Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism
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showed reduced mitochondrial degradation and retained thermogenic beige adipocytes even after the withdrawal of external stimuli. Norepinephrine signaling through the PKA pathway inhibited the recruitment of Parkin protein to mitochondria in beige adipocytes. However, mitochondrial proton uncoupling by uncoupling protein 1 (UCP1) was dispensable for Parkin recruitment and beige adipocyte maintenance. These results suggest a physiological mechanism by which external cues control mitochondrial homeostasis in thermogenic fat cells through mitophagy.
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UCP-1 is not required for cold-induced mitophagy in beige adipocytes.
“Surprisingly, UCP-1 is not required for cold-induced mitophagy in beige adipocytes [225].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [225]
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- Authors
- Lu, X., Altshuler-Keylin, S., Wang, Q., Chen, Y., Henrique Sponton, C., Ikeda, K., Maretich, P., Yoneshiro, T., & Kajimura, S.
- Affiliations
- Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.
- University of California, San Francisco (US)
- Corresponding author
- Kajimura, Shingo
- ORCID
- Venue
- Science Signaling
- Published
- 2018-04-24
- Volume
- 11
- Issue
- 527
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC6410368
- OpenAlex
- W2801649057
- Cited by
- 143
- References
- 47
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 11 · 2023: 20 · 2022: 16 · 2021: 29 · 2020: 20 · 2019: 19 · 2018: 6
- FWCI
- 12.68
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH Office of the Director (DK97441, DK108822)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- mitophagy, beige adipocytes, Parkin, UCP1, mitochondrial homeostasis, thermogenesis, norepinephrine signaling, protein kinase A, mitochondrial degradation
- MeSH terms
- Adipocytes, Beige, Uncoupling Protein 1, Animals, Cells, Cultured, Signal Transduction, Mice, Knockout, Thermogenesis, RNA Interference, Ubiquitin-Protein Ligases, Adipose Tissue, White, Mitophagy
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