Crucial role of nrf3 in smooth muscle cell differentiation from stem cells

Atherosclerosis--an inflammatory disease

Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725 · see citing works

Regulation of differentiation of vascular smooth muscle cells

Owens, G. K. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.3.487 · Cited by 1,732 · see citing works

Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors

Yamashita, J. K., Itoh, H., Hirashima, M., Ogawa, M., Nishikawa, S., Yurugi, T., Naito, M., Nakao, K., & Nishikawa, S.-I. (2000) · Nature · doi:10.1038/35040568 · Cited by 1,345 · see citing works

ER stress and diseases

Yoshida, H. (2007) · The FEBS Journal · doi:10.1111/j.1742-4658.2007.05639.x · Cited by 1,086 · see citing works

Activation of Cardiac Gene Expression by Myocardin, a Transcriptional Cofactor for Serum Response Factor

Wang, D.-Z., Chang, P. S., Wang, Z., Sutherland, L. B., Richardson, J. A., Small, E. M., Krieg, P. A., & Olson, E. N. (2001) · Cell · doi:10.1016/s0092-8674(01)00404-4 · Cited by 898 · see citing works

Abundant progenitor cells in the adventitia contribute to atherosclerosis of vein grafts in ApoE-deficient mice

Hu, Y., Zhang, Z., Torsney, E., Afzal, A. R., Davison, F. D., Metzler, B., & Xu, Q. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19628 · Cited by 680 · see citing works

Erythroid transcription factor NF-E2 is a haematopoietic-specific basic–leucine zipper protein

Andrews, N. C., Erdjument‐Bromage, H., Davidson, M. B., Tempst, P., & Orkin, S. H. (1993) · Nature · doi:10.1038/362722a0 · Cited by 637 · see citing works

Serum response factor: toggling between disparate programs of gene expression

Miano, J. M. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00110-x · Cited by 588 · see citing works

Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression

Wang, Z., Wang, D.-Z., Hockemeyer, D. F., McAnally, J., Nordheim, A., & Olson, E. N. (2004) · Nature · doi:10.1038/nature02382 · Cited by 562 · see citing works

Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers

Forman, H. J., Fukuto, J. M., & Torrès, M. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00516.2003 · Cited by 526 · see citing works

Smooth Muscle Progenitor Cells in Human Blood

Simper, D., Stalboerger, P. G., Panetta, C. J., Wang, S., & Caplice, N. M. (2002) · Circulation · doi:10.1161/01.cir.0000031525.61826.a8 · Cited by 495 · see citing works

Circulating endothelial precursors: mystery, reality, and promise

Rafii, S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8774 · Cited by 434 · see citing works

Reactive oxygen species signaling in vascular smooth muscle cells

Clempus, R. E., & Griendling, K. K. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.02.033 · Cited by 358 · see citing works

Activation of an Unfolded Protein Response during Differentiation of Antibody-secreting B Cells

Gass, J. N., Gifford, N. M., & Brewer, J. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205011200 · Cited by 306 · see citing works

Molecular Cloning and Functional Characterization of a New Cap'n' Collar Family Transcription Factor Nrf3

Kobayashi, A., Ito, E., Toki, T., Kogame, K., Takahashi, S., Igarashi, K., Hayashi, N., & Yamamoto, M. P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6443 · Cited by 299 · see citing works

Control of SRF binding to CArG box chromatin regulates smooth muscle gene expression in vivo

McDonald, O. G. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26505 · Cited by 284 · see citing works

HDAC3 is crucial in shear- and VEGF-induced stem cell differentiation toward endothelial cells

Zeng, L., Xiao, Q., Margariti, A., Zhang, Z., Zampetaki, A., Patel, S. V., Capogrossi, M. C., Hu, Y., & Xu, Q. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200605113 · Cited by 251 · see citing works

Circulating Progenitor Cells Regenerate Endothelium of Vein Graft Atherosclerosis, Which Is Diminished in ApoE-Deficient Mice

Xu, Q., Zhang, Z., Davison, F. D., & Hu, Y. (2003) · Circulation Research · doi:10.1161/01.res.0000097864.24725.60 · Cited by 193 · see citing works

Embryonic stem cell differentiation into smooth muscle cells is mediated by Nox4-produced H2O2

Xiao, Q., Luo, Z., Pepe, A. E., Margariti, A., Zeng, L., & Xu, Q. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00442.2008 · Cited by 184 · see citing works

Sphingosylphosphorylcholine induces differentiation of human mesenchymal stem cells into smooth-muscle-like cells through a TGF-β-dependent mechanism

Jeon, E. S., Moon, H. J., Lee, M. J., Song, H. Y., Kim, Y. M., Bae, Y. C., Jung, J. S., & Kim, J. H. (2006) · Journal of Cell Science · doi:10.1242/jcs.03281 · Cited by 162 · see citing works

Oxidant stress stimulates expression of the human peroxiredoxin 6 gene by a transcriptional mechanism involving an antioxidant response element

