The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice
Open accessAbstract
A translational medicine pipeline is described where human gut microbial communities and diets are re-created in gnotobiotic mice and the impact on microbe and host is defined using metagenomics.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The majority of studies in humans and mice rely on faecal samples, which provide some representation of what is occurring throughout the digestive tract”
From Diet–microbiota interactions as moderators of human metabolism (2016) · cites this paper as [120]
In the citing paper
“aspects of microbial communities and host responses that are specific to the small intestine might be obscured by faecal sampling119,120.”
From Diet–microbiota interactions as moderators of human metabolism (2016) · cites this paper as [120]
In the citing paper
“Our study corroborates previous studies showing an association between altered diets and an increase in Erysipelotrichi and Allobaculum, but various effects are shown for fat-enriched diets 29, 30, 31, 32.”
From The composition of the gut microbiota shapes the colon mucus barrier (2015) · cites this paper as [32]
In the citing paper
“Similar to the Western diet, high-fat diets in animal studies reproducibly change gut microbial community structure, decreasing the overall microbiota diversity and beneficial bacteria (e.g., A. muciniphila, Bifidobacterium, Lactobacillus, and Lactococcus) and increasing the Firmicutes:Bacteroidetes ratio and the abundance of Enterobacteriales, Clostridium cluster XVIa, Mollicutes, and B. wadswort”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [206]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Self-citationThe RAST Server: Rapid Annotations using Subsystems Technology
Aziz, R. K., Bartels, D., Best, A. A., DeJongh, M., Disz, T. L., Edwards, R. A., Formsma, K., Gerdes, S., Glass, E. M., Kubal, M., et al. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-75 · Cited by 11,893
UniFrac: a New Phylogenetic Method for Comparing Microbial Communities
Lozupone, C., & Knight, R. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.12.8228-8235.2005 · Cited by 8,227
Self-citationA core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
Self-citationObesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
Self-citationThe Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics
Cantarel, B. L., Coutinho, P. M., Rancurel, C., Bernard, T., Lombard, V., & Henrissat, B. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn663 · Cited by 6,108
Turnbaugh, P. J., Ley, R. E., Hamady, M., Fraser-Liggett, C. M., Knight, R., & Gordon, J. I. (2007) · Nature · doi:10.1038/nature06244 · Cited by 6,091
Self-citationThe KEGG resource for deciphering the genome
Kanehisa, M. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkh063 · Cited by 5,120
Topographical and Temporal Diversity of the Human Skin Microbiome
Grice, E. A., Kong, H. H., Conlan, S., Deming, C. B., Davis, J., Young, A. C., Program, N. C. S., Bouffard, G. G., Blakesley, R. W., Murray, P. R., et al. (2009) · Science · doi:10.1126/science.1171700 · Cited by 2,953
Turnbaugh, P. J., Bäckhed, F., Fulton, L., & Gordon, J. I. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.02.015 · Cited by 2,915
Self-citation
Cited by
Sorted by citations
Items 901–1,000 of 1,018
Shen, W., Wolf, P. G., Carbonero, F. G., Wei, Z., Reid, T., Gaskins, H. R., & McIntosh, M. (2014) · Journal of Nutrition · doi:10.3945/jn.114.194332 · Cited by 80
Establishment of the early-life microbiome: a DOHaD perspective
Stinson, L. F. (2019) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174419000588 · Cited by 77
The human gut microbiota and its interactive connections to diet
Milani, C., Ferrario, C., Turroni, F., Duranti, S., Mangifesta, M., van Sinderen, D., & Ventura, M. (2016) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12371 · Cited by 76
“A high-fat, high-sugar Western diet, instead of a low-fat, plant polysaccharide-rich diet, was shown to promote a shift in the gut microbiota composition toward high numbers of clostridia and a significant decrease in Bacteroidetes ((42)).”
BackgroundInfluentialWhisner, C. M., Maldonado, J., Dente, B., Krajmalnik‐Brown, R., & Bruening, M. M. (2018) · BMC Microbiology · doi:10.1186/s12866-018-1362-x · Cited by 79
Duan, Y., Zhong, Y., Xiao, H., Zheng, C., Song, B., Wang, W., Guo, Q., Li, Y., Han, H. L., Gao, J., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201900665rr · Cited by 75
Dietary fiber isolated from sweet potato residues promotes a healthy gut microbiome profile
Liu, M., Li, X., Zhou, S., Wang, T. T. Y., Zhou, S., Yang, K., Li, Y., Tian, J., & Wang, J. (2019) · Food & Function · doi:10.1039/c9fo01009b · Cited by 77
Zhu, K., Fan, H., Zeng, S., Nie, S., Zhang, Y., Tan, L., Li, C., Xu, F., Liu, Q., & Wu, G. (2021) · Food Chemistry · doi:10.1016/j.foodchem.2021.130434 · Cited by 75
Intestinal Microbiota as Novel Biomarkers of Prior Radiation Exposure
Lam, V., Moulder, J. E., Salzman, N. H., Dubinsky, E. A., Andersen, G. L., & Baker, J. E. (2012) · Radiation Research · doi:10.1667/rr2691.1 · Cited by 75
“However, diets used in the present study have well-defined protein, carbohydrate, and fat contents and may not represent the divergent composition of human diets and their impact on the intestinal microbiota (18).”
