Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

Wound repair and regeneration

Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542

Role of YAP/TAZ in mechanotransduction

Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979

The BCL-2 protein family: opposing activities that mediate cell death

Youle, R. J., & Strasser, A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2308 · Cited by 4,806

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

Wynn, T. A., & Ramalingam, T. R. (2012) · Nature Medicine · doi:10.1038/nm.2807 · Cited by 3,541

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

Oltersdorf, T., Elmore, S. W., Shoemaker, A. R., Armstrong, R. C., Augeri, D. J., Belli, B., Bruncko, M., Deckwerth, T. L., Dinges, J., Hajduk, P. J., et al. (2005) · Nature · doi:10.1038/nature03579 · Cited by 3,407

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

Czabotar, P. E., Lessene, G., Strasser, A., & Adams, J. M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3722 · Cited by 3,219

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

Souers, A. J., Leverson, J. D., Boghaert, E. R., Ackler, S. L., Catron, N. D., Chen, J., Dayton, B. D., Ding, H., Enschede, S. H., Fairbrother, W. J., et al. (2013) · Nature Medicine · doi:10.1038/nm.3048 · Cited by 3,058

The Myofibroblast

Hinz, B., Phan, S. H., Thannickal, V. J., Galli, A., Bochaton-Piallat, M.-L., & Gabbiani, G. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.070112 · Cited by 2,068

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

Tse, C., Shoemaker, A. R., Adickes, J., Anderson, M. G., Chen, J., Jin, S., Johnson, E. F., Marsh, K. C., Mitten, M. J., Nimmer, P., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5836 · Cited by 1,992

Fibrosis–a common pathway to organ injury and failure

Rockey, D. C., Bell, P. D., & Hill, J. A. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1300575 · Cited by 1,428

Inflammasome activation and metabolic remodelling in p16‐positive aging cells aggravates high‐fat diet‐induced lung fibrosis by inhibiting NEDD4L‐mediated K48‐polyubiquitin‐dependent degradation of SGK1

Gu, X., Meng, H., Peng, C., Lin, S., Li, B., Zhao, L., Yang, X., Wang, G., Cai, W., Zhou, J., et al. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1308 · Cited by 23

Assessing the progression of systemic sclerosis by monitoring the tissue optic axis using PS-OCT

Adams, D. C., Szabari, M. V., Lagares, D., McCrossan, A. F., Hariri, L. P., Tager, A. M., & Suter, M. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-59330-7 · Cited by 24

Proteomic Profiling of Fibroblasts Isolated from Chronic Wounds Identifies Disease-Relevant Signaling Pathways

Berberich, B., Thriene, K., Gretzmeier, C., Kühl, T., Bayer, H., Athanasiou, I., Rafei-Shamsabadi, D. A., Bruckner‐Tuderman, L., Nyström, A., Kiritsi, D., et al. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.02.040 · Cited by 26

Rationally-based therapeutic disease modification in systemic sclerosis: Novel strategies

Asano, Y., & Varga, J. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.12.007 · Cited by 24

Regulation of Fibroblast Apoptosis and Proliferation by Micro RNA ‐125b in Systemic Sclerosis

Kozlova, A., Pachera, E., Maurer, B., Jüngel, A., Distler, J. H. W., Kania, G., & Distler, O. (2019) · Arthritis & Rheumatology · doi:10.1002/art.41041 · Cited by 22

Persistent hypoxia promotes myofibroblast differentiation via GPR ‐81 and differential regulation of LDH isoenzymes in normal and idiopathic pulmonary fibrosis fibroblasts

Nho, R. S., Rice, C., Prasad, J. M. N., Bone, H., Farkas, L., Rojas, M. M., & Horowitz, J. C. (2023) · Physiological Reports · doi:10.14814/phy2.15759 · Cited by 23

Antibodies against specific extractable nuclear antigens (ENAs) as diagnostic and prognostic tools and inducers of a profibrotic phenotype in cultured human skin fibroblasts: are they functional?