Chowdhury, I., Mo, Y., Gao, L., Kazi, A. S., Fisher, A. B., & Feinstein, S. I. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.09.027 · Cited by 159 · see citing works

Stem cell-derived Sca-1+ progenitors differentiate into smooth muscle cells, which is mediated by collagen IV-integrin α1/β1/αv and PDGF receptor pathways

Xiao, Q., Zeng, L., Zhang, Z., Hu, Y., & Xu, Q. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00341.2006 · Cited by 128 · see citing works

Sca-1 + Progenitors Derived From Embryonic Stem Cells Differentiate Into Endothelial Cells Capable of Vascular Repair After Arterial Injury

Xiao, Q., Zeng, L., Zhang, Z., Margariti, A., Ali, Z. A., Channon, K. M., Xu, Q., & Hu, Y. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000240251.50215.50 · Cited by 126 · see citing works

Endoplasmic reticulum stress increases myofiber formation in vitro

Nakanishi, K., Dohmae, N., & Morishima, N. (2007) · The FASEB Journal · doi:10.1096/fj.06-6408com · Cited by 121 · see citing works

Nrf3 Negatively Regulates Antioxidant-response Element-mediated Expression and Antioxidant Induction of NAD(P)H:Quinone Oxidoreductase1 Gene

Kannan, S., & Jaiswal, A. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404984200 · Cited by 114 · see citing works

Multiple Signals Induce Endoplasmic Reticulum Stress in Both Primary and Immortalized Chondrocytes Resulting in Loss of Differentiation, Impaired Cell Growth, and Apoptosis

Yang, L., Carlson, S. G., McBurney, D. L., & Horton, W. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501069200 · Cited by 106 · see citing works

Complexity of CNC Transcription Factors As Revealed by Gene Targeting of the <i>Nrf3</i> Locus

Derjuga, A., Gourley, T. S., Holm, T. M., Heng, H. H. Q., Shivdasani, R. A., Ahmed, R., Andrews, N. C., & Blank, V. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.8.3286-3294.2004 · Cited by 100 · see citing works

CCAAT/Enhancer Binding Protein Homologous Protein (DDIT3) Induces Osteoblastic Cell Differentiation

Pereira, R. C., Delany, A. M., & CANALIS, E. M. (2003) · Endocrinology · doi:10.1210/en.2003-0868 · Cited by 98 · see citing works

Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation

Long, X., Creemers, E. E., Wang, D.-Z., Olson, E. N., & Miano, J. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708253104 · Cited by 96 · see citing works

The role of smooth muscle cells in atherosclerosis

Campbell, J. H., & CAMPBELL, G. R. (1994) · Current Opinion in Lipidology · doi:10.1097/00041433-199410000-00003 · Cited by 89 · see citing works

Strong Smooth Muscle Differentiation Is Dependent on Myocardin Gene Amplification in Most Human Retroperitoneal Leiomyosarcomas

Pérot, G., Derré, J., Coindre, J., Tirode, F., Lucchesi, C., Mariani, O., Gibault, L., Guillou, L., Terrier, P., & Aurias, A. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-1443 · Cited by 79 · see citing works

Splicing of HDAC7 modulates the SRF-myocardin complex during stem-cell differentiation towards smooth muscle cells

Margariti, A., Xiao, Q., Zampetaki, A., Zhang, Z., Li, H., Martin, D., Hu, Y., Zeng, L., & Xu, Q. (2009) · Journal of Cell Science · doi:10.1242/jcs.034850 · Cited by 76 · see citing works

The Nrf3 Transcription Factor Is a Membrane-bound Glycoprotein Targeted to the Endoplasmic Reticulum through Its N-terminal Homology Box 1 Sequence

Zhang, Y., Kobayashi, A., Yamamoto, M. P., & Hayes, J. D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805337200 · Cited by 74 · see citing works

Induction of unfolded protein response during neuronal induction of rat bone marrow stromal cells and mouse embryonic stem cells

Cho, Y. M., Jang, Y.-S., Jang, Y. M., Chung, S.-M., Kim, H.-S., Lee, J. H., Jeong, S., Kim, I.-K., Kim, J. J., Kim, K. S., et al. (2009) · Experimental & Molecular Medicine · doi:10.3858/emm.2009.41.6.049 · Cited by 58 · see citing works

Novel Interaction between the Transcription Factor CHOP (GADD153) and the Ribosomal Protein FTE/S3a Modulates Erythropoiesis

Cui, K., Coutts, M., Stahl, J., & Sytkowski, A. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.11.7591 · Cited by 53 · see citing works

Functional and Placental Expression Analysis of the Human NRF3 Transcription Factor

Chénais, B., Derjuga, A., Massrieh, W., Red‐Horse, K., Bellingard, V., Fisher, S. J., & Blank, V. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0379 · Cited by 50 · see citing works

