetic Deficiency of p38 MAPK Up-Regulates Heme Oxygenase-1 Gene Expression via Nrf2

Naidu, S., Vijayan, V., Santoso, S., Kietzmann, T., & Immenschuh, S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900006 · Cited by 120

A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants

Curran, S. P., Wu, X., Riedel, C. G., & Ruvkun, G. (2009) · Nature · doi:10.1038/nature08106 · Cited by 120

Oxidative stress-inducible proteins in macrophages

Ishii, T., Itoh, K., Sato, H., & Bannai, S. (1999) · Free Radical Research · doi:10.1080/10715769900300921 · Cited by 116

Vacuolar Leukoencephalopathy with Widespread Astrogliosis in Mice Lacking Transcription Factor Nrf2

Hubbs, A. F., Benkovic, S. A., Miller, D. B., O'Callaghan, J. P., Battelli, L. A., Schwegler‐Berry, D., & Ma, Q. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060898 · Cited by 116

Nrf3 Negatively Regulates Antioxidant-response Element-mediated Expression and Antioxidant Induction of NAD(P)H:Quinone Oxidoreductase1 Gene

Kannan, S., & Jaiswal, A. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404984200 · Cited by 114

Prohibitin Is a Novel Regulator of Antioxidant Response That Attenuates Colonic Inflammation in Mice

Theiss, A. L., Vijay–Kumar, M., Obertone, T. S., Jones, D. P., Hansen, J. M., Gewirtz, A. T., Merlin, D., & Sitaraman, S. V. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.03.033 · Cited by 113

Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone

Przybysz, A. J., Choe, K. P., Roberts, L. J., & Strange, K. B. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.02.004 · Cited by 112

Triterpenoid CDDO‐methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer’s disease

Dumont, M., Wille, E. J., Calingasan, N. Y., Tampellini, D., Williams, C. R., Gouras, G. K., Liby, K. T., Sporn, M. B., Beal, M. F., & Lin, M. T. S. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05970.x · Cited by 112

Dithiolethiones for cancer chemoprevention: where do we stand?

Zhang, Y., & Munday, R. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0625 · Cited by 111

Age-associated oxidative damage to the p62 promoter: implications for Alzheimer disease

Du, Y., Wooten, M. C., Gearing, M., & Wooten, M. W. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.11.003 · Cited by 108

Control of Drosophila head segment identity by the bZIP homeotic gene cnc

Mohler, J., Mahaffey, J. W., Deutsch, E., & Vani, K. (1995) · Development · doi:10.1242/dev.121.1.237 · Cited by 106

Oxidative Stress Abolishes Leptomycin B-sensitive Nuclear Export of Transcription Repressor Bach2 That Counteracts Activation of Maf Recognition Element

Hoshino, H., Kobayashi, A., Yoshida, M., Kudo, N. R., Oyake, T., Motohashi, H., Hayashi, N., Yamamoto, M. P., & Igarashi, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.20.15370 · Cited by 106

Intermittent dosing with oltipraz: relationship between chemoprevention of aflatoxin-induced tumorigenesis and induction of glutathione S-transferases.

Primiano, T., Egner, P. A., Sutter, T. R., Kelloff, G. J., Roebuck, B. D., & Kensler, T. W. (1995) · PubMed · Cited by 105

Induction of the Cytoprotective Enzyme Heme Oxygenase-1 by Statins Is Enhanced in Vascular Endothelium Exposed to Laminar Shear Stress and Impaired by Disturbed Flow

Ali, F., Zakkar, M., Karu, K., Lidington, E. A., Hamdulay, S., Boyle, J. J., Zloh, M., Bauer, A., Haskard, D. O., Evans, P. C., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.009886 · Cited by 104

Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress

Wondrak, G. T., Cabello, C. M., Villeneuve, N. F., Zhang, S., Ley, S., Li, Y., Sun, Z., & Zhang, D. D. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.04.023 · Cited by 103

The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation

Zhang, Y., Lucocq, J. M., Yamamoto, M. P., & Hayes, J. D. (2007) · Biochemical Journal · doi:10.1042/bj20070761 · Cited by 101

