The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Lineage Structure of the Human Antibody Repertoire in Response to Influenza Vaccination
Open accessAbstract
High-throughput sequencing suggests age-related differences in the changes in the human antibody repertoire after influenza vaccination.
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“Moreover, elderly individuals have decreased numbers of B-cell lineages but increased pre-vaccination mutation load in their repertoire, resulting in a less efficient response, and the diversity of the lineages is thus greatly reduced as compared with that in young individuals [131].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [131]
In the citing paper
“Furthermore, poor immune responses account for diminished efficacy of vaccines [82,85].”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [82]
In the citing paper
“As age advances, the immune system undergoes profound remodelling and decline, with major impact on health and survival [81,82].”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [82]
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Metadata
- Authors
- Jiang, N., He, J., Weinstein, J. A., Penland, L., Sasaki, S., He, X.-S., Dekker, C. L., Zheng, N.-Y., Huang, M., Sullivan, M., Wilson, P. C., Greenberg, H. B., Davis, M. M., Fisher, D. S., & Quake, S. R.
- Affiliations
- Stanford Medicine (US)
- Stanford University (US)
- VA Palo Alto Health Care System (US)
- University of Chicago (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Jiang, Ning
- He, Jiankui
- Weinstein, Joshua A.
- Quake, Stephen R.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2013-02-06
- Volume
- 5
- Issue
- 171
- Pages
- 171ra19-171ra19
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3699344
- OpenAlex
- W2097816699
- Cited by
- 335
- References
- 30
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 16 · 2023: 13 · 2022: 21 · 2021: 26 · 2020: 33 · 2019: 30 · 2018: 23 · 2017: 33 · 2016: 39 · 2015: 39 · 2014: 31 · 2013: 17
- FWCI
- 23.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (UL1TR001085)
- National Institute on Aging (K99AG040149)
- National Institute of Allergy and Infectious Diseases (U19AI090019, U19AI057229)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Monoclonal and Polyclonal Antibodies Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Keywords
- human antibody repertoire, influenza vaccination, immunogenomics, clonal architecture, somatic hypermutation, age-related immune decline, isotype distribution, long-read sequencing
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Antibodies, Viral, Child, Humans, Immunoglobulin M, Immunoglobulin Isotypes, Influenza, Human, Middle Aged, Mutation, Phylogeny, Vaccination, Genetic Variation, Cluster Analysis, Somatic Hypermutation, Immunoglobulin, Young Adult
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