The origin of post-injury neointimal cells in the rat balloon injury model

Rodriguez-Menocal, L., St-Pierre, M., Wei, Y., Khan, S. J., Mateu, D., Calfa, M., Rahnemai‐Azar, A. A., Striker, G. E., Pham, S. M., & Vázquez-Padrón, R. I. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn265 · Cited by 43 · see citing works

Endoplasmic reticulum association and N‐linked glycosylation of the human Nrf3 transcription factor

Nouhi, Z., Chevillard, G., Derjuga, A., & Blank, V. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.10.041 · Cited by 43 · see citing works

Proteomic analysis reveals higher demand for antioxidant protection in embryonic stem cell‐derived smooth muscle cells

Yin, X., Mayr, M., Xiao, Q., Wang, W., & Xu, Q. (2006) · PROTEOMICS · doi:10.1002/pmic.200600351 · Cited by 29 · see citing works

Lacking cytokine production in ES cells and ES-cell-derived vascular cells stimulated by TNF-α is rescued by HDAC inhibitor trichostatin A

Zampetaki, A., Zeng, L., Xiao, Q., Margariti, A., Hu, Y., & Xu, Q. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00152.2007 · Cited by 27 · see citing works

The cap 'n' collar family member NF-E2-related factor 3 (Nrf3) is expressed in mesodermal derivatives of the avian embryo

Etchevers, H. (2005) · The International Journal of Developmental Biology · doi:10.1387/ijdb.041942he · Cited by 14 · see citing works

Role of nrf2 in oxidative stress and toxicity

Ma, Q. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140320 · Cited by 4,903 · see citing works

Stress-activated cap’n’collar transcription factors in aging and human disease

Sykiotis, G. P., & Bohmann, D. (2010) · Science Signaling · doi:10.1126/scisignal.3112re3 · Cited by 776 · see citing works

Antioxidant response elements: Discovery, classes, regulation and potential applications

Raghunath, A., Sundarraj, K., Raju, N., Arfuso, F., Bian, J., Kumar, A. P., Sethi, G., & Perumal, E. (2018) · Redox Biology · doi:10.1016/j.redox.2018.05.002 · Cited by 470 · see citing works

Reactive oxygen species: key regulators in vascular health and diseases

Chen, Q., Wang, Q., Zhu, J., Xiao, Q., & Zhang, L. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13828 · Cited by 344 · see citing works

Origin and differentiation of vascular smooth muscle cells

Wang, G., Jacquet, L., Karamariti, E., & Xu, Q. (2015) · The Journal of Physiology · doi:10.1113/jp270033 · Cited by 300 · see citing works

Reactive Oxygen Species Generation and Atherosclerosis

Nowak, W. N., Deng, J., Ruan, X. Z., & Xu, Q. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309228 · Cited by 179 · see citing works

Myocardin in biology and disease

Miano, J. M. (2015) · Journal of Biomedical Research · doi:10.7555/jbr.29.20140151 · Cited by 145 · see citing works

Resident vascular progenitor cells

Torsney, E., & Xu, Q. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.09.006 · Cited by 136 · see citing works

Nox, Reactive Oxygen Species and Regulation of Vascular Cell Fate

Burtenshaw, D., Hakimjavadi, R., Redmond, E. M., & Cahill, P. A. (2017) · Antioxidants · doi:10.3390/antiox6040090 · Cited by 136 · see citing works

NFE2L3 (NRF3): the Cinderella of the Cap‘n’Collar transcription factors

Chevillard, G., & Blank, V. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0747-x · Cited by 101 · see citing works

Smooth Muscle Cell Differentiation In Vitro

Xie, C., Ritchie, R. P., Huang, H., Zhang, J., & Chen, Y. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.221101 · Cited by 98 · see citing works

Smooth Muscle Cell Differentiation: Model Systems, Regulatory Mechanisms, and Vascular Diseases

Shi, N., & Chen, S. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25208 · Cited by 97 · see citing works

Adventitial Stem Cells in Vein Grafts Display Multilineage Potential That Contributes to Neointimal Formation

Chen, Y., Wong, M. M., Campagnolo, P., Simpson, R., Winkler, B. M., Margariti, A., Hu, Y., & Xu, Q. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.300902 · Cited by 97 · see citing works

Smooth Muscle Cells Differentiated From Reprogrammed Embryonic Lung Fibroblasts Through DKK3 Signaling Are Potent for Tissue Engineering of Vascular Grafts

Karamariti, E., Margariti, A., Winkler, B. M., Wang, X., Hong, X., Baban, D. F., Ragoussis, J., Huang, Y. C., Han, J. J., Wong, M. M., et al. (2013) · Circulation Research · doi:10.1161/circresaha.111.300415 · Cited by 91 · see citing works

Pluripotent stem cell differentiation into vascular cells: A novel technology with promises for vascular re(generation)

Kane, N. M., Xiao, Q., Baker, A. H., Luo, Z., Xu, Q., & Emanueli, C. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.10.004 · Cited by 89 · see citing works