Suppression of Rat Thromboxane Synthase Gene Transcription by Peroxisome Proliferator-activated Receptor γ in Macrophages via an Interaction with NRF2

Ikeda, Y., Sugawara, A., Taniyama, Y., Uruno, A., Igarashi, K., Arima, S., Ito, S., & Takeuchi, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002319200 · Cited by 100

Complexity of CNC Transcription Factors As Revealed by Gene Targeting of the Nrf3 Locus

Derjuga, A., Gourley, T. S., Holm, T. M., Heng, H. H. Q., Shivdasani, R. A., Ahmed, R., Andrews, N. C., & Blank, V. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.8.3286-3294.2004 · Cited by 100

Amyotrophic lateral sclerosis: A 40-year personal perspective

Eisen, A. (2009) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2008.07.072 · Cited by 99

Activation of Nrf2 and accumulation of ubiquitinated A170 by arsenic in osteoblasts

Aono, J., Yanagawa, T., Itoh, K., Li, B., Yoshida, H., Kumagai, Y., Yamamoto, M. P., & Ishii, T. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00728-9 · Cited by 99

Novel cytoprotective mechanism of anti-parkinsonian drug deprenyl: PI3K and Nrf2-derived induction of antioxidative proteins

Nakaso, K., Nakamura, C., Sato, H., Imamura, K., Takeshima, T., & Nakashima, K. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.11.095 · Cited by 99

Cul3 overexpression depletes Nrf2 in breast cancer and is associated with sensitivity to carcinogens, to oxidative stress, and to chemotherapy

Loignon, M., Miao, W., Hu, L., Bier, A., Bismar, T. A., Scrivens, P. J., Mann, K. K., Basik, M., Bouchard, A., Fiset, P., et al. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-1186 · Cited by 99

Induction of Heme Oxygenase-1 (HO-1) and NAD[P]H: Quinone Oxidoreductase 1 (NQO1) by a Phenolic Antioxidant, Butylated Hydroxyanisole (BHA) and Its Metabolite, tert-Butylhydroquinone (tBHQ) in Primary-Cultured Human and Rat Hepatocytes

Keum, Y., Han, Y., Liew, C. V., Kim, J. H., Xu, C., Yuan, X., Shakarjian, M. P., Chong, S., & Kong, A. T. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-9094-2 · Cited by 98

Ascorbic acid restores sensitivity to imatinib via suppression of Nrf2-dependent gene expression in the imatinib-resistant cell line

Tarumoto, T., Nagai, T., Ohmine, K., Miyoshi, T., Nakamura, M., Kondo, T., Mitsugi, K., Nakano, S., Muroi, K., Komatsu, N., et al. (2004) · Experimental Hematology · doi:10.1016/j.exphem.2004.01.007 · Cited by 97

Oxidative damage to the promoter region of SQSTM1/p62 is common to neurodegenerative disease

Du, Y., Wooten, M. C., & Wooten, M. W. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.05.015 · Cited by 96

Activating Transcription Factor 3 Is a Novel Repressor of the Nuclear Factor Erythroid-Derived 2–Related Factor 2 (Nrf2)–Regulated Stress Pathway

Brown, S. L., Sekhar, K. R., Rachakonda, G., Sasi, S., & Freeman, M. L. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2170 · Cited by 95

Nrf2 Possesses a Redox-insensitive Nuclear Export Signal Overlapping with the Leucine Zipper Motif

Li, W., Jain, M. R., Chen, C., Yue, X., Hebbar, V., Zhou, R., & Kong, A.-N. T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410601200 · Cited by 95

Crucial role of nrf3 in smooth muscle cell differentiation from stem cells

Pepe, A. E., Xiao, Q., Zampetaki, A., Zhang, Z., Kobayashi, A., Hu, Y., & Xu, Q. (2010) · Circulation Research · doi:10.1161/circresaha.109.211417 · Cited by 94

Activation of Maf/AP-1 Repressor Bach2 by Oxidative Stress Promotes Apoptosis and Its Interaction with Promyelocytic Leukemia Nuclear Bodies