Corallo, C., Cheleschi, S., Cutolo, M., Soldano, S., Fioravanti, A., Volpi, N., Franci, D., Nuti, R., & Giordano, N. G. (2019) · Arthritis Research & Therapy · doi:10.1186/s13075-019-1931-x · Cited by 22

The Role of Pro-fibrotic Myofibroblasts in Systemic Sclerosis: From Origin to Therapeutic Targeting

Romano, E., Rosa, I., Fioretto, B. S., Matucci‐Cerinic, M., & Manetti, M. (2021) · Current Molecular Medicine · doi:10.2174/0929867328666210325102749 · Cited by 24

Targeting the BCL2 Family: Advances and Challenges in BH3 Mimetic-Based Therapies

Mukherjee, N., Sheetz, J., & Shellman, Y. G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26209859 · Cited by 24

Targeting of MCL-1 in breast cancer-associated fibroblasts reverses their myofibroblastic phenotype and pro-invasive properties

Bonneaud, T. L., Lefebvre, C. C., Nocquet, L., Basseville, A., Roul, J., Weber, H., Campone, M., Juin, P. P., & Souazé, F. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05214-9 · Cited by 23

Facile fabrication of PEG-coated PLGA microspheres via SPG membrane emulsification for the treatment of scleroderma by ECM degrading enzymes

Ohta, S., Matsuura, M., Kawashima, Y., Cai, X., Taniguchi, M., Okochi, H., Asano, Y., Sato, S., & Ito, T. (2019) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2019.04.028 · Cited by 18

Survival of activated myofibroblasts in canine myxomatous mitral valve disease and the role of apoptosis

Blake, R. R., Markby, G. R., Culshaw, G., Pereira, Y. M., Lu, C.-C., & CORCORAN, B. M. (2019) · Research in Veterinary Science · doi:10.1016/j.rvsc.2019.11.004 · Cited by 18

How to Keep Myofibroblasts under Control: Culture of Mouse Skin Fibroblasts on Soft Substrates

Son, D. O., Benítez, R., Diao, L., & Hinz, B. (2024) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2024.05.033 · Cited by 18

Mitochondrial antiviral signaling protein is crucial for the development of pulmonary fibrosis

Kim, S., Lee, J. Y., Yoon, C. M., Shin, H. J., Lee, S. W., Rosas, I. O., Herzog, E. L., Cruz, C. S. D., Kaminski, N., & Kang, M. (2020) · European Respiratory Journal · doi:10.1183/13993003.00652-2020 · Cited by 18

Extracellular Targets to Reduce Excessive Scarring in Response to Tissue Injury

Fertala, J., Wang, M. L., Rivlin, M. R., Beredjiklian, P. K., Abboud, J. A., Arnold, W. V., & Fertala, A. (2023) · Biomolecules · doi:10.3390/biom13050758 · Cited by 18

BCL-2 Modulates IRE1α Activation to Attenuate Endoplasmic Reticulum Stress and Pulmonary Fibrosis

Saux, C. J. L., Ho, T. C., Brumwell, A. M., Kathiriya, J. J., Wei, Y. J., Hughes, J. B., Garakani, K., Atabai, K., Auyeung, V. C., Papa, F. R., et al. (2023) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2023-0109oc · Cited by 16

Novel role of long non-coding RNAs in autoimmune cutaneous disease

Muntyanu, A., Le, M., Ridha, Z., O’Brien, E. A., Litvinov, I. V., Lefrançois, P., & Netchiporouk, E. (2021) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-021-00639-x · Cited by 16

Proapoptotic Bcl-2 inhibitor as potential host directed therapy for pulmonary tuberculosis

Singh, M., Sarhan, M. O., Damiba, N. N. L., Singh, A., Villabona-Rueda, A. F., Nino-Meza, O. J., Chen, X., Masias-Leon, Y., Ruiz-Gonzalez, C. E., Ordoñez, A. A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58190-x · Cited by 17

Fibroblasts as regulators of lung immunity, repair and fibrosis

Bell, P. T., & Belz, G. T. (2026) · Nature reviews. Immunology · doi:10.1038/s41577-026-01268-4 · Cited by 19

Expression Quantitative Trait Locus Analysis in Systemic Sclerosis Identifies New Candidate Genes Associated With Multiple Aspects of Disease Pathology