The Generation, Detection, and Effects of Reactive Drug Metabolites

Stachulski, A. V., Baillie, T. A., Park, B. K., Obach, R. S., Dalvie, D., Williams, D. P., Srivastava, A., Regan, S., Antoine, D. J., Goldring, C. E., et al. (2012) · Medicinal Research Reviews · doi:10.1002/med.21273 · Cited by 88 · see citing works

Reactive Oxygen Species in Vascular Formation and Development

Zhou, Y., Yan, H. M., Guo, M., Zhu, J., Xiao, Q., & Zhang, L. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/374963 · Cited by 85 · see citing works

Differential and overlapping targets of the transcriptional regulators NRF1, NRF2, and NRF3 in human cells

Liu, P., Kerins, M. J., Tian, W., Neupane, D., Zhang, D. D., & Ooi, A. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009591 · Cited by 82 · see citing works

Cellular stress responses and dysfunctional Mitochondrial–cellular senescence, and therapeutics in chronic respiratory diseases

Manevski, M., Muthumalage, T., Devadoss, D., Sundar, I. K., Wang, Q., Singh, K. P., Unwalla, H. J., Chand, H. S., & Rahman, I. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101443 · Cited by 83 · see citing works

Keap1/Nrf2/ARE redox-sensitive signaling system as a pharmacological target

Зенков, Н. К., Брониславовна, М. Е., & Tkachev, V. (2013) · Biochemistry (Moscow) · doi:10.1134/s0006297913010033 · Cited by 81 · see citing works

Epigenetic mechanisms regulate NADPH oxidase-4 expression in cellular senescence.

Sanders, Y., Liu, H., Liu, G., & Thannickal, V. (2015) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2014.12.008 · Cited by 77 · see citing works

Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells

Yu, X., Zhang, L., Wen, G., Zhao, H., Luong, L. A., Chen, Q., Huang, Y., Zhu, J., Ye, S., Xu, Q., et al. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.206 · Cited by 79 · see citing works

MicroRNA-22 Regulates Smooth Muscle Cell Differentiation From Stem Cells by Targeting Methyl CpG–Binding Protein 2

Zhao, H., Wen, G., Huang, Y., Yu, X., Chen, Q., Afzal, T. A., Luong, L. A., Zhu, J., Ye, S., Zhang, L., et al. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.305212 · Cited by 74 · see citing works

Novel Therapeutic Effects of Leonurine On Ischemic Stroke: New Mechanisms of BBB Integrity

Zhang, Q.-Y., Wang, Z., Sun, D.-M., Wang, Y., Xu, P., Wu, W., Liu, X., & Zhu, Y. Z. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7150376 · Cited by 74 · see citing works

The dual role of mir-146a in metastasis and disease progression

Alipour, S., Shiva, G. G.-A., Babaei, G., Jeddi, F., Hosein, A., & Parsa, H. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110099 · Cited by 63 · see citing works

MicroRNA-200C and -150 play an important role in endothelial cell differentiation and vasculogenesis by targeting transcription repressor ZEB1

Luo, Z., Wen, G., Wang, G., Pu, X., Ye, S., Xu, Q., Wang, W., & Xiao, Q. (2013) · Stem Cells · doi:10.1002/stem.1448 · Cited by 62 · see citing works

Nrf3-Pla2g7 interaction plays an essential role in smooth muscle differentiation from stem cells

Xiao, Q., Pepe, A. E., Wang, G., Luo, Z., Zhang, L., Zeng, L., Zhang, Z., Hu, Y., Ye, S., & Xu, Q. (2012) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.111.243188 · Cited by 56 · see citing works

Developmental Expression of the Nfe2-Related Factor (Nrf) Transcription Factor Family in the Zebrafish, Danio rerio

Williams, L., Timme‐Laragy, A. R., Goldstone, J. V., McArthur, A. G., Stegeman, J. J., Smolowitz, R. M., & Hahn, M. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079574 · Cited by 52 · see citing works

A far-upstream AP-1/Smad binding box regulates human NOX4 promoter activation by transforming growth factor-β

Bai, G., Hock, T., Logsdon, N. J., Zhou, Y., & Thannickal, V. J. (2014) · Gene · doi:10.1016/j.gene.2014.02.026 · Cited by 52 · see citing works

Differentiation and Application of Induced Pluripotent Stem Cell–Derived Vascular Smooth Muscle Cells

Maguire, E. M., Xiao, Q., & Xu, Q. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309196 · Cited by 52 · see citing works

Nrf3-mediated mitochondrial superoxide promotes cardiomyocyte apoptosis and impairs cardiac functions by suppressing Pitx2

Chen, Q., Zheng, A., Xu, X., Shi, Z., Yang, M., Sun, S., Wang, L., Wang, Y., Zhao, H., Xiao, Q., et al. (2025) · Circulation · doi:10.1161/circulationaha.124.070286 · Cited by 54 · see citing works

Dual Oxidase Maturation factor 1 (DUOXA1) overexpression increases reactive oxygen species production and inhibits murine muscle satellite cell differentiation

