Cited by 342T-cell and B-cell ImmunologyMonoclonal and Polyclonal Antibodies Researchvaccines and immunoinformatics approaches

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Lineage Structure of the Human Antibody Repertoire in Response to Influenza Vaccination

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Jiang, Ning, He, Jiankui, Weinstein, Joshua A., Penland, Lolita, Sasaki, Sanae, He, Xiao-Song, Dekker, Cornelia L., Zheng, Nai-Ying, Huang, Min, Sullivan, Meghan, Wilson, Patrick C., Greenberg, Harry B., Davis, Mark M., Fisher, Daniel S., Quake, Stephen R.·2013·Science Translational Medicine

DOI 10.1126/scitranslmed.3004794PMC PMC3699344

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Abstract

High-throughput sequencing suggests age-related differences in the changes in the human antibody repertoire after influenza vaccination.

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Authors: Jiang, N., He, J., Weinstein, J. A., Penland, L., Sasaki, S., He, X.-S., Dekker, C. L., Zheng, N.-Y., Huang, M., Sullivan, M., Wilson, P. C., Greenberg, H. B., Davis, M. M., Fisher, D. S., & Quake, S. R.
Affiliations: Stanford Medicine (US)
Stanford University (US)
VA Palo Alto Health Care System (US)
University of Chicago (US)
Howard Hughes Medical Institute (US)
Corresponding author: Jiang, Ning
He, Jiankui
Weinstein, Joshua A.
Quake, Stephen R.
ORCID: Jiang, Ning
Weinstein, Joshua A.
Penland, Lolita
Dekker, Cornelia L.
Zheng, Nai-Ying
Wilson, Patrick C.
Greenberg, Harry B.
Davis, Mark M.
Fisher, Daniel S.
Quake, Stephen R.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2013-02-06
Volume: 5
Issue: 171
Pages: 171ra19-171ra19
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.3004794
PMC: PMC3699344
OpenAlex: W2097816699
Cited by: 335
References: 30
Citations by year: 2026: 7 · 2025: 7 · 2024: 16 · 2023: 13 · 2022: 21 · 2021: 26 · 2020: 33 · 2019: 30 · 2018: 23 · 2017: 33 · 2016: 39 · 2015: 39 · 2014: 31 · 2013: 17
FWCI: 23.03
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health (UL1TR001085)
National Institute on Aging (K99AG040149)
National Institute of Allergy and Infectious Diseases (U19AI090019, U19AI057229)
National Center for Advancing Translational Sciences
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Monoclonal and Polyclonal Antibodies Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
Keywords: human antibody repertoire, influenza vaccination, immunogenomics, clonal architecture, somatic hypermutation, age-related immune decline, isotype distribution, long-read sequencing
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Aging, Antibodies, Viral, Child, Humans, Immunoglobulin M, Immunoglobulin Isotypes, Influenza, Human, Middle Aged, Mutation, Phylogeny, Vaccination, Genetic Variation, Cluster Analysis, Somatic Hypermutation, Immunoglobulin, Young Adult

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Lineage Structure of the Human Antibody Repertoire in Response to Influenza Vaccination

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