The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells
Abstract
Genetically engineered T memory stem cells preserve differentiation activity for decades after patient infusion.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In the mouse skin, resident memory T cells persist over long time periods”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Biasco et al., 2015
Citations
Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846
GREAT improves functional interpretation of cis-regulatory regions
McLean, C. Y., Bristor, D., Hiller, M., Clarke, S. L., Schaar, B. T., Lowe, C. B., Wenger, A. M., & Bejerano, G. (2010) · Nature Biotechnology · doi:10.1038/nbt.1630 · Cited by 4,502
A human memory T cell subset with stem cell–like properties
Gattinoni, L., Lugli, E., Ji, Y., Pos, Z., Paulos, C. M., Quigley, M. F., Almeida, J. R., Gostick, E., Yu, Z., Carpenito, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2446 · Cited by 1,974
Transcriptional control of effector and memory CD8+ T cell differentiation
Kaech, S. M., & Cui, W. (2012) · Nature Reviews Immunology · doi:10.1038/nri3307 · Cited by 1,628
T Lymphocyte-Directed Gene Therapy for ADA − SCID: Initial Trial Results After 4 Years
Blaese, R. M., Culver, K. W., Miller, A. D., Carter, C. S., Fleisher, T. A., Clerici, M., Shearer, G. M., Chang, L., Chiang, Y. L., Tolstoshev, P., et al. (1995) · Science · doi:10.1126/science.270.5235.475 · Cited by 1,546
Howe, S. J., Mansour, M. R., Schwarzwaelder, K., Bartholomae, C., Hubank, M., Kempski, H., Brugman, M. H., Pike-Overzet, K., Chatters, S. J., de Ridder, D., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35798 · Cited by 1,286
Lentiviral Hematopoietic Stem Cell Gene Therapy Benefits Metachromatic Leukodystrophy
Biffi, A., Montini, E., Lorioli, L., Cesani, M., Fumagalli, F., Plati, T., Baldoli, C., Martino, S., Calabria, A., Canale, S., et al. (2013) · Science · doi:10.1126/science.1233158 · Cited by 1,180
Self-citationCorrection of ADA-SCID by Stem Cell Gene Therapy Combined with Nonmyeloablative Conditioning
Aiuti, A., Slavin, S., Aker, M., Ficara, F., Deola, S., Mortellaro, A., Morecki, S., Andolfi, G., Tabucchi, A., Carlucci, F., et al. (2002) · Science · doi:10.1126/science.1070104 · Cited by 1,142
Self-citationLentiviral Hematopoietic Stem Cell Gene Therapy in Patients with Wiskott-Aldrich Syndrome
Aiuti, A., Biasco, L., Scaramuzza, S., Ferrua, F., Cicalese, M. P., Baricordi, C., Dionisio, F., Calabria, A., Giannelli, S., Castiello, M. C., et al. (2013) · Science · doi:10.1126/science.1233151 · Cited by 1,025
Self-citationGene Therapy for Immunodeficiency Due to Adenosine Deaminase Deficiency
Aiuti, A., Cattaneo, F., Galimberti, S., Benninghoff, U., Cassani, B., Callegaro, L., Scaramuzza, S., Andolfi, G., Mirolo, M., Brigida, I., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0805817 · Cited by 1,018
Self-citation
Cited by
Sorted by citations
Gene therapy returns to centre stage
Naldini, L. (2015) · Nature · doi:10.1038/nature15818 · Cited by 1,184
T memory stem cells in health and disease
Gattinoni, L., Speiser, D. E., Lichterfeld, M. D., & Bonini, C. (2017) · Nature Medicine · doi:10.1038/nm.4241 · Cited by 657
Self-citationSabatino, M., Hu, J., Sommariva, M., Gautam, S., Fellowes, V. S., Hocker, J. D., Dougherty, S. C., Qin, H., Klebanoff, C. A., Fry, T. J., et al. (2016) · Blood · doi:10.1182/blood-2015-11-683847 · Cited by 389
Successful and Maladaptive T Cell Aging
Goronzy, J. J., & Weyand, C. M. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.010 · Cited by 362
Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans
Galletti, G., De Simone, G., Mazza, E. M. C., Puccio, S., Mezzanotte, C., Bi, T. M., Davydov, A. N., Metsger, M., Scamardella, E., Alvisi, G., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0791-5 · Cited by 299
Lentiviral gene therapy for X-linked chronic granulomatous disease
Kohn, D. B., Booth, C., Kang, E. M., Pai, S., Shaw, K. L., Santilli, G., Armant, M. A., Buckland, K. F., Choi, U., Ravin, S. S. D., et al. (2020) · Nature Medicine · doi:10.1038/s41591-019-0735-5 · Cited by 263
Self-citationBiasco, L., Pellin, D., Scala, S., Dionisio, F., Basso-Ricci, L., Leonardelli, L., Scaramuzza, S., Baricordi, C., Ferrua, F., Cicalese, M. P., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.04.016 · Cited by 243