Muto, A., Tashiro, S., Tsuchiya, H., Kume, A., Kanno, M., Ito, E., Yamamoto, M. P., & Igarashi, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112003200 · Cited by 92

Flunarizine induces Nrf2-mediated transcriptional activation of heme oxygenase-1 in protection of auditory cells from cisplatin

So, H.-S., Kim, H.-J., Lee, J.-H., Lee, J.-H., Sy, P., Park, C., Kim, Y.-H., Jk, K., Lee, K.-M., Kim, K.-S., et al. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401863 · Cited by 89

Nrf2 activation by sulforaphane restores the age-related decrease of TH1 immunity: Role of dendritic cells

Kim, H., Barajas, B., Wang, M., & Nel, A. E. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.01.016 · Cited by 89

Nrf1 in a complex with fosB, c-jun, junD and ATF2 forms the AP1 component at the TNF promoter in stimulated mast cells

Novotny, V., Prieschl, E. E., Csonga, R., Fabjani, G., & Baumruker, T. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.23.5480 · Cited by 88

Altered Disposition of Acetaminophen in Nrf2-null and Keap1-knockdown Mice

Reisman, S. A., Csanaky, I. L., Aleksunes, L. M., & Klaassen, C. D. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp047 · Cited by 87

The relationship between Helicobacter pylori infection and promoter polymorphism of the Nrf2 gene in chronic gastritis

Arisawa, T., Tahara, T., Shibata, T., Nagasaka, M., Nakamura, M., Kamiya, Y., Fujita, H., Hasegawa, S., Takagi, T., Wang, F.-Y., et al. (2007) · International Journal of Molecular Medicine · doi:10.3892/ijmm.19.1.143 · Cited by 82

Activation of the Nrf2–ARE pathway in muscle and spinal cord during ALS-like pathology in mice expressing mutant SOD1

Kraft, A. D., Resch, J. M., JOHNSON, D., & JOHNSON, J. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.05.026 · Cited by 82

Simvastatin activates Keap1/Nrf2 signaling in rat liver

Habeos, I. G., Ziros, P. G., Chartoumpekis, D. V., Psyrogiannis, A. I., Kyriazopoulou, V. E., & Papavassiliou, A. G. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0393-4 · Cited by 78

c-Maf negatively regulates ARE-mediated detoxifying enzyme genes expression and anti-oxidant induction

Dhakshinamoorthy, S., & Jaiswal, A. K. (2002) · Oncogene · doi:10.1038/sj.onc.1205642 · Cited by 77

Repression of cancer protective genes by 17β-estradiol: Ligand-dependent interaction between human Nrf2 and estrogen receptor α

Ansell, P. J., Lo, S.-C., Newton, L. G., Espinosa-Nicholas, C., Zhang, D. D., Liu, J.-H., Hannink, M., & Lubahn, D. B. (2005) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.08.002 · Cited by 75

Nrf2 activity is lost in the spinal cord and its astrocytes of aged mice

Duan, W., Zhang, R., Guo, Y., Jiang, Y., Huang, Y., Jiang, H., & Li, C. (2009) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-009-9194-5 · Cited by 75

The Nrf3 Transcription Factor Is a Membrane-bound Glycoprotein Targeted to the Endoplasmic Reticulum through Its N-terminal Homology Box 1 Sequence

Zhang, Y., Kobayashi, A., Yamamoto, M. P., & Hayes, J. D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805337200 · Cited by 75

The Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by t-butyl hydroquinone but not by endoplasmic reticulum stressors

Zhang, Y., Lucocq, J. M., & Hayes, J. D. (2008) · Biochemical Journal · doi:10.1042/bj20081575 · Cited by 72

Activation of SKN-1 by novel kinases in Caenorhabditis elegans

Kell, A. M., Ventura, N., Kahn, N., & Johnson, T. E. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.08.025 · Cited by 72

Nrf2 gene promoter polymorphism is associated with ulcerative colitis in a Japanese population.

