Beyond phylotyping: understanding the impact of gut microbiota on host biology
Open accessAbstract
Background: Microbial constituents of the gut microbiome interact with each other and the host to alter the luminal environment and impact development, motility, and homeostasis of the gut. Powerful methods are becoming available to investigate connections between the gut microbiome and human health. While high‐throughput sequencing of 16S rRNA genes can be used to identify and enumerate microbes in the gut, advances in several techniques (e.g., metagenomics, metatranscriptomics, metabolomics, and metaproteomics) are providing a clearer view as to the specific activities of the microbiota in the context of functional host–microbe interactions. Testing emergent hypotheses regarding microbial effects on host biology, which arise from analyses of ‘Big Data’ generated from massive parallel high‐throughput sequencing technology and spectroscopic techniques, to guide translational research is an important goal for the future. Insights regarding the fundamental operating principles of the gut microbiota should lay the foundation for rational manipulation of the microbiota to promote human health. Purpose: In this review, we provide an overview of current research on the gut microbiome emphasizing current state‐of‐the‐art technologies, approaches, and directions for improvement of our understanding of the impact of the gut microbiota with specific focus on gastrointestinal motility disorders.
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GI motility and the gut microbiota have reciprocal effects, indicating a bidirectional relationship.
“GI motility and the gut microbiota have reciprocal effects (reviewed in 1), highlighting a bidirectional relationship (Figure 3).”
From The gut Microbiome in adult and pediatric functional gastrointestinal disorders (2019) · cites this paper as [1]
Accelerated GI transit can alter the composition and spatial organization of microbial communities by creating luminal conditions suited for specific bacterial taxa or by affecting bacterial adherence.
“In turn, accelerated GI transit can alter the composition and spatial organization of microbial communities by creating luminal conditions suited for the growth of specific bacterial taxa or by affecting bacterial adherence1.”
From The gut Microbiome in adult and pediatric functional gastrointestinal disorders (2019) · cites this paper as [1]
The microbiota regulates, via different mechanisms, some important physiological functions of the host, such as those related to energy expenditure, satiety and glucose homeostasis.
“The microbiota regulates, via different mechanisms, some important physiological functions of the host, such as those related to energy expenditure, satiety and glucose homeostasis [10,11] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [11]
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- Authors
- Reigstad, C. S., & Kashyap, P. C.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Kashyap, Purna C.
- ORCID
- Kashyap, Purna C.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2013-04-18
- Volume
- 25
- Issue
- 5
- Pages
- 358-372
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- PMC
- PMC4524550
- OpenAlex
- W2169083255
- Cited by
- 66
- References
- 98
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 8 · 2023: 4 · 2022: 9 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 7 · 2017: 3 · 2016: 7 · 2015: 3 · 2014: 7
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Center for Individualized Medicine, Mayo Clinic
- National Institute of Diabetes and Digestive and Kidney Diseases (K08DK100638, P30DK084567)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- gut microbiota, host-microbe interactions, gastrointestinal motility disorders, 16S rRNA gene sequencing, metagenomics, metatranscriptomics, metabolomics, metaproteomics, microbiome manipulation, human health
- MeSH terms
- Animals, Gastrointestinal Diseases, Humans, Gastrointestinal Tract, Metagenome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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