Self-citationThe epigenetic control of stemness in CD8 + T cell fate commitment
Pace, L., Goudot, C., Zueva, E., Gueguen, P., Burgdorf, N., Waterfall, J. J., Quivy, J., Almouzni, G., & Amigorena, S. (2018) · Science · doi:10.1126/science.aah6499 · Cited by 232
The role of cytokines in T‐cell memory in health and disease
Raeber, M. E., Zurbuchen, Y., Impellizzieri, D., & Boyman, O. (2018) · Immunological Reviews · doi:10.1111/imr.12644 · Cited by 232
Fuertes Marraco, S. A., Soneson, C., Cagnon, L., Gannon, P. O., Allard, M., Maillard, S. A., Montandon, N., Rufer, N., Waldvogel, S., Delorenzi, M., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa3700 · Cited by 206
Gene therapy targeting haematopoietic stem cells for inherited diseases: progress and challenges
Cavazzana, M., Bushman, F. D., Miccio, A., André‐Schmutz, I., & Six, E. M. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0020-9 · Cited by 205
Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT
Noviello, M., Manfredi, F., Ruggiero, E., Perini, T., Oliveira, G., Cortesi, F., Simone, P. D., Toffalori, C., Gambacorta, V., Greco, R., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08871-1 · Cited by 203
Self-citationNew cell sources for T cell engineering and adoptive immunotherapy
Themeli, M., Rivière, I., & Sadelain, M. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.03.011 · Cited by 179
Blaeschke, F., Stenger, D., Kaeuferle, T., Willier, S., Lotfi, R., Kaiser, A. D., Assenmacher, M., Döring, M., Feucht, J., & Feuchtinger, T. (2018) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-018-2155-7 · Cited by 155
Biasco, L., Izotova, N., Rivat, C., Ghorashian, S., Richardson, R., Guvenel, A., Hough, R. E., Wynn, R. F., Popova, B., Lopes, A., et al. (2021) · Nature Cancer · doi:10.1038/s43018-021-00207-7 · Cited by 155
Self-citationIL15 and T-cell Stemness in T-cell–Based Cancer Immunotherapy
Pilipow, K., Roberto, A., Roederer, M., Waldmann, T. A., Mavilio, D., & Lugli, E. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-1498 · Cited by 138
Antioxidant metabolism regulates CD8+ T memory stem cell formation and antitumor immunity
Pilipow, K., Scamardella, E., Puccio, S., Gautam, S., Paoli, F. D., Mazza, E. M. C., Simone, G. D., Polletti, S., Buccilli, M., Zanon, V., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.122299 · Cited by 136
CDK4/6 Inhibition Promotes Antitumor Immunity through the Induction of T-cell Memory
Lelliott, E. J., Kong, I. Y., Zethoven, M., Ramsbottom, K. M., Martelotto, L. G., Meyran, D., Zhu, J. J., Costacurta, M., Kirby, L., Sandow, J. J., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1554 · Cited by 129
T-cell defects in patients with ARPC1B germline mutations account for combined immunodeficiency
Brigida, I., Zoccolillo, M., Cicalese, M. P., Pfajfer, L., Barzaghi, F., Scala, S., Oleaga‐Quintas, C., Álvarez‐Álvarez, J. A., Sereni, L. P., Giannelli, S., et al. (2018) · Blood · doi:10.1182/blood-2018-07-863431 · Cited by 125
Self-citationOliveira, G., Ruggiero, E., Stanghellini, M. T. L., Cieri, N., D’Agostino, M., Fronza, R., Lulay, C., Dionisio, F., Mastaglio, S., Greco, R., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac8265 · Cited by 121
Self-citationImproving CAR T-Cell Persistence
Pietrobon, V., Todd, L. A., Goswami, A., Stefanson, O., Yang, Z., & Marincola, F. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910828 · Cited by 124
Scala, S., Ricci, L. B., Dionisio, F., Pellin, D., Giannelli, S., Salerio, F. A., Leonardelli, L., Cicalese, M. P., Ferrua, F., Aiuti, A., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0195-3 · Cited by 116
Self-citationThe Single-Cell Phenotypic Identity of Human CD8+ and CD4+ T Cells
Brummelman, J., Pilipow, K., & Lugli, E. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.05.007 · Cited by 113
Tantalo, D. G. M., Oliver, A. J., von Scheidt, B., Harrison, A. J., Mueller, S. N., Kershaw, M. H., & Slaney, C. Y. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-002555 · Cited by 112
Stem, Effector, and Hybrid States of Memory CD8+ T Cells
Lugli, E., Galletti, G., Boi, S. K., & Youngblood, B. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.11.004 · Cited by 107
Gene Therapy for X-Linked Severe Combined Immunodeficiency: Where Do We Stand?