Kerick, M., González‐Serna, D., Carnero‐Montoro, E., Teruel, M., Acosta‐Herrera, M., Makowska, Z., Buttgereit, A., Babaei, S., Barturen, G., López‐Isac, E., et al. (2021) · Arthritis & Rheumatology · doi:10.1002/art.41657 · Cited by 14

The senolytic drug ABT-263 accelerates ovarian aging in older female mice

Xia, X., Yang, Y., Liu, P., Chen, L., Dai, X., Xue, P., & Wang, Y. (2024) · Scientific Reports · doi:10.1038/s41598-024-73828-4 · Cited by 15

Mechanosensing regulates pDC activation in the skin through NRF2 activation

Chaudhary, V., Mishra, B., Kioon, M. D. A., Du, Y., Ivashkiv, L. B., Crow, M. K., & Barrat, F. J. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20240852 · Cited by 15

A Small Molecule BH3-mimetic Suppresses Cigarette Smoke-Induced Mucous Expression in Airway Epithelial Cells

Hussain, S. S., George, S., Singh, M., Jayant, R. D., Hu, C.-A. A., Sopori, M. L., & Chand, H. S. (2018) · Scientific Reports · doi:10.1038/s41598-018-32114-w · Cited by 14

Reduced SPAG17 Expression in Systemic Sclerosis Triggers Myofibroblast Transition and Drives Fibrosis

Sapao, P., Roberson, E. D. O., Shi, B., Assassi, S., Skaug, B. A., Lee, F., Naba, A., White, B. E. P., Córdova-Fletes, C., Tsou, P., et al. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.08.052 · Cited by 14

Fibromodulin selectively accelerates myofibroblast apoptosis in cutaneous wounds by enhancing interleukin 1β signaling

Jiang, W., Pang, X., Ha, P., Li, C., Chang, G. X., Zhang, Y., Bossong, L. A., Ting, K., Soo, C. B., & Zheng, Z. S. (2025) · Nature Communications · doi:10.1038/s41467-025-58906-z · Cited by 13

Mechanical stiffness promotes skin fibrosis through FAPα-AKT signaling pathway

He, J., Fang, B., Shan, S., & Li, Q. (2023) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2023.12.004 · Cited by 13

Extracellular Vesicles Derived from Adipose Stem Cells Alleviate Systemic Sclerosis by Inhibiting TGF-β Pathway

Kim, E., Kim, H. K., Sul, J. H., Lee, J., Baek, S. H., Cho, Y., Han, J., Kim, J., Park, S., Park, J. H., et al. (2024) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2023.191 · Cited by 13

Effect of ABT-263 on Intestinal Fibrosis in Human Myofibroblasts, Human Intestinal Organoids, and the Mouse Salmonella typhimurium Model

Johnson, L. A., Rodansky, E. S., Tran, A., Collins, S., Eaton, K. A., Malamet, B. J., Steiner, C. A., Huang, S., Spence, J. R., & Higgins, P. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izab166 · Cited by 13

The pathophysiology and treatment of musculoskeletal fibrosis

Sheets, K., Overbey, J., Ksajikian, A., Bovid, K. M., Kenter, K., & Li, Y. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30217 · Cited by 14

GRIM-19-mediated induction of mitochondrial STAT3 alleviates systemic sclerosis by inhibiting fibrosis and Th2/Th17 cells

Jeong, H. Y., Park, J., Choi, J. W., Lee, K. H., Yang, S. C., Kang, H. Y., Cho, S., Lee, S.-Y., Lee, A. R., Park, Y., et al. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01366-0 · Cited by 13

Anti-aging therapy for pulmonary fibrosis

Zhou, Y., & Lagares, D. (2021) · Nature Aging · doi:10.1038/s43587-021-00035-5 · Cited by 13

Modulating in vitro lung fibroblast activation via senolysis of senescent human alveolar epithelial cells

Spina, J. S., Carr, T. L., Phillips, L. A., Knight, H., Crosbie, N. E., Lloyd, S. M., Jhala, M. A., Lam, T. J., Kármán, J., Clements, M. E., et al. (2024) · Aging · doi:10.18632/aging.205994 · Cited by 12