Sandiford, S. D. E., Kennedy, K. A., Xie, X., Pickering, J. G., & Li, S. S.-C. (2014) · Cell Communication and Signaling · doi:10.1186/1478-811x-12-5 · Cited by 50 · see citing works

Vascular differentiation from embryonic stem cells: Novel technologies and therapeutic promises

Descamps, B., & Emanueli, C. (2012) · Vascular Pharmacology · doi:10.1016/j.vph.2012.03.007 · Cited by 48 · see citing works

Nfe2l3 (Nrf3) deficiency predisposes mice to T-cell lymphoblastic lymphoma

Chevillard, G., Paquet, M., & Blank, V. (2010) · Blood · doi:10.1182/blood-2010-02-271460 · Cited by 48 · see citing works

Elevated expression of NFE2L3 predicts the poor prognosis of pancreatic cancer patients

Wang, H., Zhan, M., Yang, R., Shi, Y., Liu, Q., & Wang, J. (2018) · Cell Cycle · doi:10.1080/15384101.2018.1520558 · Cited by 44 · see citing works

Functional Involvements of Heterogeneous Nuclear Ribonucleoprotein A1 in Smooth Muscle Differentiation from Stem Cells In Vitro and In Vivo

Huang, Y., Lin, L., Yu, X., Wen, G., Pu, X., Zhao, H., Fang, C., Zhu, J., Ye, S., Zhang, L., et al. (2013) · Stem Cells · doi:10.1002/stem.1324 · Cited by 42 · see citing works

Dickkopf Homolog 3 Induces Stem Cell Differentiation into Smooth Muscle Lineage via ATF6 Signalling

Wang, X., Karamariti, E., Simpson, R., Wang, W., & Xu, Q. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.641415 · Cited by 41 · see citing works

Sp1-dependent Activation of HDAC7 Is Required for Platelet-derived Growth Factor-BB-induced Smooth Muscle Cell Differentiation from Stem Cells

Zhang, L., Jin, M., Margariti, A., Wang, G., Luo, Z., Zampetaki, A., Zeng, L., Ye, S., Zhu, J., & Xiao, Q. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.153999 · Cited by 41 · see citing works

Nrf2 regulates mass accrual and the antioxidant endogenous response in bone differently depending on the sex and age

Pellegrini, G., Cregor, M. D., McAndrews, K., Morales, C. C., McCabe, L. D., McCabe, G. P., Peacock, M., Burr, D. B., Weaver, C. M., & Bellido, T. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171161 · Cited by 42 · see citing works

Functional Impact of Heterogeneous Nuclear Ribonucleoprotein A2/B1 in Smooth Muscle Differentiation from Stem Cells and Embryonic Arteriogenesis

Wang, G., Xiao, Q., Luo, Z., Ye, S., & Xu, Q. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.297028 · Cited by 38 · see citing works

The mechanism of stem cell differentiation into smooth muscle cells

Wang, G., Luo, Z., Xu, Q., & Xiao, Q. (2010) · Thrombosis and Haemostasis · doi:10.1160/th09-11-0794 · Cited by 34 · see citing works

MicroRNA-214 regulates smooth muscle cell differentiation from stem cells by targeting RNA-binding protein QKI

Wu, Y., Li, Z., Yang, M., Dai, B., Hu, F., Yang, F., Zhu, J., Chen, T., & Zhang, L. (2017) · Oncotarget · doi:10.18632/oncotarget.15189 · Cited by 34 · see citing works

Splicing of Histone Deacetylase 7 Modulates Smooth Muscle Cell Proliferation and Neointima Formation Through Nuclear β-Catenin Translocation

Zhou, B., Margariti, A., Zeng, L., Habi, O., Xiao, Q., Martin, D., Wang, G., Hu, Y., Wang, X., & Xu, Q. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.230888 · Cited by 34 · see citing works

miRNA ‐200c‐ 3p promotes endothelial to mesenchymal transition and neointimal hyperplasia in artery bypass grafts

Chen, D., Zhang, C., Chen, J., Yang, M., Afzal, T. A., An, W., Maguire, E. M., He, S., Luo, J., Wang, X., et al. (2020) · The Journal of Pathology · doi:10.1002/path.5574 · Cited by 33 · see citing works

MicroRNA-29a promotes smooth muscle cell differentiation from stem cells by targeting YY1

Jin, M., Wu, Y., Wang, Y., Yu, D., Yang, M., Yang, F., Feng, C., & Chen, T. (2016) · Stem Cell Research · doi:10.1016/j.scr.2016.07.011 · Cited by 33 · see citing works

Chromobox Protein Homolog 3 Is Essential for Stem Cell Differentiation to Smooth Muscles In Vitro and in Embryonic Arteriogenesis

Xiao, Q., Wang, G., Yin, X., Luo, Z., Margariti, A., Zeng, L., Mayr, M., Ye, S., & Xu, Q. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.230110 · Cited by 32 · see citing works

Progenitor Cells in Arteriosclerosis: Good or Bad Guys?