BackgroundThe potential for probiotic manipulation of the gastrointestinal microbiome
Rauch, M., & Lynch, S. V. (2011) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2011.11.004 · Cited by 80
Sartor, R. B. (2011) · Mucosal Immunology · doi:10.1038/mi.2010.87 · Cited by 75
Chen, M., Shao, L., Zhang, W., Wang, C., Zhou, H., Huang, W., & Yuan, C. (2017) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2017.12.011 · Cited by 74
Impact of genistein on the gut microbiome of humanized mice and its role in breast tumor inhibition
Paul, B., Royston, K. J., Li, Y., Stoll, M. L., Skibola, C. F., Wilson, L. S., Barnes, S., Morrow, C. D., & Tollefsbol, T. O. (2017) · PLoS ONE · doi:10.1371/journal.pone.0189756 · Cited by 77
“Firstly, the composition of bacterial communities as well as their relative abundances can inform about health status and disease conditions [40].”
BackgroundThe gut microbiota in neuropsychiatric disorders
Grochowska, M., Wojnar, M., & Radkowski, M. (2018) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2018-008 · Cited by 77
Cordycepin reduces weight through regulating gut microbiota in high-fat diet-induced obese rats
An, Y., Li, Y., Wang, X., Chen, Z., Xu, H., Wu, L., Li, S., Wang, C., Luan, W., Wang, X., et al. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-018-0910-6 · Cited by 75
Estradiol and high fat diet associate with changes in gut microbiota in female ob/ob mice
Acharya, K. D., Gao, X., Bless, E. P., Chen, J., & Tetel, M. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-56723-1 · Cited by 74
Microbiome: Effects of Ageing and Diet
Salazar, N., González, S., Nogacka, A. M., Ríos-Covián, D., Arboleya, S., Gueimonde, M., & Reyes‐Gavilán, C. G. D. L. (2019) · Current Issues in Molecular Biology · doi:10.21775/cimb.036.033 · Cited by 75
“The rRNA gene sequencing has also generated insight into host–microbe interactions, showing a direct correlation between gut microbiota, diet and health and yielding hypotheses about microbiota-based disease mechanisms (Turnbaugh et al., 2009b; Muegge et al., 2011; Claesson et al., 2012).”
BackgroundThe role of gut microbiota in the resistance to obesity in mice fed a high fat diet
Cao, W., Chin, Y., Chen, X., Mi, Y., Xue, C., Wang, Y., & Tang, Q. (2019) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2019.1686608 · Cited by 73
“Thus, future studies involving gut microbiota transplantation of L mice to germfree mice would be required to explore the causative function of gut microbiota for obesity development (Turnbaugh et al. 2008, 2009; Ridaura et al. 2013).”
BackgroundHe, F., & Li, Y. (2021) · Journal of Ovarian Research · doi:10.1186/s13048-021-00799-9 · Cited by 77
Zeb, F., Osaili, T. M. I., Obaid, R. S., Naja, F., Radwan, H. M., Ismail, L. C., Hasan, H. A., Hashim, M. S., Alam, I., Sehar, B., et al. (2023) · Nutrients · doi:10.3390/nu15020259 · Cited by 74
“The host physiology, environment, and daily dietary changes all play a role in gut microbiota homeostasis [106].”
BackgroundUnraveling the Role of the Human Gut Microbiome in Health and Diseases
Khalil, M., Ciaula, A. D., Mahdi, L., Jaber, N., Palo, D. M. D., Graziani, A., Baffy, G., & Portincasa, P. (2024) · Microorganisms · doi:10.3390/microorganisms12112333 · Cited by 100
“In this respect, a dietary shift from a low-fat, plant polysaccharide-rich diet to a high-fat, high-sugar diet is sufficient to modify the microbiome composition rapidly [303].”