Arisawa, T., Tahara, T., Shibata, T., Nagasaka, M., Nakamura, M., Kamiya, Y., Fujita, H., Yoshioka, D., Okubo, M., Sakata, M., et al. (2008) · PubMed · Cited by 71

The Triterpenoid CDDO-Imidazolide Confers Potent Protection against Hyperoxic Acute Lung Injury in Mice

Reddy, N. M., Vegiraju, S., Yates, M. S., Kleeberger, S. R., Hassoun, P. M., Yamamoto, M. P., Liby, K. T., Sporn, M. B., Kensler, T. W., & Reddy, S. P. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200905-0670oc · Cited by 70

The p65 Isoform of Nrf1 Is a Dominant Negative Inhibitor of ARE-mediated Transcription

Wang, W., Kwok, A. M., & Chan, J. Y. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700159200 · Cited by 68

A cap ‘n’ collar protein isoform contains a selective Hox repressor function

McGinnis, N., Ragnhildstveit, E., Veraksa, A. N., & McGinnis, W. J. (1998) · Development · doi:10.1242/dev.125.22.4553 · Cited by 68

The susceptibility to vitiligo is associated with NF‐E2‐related factor2 (Nrf2) gene polymorphisms: a study on Chinese Han population

Guan, C., Zhou, M., Xu, A., Kang, K., Liu, J., Wei, X., Li, Y., Zhao, D., & Hong, W. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00752.x · Cited by 67

Erythroid Maturation and Globin Gene Expression in Mice With Combined Deficiency of NF-E2 and Nrf-2

Martin, F., van Deursen, J. M., Shivdasani, R. A., Jackson, C. W., Troutman, A. G., & Ney, P. A. (1998) · Blood · doi:10.1182/blood.v91.9.3459 · Cited by 63

Chromosomal localization of the human NF-E2 family of bZIP transcription factors by fluorescence in situ hybridization

Chan, J. Y., Cheung, M., Moi, P., Chan, K., & Kan, Y. (1995) · Human Genetics · doi:10.1007/bf00225191 · Cited by 61

Cap ‘n’ collar B cooperates with a small Maf subunit to specify pharyngeal development and suppress Deformed homeotic function in the Drosophila head

Veraksa, A. N., McGinnis, N., Li, X., Mohler, J., & McGinnis, W. J. (2000) · Development · doi:10.1242/dev.127.18.4023 · Cited by 61

Toxicogenomics of endoplasmic reticulum stress inducer tunicamycin in the small intestine and liver of Nrf2 knockout and C57BL/6J mice

Nair, S., XU, C., Shen, G., Hebbar, V., Gopalakrishnan, A., Hu, R., JAIN, M., Liew, C. V., CHAN, J., & KONG, A. (2006) · Toxicology Letters · doi:10.1016/j.toxlet.2006.10.012 · Cited by 60

Caloric Restriction and Experimental Carcinogenesis

Kritchevsky, D. (2002) · Hybridoma and Hybridomics · doi:10.1089/153685902317401753 · Cited by 56

Identification of NRF2, a member of the NF-E2 family of transcription factors, as a substrate for caspase-3(-like) proteases

Ohtsubo, T., Kamada, S., Mikami, T., Murakami, H., & Tsujimoto, Y. (1999) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400566 · Cited by 55

Role of Gα12 and Gα13 as Novel Switches for the Activity of Nrf2, a Key Antioxidative Transcription Factor

Cho, M. K., Kim, W., Ki, S. H., Hwang, J., Choi, S., Lee, C. H., & Kim, S. G. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02065-06 · Cited by 54

ERRβ: A potent inhibitor of Nrf2 transcriptional activity

Zhou, W., Lo, S., Liu, J.-H., Hannink, M., & Lubahn, D. B. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.08.011 · Cited by 53

Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population

Siedliński, M., Postma, D. S., Boer, J. M. A., van der Steege, G., Schouten, J. P., Smit, H. A., & Boezen, H. M. (2009) · Respiratory Research · doi:10.1186/1465-9921-10-73 · Cited by 51

Repression of PML Nuclear Body-Associated Transcription by Oxidative Stress-Activated Bach2

Tashiro, S., Muto, A., Tanimoto, K., Tsuchiya, H., Suzuki, H., Hoshino, H., Yoshida, M., Walter, J. K., & Igarashi, K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.8.3473-3484.2004 · Cited by 51