Campagnolo, P., Wong, M. M., & Xu, Q. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3506 · Cited by 31 · see citing works

Updated perspectives on vascular cell specification and pluripotent stem cell-derived vascular organoids for studying vasculopathies

Liu, C., Niu, K., & Xiao, Q. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa313 · Cited by 31 · see citing works

Nrf3 promotes UV-induced keratinocyte apoptosis through suppression of cell adhesion

Siegenthaler, B., Defila, C., Muzumdar, S., Beer, H., Meyer, M., Tanner, S. L., Bloch, W., Blank, V., Schäfer, M., & Werner, S. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0074-y · Cited by 28 · see citing works

Glycoprotein M6B Interacts with TβRI to Activate TGF-β-Smad2/3 Signaling and Promote Smooth Muscle Cell Differentiation

Zhang, X., Xie, H., Chang, P., Zhao, H., Xia, Y., Zhang, L., Guo, X., Huang, C., Yan, F., Hu, L., et al. (2018) · Stem Cells · doi:10.1002/stem.2938 · Cited by 28 · see citing works

Mitogen-Activated Protein Kinase 14 Is a Novel Negative Regulatory Switch for the Vascular Smooth Muscle Cell Contractile Gene Program

Long, X., Cowan, S. L., & Miano, J. M. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300645 · Cited by 25 · see citing works

Angiotensin II promotes differentiation of mouse embryonic stem cells to smooth muscle cells through PI3-kinase signaling pathway and NF-κB

Zheng, X., Wu, Y., Zhu, L., Chen, Q., Zhou, Y., Yan, H. M., Chen, T., Xiao, Q., Zhu, J., & Zhang, L. (2013) · Differentiation · doi:10.1016/j.diff.2012.11.003 · Cited by 24 · see citing works

Functions of Heterogeneous Nuclear Ribonucleoproteins in Stem Cell Potency and Differentiation

Chen, Q., Jin, M., Zhu, J., Xiao, Q., & Zhang, L. (2013) · BioMed Research International · doi:10.1155/2013/623978 · Cited by 22 · see citing works

Embryonic stem cell-specific signature in cervical cancer

Organista‐Nava, J., Gómez‐Gómez, Y., & Gariglio, P. (2013) · Tumor Biology · doi:10.1007/s13277-013-1321-y · Cited by 22 · see citing works

Vascular smooth muscle cell differentiation – 2010

Miano, J. M. (2010) · Journal of Biomedical Research · doi:10.1016/s1674-8301(10)60026-7 · Cited by 22 · see citing works

Nrf2-Mediated Dichotomy in the Vascular System: Mechanistic and Therapeutic Perspective

Wu, W., Hendrix, A., Nair, S., & Cui, T. (2022) · Cells · doi:10.3390/cells11193042 · Cited by 20 · see citing works

In vitro differentiation of endometrial regenerative cells into smooth muscle cells: A potential approach for the management of pelvic organ prolapse

Chen, X., Kong, X., Liu, D., GAO, P., Zhang, Y., Li, P., & Liu, M. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2593 · Cited by 20 · see citing works

Peroxisome proliferator‐activated receptor δ inhibits Porphyromonas gingivalis lipopolysaccharide‐induced activation of matrix metalloproteinase‐2 by downregulating NADPH oxidase 4 in human gingival fibroblasts

Yoo, T., Ham, S. A., Hwang, J. S., Lee, W. J., Paek, K. S., Oh, J., Kim, J., Do, J. T., Han, C., Kim, J., et al. (2015) · Molecular Oral Microbiology · doi:10.1111/omi.12137 · Cited by 17 · see citing works

NFE2L3 drives hepatocellular carcinoma cell proliferation by regulating the proteasome‐dependent degradation of ISGylated p53

Ren, Y., Yang, J., Ding, Z., Zheng, M., Qiu, L., Tang, A., & Huang, D. (2023) · Cancer Science · doi:10.1111/cas.15887 · Cited by 16 · see citing works

NAT10 promotes the progression of clear cell renal cell carcinoma by regulating ac4C acetylation of NFE2L3 and activating AKT/GSK3β signaling pathway

Sun, Z., Wang, Y., Zheng, C., Xiao, L., Zang, Y., Fang, L., Cui, X., Chang, M., Sun, Q., Li, W., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07528-w · Cited by 15 · see citing works

Oxidative status interactome map: towards novel approaches in experiment planning, data analysis, diagnostics and therapy

Zolotukhin, P. V., Kozlova, Y., Dovzhik, A. D., Коваленко, К. А., Kutsyn, K., Александрова, А. А., & Shkurat, T. P. (2013) · Molecular BioSystems · doi:10.1039/c3mb70096h · Cited by 15 · see citing works

Cartilage oligomeric matrix protein is a novel notch ligand driving embryonic stem cell differentiation towards the smooth muscle lineage

Ma, B., Yao, F., Xie, N., Mao, C., Liu, F., Gong, Z., Zhao, G., Liu, Z., Cai, Z., Yu, F. Z., et al. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.07.002 · Cited by 14 · see citing works