Characterization of the Gut Microbiota in the Red Panda (Ailurus fulgens)
Kong, F., Zhao, J., Han, S., Zeng, B., Yang, J., Si, X., Ben-qing, Y., Yang, M., Xu, H., & Li, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087885 · Cited by 73
“Diet has been considered as a major driver shaping mammalian gut microbial community structures [6,18,19,20].”
BackgroundTowards an integrated understanding of gut microbiota using insects as model systems
Pernice, M., Simpson, S. J., & Ponton, F. (2014) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2014.05.016 · Cited by 75
“For instance, using the same set of samples from lean and obese twins, different species assemblages appear to lead to very similar functional profiles, demonstrating the presence of a shared core of metabolic capabilities in the microbiome (Turnbaugh et al., 2009).”
Digesting the emerging role for the gut microbiome in central nervous system demyelination
Joscelyn, J., & Kasper, L. H. (2014) · Multiple Sclerosis Journal · doi:10.1177/1352458514541579 · Cited by 74
Shin, J., Sim, M., Lee, J., & Shin, D. (2016) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-016-0121-7 · Cited by 75
“However, a high-fat diet caused a significant increment in the abundance of Catenibacterium mitsuokai [7].”
Lucan, S. C., & DiNicolantonio, J. J. (2014) · Public Health Nutrition · doi:10.1017/s1368980014002559 · Cited by 76
“due to their personal genetic susceptibility((48,63)) or that of their resident gut microbes((131))), there is good reason to believe that rapidly absorbable carbohydrates tend to promote obesity, and diseases commonly associated with it, in general.”
BackgroundDysbiotic gut microbiome: A key element of Crohn's disease
Øyri, S. F., Műzes, G., & Sípos, F. (2015) · Comparative Immunology Microbiology and Infectious Diseases · doi:10.1016/j.cimid.2015.10.005 · Cited by 78
Pérez, M. M., Martins, L. M. S., Dias, M. S., Pereira, C. A., Leite, J. A., Gonçalves, E. C. S., de Almeida, P. Z., de Freitas, E. N., Tostes, R. C., Ramos, S. G., et al. (2018) · Immunology · doi:10.1111/imm.13028 · Cited by 77
Gnotobiotics: Past, present and future
Basic, M., & Bleich, A. (2019) · Laboratory Animals · doi:10.1177/0023677219836715 · Cited by 73
The Role of Gut Microbiome in Sleep Quality and Health: Dietary Strategies for Microbiota Support
Sejbuk, M., Siebieszuk, A., & Witkowska, A. M. (2024) · Nutrients · doi:10.3390/nu16142259 · Cited by 83
“The Western diet, rich in sugar and fat, can affect the gut microbiota within one day [190].”
BackgroundMicrobiota Metabolite Regulation of Host Immune Homeostasis: A Mechanistic Missing Link
Steinmeyer, S. H., Lee, K., Jayaraman, A., & Alaniz, R. C. (2015) · Current Allergy and Asthma Reports · doi:10.1007/s11882-015-0524-2 · Cited by 73
Is Obesity a Risk Factor for Vaccine Non-Responsiveness?
Young, K. M., Gray, C. M., & Bekker, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082779 · Cited by 73
“levels of immune activation [17–20].”
Obesogens: How They Are Identified and Molecular Mechanisms Underlying Their Action
Mohajer, N., Du, C. Y., Checkcinco, C., & Blumberg, B. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.780888 · Cited by 72
Corrie, L., Awasthi, A., Kaur, J., Vishwas, S., Gulati, M., Kaur, I. P., Gupta, G., Kommineni, N., Dua, K., & Singh, S. K. (2023) · Pharmaceuticals · doi:10.3390/ph16020197 · Cited by 76
“As a result, hepatic lipogenesis got enhanced, and hepatic lipoprotein lipase (LPL) as well as sterol regulatory element-binding proteins (SREBPs) were stimulated [120].”
BackgroundOur Unindicted Coconspirators: Human Metabolism from a Microbial Perspective
Goodman, A. L., & Gordon, J. I. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.07.001 · Cited by 73
Self-citationIs there a relationship between intestinal microbiota, dietary compounds, and obesity?