MEOX1 triggers myofibroblast apoptosis resistance, contributing to pulmonary fibrosis in mice

Jin, L., Bao, B., Huang, X., Tao, J., Duan, J., Zhong, W., Zhang, C., Liu, Y., Chen, H., Yang, N., et al. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31442 · Cited by 11

Tension-induced organelle stress: an emerging target in fibrosis

Kai, F., Leidal, A. M., & Weaver, V. M. (2025) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2024.12.006 · Cited by 11

Therapeutic Effects of Omentin-1 on Pulmonary Fibrosis by Attenuating Fibroblast Activation via AMP-Activated Protein Kinase Pathway

Zhou, Y., Zhang, Y., Cheng, H., Li, X., Feng, D., Yue, S., Xu, J., Xie, H., & Luo, Z. (2022) · Biomedicines · doi:10.3390/biomedicines10112715 · Cited by 10

Regulation of cardiac fibroblast cell death by unfolded protein response signaling

Rowland, M. B., Moore, P. E., & Correll, R. N. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2023.1304669 · Cited by 10

Sanglifehrin A mitigates multiorgan fibrosis by targeting the collagen chaperone cyclophilin B

Flaxman, H. A., Chrysovergi, M.-A., Han, H., Kabir, F., Lister, R. T., Chang, C., Yvon, R., Black, K. E., Weigert, A., Savai, R., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.171162 · Cited by 13

A novel Mcl-1 inhibitor synergizes with venetoclax to induce apoptosis in cancer cells

Zhao, T., He, Q., Xie, S., Zhan, H., Jiang, C., Lin, S., Liu, F., Wang, C., Chen, G., & Zeng, H. (2023) · Molecular Medicine · doi:10.1186/s10020-022-00565-7 · Cited by 10

Regulation of Mesenchymal Cell Fate by Transfer of Active Gasdermin-D via Monocyte-Derived Extracellular Vesicles

Sarkar, A., Das, S., Bone, H., DeVengencie, I., Prasad, J. M. N., Farkas, D., Londino, J. D., Nho, R. S., Rojas, M. M., & Horowitz, J. C. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200511 · Cited by 10

Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis

Liu, L., Sun, Y., Zhao, Y., Wang, Q., Guo, H. B., Guo, R., Liu, Y., Fu, S., Zhang, L., Li, Y., et al. (2018) · Cancer Science · doi:10.1111/cas.13825 · Cited by 10

The Importance of Cancer-Associated Fibroblasts in the Pathogenesis of Head and Neck Cancers

Raudenská, M., Svobodová, M., Gumulec, J., Falk, M., & Masařík, M. (2020) · Klinicka onkologie · doi:10.14735/amko202039 · Cited by 10

The matricellular protein CCN5 induces apoptosis in myofibroblasts through SMAD7-mediated inhibition of NFκB

Nguyen, M. T., Lee, M.-A., Kim, Y., Kook, H., Jeong, D., Jang, S. P., Kwak, T. H., & Park, W. J. (2022) · PLoS ONE · doi:10.1371/journal.pone.0269735 · Cited by 10

Melanocortin therapies to resolve fibroblast-mediated diseases

Khodeneva, N., Sugimoto, M. A., Davan-Wetton, C. S. A., & Montero‐Melendez, T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1084394 · Cited by 10

m6A modification in non-coding RNAs: Mechanisms and potential therapeutic implications in fibrosis

Zhou, Y., Jian, N., Jiang, C., & Wang, J. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117331 · Cited by 11

Towards a Unified Approach in Autoimmune Fibrotic Signalling Pathways

Sisto, M., & Lisi, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24109060 · Cited by 9

Repurposing Navitoclax to block SARS‐CoV‐2 fusion and entry by targeting heptapeptide repeat sequence 1 in S2 protein

Jiao, F., Andrianov, A. M., Wang, L., Furs, K. V., Gonchar, A. V., Wang, Q., Xu, W., Lu, L., Xia, S., Tuzikov, A. V., et al. (2023) · Journal of Medical Virology · doi:10.1002/jmv.29145 · Cited by 9