Cavazzana, M., Six, E., Lagresle-Peyrou, C., André-Schmutz, I., & Hacein-Bey-Abina, S. (2016) · Human Gene Therapy · doi:10.1089/hum.2015.137 · Cited by 106
Neonatal thymectomy reveals differentiation and plasticity within human naive T cells
van den Broek, T., Delemarre, E. M., Janssen, W. J. M., Nievelstein, R. A. J., Broen, J. C., Tesselaar, K., Borghans, J. A. M., Nieuwenhuis, E. E. S., Prakken, B. J., Mokry, M., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84997 · Cited by 104
Twenty-Five Years of Gene Therapy for ADA-SCID: From Bubble Babies to an Approved Drug
Ferrua, F., & Aiuti, A. (2017) · Human Gene Therapy · doi:10.1089/hum.2017.175 · Cited by 109
Self-citationAutomated manufacture of autologous CD19 CAR-T cells for treatment of non-hodgkin lymphoma
Jackson, Z., Roe, A., Sharma, A. A., Lopes, F. B. T. P., Talla, A., Kleinsorge-Block, S., Zamborsky, K., Schiavone, J., Manjappa, S., Schauner, R., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01941 · Cited by 102
Adoptive T-cell therapy for cancer: the era of engineered T cells
Bonini, C., & Mondino, A. (2015) · European Journal of Immunology · doi:10.1002/eji.201545552 · Cited by 93
Self-citationPalani, H. K., Arunachalam, A. K., Yasar, M., Venkatraman, A., Kulkarni, U., Lionel, S. A., Selvarajan, S., Korula, A., Abraham, A., George, B., et al. (2023) · Bone Marrow Transplantation · doi:10.1038/s41409-022-01866-5 · Cited by 89
Surmounting the obstacles that impede effective CAR T cell trafficking to solid tumors
Donnadieu, E., Dupré, L., Pinho, L. G., & Cotta-de-Almeida, V. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.1mr0520-746r · Cited by 85
Redeker, A., & Arens, R. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00345 · Cited by 79
Clinical Applications of Gene Therapy for Primary Immunodeficiencies
Cicalese, M. P., & Aiuti, A. (2015) · Human Gene Therapy · doi:10.1089/hum.2015.047 · Cited by 80
Self-citationBorel, F., Tang, Q., Gernoux, G., Greer, C., Wang, Z., Barzel, A., Kay, M. A., Shultz, L. D., Greiner, D. L., Flotte, T. R., et al. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.09.020 · Cited by 79
Reconstitution of T Cell Subsets Following Allogeneic Hematopoietic Cell Transplantation
Dekker, L., de Koning, C. C. H., Lindemans, C. A., & Nierkens, S. (2020) · Cancers · doi:10.3390/cancers12071974 · Cited by 82
Wang, Z., Ahmed, S. U., Labib, M., Wang, H., Hu, X., Wei, J., Yao, Y., Moffat, J., Sargent, E. H., & Kelley, S. O. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00820-y · Cited by 76
Aparicio, C., Acebal, C., & González‐Vallinas, M. (2023) · Experimental Hematology and Oncology · doi:10.1186/s40164-023-00435-w · Cited by 82
Human TSCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness
del Amo, P. C., Lahoz-Beneytez, J., Boelen, L., Ahmed, R., Miners, K. L., Zhang, Y., Roger, L., Jones, R. E., Marraco, S. A. F., Speiser, D. E., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2005523 · Cited by 76
Firor, A. E., Jares, A., & Ma, Y. (2015) · Experimental Biology and Medicine · doi:10.1177/1535370215584936 · Cited by 75
The antitumor capacity of mesothelin-CAR-T cells in targeting solid tumors in mice
Zhang, Q., Liu, G., Liu, J., Yang, M., Fu, J. L., Liu, G., Li, D., Gu, Z., Zhang, L., Pan, Y., et al. (2021) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2021.02.013 · Cited by 70
In Situ Programming of CAR T Cells