Kałużna‐Czaplińska, J., Gątarek, P., Chartrand, M. S., Dadar, M., & Bjørklund, G. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.10.010 · Cited by 72
Diet and rosacea: the role of dietary change in the management of rosacea
Weiss, E., & Katta, R. (2017) · Dermatology Practical & Conceptual · doi:10.5826/dpc.0704a08 · Cited by 72
Mekuchi, M., Asakura, T., Sakata, K., Yamaguchi, T., Teruya, K., & Kikuchi, J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197256 · Cited by 73
Gut microbiota: a potential manipulator for host adipose tissue and energy metabolism
Rong, B., Tianyu, X., Tiantian, Z., Feng, R., Huang, H., Wu, Q., & Sun, C. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.10.020 · Cited by 73
Zhang, X., Chen, Y., Zhu, J., Zhang, M., Ho, C., Huang, Q., & Cao, J. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800274 · Cited by 71
Bibliometric analysis of research on the role of intestinal microbiota in obesity
Yao, H., Wan, J., Wang, C., Li, L., Wang, J., Li, Y., Huang, W., Zeng, J., Wang, Q., & Yuan, C. (2018) · PeerJ · doi:10.7717/peerj.5091 · Cited by 78
“…Kau et al. 2011; Le Chatelier et al. 2013; Ley et al. 2005; Ley et al. 2006; O'Hara & Shanahan 160 2006; Qin et al. 2010; Ridaura et al. 2013; Tremaroli & Bäckhed 2012; Turnbaugh et al. 2008; 161 Turnbaugh et al. 2009a; Turnbaugh et al. 2006; Turnbaugh et al. 2009b; Vijay-Kumar et al. 162 2010).”
BackgroundMethodJeckelmann, J.-M., & Erni, B. (2020) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2020.183412 · Cited by 71
The central role of the gut in intensive care
Corriero, A., Gadaleta, R. M., Puntillo, F., Inchingolo, F., Moschetta, A., & Brienza, N. (2022) · Critical Care · doi:10.1186/s13054-022-04259-8 · Cited by 78
“The GM composition varies among individuals, changing throughout life due to intrinsic factors like age and genetics and extrinsic modifiable factors like diet [8], environment, and drug use [9].”
BackgroundDigesting the complex metabolic effects of diet on the host and microbiome
Carmody, R. N., Varady, K. A., & Turnbaugh, P. J. (2024) · Cell · doi:10.1016/j.cell.2024.06.032 · Cited by 76
Self-citationThe effects of the microbiota on the host immune system
Karczewski, J., Poniedziałek, B., Adamski, Z., & Rzymski, P. (2014) · Autoimmunity · doi:10.3109/08916934.2014.938322 · Cited by 73
“Because members of the microbiota have their own substrate preference and there is competition for limited resources, alterations in the components of the diet, particularly the type and quantity of fat and polysaccharides, result in changes in composition and function of the microbiota [119].”
BackgroundZhou, A. L., Hergert, N., Rompato, G., & Lefevre, M. (2014) · Journal of Nutrition · doi:10.3945/jn.114.199778 · Cited by 73
Comparative Analysis of Functional Metagenomic Annotation and the Mappability of Short Reads
Carr, R., & Borenstein, E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105776 · Cited by 72
“Other studies, however, apply different protocols, such as assigning the annotation of potentially sub optimal alignments to enrich for functional annotations [19], or averaging over multiple high-scoring hits (e.”
MethodGerm-Free Mice Model for Studying Host–Microbial Interactions
Bhattarai, Y., & Kashyap, P. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3661-8_8 · Cited by 72
Fish oil, lard and soybean oil differentially shape gut microbiota of middle-aged rats
Li, H., Zhu, Y., Zhao, F., Song, S., Li, Y., Xu, X., Zhou, G., & Li, C. (2017) · Scientific Reports · doi:10.1038/s41598-017-00969-0 · Cited by 72
The microbiome and systemic lupus erythematosus
Katz-Agranov, N. S., & Zandman‐Goddard, G. (2017) · Immunologic Research · doi:10.1007/s12026-017-8906-2 · Cited by 73
The gut microbiota, environment and diseases of modern society
Kelsen, J. R., & Wu, G. D. (2012) · Gut Microbes · doi:10.4161/gmic.21333 · Cited by 77
“Indeed, a number of studies demonstrate that similar alterations in the gut microbiota are observed in mice, with endogenous or humanized gut microbiota, fed high fat, high calorie chow reminiscent of “Westernized” diet.(32,49-51) More recently, it has been suggested that the association between the gut microbiota and…”
BackgroundLi, X., Liang, S., Xia, Z., Qu, J., Liu, H., Liu, C., Yang, H., Wang, J. Z., Madsen, L., Hou, Y., et al. (2018) · GigaScience · doi:10.1093/gigascience/giy100 · Cited by 68
Zhu, Z., Han, Y., Ding, Y., Zhu, B., Song, S., & Xiao, H. (2021) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12754 · Cited by 69
“The phylum-level changes, in particular the relative abundance of Bacteroidetes and Firmicutes, in the micro- biota are known to be associated with obesity (Turnbaugh et al., 2009).”