Distinct fibroblast functions associated with fibrotic and immune-mediated inflammatory diseases and their implications for therapeutic development

M. S. Barron, A., Fabre, T., & De, S. (2024) · F1000Research · doi:10.12688/f1000research.143472.1 · Cited by 8

Cells of all trades – on the importance of spatial positioning of senescent cells in development, healing and aging

Dworak, H., Rozmaric, T., Grillari, J., & Ogrodnik, M. B. (2025) · FEBS Letters · doi:10.1002/1873-3468.70037 · Cited by 8

Pathophysiology in Systemic Sclerosis: Current Insights and Future Perspectives

Al-Gburi, S., Moinzadeh, P., & Krieg, T. (2025) · Sclerosis · doi:10.3390/sclerosis3020017 · Cited by 8

The Role of Autophagy and Apoptosis in Affected Skin and Lungs in Patients with Systemic Sclerosis

Spasovski, V., Andjelković, M., Parezanovic, M., Komazec, J., Ugrin, M., Klaassen, K., & Stojiljković, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311212 · Cited by 8

PTEN hinders the formation of scars by regulating the levels of proteins in the extracellular matrix and promoting the apoptosis of dermal fibroblasts through Bcl-xL

Li, S., Wang, Y., Chen, Y., Zhang, H., Shen, K., & Guan, H. (2024) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2024.109912 · Cited by 8

Recent Advances in Molecular Diagnosis of Pulmonary Fibrosis for Precision Medicine

Jeong, M. H., Han, H., Lagares, D., & Im, H. (2022) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.2c00028 · Cited by 10

The myofibroblast and Giulio Gabbiani: An inseparable couple celebrates their 50 years golden wedding anniversary

Desmoulière, A., & Hinz, B. (2021) · Wound Repair and Regeneration · doi:10.1111/wrr.12942 · Cited by 9

Reimagining Fibrosis Research, Outcomes, and Therapeutics Through the Lens of Resolution

Fortier, S. M., Redente, E. F., & Peters-Golden, M. L. (2025) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/a-2666-7479 · Cited by 7

Integrating Senescence and Oxidative Stress in Cardiac Disease

Yun, H. R., Singh, M. K., Han, S., Ranbhise, J. S., Ha, J., Kim, S. S., & Kang, I. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262411917 · Cited by 8

Proinflammatory cytokines sensitise mesenchymal stromal cells to apoptosis

Payne, N. L., Pang, S. H. M., Freeman, A. J., Ozkocak, D. C., Limar, J. W., Wallis, G., Zheng, D., Mendonca, S., O’Reilly, L. A., Gray, D. H. D., et al. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02412-0 · Cited by 7

Hippo signaling in mechanobiology: Mechanical control of YAP/TAZ and their roles in disease

Kim, Y., Lee, H., Lee, J.-H., Kim, W., & Cha, B. (2026) · Mechanobiology · doi:10.1177/29780241261430920 · Cited by 7

A Comprehensive Review on Molecular Mechanism Involved in Arsenic Trioxide Mediated Cerebral Neurodegenerative and Infectious Diseases

Negi, V., Singh, P. K., Singh, L., Pandey, R. K., & Kumar, S. (2023) · Infectious Disorders - Drug Targets · doi:10.2174/0118715265262440231103094609 · Cited by 6

Blocking antibodies against integrin-α3, -αM, and -αMβ2 de-differentiate myofibroblasts, and improve lung fibrosis and kidney fibrosis

White, M. J. V., Ozkan, M., Medellin, J. E. G., Raczy, M. M., Koss, K. M., Solanki, A., Zhang, Z. J., Alpar, A. T., Naved, B. A., Wertheim, J. A., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-70737-4 · Cited by 11

Why Stress Matters: An Introduction

Tschumperlin, D. J. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1382-5_12 · Cited by 6

Topical Administration of an Apoptosis Inducer Mitigates Bleomycin-Induced Skin Fibrosis

Huda, M. N., Borrego, E. A., Guerena, C. D., Varela-Ramı́rez, A., Aguilera, R. J., Hamadani, C. M., Tanner, E. E. L., Badruddoza, A. Z. M., Agarwal, S. K., & Nurunnabi, M. (2023) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.3c00039 · Cited by 6