Parayath, N. N., & Stephan, M. T. (2021) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-070620-033348 · Cited by 73
Harnessing CD3 diversity to optimize CAR T cells
Cárdenas, R. M.-H. V., Brandl, S. M., Meléndez, A. V., Schlaak, A. E., Buschky, A., Peters, T., Beier, F., Serrels, B., Taromi, S., Raute, K., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01658-z · Cited by 72
Koelle, S., Espinoza, D. A., Wu, C., Xu, J., Lu, R., Li, B., Donahue, R. E., & Dunbar, C. E. (2017) · Blood · doi:10.1182/blood-2016-07-728691 · Cited by 62
Cencioni, M. T., Genchi, A., Brittain, G., de Silva, T. I., Sharrack, B., Snowden, J. A., Alexander, T., Greco, R., & Muraro, P. A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.813957 · Cited by 61
Madison, B., Patil, D. P., Richter, M., Li, X., Tong, M., Cranert, S. A., Wang, X., Martin, R. M., Xi, H., Tan, Y., et al. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.06.003 · Cited by 61
T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications
Chi, X., Luo, S., Ye, P., Hwang, W., Cha, J., Yan, X., & Yang, W. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1104771 · Cited by 62
Schmueck‐Henneresse, M., Omer, B. A., Shum, T., Tashiro, H., Mamonkin, M., Lapteva, N., Sharma, S., Rollins, L. A., Dotti, G., Reinke, P., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601494 · Cited by 57
Mpande, C. A. M., Dintwe, O., Musvosvi, M., Mabwe, S., Bilek, N., Hatherill, M., Nemes, E., & Scriba, T. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00324 · Cited by 54
Ruggiero, E., Carnevale, E., Prodeus, A., Magnani, Z. I., Camisa, B., Merelli, I., Politano, C., Stasi, L., Potenza, A., Cianciotti, B. C., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abg8027 · Cited by 58
Self-citationThe Role of Conditioning in Hematopoietic Stem-Cell Gene Therapy
Bernardo, M. E., & Aiuti, A. (2016) · Human Gene Therapy · doi:10.1089/hum.2016.103 · Cited by 56
Self-citationStem cell like memory T cells: A new paradigm in cancer immunotherapy
Wang, F., Cheng, F., & Fang, Z. (2022) · Clinical Immunology · doi:10.1016/j.clim.2022.109078 · Cited by 53
The Progress and Prospects of Immune Cell Therapy for the Treatment of Cancer
Han, J., Zhang, B., Zheng, S., Jiang, Y. H., Zhang, X., & Mao, K. (2024) · Cell Transplantation · doi:10.1177/09636897241231892 · Cited by 57
Progress and challenges in developing allogeneic cell therapies
Deuse, T., & Schrepfer, S. (2025) · Cell Stem Cell · doi:10.1016/j.stem.2025.03.004 · Cited by 51
Xu, X., Song, D.-G., Poussin, M., Ye, Q., Sharma, P., Rodríguez-García, A., Tang, Y., & Powell, D. J. (2016) · Oncotarget · doi:10.18632/oncotarget.10510 · Cited by 51
Denk, D., Singh, A., Kasler, H. G., D’Amico, D., Rey, J., Alcober-Boquet, L., Gorol, J. M., Steup, C., Tiwari, R., Kwok, R., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00996-x · Cited by 58
Stem cell-like memory T cells: The generation and application
Wang, Y., Qiu, F., Xu, Y., Hou, X., Zhang, Z., Huang, L., Wang, H., Xing, H., & Wu, S. (2021) · Journal of Leukocyte Biology · doi:10.1002/jlb.5mr0321-145r · Cited by 49
Prolonged Antiretroviral Therapy Preserves HIV-1-Specific CD8 T Cells with Stem Cell-Like Properties
Viganó, S., Negron, J., Ouyang, Z., Rosenberg, E. S., Walker, B. D., Lichterfeld, M. D., & Yu, X. G. (2015) · Journal of Virology · doi:10.1128/jvi.00789-15 · Cited by 47
T-Cell Therapy: Options for Infectious Diseases: Table 1.