BackgroundInfluentialBoutin, R. C. T., Sbihi, H., McLaughlin, R. J., Hahn, A. S., Konwar, K. M., Loo, R., Dai, D. L., Petersen, C., Brinkman, F. S. L., Winsor, G. L., et al. (2021) · mBio · doi:10.1128/mbio.03396-20 · Cited by 75
“Functional redundancy among bacterial taxa in the gut often results in similar functional capacities of bacterial communities that differ in the identity and relative abundances of the specific microbes present (58, 59).”
BackgroundModulation of gut microbiota by bioactive compounds for prevention and management of type 2 diabetes
Sharma, B. R., Jaiswal, S., & Veeranna, R. P. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113148 · Cited by 75
Gut microbiota composition and its effects on obesity and insulin resistance
Caricilli, A. M., & Saad, M. J. A. (2014) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000067 · Cited by 72
“As expected, in formerly germ-free mice harboring human faecal microbiota, Erysipelotrichi were also found to increase after feeding them with a high-fat diet [21].”
BackgroundLinking Peripartal Dynamics of Ruminal Microbiota to Dietary Changes and Production Parameters
Derakhshani, H., Tun, H. M., Cardoso, F. C., Plaizier, J. C., Khafipour, E., & Loor, J. J. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02143 · Cited by 74
“…by a more competitive ruminal ecosystem which selectively favors the growth of bacterial lineages that are flexible in harvesting energy, such as certain members of Bacteroidetes and Firmicutes that possess large repertoires of genes involved in carbohydrate metabolism (Turnbaugh et al., 2009b).”
BackgroundStructural basis for the regulation of β-glucuronidase expression by human gut Enterobacteriaceae
Little, M. S., Pellock, S. J., Walton, W. G., Tripathy, A., & Redinbo, M. R. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1716241115 · Cited by 72
“Microbial carbohydrate utilization plays a critical role in the diversity, abundance, and metabolic activity of both commensal and potentially pathogenic bacteria in the mammalian intestine (3, 4).”
BackgroundBeyond phylotyping: understanding the impact of gut microbiota on host biology
Reigstad, C. S., & Kashyap, P. C. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12134 · Cited by 66
COMPANION ANIMALS SYMPOSIUM: Humanized animal models of the microbiome1
Gootenberg, D. B., & Turnbaugh, P. J. (2010) · Journal of Animal Science · doi:10.2527/jas.2010-3371 · Cited by 72
“This change in adiposity occurred even though there was no significant difference in chow consumption between the 2 groups of recipient mice and the 2 groups of recipients were matched at the start of the experiment for age, BW, and body fat (Turnbaugh et al., 2009b).”
BackgroundMethodInfluentialSelf-citationAutologous fecal microbiota transplantation for the treatment of inflammatory bowel disease
Basson, A. R., Zhou, Y., Seo, B., Rodriguez‐Palacios, A., & Cominelli, F. (2020) · Translational research · doi:10.1016/j.trsl.2020.05.008 · Cited by 74
Gut Microbiota and Obesity in Adults and Children: The State of the Art
Petraroli, M., Castellone, E., Patianna, V. D., & Esposito, S. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.657020 · Cited by 68
“Indeed, as clarified by Turnbaugh in 2008–2009 in animal models of the human intestinal ecosystem obtained by fecal transplantation, the switch from a low-fat/vegetable-polysaccharide-rich diet to a “Western” diet may modify the gut microbiota structure within a single day due to the increase in the relative abundance…”
BackgroundMetagenomics and artificial intelligence in the context of human health
Wani, A. K., Roy, P., Gahlawat, V. K., & Mir, T. U. G. (2022) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2022.105267 · Cited by 72
Oligosaccharides Might Contribute to the Antidiabetic Effect of Honey: A Review of the Literature
Erejuwa, O. O., Sulaiman, S. A., & Wahab, M. S. A. (2011) · Molecules · doi:10.3390/molecules17010248 · Cited by 67
“crucial to the microbiota ecosystem which may improve or exacerbate insulin resistance and diabetes mellitus [10,39-45].”
BackgroundA perspective on NETosis in diabetes and cardiometabolic disorders
Fadini, G. P., Menegazzo, L., Scattolini, V., Gintoli, M., Albiero, M., & Avogaro, A. (2015) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2015.11.008 · Cited by 70
Bacteroides fragilis metabolises exopolysaccharides produced by bifidobacteria
Ríos-Covián, D., Cuesta, I., Álvarez-Buylla, J. R., Ruas‐Madiedo, P., Gueimonde, M., & Reyes‐Gavilán, C. G. D. L. (2016) · BMC Microbiology · doi:10.1186/s12866-016-0773-9 · Cited by 69
“Microbiota of adult healthy people is dominated by the phyla Firmicutes and Bacteroidetes, even though the composition at the species level is highly variable among individuals [2, 3].”