Use of non-small cell lung cancer multicellular tumor spheroids to study the impact of chemotherapy

Hulo, P., Deshayes, S., Fresquet, J., Chené, A., Blandin, S., Boisgerault, N., Fonteneau, J., Treps, L., Denis, M. G., Bennouna, J., et al. (2024) · Respiratory Research · doi:10.1186/s12931-024-02791-5 · Cited by 7

Co-delivery nanoparticle targeting CAF for simultaneous activating T cell plus NKT cell attack in solid tumor

Xiang, Y., Zhang, L., Ye, J., Chen, Y., Ren, Q., Su, B., Xu, X., & Zhang, Q. (2026) · Journal of Advanced Research · doi:10.1016/j.jare.2026.03.011 · Cited by 8

The dynamics of cell–extracellular matrix interactions, with implications for tissue engineering

Petreaca, M. L., & Martins‐Green, M. M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818422-6.00007-1 · Cited by 7

Cadherin-11 targeted cell-specific liposomes enabled skin fibrosis treatment by inducing apoptosis

Bhatt, H. N., Diwan, R., Estevao, I. L., Dong, R., Smith, J., Xiao, C., Agarwal, S. K., & Nurunnabi, M. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.04.029 · Cited by 5

Promoting apoptosis is key to reversing fibrosis

Collison, J. (2018) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.222 · Cited by 5

Myofibroblast differentiation is governed by adhesion mechanics, and inhibition of Talin2 reverses lung and kidney fibrosisPreprint

White, M. J. V., Ozkan, M., Medellin, J. E. G., Solanki, A., & Hubbell, J. A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.07.447403 · Cited by 5

How a fibroblast ages: a role for bone morphogenetic protein 4 in protecting lung fibroblasts from senescence in pulmonary fibrosis

Farkas, L., Horowitz, J. C., & Mora, A. L. (2022) · European Respiratory Journal · doi:10.1183/13993003.01702-2022 · Cited by 5

Natural killer cell immunotherapy reverses lung fibrosis by eliminating senescent fibroblasts

Merkt, W., Rodon, L., Deicher, F. S., Freitag, M., Claus, M., Lister, R. T., Han, H., Zhou, Y., Horne, A., Stütz, A. N., et al. (2026) · Science Translational Medicine · doi:10.1126/scitranslmed.adq5442 · Cited by 6

ABT-263 exerts a protective effect on upper urinary tract damage by alleviating neurogenic bladder fibrosis

Wen, Y., Wu, J., Pu, Q., He, X., Wang, J., Feng, J., Zhang, Y., Si, F., Wen, J., & Yang, J.-H. (2023) · Renal Failure · doi:10.1080/0886022x.2023.2194440 · Cited by 4

Fibroblasts in AKI: small army, big help

Zhu, S., Gui, Y., Liu, J.-J., Liu, S., & Zhou, D. F. (2025) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2025.05.012 · Cited by 4

Wet-dry-wet drug screen leads to the synthesis of TS1, a novel compound reversing lung fibrosis through inhibition of myofibroblast differentiation

Ring, N., Volpe, M. C., Stepišnik, T., Mamolo, M. G., Panov, P., Kocev, D., Vodret, S., Fortuna, S., Calabretti, A., Rehman, M., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04439-4 · Cited by 4

Mitochondrial physiology: An overview

Infantino, V., Todisco, S., & Convertini, P. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-88462-4.00001-8 · Cited by 5

Nerve Growth Factor (NGF) modulates in vitro induced myofibroblasts by highlighting a differential protein signature

Esposito, G., Balzamino, B. O., Stigliano, E., Biamonte, F., Urbani, A., & Micera, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-81040-x · Cited by 4

Myofibroblast Functions in Tissue Repair and Fibrosis: An Introduction

Thannickal, V. J. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1382-5_2 · Cited by 4

Methods for Studying Myofibroblast Apoptotic Pathways

Zhou, Y., & Lagares, D. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1382-5_9 · Cited by 4

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Untitled work

Santiago (2001) · doi:10.1002/1529-0131(200107)44:7