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In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells
Abstract
Genetically engineered T memory stem cells preserve differentiation activity for decades after patient infusion.
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“In the mouse skin, resident memory T cells persist over long time periods”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Biasco et al., 2015
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Metadata
- Authors
- Biasco, L., Scala, S., Basso Ricci, L., Dionisio, F., Baricordi, C., Calabria, A., Giannelli, S., Cieri, N., Barzaghi, F., Pajno, R., Al-Mousa, H., Scarselli, A., Cancrini, C., Bordignon, C., Roncarolo, M. G., Montini, E., Bonini, C., & Aiuti, A.
- Affiliations
- The San Raffaele Telethon Institute for Gene Therapy (IT)
- Vita-Salute San Raffaele University (IT)
- San Raffaele Telethon Institute for Gene Therapy (TIGET), Division of Regenerative Medicine, Stem Cells, and Gene Therapy, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan 20132, Italy.
- IRCCS Ospedale San Raffaele (IT)
- IRCCS San Raffaele Roma (IT)
- King Faisal Specialist Hospital & Research Centre, Riyadh 11211, Saudi Arabia.
- University of Rome Tor Vergata (IT)
- Corresponding author
- Biasco, Luca
- Scala, Serena
- Aiuti, Alessandro
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2015-02-04
- Volume
- 7
- Issue
- 273
- Pages
- 273ra13-273ra13
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2060838652
- Cited by
- 175
- References
- 50
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 16 · 2023: 15 · 2022: 19 · 2021: 20 · 2020: 16 · 2019: 15 · 2018: 17 · 2017: 17 · 2016: 13 · 2015: 17
- FWCI
- 14.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Funders
- Italian Telethon Foundation
- Italian Ministero della Salute (RF-2009-1485896)
- Advanced Cell_based Therapies for the treatment of Primary ImmunoDeficiency (HEALTH-F5-2010-261387)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › CAR-T cell therapy research
- Keywords
- gene therapy, inherited immunodeficiency, hematopoietic stem cell transplantation, conditioning regimen
- MeSH terms
- Adult, Cell Survival, Child, Clone Cells, Genetic Engineering, Hematopoietic Stem Cells, Humans, Immunologic Memory, Interleukin-2, Longitudinal Studies, Phenotype, T-Lymphocytes, Tetradecanoylphorbol Acetate, Time Factors, Tissue Donors, Genetic Therapy, Lymphocyte Subsets, Cell Tracking
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