BackgroundBifari, F., Ruocco, C., Decimo, I., Fumagalli, G. F., Valerio, A., & Nisoli, E. (2017) · Genes & Nutrition · doi:10.1186/s12263-017-0582-2 · Cited by 70
Pathophysiology of Necrotizing Enterocolitis: An Update
Bazacliu, C., & Neu, J. (2018) · Current Pediatric Reviews · doi:10.2174/1573396314666181102123030 · Cited by 71
Niccolai, E., Boem, F., Russo, E., & Amedei, A. (2019) · Nutrients · doi:10.3390/nu11010156 · Cited by 70
Hrncirova, L., Machova, V., Trckova, E., Krejsek, J., & Hrncir, T. (2019) · Microorganisms · doi:10.3390/microorganisms7100383 · Cited by 68
“[17] showed that the human gut microbiota could be successfully transferred from generation to generation without a significant drop in diversity.”
BackgroundWatt, E., Gemmell, M., Berry, S., Glaire, M. A., Farquharson, F. M., Louis, P., Murray, G. I., El-Omar, E. M., & Hold, G. L. (2016) · Microbiome · doi:10.1186/s40168-016-0207-9 · Cited by 69
Assal, K. A., Prifti, E., Belda, E., Sala, P., Clément, K., Dao, M. C., Dore, J. M., Levenez, F., Taddei, C. R., Fonseca, D. C., et al. (2020) · Nutrients · doi:10.3390/nu12020278 · Cited by 72
“For instance, high-fat diets can alter gut microbiota composition [6] and this change may be associated with obesity [5].”
BackgroundYao, N., Qi, J., Dobbins, M. T., Liang, X. T., Wang, J., Chen, S., Ma, J., & Jiang, G. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01665 · Cited by 67
Interactions between gut microbiota and skeletal muscle
Gizard, F., Fernandez, A., & Vadder, F. D. (2020) · Nutrition and Metabolic Insights · doi:10.1177/1178638820980490 · Cited by 70
Staubach, F., Künzel, S., Baines, A. C., Yee, A., McGee, B. M., Bäckhed, F., Baines, J. F., & Johnsen, J. M. (2012) · The ISME Journal · doi:10.1038/ismej.2011.204 · Cited by 69
“…is seemingly in contrast to a previous report that found no difference between the populations of the mucosa and lumen in a humanized mouse model (Turnbaugh et al., 2009), this apparent discrepancy may be attributable to the current study being based on sampling of unperturbed native bacterial…”
ResultRecent transcriptomics advances and emerging applications in food science
Valdés, A., Ibáñez, C., Simó, C., & García‐Cañas, V. (2013) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2013.06.014 · Cited by 67
Functional profiling of the gut microbiome in disease-associated inflammation
Börnigen, D., Morgan, X. C., Franzosa, E. A., Ren, B., Xavier, R. J., Garrett, W. S., & Huttenhower, C. (2013) · Genome Medicine · doi:10.1186/gm469 · Cited by 72
“to a low-fat/low-protein diet) tend to quickly change the relative abundance of microbial taxa but not their presence or absence [105,106].”
BackgroundEffects of different diets on intestinal microbiota and nonalcoholic fatty liver disease development
Liu, J., Zou, W., Chen, S.-J., Wei, H., Yin, Y., Zou, Y.-Y., & Lu, F. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i32.7353 · Cited by 67
Guo, Y. H., Liu, C., Shan, C., Chen, Y., Li, H., Huang, Z., & Zou, D. (2016) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2857 · Cited by 67
“However, some research has shown that dietary ingredients have a role in the regulation of microbial ecology.(26,27) Still, the results of the previously mentioned studies and our study with ZDF rats suggest that changes to the gastrointestinal flora after RYGB are unique and conserved.”
ResultComparative analysis of the gut microbiota of black bears in China using high-throughput sequencing
Song, C., Wang, B., Tan, J., Zhu, L., Lou, D., & Cen, X. (2016) · Molecular Genetics and Genomics · doi:10.1007/s00438-016-1282-0 · Cited by 68
“Many factors contribute to the community structure of host intestinal microbiota, such as diet (Turnbaugh et al. 2009; Muegge et al. 2011), geography (Yatsunenko et al. 2012), and seasonal changes (Sommer et al. 2016; Sun et al. 2016).”
BackgroundDoes the Gut Microbiota Influence Immunity and Inflammation in Multiple Sclerosis Pathophysiology?
