Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins
Open accessAbstract
The bioavailability of members of the transforming growth factor β (TGF-β) family is controlled by a number of mechanisms. Bona fide TGF-β is sequestered into the matrix in a latent state and must be activated before it can bind to its receptors. Here, we review the molecules and mechanisms that regulate the bioavailability of TGF-β and compare these mechanisms with those used to regulate other TGF-β family members. We also assess the physiological significance of various latent TGF-β activators, as well as other extracellular modulators of TGF-β family signaling, by examining the available in vivo data from knockout mouse models and other biological systems.
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Tumor in the Crossfire: Inhibiting TGF-β to Enhance Cancer Immunotherapy
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ECM1 attenuates hepatic fibrosis by interfering with mediators of latent TGF-β1 activation
Link, F., Li, Y., Zhao, J., Munker, S., Fan, W., Nwosu, Z. C., Ye, Y., Wang, S., Huang, C., Hammad, S., et al. (2024) · Gut · doi:10.1136/gutjnl-2024-333213 · Cited by 64 · see citing works
Cellular machinery for sensing mechanical force
Lim, C.-G., Jang, J. J., & Kim, C. (2018) · BMB Reports · doi:10.5483/bmbrep.2018.51.12.237 · Cited by 60 · see citing works
Sato, R., Imamura, K., Semba, T., Tomita, Y., Saeki, S., Ikeda, K., Komohara, Y., Suzuki, M., Sakagami, T., Saya, H., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-3941 · Cited by 60 · see citing works
Trinh‐Minh, T., Chen, C.-W., Manh, C. T., Li, Y., Zhu, H., Zhou, X., Chakraborty, D., Zhang, Y., Rauber, S., Dees, C., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci159884 · Cited by 67 · see citing works
Li, J., Chen, F., Peng, Y., Lv, Z., Lin, X., Chen, Z., & Wang, H. (2020) · Cells · doi:10.3390/cells9020296 · Cited by 58 · see citing works
Miller, S. M., Cybulski, V., Whitacre, M., Bess, L. S., Livesay, M. T., Walsh, L. M., Burkhart, D. J., Bazin, H. G., & Evans, J. T. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00406 · Cited by 58 · see citing works
Transforming Growth Factor-β: An Agent of Change in the Tumor Microenvironment
Stuelten, C. H., & Zhang, Y. E. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.764727 · Cited by 57 · see citing works
The role of TGF-β2 in cartilage development and diseases
Duan, M., Wang, Q., Liu, Y., & Xie, J. (2021) · Bone and Joint Research · doi:10.1302/2046-3758.108.bjr-2021-0086 · Cited by 55 · see citing works
Molecular Engineering of the TGF-β Signaling Pathway
Zi, Z. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.05.022 · Cited by 54 · see citing works
Akasaka, E., Kleiser, S., Sengle, G., Bruckner‐Tuderman, L., & Nyström, A. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.10.024 · Cited by 53 · see citing works
Actin Cytoskeleton and Regulation of TGFβ Signaling: Exploring Their Links
Melchionna, R., Trono, P., Tocci, A., & Nisticò, P. (2021) · Biomolecules · doi:10.3390/biom11020336 · Cited by 55 · see citing works
André, P., Joshi, S. R., Briscoe, S. D., Alexander, M. J., Li, G., & Kumar, R. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2021.814222 · Cited by 53 · see citing works
Mechanisms of myeloid cell entry to the healthy and diseased central nervous system
Amann, L., Masuda, T., & Prinz, M. (2023) · Nature Immunology · doi:10.1038/s41590-022-01415-8 · Cited by 50 · see citing works
Fibronectin has multifunctional roles in posterior capsular opacification (PCO)
Shihan, M. H., Kanwar, M., Wang, Y., Jackson, E., Faranda, A. P., & Duncan, M. K. (2020) · Matrix Biology · doi:10.1016/j.matbio.2020.02.004 · Cited by 50 · see citing works
- Authors
- Robertson, I. B., & Rifkin, D. B.
- Affiliations
- New York University (US)
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2016-06
- Volume
- 8
- Issue
- 6
- Pages
- a021907
- ISSN
- 1943-0264 (ISSN-L)
- PMC
- PMC4888822
- OpenAlex
- W2414680576
- Cited by
- 403
- References
- 212
- Citations by year
- 2026: 33 · 2025: 33 · 2024: 35 · 2023: 46 · 2022: 71 · 2021: 55 · 2020: 48 · 2019: 30 · 2018: 30 · 2017: 20 · 2016: 2
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (AR49698)
- National Cancer Institute (R01CA034282)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (P01AR049698)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- TGF-beta, TGF-beta superfamily, latent TGF-beta, extracellular matrix, knockout mouse models, TGF-beta receptor
- MeSH terms
- Fibrillins, Protein Domains, Animals, Biological Availability, Carrier Proteins, Extracellular Matrix, Glycosylation, Humans, Phylogeny, Signal Transduction, Transforming Growth Factor beta, Mice, Knockout, Mice, Latent TGF-beta Binding Proteins, Protein Multimerization
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