Lysosome Functions in Atherosclerosis: A Potential Therapeutic Target

Wang, Z., Li, X., Moura, A. K., Hu, J. Z., Wang, Y., & Zhang, Y. (2025) · Cells · doi:10.3390/cells14030183 · Cited by 13 · see citing works

SIRT3 Represses Vascular Remodeling via Reducing Mitochondrial Ac-CoA Accumulation in Vascular Smooth Muscle Cells

You, M., Wang, B., Li, L., Liu, M., Wang, L., Cao, T., Zhou, Q., Mou, A., Wang, H., Sun, M., et al. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.125.322428 · Cited by 13 · see citing works

Tissue engineering to treat pelvic organ prolapse

Yang, D., Zhang, M., & Liu, K. (2021) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2021.1958184 · Cited by 13 · see citing works

NFE2L3 promotes tumor progression and predicts a poor prognosis of bladder cancer

Qian, J., Huang, C., Zhu, Z., He, Y., Wang, Y., Feng, N., He, S., Li, X., Zhou, L., Zhang, C., et al. (2022) · Carcinogenesis · doi:10.1093/carcin/bgac006 · Cited by 13 · see citing works

NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5

Gurri, S., Siegenthaler, B., Cangkrama, M., Restivo, G., Huber, M., Saliba, J., Dummer, R., Blank, V., Hohl, D., & Werner, S. (2023) · EMBO Molecular Medicine · doi:10.15252/emmm.202317761 · Cited by 12 · see citing works

Embryonic stem cells as a cell source for tissue engineering

Khademhosseini, A., Ashammakhi, N. A., Karp, J. M., Gerecht, S., Ferreira, L., Annabi, N., Darabi, M. A., Sirabella, D., Vunjak‐Novakovic, G., & Langer, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818422-6.00027-7 · Cited by 12 · see citing works

An updated view on stem cell differentiation into smooth muscle cells

Zhang, L., Zhou, Y., Zhu, J., & Xu, Q. (2012) · Vascular Pharmacology · doi:10.1016/j.vph.2012.02.014 · Cited by 10 · see citing works

Prickle1 as positive regulator of oligodendrocyte differentiation

Zilkha‐Falb, R., Gurevich, M., Hanael, E., & Achiron, A. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.09.018 · Cited by 9 · see citing works

New insight into the CNC-bZIP member, NFE2L3, in human diseases

Xiong, G., Li, J., Yao, F., Yang, F., & Xiang, Y. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1430486 · Cited by 7 · see citing works

Embryonic Stem Cells as a Cell Source for Tissue Engineering

Khademhosseini, A., Karp, J. M., Gerecht, S., Ferreira, L., Annabi, N., Sirabella, D., Vunjak‐Novakovic, G., & Langer, R. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-398358-9.00032-x · Cited by 7 · see citing works

Vascular Smooth Muscle Cell Development and Cardiovascular Malformations

Qi, L., Kong, W., & Fu, Y. (2021) · Cardiology Discovery · doi:10.1097/cd9.0000000000000035 · Cited by 6 · see citing works

Over-Expression of HSP47 Augments Mouse Embryonic Stem Cell Smooth Muscle Differentiation and Chemotaxis

Wong, M. M., Yin, X., Potter, C. M. F., Yu, B., Cai, H., Bernardini, E. D., & Xu, Q. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086118 · Cited by 6 · see citing works

Novel roles of Nrf3–Trim5 axis in vascular smooth muscle cell dysfunctions and neointimal hyperplasia

Chen, Q., Sun, S., Shi, Z., Wang, L., Wang, Y., Zheng, A., Xu, X., Yang, M., Sun, K., Xiao, Q., et al. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf084 · Cited by 5 · see citing works

DJ‐1 Regulates Differentiation of Human Mesenchymal Stem Cells into Smooth Muscle‐like Cells in Response to Sphingosylphosphorylcholine

Baek, S., Lee, K. P., Jung, S. H., Cui, L., Ko, K., Kim, B., & Won, K. (2017) · PROTEOMICS · doi:10.1002/pmic.201700208 · Cited by 5 · see citing works

A Comprehensive Review of Epigenetic Regulation of Vascular Smooth Muscle Cells During Development and Disease

Natalí, L., de la Cruz-Thea, B., Godino, A., Conde, C. B., Peinado, V. I., & Musri, M. M. (2026) · Biomolecules · doi:10.3390/biom16010173 · Cited by 4 · see citing works

Nrf3 promotes the proliferation and migration of triple‑negative breast cancer by activating PI3K/AKT/mTOR and epithelial‑mesenchymal transition

Chen, W.-M., Hu, Q., Hou, W., Chen, M.-W., Chen, Y., & Tang, J. (2023) · Oncology Letters · doi:10.3892/ol.2023.14030 · Cited by 4 · see citing works

The CNC-family transcription factor NRF3: A crucial therapeutic target for cancer treatment