Adamczyk-Sowa, M. H., Medrek, A., Madej, P., Michlicka, W., & Dobrakowski, P. P. (2017) · Journal of Immunology Research · doi:10.1155/2017/7904821 · Cited by 68
“[41] demonstrated that the intestinal microflora is related to obesity.”
BackgroundKatsimichas, T., Ohtani, T., Motooka, D., Tsukamoto, Y., Kioka, H., Nakamoto, K., Konishi, S., Chimura, M., Sengoku, K., Miyawaki, H., et al. (2018) · Circulation Journal · doi:10.1253/circj.cj-17-1285 · Cited by 67
Miyoshi, J., Leone, V., Nobutani, K., Musch, M. W., Martinez, K., Wang, Y., Miyoshi, S., Bobe, A. M., Eren, A. M., & Chang, E. B. (2018) · PeerJ · doi:10.7717/peerj.5166 · Cited by 66
Zheng, S., Huang, K., Zhao, C., Xu, W., Sheng, Y., Luo, Y., & He, X. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.09.007 · Cited by 68
The Role of Probiotics and Their Metabolites in the Treatment of Depression
Jach, M. E., Serefko, A., Szopa, A., Sajnaga, E., Golczyk, H., Santos, L. S., Borowicz, K. K., & Sieniawska, E. (2023) · Molecules · doi:10.3390/molecules28073213 · Cited by 75
Lewis, W. B., Moore, F. R., & Wang, S. (2016) · The Auk · doi:10.1642/auk-16-120.1 · Cited by 66
“The makeup of the gut microbiota can be influenced by a variety of factors, including diet, environment, host genetics, and immune function (Turnbaugh et al. 2009, Benson et al. 2010, Dimitriu et al. 2013, David et al. 2014, Roberts et al. 2014, Goodrich et al. 2016); therefore, any change in the…”
BackgroundSex Differences in Pulmonary Responses to Ozone in Mice. Role of the Microbiome
Cho, Y., Abu-Ali, G., Tashiro, H., Brown, T. A., Osgood, R. S., Kasahara, D. I., Huttenhower, C., & Shore, S. A. (2018) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0099oc · Cited by 64
Ormsby, M. J., Johnson, S. A., Carpena, N., Meikle, L. M., Goldstone, R. J., McIntosh, A., Wessel, H. M., Hulme, H., McConnachie, C. C., Connolly, J. P. R., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.01.078 · Cited by 71
“Sudden changes in diet have been shown to result in rapid changes in the gut microbiota (Turnbaugh et al., 2009; Martinez-Medina et al., 2014; Agus et al., 2016), whereas the inflammation associated with CD results in markedly decreased microbial diversity (Tamboli et al.”
BackgroundNutrient-Sensing Mechanisms in the Gut as Therapeutic Targets for Diabetes
Breen, D. M., Rasmussen, B. A., Côté, C. D., Jackson, V. M., & Lam, T. K. T. (2013) · Diabetes · doi:10.2337/db13-0523 · Cited by 69
“In mice switched from a regular chow to a high-fat diet, the gut microbiota composition is altered in as little as 24 h (75), resulting in increased levels of Firmicutes (76).”
BackgroundAdam, E., Groenenboom, A. E., Kurm, V., Rajewska, M., Schmidt, R., Tyc, O., Weidner, S., Berg, G., de Boer, W., & Salles, J. F. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01079 · Cited by 67
“Analogous events, leading to changes in the human gut microbiome , are the application of broad spectrum antibiotics, fecal transplantations (Landy et al., 2011; de Vos, 2013) or considerable changes in diet (Turnbaugh et al., 2009).”
The lung microbiome: clinical and therapeutic implications
Fabbrizzi, A., Amedei, A., Lavorini, F., Renda, T., & Fontana, G. A. (2019) · Internal and Emergency Medicine · doi:10.1007/s11739-019-02208-y · Cited by 68
“discovered that the gut microbiota of younger adults mice highly depends on their diet and lifestyle, suggesting a similar situation in human [28].”
BackgroundResearch progress of gut microbiota and obesity caused by high-fat diet
Fan, S., Chen, S., & Lin, L. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1139800 · Cited by 71
“The human gut microbiota is highly responsive to changes in food intake and the physiological state of the digestive system (Turnbaugh et al., 2009; Qin et al., 2020), with alterations observed within a period as short as 24 hours (David et al.”
BackgroundGut Microbiota and Host Reaction in Liver Diseases
Fukui, H. (2015) · Microorganisms · doi:10.3390/microorganisms3040759 · Cited by 64
“These mice had increased adiposity and their microbiota showed an increase in the representation of the Erysipelotrichi class of bacteria and the Bacilli (mainly Enterococcus) within the Firmicutes phylum as well as a decrease in the proportional representation of members of the Bacteroidetes [68].”
