Cited by 155T-cell and B-cell ImmunologyTGF-β signaling in diseasesCancer Immunotherapy and Biomarkers

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Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo

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Cuende, Julia, Liénart, Stéphanie, Dedobbeleer, Olivier, van der Woning, Bas, De Boeck, Gitte, Stockis, Julie, Huygens, Caroline, Colau, Didier, Somja, Joan, Delvenne, Philippe, Hannon, Muriel, Baron, Frédéric, Dumoutier, Laure, Renauld, Jean-Christophe, De Haard, Hans, Saunders, Michael, Coulie, Pierre G., Lucas, Sophie·2015·Science Translational Medicine

DOI 10.1126/scitranslmed.aaa1983

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Abstract

Monoclonal antibodies that inhibit human T reg function in vivo may be used therapeutically in cancer or infections.

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Authors: Cuende, J., Liénart, S., Dedobbeleer, O., van der Woning, B., De Boeck, G., Stockis, J., Huygens, C., Colau, D., Somja, J., Delvenne, P., Hannon, M., Baron, F., Dumoutier, L., Renauld, J.-C., De Haard, H., Saunders, M., Coulie, P. G., & Lucas, S.
Affiliations: de Duve Institute (BE)
arGEN-X BVBA, Technologiepark 30, B9052 Zwijnaarde, Gent, Belgium.
Ludwig Cancer Research (BE)
University of Liège (BE)
Argenx (Belgium) (BE)
Corresponding author: Cuende, Julia
Liénart, Stéphanie
Lucas, Sophie
ORCID: Liénart, Stéphanie
Stockis, Julie
Colau, Didier
Somja, Joan
Delvenne, Philippe
Baron, Frédéric
Dumoutier, Laure
Renauld, Jean-Christophe
Coulie, Pierre G.
Lucas, Sophie
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2015-04-22
Volume: 7
Issue: 284
Pages: 284ra56-284ra56
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.aaa1983
OpenAlex: W2113024959
Cited by: 155
References: 59
Citations by year: 2026: 6 · 2025: 8 · 2024: 17 · 2023: 13 · 2022: 16 · 2021: 20 · 2020: 17 · 2019: 15 · 2018: 14 · 2017: 12 · 2016: 12 · 2015: 5
FWCI: 7.04
Type: journal article
Language: en
Open access: green
orbi.uliege.be
Licence: other-oa
www.sciencemag.org/about/science-licenses-journal-article-reuse (vor, 366 d)
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
ORBi (University of Liège) (submittedVersion, other-oa)
Funders: Fondation contre le Cancer (Belgium)
Fonds J. Maisin (Belgium)
Fonds National pour la Recherche Scientifique
Belgian Cancer Plan (Action 29_024)
Fonds National pour la Recherche Scientifique (Belgium)
Fondation Salus Sanguinis (Belgium)
Actions de Recherche Concertees (ARC 09/14-021)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords: regulatory T cells, GARP, TGF-β1, monoclonal antibodies, TGF-β1 activation, immunosuppression, graft-versus-host disease, cancer immunotherapy, conformational epitopes, cancer vaccines, CTLA-4, PD-1/PD-L1
MeSH terms: Animals, Antibodies, Monoclonal, Epitopes, Graft vs Host Disease, Humans, Immunosuppressive Agents, Membrane Proteins, Methylation, Mice, Inbred BALB C, Mice, Transgenic, Protein Binding, Protein Conformation, Autoimmunity, Mice, SCID, Mice, Inbred NOD, T-Lymphocytes, Regulatory, Mice, Transforming Growth Factor beta1

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Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo

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