Yan, L., Li, X., Xu, J., Tang, S., Wang, G., Shi, M., & Liu, P. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167794 · Cited by 3 · see citing works

NFE2L3 regulates inflammation and oxidative stress-related genes in the colon

Yaker, L., Saliba, J., Scott, L. P. C., Sood, A. K., Gujral, P., Orozco-Alonso, E., Yan, X., Yeh, A., & Blank, V. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2025.119987 · Cited by 4 · see citing works

Carnosine Synthase (TsATPGD) Alleviates Lipid Peroxidation Under Transcriptional Control by an Nfe2-like Gene in Tridacna Squamosa

Yang, Z., Wong, N.-K., Mao, F., Wu, S., Yi, W., Yu, Z., & Zhang, Y. (2024) · Antioxidants · doi:10.3390/antiox13111351 · Cited by 2 · see citing works

Feed-Forward and Feed-Back Circuits of the NRF2/AP-1 Composite Pathway

Zolotukhin, P. V., & Belanova, A. A. (2016) · InTech eBooks · doi:10.5772/65216 · Cited by 2 · see citing works

Targeting autophagy to treat neointimal hyperplasia in vascular disease

Yan, R., Tual-Chalot, S., & Stellos, K. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf104 · Cited by 1 · see citing works

Application of A Novel Triclustering Method in Analyzing Three Dimensional Transcriptomics Data

Bhar, A. (2015) · doi:10.53846/goediss-5150 · Cited by 1 · see citing works

Functional impact of microRNA-34a on stem cell differentiation towards smooth muscle cell

Yu, X. (2014)

Embryonic Stem Cells as a Cell Source for Tissue

Karp, J. M., Gerecht, S., & Ferreira, L. (2014)

The Mechanism of Stem Cell Differentiation into Smooth Muscle Cells

Simpson, R., & Xu, Q. (2013) · Humana Press eBooks · doi:10.1007/978-1-62703-417-3_1

Behavioral, neurochemical, and neuroimmune changes in Nrf2 knockout mice following early postnatal exposure to valproic acid

Furnari, M. A. (2013) · doi:10.7282/t39s1pn0

Circulation Research Thematic Synopsis

Editors, T. (2012) · Circulation Research · doi:10.1161/res.0b013e3182614cf7

NFE2L3 is differentially expressed in high-grade serous ovarian cancers.Preprint

Mamoor, S. (2020) · doi:10.31219/osf.io/mw5yg

The Role of Progenitor Cells in the Pathogenesis of Arteriosclerosis

Zhang, Y., Guan, Z., Gong, H., Ni, Z., Xiao, Q., Guo, X., & Xu, Q. (2024) · Cardiology Discovery · doi:10.1097/cd9.0000000000000130

A comprehensive review of the emerging role of NRF3 in ovarian cancer tumorigenesis and progression

Hosseinzadeh, M., Karimi, A., Rashid, M., & Sadeghi, M. R. (2026) · Journal of Ovarian Research · doi:10.1186/s13048-026-01987-1

Linagliptin increases the expression of LRP2 independent of Nrf2 in streptozotocin‐induced diabetic mice

Promsuwan, S., Takiyama, Y., Takiyama, T., Takiyama, Y., Kitsunai, H., & Nomoto, H. (2026) · Journal of Diabetes Investigation · doi:10.1111/jdi.70454

Mitochondrial remodeling in heart failure with reduced ejection fraction

Chen, X. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1958014

Abstract 5474: Crucial Role of Nrf3 in Smooth Muscle Cell Differentiation From Stem Cells and Vessel Injury-Induced Neointima Formation

Pepe, A. E., Xiao, Q., Zampetaki, A., Hu, Y., & Xu, Q. (2009) · Circulation · doi:10.1161/circ.120.suppl_18.s1098-b

Nrf3-Pla2g7 interaction plays an essential role in smooth muscle differentiation from stem cells

Xiao, Q., Pepe, A. E., Wang, G., Luo, Z., Zhang, L., Zeng, L., Zhang, Z., Hu, Y., Ye, S., & Xu, Q. (2012) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.111.243188 · Cited by 56 · see citing works

Crucial Role of Nrf3 in Smooth Muscle Cell Differentiation From Stem Cells and Vessel Injury-induced Neointima Formation

Pepe, A. E., Xiao, Q., Zampetaki, A., Hu, Y., & Xu, Q. (2009) · Research Portal (King's College London)

Embryonic stem cell differentiation into smooth muscle cells is mediated by Nox4-produced H2O2

Xiao, Q., Luo, Z., Pepe, A. E., Margariti, A., Zeng, L., & Xu, Q. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00442.2008 · Cited by 184 · see citing works

Novel roles of Nrf3–Trim5 axis in vascular smooth muscle cell dysfunctions and neointimal hyperplasia

Chen, Q., Sun, S., Shi, Z., Wang, L., Wang, Y., Zheng, A., Xu, X., Yang, M., Sun, K., Xiao, Q., et al. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf084 · Cited by 5 · see citing works