Parida, S. K., Poiret, T., Zhenjiang, L., Meng, Q., Heyckendorf, J., Lange, C. G., Ambati, A., Rao, M., Valentini, D., Ferrara, G., et al. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ615 · Cited by 50
Development and Function of Protective and Pathologic Memory CD4 T Cells
Jaigirdar, S. A., & MacLeod, M. K. L. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00456 · Cited by 49
The roles of stem cell memory T cells in hematological malignancies
Xu, L., Zhang, Y., Luo, G., & Li, Y. (2015) · Journal of Hematology & Oncology · doi:10.1186/s13045-015-0214-5 · Cited by 47
Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway
Kared, H., Tan, S. W., Lau, M. C., Chevrier, M., Tan, C. T. Y., How, W., Wong, G. C. L., Strickland, M., Malleret, B., Amoah, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14442-6 · Cited by 49
Analyzing the Genotoxicity of Retroviral Vectors in Hematopoietic Cell Gene Therapy
Biasco, L., Rothe, M., Büning, H., & Schambach, A. (2017) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2017.10.002 · Cited by 45
Self-citationCianciotti, B. C., Ruggiero, E., Campochiaro, C., Oliveira, G., Magnani, Z. I., Baldini, M., Doglio, M., Tassara, M. G., Manfredi, A. A., Baldissera, E. M., et al. (2019) · Arthritis & Rheumatology · doi:10.1002/art.41157 · Cited by 44
Self-citationSchrödinger’s T Cells: Molecular Insights Into Stemness and Exhaustion
Gonzalez, N. M., Zou, D., Gu, A., & Chen, W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.725618 · Cited by 46
Sanctis, F. D., Lamolinara, A., Boschi, F., Musiu, C., Caligola, S., Trovato, R., Fiore, A., Frusteri, C., Anselmi, C., Poffe, O., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003549 · Cited by 46
T Cell Reprogramming Against Cancer
Katz, S. G., & Rabinovich, P. M. (2019) · Methods in molecular biology · doi:10.1007/978-1-0716-0203-4_1 · Cited by 45
Effect of radiotherapy on T cell and PD-1 / PD-L1 blocking therapy in tumor microenvironment
Chen, C., Liu, Y., & Cui, B. (2021) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2020.1840254 · Cited by 43
Panchal, N., Houghton, B., Díez, B., Ghosh, S., Ricciardelli, I., Thrasher, A. J., Gaspar, H. B., & Booth, C. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.02.053 · Cited by 42
Timpanaro, A., Piccand, C., Dzhumashev, D., Anton-Joseph, S., Robbi, A., Moser, J. J., Rössler, J. K., & Bernasconi, M. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02838-3 · Cited by 36
Synthetic biology approaches to engineer T cells
Wu, C., Rupp, L. J., Roybal, K. T., & Lim, W. A. (2015) · Current Opinion in Immunology · doi:10.1016/j.coi.2015.06.015 · Cited by 35
Reversion Mosaicism in Primary Immunodeficiency Diseases
Miyazawa, H., & Wada, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.783022 · Cited by 34
Reference range of naïve T and T memory lymphocyte subsets in peripheral blood of healthy adult
Xia, Y., Liu, A., Li, W., Liu, Y., Zhang, G., Ye, S., Zhao, Z.-R., Shi, J., Jia, Y., Liu, X., et al. (2021) · Clinical & Experimental Immunology · doi:10.1093/cei/uxab038 · Cited by 34
Cornetta, K. G., Lin, T., Pellin, D., & Kohn, D. B. (2022) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2022.11.009 · Cited by 35
Hematopoiesis during Ontogenesis, Adult Life, and Aging
Belyavsky, A. V., Петинати, Н. А., & Дризе, Н. И. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179231 · Cited by 37
TIM-3, LAG-3, or 2B4 gene disruptions increase the anti-tumor response of engineered T cells
Cianciotti, B. C., Magnani, Z. I., Ugolini, A., Camisa, B., Merelli, I., Vavassori, V., Potenza, A., Imparato, A., Manfredi, F., Abbati, D., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1315283 · Cited by 32