Functional and Placental Expression Analysis of the Human NRF3 Transcription Factor

Chénais, B., Derjuga, A., Massrieh, W., Red‐Horse, K., Bellingard, V., Fisher, S. J., & Blank, V. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0379 · Cited by 50

Adenosine induces hemeoxygenase‐1 expression in microglia through the activation of phosphatidylinositol 3‐kinase and nuclear factor E2‐related factor 2

Min, K., Kim, J.-H., Jou, I., & Joe, E.-H. (2008) · Glia · doi:10.1002/glia.20676 · Cited by 47

The role of c-Jun phosphorylation in EpRE activation of phase II genes

Levy, S., Jaiswal, A. K., & Forman, H. J. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.07.036 · Cited by 45

Endoplasmic reticulum association and N‐linked glycosylation of the human Nrf3 transcription factor

Nouhi, Z., Chevillard, G., Derjuga, A., & Blank, V. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.10.041 · Cited by 44

DJ-1 Changes in G93A-SOD1 Transgenic Mice: Implications for Oxidative Stress in ALS

Lev, N., Ickowicz, D., Barhum, Y., Melamed, E., & Offen, D. (2008) · Journal of Molecular Neuroscience · doi:10.1007/s12031-008-9138-7 · Cited by 42

PIAS3 Interacts with ATF1 and Regulates the Human Ferritin H Gene through an Antioxidant-responsive Element

Iwasaki, K., Hailemariam, K., & Tsuji, Y. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701477200 · Cited by 41

Renal protection by 3H-1,2-dithiole-3-thione against cisplatin through the Nrf2-antioxidant pathway

Park, H.-M., Cho, J., Lee, H., Shim, G.-S., & Kwak, M. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.06.021 · Cited by 39

Role of a fetal defence mechanism against oxidative stress in the aetiology of preeclampsia

Wruck, C. J., Huppertz, B., Bose, P., Brandenburg, L., Pufe, T., & Kadyrov, M. (2009) · Histopathology · doi:10.1111/j.1365-2559.2009.03339.x · Cited by 38

Ablation of Nrf2 Function Does Not Increase the Erythroid or Megakaryocytic Cell Lineage Dysfunction Caused by p45 NF-E2 Gene Disruption

Kuroha, T., Takahashi, S., Komeno, T., Itoh, K., Nagasawa, T., & Yamamoto, M. (1998) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021947 · Cited by 38

Reactive Oxygen Species and Aging: Evolving Questions

Dugan, L. L., & Quick, K. L. (2005) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2005.26.pe20 · Cited by 34

Fetal Alz-50 Clone 1 Interacts with the Human Orthologue of the Kelch-like Ech-Associated Protein

Strachan, G. D., Morgan, K. L., Otis, L. L., Caltagarone, J., Gittis, A. H., Bowser, R. P., & Jordan‐Sciutto, K. L. (2004) · Biochemistry · doi:10.1021/bi0494166 · Cited by 34

Specific cleavage of DJ-1 under an oxidative condition

Ooe, H., Maita, C., Maita, H., Iguchi‐Ariga, S. M. M., & Ariga, H. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.06.067 · Cited by 26

Alzheimer’s Disease: What Multiphoton Microscopy Teaches Us

Bacskai, B. J., & Hyman, B. T. (2002) · The Neuroscientist · doi:10.1177/107385802236963 · Cited by 25

Modulating Longevity in Drosophila by Over‐ and Underexpression of Glutamate‐Cysteine Ligase

Luchak, J. M., Prabhudesai, L., Sohal, R. S., Radyuk, S. N., & Orr, W. C. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1404.000 · Cited by 22

Nrf2 Activation Enhances Biliary Excretion of Sulfobromophthalein by Inducing Glutathione-S-Transferase Activity

Reisman, S. A., Csanaky, I. L., Yeager, R. L., & Klaassen, C. D. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp045 · Cited by 21

Lower Expression of Nrf2 MRNA in Older Donor Livers: A Possible Contributor to Increased Ischemia–Reperfusion Injury?