BackgroundInfluentialKumar, A., Henderson, A. J., Forster, G. M., Goodyear, A., Weir, T. L., Leach, J. E., DOW, S. W., & Ryan, E. P. (2012) · BMC Microbiology · doi:10.1186/1471-2180-12-71 · Cited by 65
Taxonomic and predicted metabolic profiles of the human gut microbiome in pre-Columbian mummies
Santiago-Rodríguez, T. M., Fornaciari, G., Luciani, S., Dowd, S. E., Toranzos, G. A., Marota, I., & Cano, R. J. (2016) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiw182 · Cited by 69
Guo, X., Cheng, M., Zhang, X., Cao, J., Wu, Z., & Weng, P. (2017) · International Journal of Food Science & Technology · doi:10.1111/ijfs.13479 · Cited by 66
“…conditions by diluting a freshly voided human faecal sample (1 g) in 10 mL reduced phosphate-buffered saline (PBS, 0.1 M, pH 7.2), the faecal material was then suspended by vortexing, and 0.2 mL of the suspension introduced by gavage, into each germ-free recipient (Turnbaugh et al., 2009).”
BackgroundMethodInfluentialShiffman, M. E., Soo, R. M., Dennis, P. G., Morrison, M., Tyson, G. W., & Hugenholtz, P. (2017) · Europe PMC (PubMed Central) · doi:10.7717/peerj.4075 · Cited by 66
“(Turnbaugh et al., 2009) or woodrats (Neotoma lepida) (Kohl & Dearing, 2016; Magnanou, Malenke & Dearing, 2009), which more closely mimic the koala’s endogenous enzymes for detoxification (Hume, 1999), would facilitate these experiments.”
BackgroundMethodInfluentialWilkowska, A., Nowak, A., Antczak-Chrobot, A., Motyl, I., Czyżowska, A., & Paliwoda, A. (2019) · Foods · doi:10.3390/foods8090365 · Cited by 66
Short-term dietary changes can result in mucosal and systemic immune depression
Siracusa, F., Schaltenberg, N., Kumar, Y., Lesker, T. R., Steglich, B., Liwinski, T., Cortesi, F., Frommann, L., Diercks, B.-P., Bönisch, F., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01587-x · Cited by 64
Luo, Y., Zhang, L., Li, H., Smidt, H., Wright, A. G., Zhang, K., Ding, X., Zeng, Q., Bai, S., Wang, J., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00966 · Cited by 63
“In humanized gnotobiotic mice, consumption of a Western diet was associated with an increase in the relative abundance of Firmicutes, the Bacilli (mainly Enterococcus) and a decrease in the proportional representation of members of the Bacteroidetes (Turnbaugh et al., 2009).”
BackgroundPride, D. T., Salzman, J., & Relman, D. A. (2012) · Environmental Microbiology · doi:10.1111/j.1462-2920.2012.02775.x · Cited by 60
“There now are numerous studies characterizing the interplay between diet and bacterial community members in the human gastrointestinal tract [1-3] that highlight the important contribution of bacteria to human physiology, and conversely, diet on community composition.”
Metadata
- Authors
- Turnbaugh, P. J., Ridaura, V. K., Faith, J. J., Rey, F. E., Knight, R., & Gordon, J. I.
- Affiliations
- Washington University in St. Louis (US)
- University of Colorado Boulder (US)
- Corresponding author
- Gordon, Jeffrey I.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2009-11-11
- Volume
- 1
- Issue
- 6
- Pages
- 6ra14-6ra14
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC2894525
- OpenAlex
- W2136552678
- Cited by
- 3,058
- References
- 27
- Citations by year
- 2026: 71 · 2025: 112 · 2024: 140 · 2023: 158 · 2022: 201 · 2021: 251 · 2020: 269 · 2019: 288 · 2018: 248 · 2017: 246 · 2016: 237 · 2015: 198 · 2014: 183 · 2013: 173 · 2012: 131
- FWCI
- 37.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Crohn's and Colitis Foundation
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 70977, R01DK070977)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- gut microbiota, diet, fecal microbiota transplantation, Western diet, high-fat high-sugar diet, bacterial colonization, intergenerational transmission, adiposity, metabolic pathways, germ-free mice, 16S rRNA gene sequences
- MeSH terms
- Animals, Bacteria, Diet, Energy Metabolism, Germ-Free Life, Humans, Intestines, Male, Mice, Inbred C57BL, Molecular Sequence Data, RNA, Ribosomal, 16S, Genomics, Adiposity, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