Self-citationSoheili, T. S., Rivière, J., Ricciardelli, I., Durand, A., Verhoeyen, E., Derrien, A., Lagresle‐Peyrou, C., Basile, G. D. S., Cosset, F., Amrolia, P. J., et al. (2016) · Blood · doi:10.1182/blood-2016-07-729871 · Cited by 29
Sharma, R., Dever, D. P., Lee, C. M., Azizi, A., Pan, Y., Camarena, J., Köhnke, T., Bao, G., Porteus, M. H., & Majeti, R. (2021) · Nature Communications · doi:10.1038/s41467-020-20792-y · Cited by 30
Luo, X., Meng, Q., Rao, M., Liu, Z., Paraschoudi, G., Dodoo, E., & Maeurer, M. J. (2018) · Immunology · doi:10.1111/imm.12991 · Cited by 32
Zanon, V., Pilipow, K., Scamardella, E., Paoli, F. D., Simone, G. D., Price, D. A., Martínez-Usatorre, A., Romero, P. J., Mavilio, D., Roberto, A., et al. (2017) · European Journal of Immunology · doi:10.1002/eji.201646732 · Cited by 29
Sandri, S., Sanctis, F. D., Lamolinara, A., Boschi, F., Poffe, O., Trovato, R., Fiore, A., Sartori, S., Sbarbati, A., Bondanza, A., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.18115 · Cited by 30
Circulating hematopoietic stem/progenitor cell subsets contribute to human hematopoietic homeostasis
Quaranta, P., Ricci, L. B., Hernández, R. J., Pacini, G., Naldini, M. M., Barcella, M., Seffin, L., Pais, G., Spinozzi, G., Benedicenti, F., et al. (2024) · Blood · doi:10.1182/blood.2023022666 · Cited by 28
Self-citationChicaybam, L., Abdo, L. D. M., Carneiro, M., Peixoto, B., Viegas, M. S., de Sousa, P., Fornazin, M. C., Spago, M. C., Laranjeira, A. B. A., de Campos-Lima, P. O., et al. (2019) · Human Gene Therapy · doi:10.1089/hum.2018.218 · Cited by 27
Cartwright, E. K., Palesch, D., Mavigner, M., Paiardini, M., Chahroudi, A., & Silvestri, G. (2016) · Journal of Virology · doi:10.1128/jvi.00492-16 · Cited by 26
Chen, T., Deng, J., Zhang, Y., Liu, B., Liu, R., Zhu, Y., Zhou, M., Lin, Y., Xia, B., Lin, K., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-01938-8 · Cited by 27
Yadak, R., Cabrera-Pérez, R., Torres‐Torronteras, J., Bugiani, M., Haeck, J. C., Huston, M. W., Bogaerts, E., Goffart, S., Jacobs, E. H., Stok, M., et al. (2018) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2018.01.001 · Cited by 25
Self-citationSoares, M. V. D., Azevedo, R. I., Ferreira, I., Bucar, S., Ribeiro, A. C., Vieira, A. I. S., Pereira, P. N. G., Ribeiro, R. M., Ligeiro, D., Alho, A. C., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00334 · Cited by 27
Zhang, Y., Wang, N., Ding, M., Yang, Y., Wang, Z., Huang, L., Zhu, W., Mellor, A. L., Hou, X., Zhou, C., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01012 · Cited by 23
Early-phenotype CAR-T cells for the treatment of pediatric cancers
Meyran, D., Terry, R. L., Zhu, J. J., Haber, M., Ziegler, D. S., Ekert, P. G., Trapani, J. A., Darcy, P. K., & Neeson, P. J. (2021) · Annals of Oncology · doi:10.1016/j.annonc.2021.07.018 · Cited by 24
Nonclinical safety assessment of engineered T cell therapies
Lebrec, H. N., Maier, C. C., Maki, K., Ponce, R. A., Shenton, J. M., & Green, S. (2021) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2021.105064 · Cited by 25
CD8-positive memory T cells in tumor-draining lymph nodes of patients with breast cancer
Vahidi, Y., Bagheri, M., Ghaderi, A. A., & Faghih, Z. S. (2020) · BMC Cancer · doi:10.1186/s12885-020-6714-x · Cited by 22
Mittra, S., Harding, S. M., & Kaech, S. M. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2300049 · Cited by 20
Genome-edited adult stem cells: Next-generation advanced therapy medicinal products