Zaman, M. B., Leonard, M. O., Ryan, E. J., Nolan, N. P., Hoti, E., Maguire, D., Mulcahy, H. E., Traynor, O., Taylor, C. T., Hegarty, J. E., et al. (2007) · Transplantation · doi:10.1097/01.tp.0000288229.53064.e2 · Cited by 20

Association between promoter polymorphisms of nuclear factor-erythroid 2-related factor 2 gene and peptic ulcer diseases

Arisawa, T., Tahara, T., Shibata, T., Nagasaka, M., Nakamura, M., Kamiya, Y., Fujita, H., Yoshioka, D., Arima, Y., Okubo, M., et al. (2007) · International Journal of Molecular Medicine · doi:10.3892/ijmm.20.6.849 · Cited by 20

Disruption of the Keap1-Containing Ubiquitination Complex as an Antioxidant Therapy

Kern, J. T., Hannink, M., & Hess, J. F. (2007) · Current Topics in Medicinal Chemistry · doi:10.2174/156802607780906825 · Cited by 17

Pharmacokinetics and Therapeutic Effects of Oltipraz after Consecutive or Intermittent Oral Administration in Rats with Liver Cirrhosis Induced by Dimethylnitrosamine

Bae, S. K., Lee, S. J., Kim, T., Kim, J. W., Lee, I., Kim, S. G., & Lee, M. G. (2006) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20597 · Cited by 15

Phase 2 Protein Inducers in the Diet Promote Healthier Aging

Noyan-Ashraf, M. H., Sadeghinejad, Z., Davies, G. F., Ross, A. R. S., Saucier, D. M., Harkness, T. A. A., & Juurlink, B. H. J. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.11.1168 · Cited by 7

Reduced Nrf2 and Phase II enzymes expression in immune-mediated spinal cord motor neuron injury

Guo, Y., Liu, Y., Xu, L., Wu, D., Wu, H., & Li, C. (2009) · Neurological Research · doi:10.1179/174313209x385563 · Cited by 6

Ultrastructural evidence of neurofilament involvement in immune-mediated motor neuron injury

Liu, Y., Guo, Y., Xu, L., Wu, S., Wu, D., Yang, C., & Li, C. (2008) · Neurological Research · doi:10.1179/016164108x323780 · Cited by 1

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

Łoboda, A., Damulewicz, M., Pyza, E., Józkowicz, A., & Dulak, J. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2223-0 · Cited by 2,709

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

Hayes, J. D., & Dinkova‐Kostova, A. T. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.02.002 · Cited by 2,210

Selective autophagy mediated by autophagic adapter proteins

Johansen, T., & Lamark, T. (2011) · Autophagy · doi:10.4161/auto.7.3.14487 · Cited by 1,788

The Biology of Proteostasis in Aging and Disease

Labbadia, J., & Morimoto, R. I. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-033955 · Cited by 1,472

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

Lei, G., Zhang, Y., Koppula, P., Liu, X., Zhang, J., Lin, S. H., Ajani, J. A., Xiao, Q., Liao, Z., Wang, H., et al. (2020) · Cell Research · doi:10.1038/s41422-019-0263-3 · Cited by 1,318

Preserving transcriptional stress responses as an anti‐aging strategy

Cheng, Y., Pitoniak, A., Wang, J., & Bohmann, D. (2021) · Aging Cell · doi:10.1111/acel.13297 · Cited by 16

Mechanisms and functions of Nrf2 signaling in Drosophila

Pitoniak, A., & Bohmann, D. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.020 · Cited by 129

SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans

Blackwell, T. K., Steinbaugh, M. J., Hourihan, J. M., Ewald, C. Y., & Isik, M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.008 · Cited by 622

Declining signal dependence of Nrf2‐ Maf S ‐regulated gene expression correlates with aging phenotypes

Rahman, M. M., Sykiotis, G. P., Nishimura, M., Bodmer, R., & Bohmann, D. (2013) · Aging Cell · doi:10.1111/acel.12078 · Cited by 100

Drosophila Nrf2/Keap1 Mediated Redox Signaling Supports Synaptic Function and Longevity and Impacts on Circadian Activity

Spiers, J. G., Breda, C., Robinson, S., Giorgini, F., & Steinert, J. R. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00086 · Cited by 40