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Cited by 196Hippo pathway signaling and YAP/TAZAutophagy in Disease and TherapyCell death mechanisms and regulation

Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1

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Zhang, Huabing, Ramakrishnan, Sadeesh K., Triner, Daniel, Centofanti, Brook, Maitra, Dhiman, Győrffy, Balázs, Sebolt-Leopold, Judith S., Dame, Michael K. +5 more·2015·Science Signaling
DOI 10.1126/scisignal.aac5418PMC PMC4818013
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Abstract

In an oxygen- and nutrient-deprived environment, verteporfin kills colon cancer cells by inducing proteotoxicity.

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Authors
Zhang, H., Ramakrishnan, S. K., Triner, D., Centofanti, B., Maitra, D., Győrffy, B., Sebolt-Leopold, J. S., Dame, M. K., Varani, J., Brenner, D. E., Fearon, E. R., Omary, M. B., & Shah, Y. M.
Affiliations
  • University of Michigan (US)
  • Semmelweis University (HU)
  • Department of Radiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Corresponding author
  • Zhang, Huabing
  • Ramakrishnan, Sadeesh K.
  • Shah, Yatrik M.
ORCID
Venue
Science Signaling
Publisher
American Association for the Advancement of Science (AAAS)
Published
2015-10-06
Volume
8
Issue
397
Pages
ra98-ra98
ISSN
  • 1937-9145 (ISSN-L)
  • 1945-0877
DOI
10.1126/scisignal.aac5418
PMC
PMC4818013
OpenAlex
W2266087322
Cited by
196
References
2
Citations by year
2026: 12 · 2025: 12 · 2024: 13 · 2023: 18 · 2022: 16 · 2021: 17 · 2020: 21 · 2019: 27 · 2018: 21 · 2017: 24 · 2016: 14 · 2015: 1
FWCI
10.64
Type
journal article
Language
en
Open access
Licence
www.sciencemag.org/about/science-licenses-journal-article-reuse (vor, 366 d)
Locations
  • Science Signaling (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Semmelweis University Repository (Semmelweis University) (submittedVersion)
Funders
  • NIH (CA148828, DK095201, CA181855-01, CA046592-26S3, DK52951)
  • University of Michigan Gastrointestinal Peptide Research Center (DK034933, GI SPORE CA130810)
  • OTKA (Hungarian Scientific Research Fund) (K108655)
  • American Heart Association (15POST22650034)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords
verteporfin, colorectal cancer, YAP, TAZ, Hippo signaling pathway, proteotoxicity, protein oligomerization, p62, STAT3, autophagy, proteasome, tumor microenvironment, hypoxia, nutrient deprivation, tumor growth inhibition
MeSH terms
Verteporfin, YAP-Signaling Proteins, Acyltransferases, Adenocarcinoma, Adenoma, Animals, Antineoplastic Agents, Autophagy, Cell Division, Colonic Neoplasms, Humans, Mice, Inbred C57BL, Molecular Weight, Neoplasm Proteins, Phosphoproteins, Phosphorylation, Adenomatous Polyposis Coli, Porphyrins, Protein Processing, Post-Translational, Transcription Factors, Transcription, Genetic, Apoptosis, Genes, APC, Mice, Knockout, Xenograft Model Antitumor Assays, Cell Line, Tumor, Proteasome Endopeptidase Complex, Adaptor Proteins, Signal Transducing, STAT3 Transcription Factor, Mice, Protein Multimerization, HEK293 Cells

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