Benabdellah, K., Sánchez-Hernández, S., Aguilar-González, A., Maldonado‐Pérez, N., Gutiérrez-Guerrero, A., Cortijo-Gutierréz, M., Ramos-Hernández, I., Tristán‐Manzano, M., Galindo‐Moreno, P., Herrera, C., et al. (2020) · Stem Cells Translational Medicine · doi:10.1002/sctm.19-0338 · Cited by 21
Achini, F., Snowden, J. A., Corbacioglu, S., Greco, R., & Parties, T. E. A. D. (. A. P. D. (. W. (2022) · British Journal of Haematology · doi:10.1111/bjh.18176 · Cited by 19
Efficient derivation of chimeric-antigen receptor-modified TSCM cells
Kranz, E. O., Kuhlmann, C. J., Chan, J., Kim, P. Y., Chen, I. S. Y., & Kamata, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.877682 · Cited by 18
Tissue‐resident and memory properties of human T‐cell and NK‐cell subsets
Lugli, E., Hudspeth, K. L., Roberto, A., & Mavilio, D. (2016) · European Journal of Immunology · doi:10.1002/eji.201545702 · Cited by 20
Hartnell, F., Esposito, I., Swadling, L., Brown, A., Phetsouphanh, C., de Lara, C., Gentile, C., Turner, B., Dorrell, L., Capone, S., et al. (2020) · Hepatology · doi:10.1002/hep.31160 · Cited by 18
Pan, H., Yang, X., Wang, J., Liang, H., Jiang, Z., Zhao, L., Wang, Y., Liang, Z., Shen, X., Lin, Q., et al. (2023) · Virologica Sinica · doi:10.1016/j.virs.2023.01.003 · Cited by 19
Integrating Vectors for Gene Therapy and Clonal Tracking of Engineered Hematopoiesis
Biasco, L., Rothe, M., Schott, J. W., & Schambach, A. (2017) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2017.06.009 · Cited by 17
Self-citationT cell gene therapy to treat immunodeficiency
Panchal, N., Ghosh, S., & Booth, C. (2020) · British Journal of Haematology · doi:10.1111/bjh.17070 · Cited by 18
Metadata
- Authors
- Biasco, L., Scala, S., Basso Ricci, L., Dionisio, F., Baricordi, C., Calabria, A., Giannelli, S., Cieri, N., Barzaghi, F., Pajno, R., Al-Mousa, H., Scarselli, A., Cancrini, C., Bordignon, C., Roncarolo, M. G., Montini, E., Bonini, C., & Aiuti, A.
- Affiliations
- The San Raffaele Telethon Institute for Gene Therapy (IT)
- Vita-Salute San Raffaele University (IT)
- San Raffaele Telethon Institute for Gene Therapy (TIGET), Division of Regenerative Medicine, Stem Cells, and Gene Therapy, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan 20132, Italy.
- IRCCS Ospedale San Raffaele (IT)
- IRCCS San Raffaele Roma (IT)
- King Faisal Specialist Hospital & Research Centre, Riyadh 11211, Saudi Arabia.
- University of Rome Tor Vergata (IT)
- Corresponding author
- Biasco, Luca
- Scala, Serena
- Aiuti, Alessandro
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2015-02-04
- Volume
- 7
- Issue
- 273
- Pages
- 273ra13-273ra13
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2060838652
- Cited by
- 175
- References
- 50
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 16 · 2023: 15 · 2022: 19 · 2021: 20 · 2020: 16 · 2019: 15 · 2018: 17 · 2017: 17 · 2016: 13 · 2015: 17
- FWCI
- 14.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Funders
- Italian Telethon Foundation
- Italian Ministero della Salute (RF-2009-1485896)
- Advanced Cell_based Therapies for the treatment of Primary ImmunoDeficiency (HEALTH-F5-2010-261387)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › CAR-T cell therapy research
- Keywords
- gene therapy, inherited immunodeficiency, hematopoietic stem cell transplantation, conditioning regimen
- MeSH terms
- Adult, Cell Survival, Child, Clone Cells, Genetic Engineering, Hematopoietic Stem Cells, Humans, Immunologic Memory, Interleukin-2, Longitudinal Studies, Phenotype, T-Lymphocytes, Tetradecanoylphorbol Acetate, Time Factors, Tissue Donors, Genetic Therapy, Lymphocyte Subsets, Cell Tracking
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review