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Mechanical stress‐caused chondrocyte dysfunction and cartilage injury can be attenuated by dioscin via activating sirtuin1/forkhead box O1

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The Possibility of Polygonum cuspidatum against Osteoarthritis based on Network Pharmacology

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Bioinformatics and system biology analysis revealed the crosstalk between COVID‐19 and osteoarthritis

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Potential Targets and Molecular Mechanism of Quercetin Against Knee Osteoarthritis

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Bioinformatics Analysis and Experimental Validation of Mitochondrial Autophagy Genes in Knee Osteoarthritis

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O-GlcNAc transferase influences the progression of degenerative cartilage disease in lumbar facet joint osteoarthritis through FoxO1 and EGR1

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The repair effect and mechanism of continuous passive motion on osteoarthritis in a rabbit model.

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Elucidation of the Underlying Mechanism of Gujian Oral Liquid Acting on Osteoarthritis through Network Pharmacology, Molecular Docking, and Experiment

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Transient FOXO1 inhibition in pancreatic endoderm promotes the generation of NGN3+ endocrine precursors from human iPSCs

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Reprogramming of lipid secretome in senescent synovial fibroblasts ameliorate osteoarthritis developmentPreprint

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Characterization of gene expression profiles in Alzheimer’s disease and osteoarthritis: A bioinformatics study

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Advantages and Possibility of Transcription Factors FOXOs in HCC

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Molecular characterization of superficial zone chondrocytes under pro-inflammatory and biomechanical stress conditions

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Investigation of the Potential Key Genes and the Multitarget Mechanisms of Polygonum cuspidatum against Heart Failure Based on Network Pharmacology and Experimental Validation

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Integrative analysis of microRNA-320a-related genes in osteoarthritis cartilage

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Repurposing the antihistamine cyproheptadine for osteoarthritis: nothing to sneeze at

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Intra-articular injections of liposomal adenosine improve clinical outcomes and slow radiologic progression in a preclinical canine model of osteoarthritis

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FoxO signaling in regulated cell death and its therapeutic implications in inflammation

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Integrated transcriptomic and functional analysis reveals tissue-specific molecular pathology in adolescent idiopathic scoliosis

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Mechanism of icariin for the treatment of osteoarthritis based on network pharmacology and molecular docking method.

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EphrinB2 ‐mediated chondrocyte autophagy induces post‐traumatic arthritis via rupture of cartilage homeostasis

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Age-related increase in matrix stiffness downregulates α-Klotho in chondrocytes and induces cartilage degenerationPreprint

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Screening of Osteoarthritis-Related Genes and Function Determination Based on Bioinformatics ToolsPreprint

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Loss of Autophagy In Tibial Growth Plate Chondrocytes Causes Increased Chondrocyte Apoptosis In Young Rats With Chronic Renal InsufficiencyPreprint

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Rhoifolin Ameliorates Osteoarthritis via the Nrf2/NF-κb Axis: in vitro and in vivo ExperimentsPreprint

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Importance of FoxO3 Level in Progression of Nodal Osteoarthritis Disease

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A novel transcript of LncRNA ELDR promotes chondrocyte senescence and osteoarthritis progression by tuning chromosomal dynamicsPreprint

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Genome Editing to Abrogate Muscle Atrophy

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Exploring the mechanisms of age-related osteoarthritis associated with ferroptosis and autophagy using transcriptomics-based integrated analysisPreprint

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Role and Application of Biomolecules for Regeneration of Cartilage Tissue

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Luteolin Regulating Synthesis and Catabolism of Osteoarthritis Chondrocytes Via Activating AutophagyPreprint

Liu, F., Ding, Z., Li, S., Huang, W. H., Zhou, S., Han, Y., Liu, L., Li, Y., Yin, Z., & Li, Y. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4627117

O fator de neurotrófico derivado do cérebro (BDNF) como proteína importante para os efeitos terapêuticos do plasma rico em plaquetas em modelo de osteoartrite experimental

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Research Progress in Targeting Senescent Cells in the Treatment of Osteoarthritis

王, 鹏. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.1441054

Identification and prediction of biomarkers, immune infiltration features, molecular regulatory mechanisms, and potential therapeutic agents associated with cuproptosis in osteoarthritic cartilagePreprint

Li, X., Zheng, D., Guo, R. M., Guan, H., Zhou, F., & Ai, W. (2024) · Research Square · doi:10.21203/rs.3.rs-4842592/v1

Application of Drug-Loading Method Using Hydrogel Microspheres in Articular Cartilage

崔, 静. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.14112875

Detrimental Effect of T261I and R287W SMAD3 Variants on Early Osteoarthritis: A Potential Anti‐Inflammatory Molecule for Personalized Treatment

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MSX2 serves as a chondroprotective factor in osteoarthritis: insights from expression analysis and functional validation studies

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Molecular mechanisms of SIRT1 in regulating ageing and related intervention strategies

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Muscular fiber properties and multi-omics investigation of larval and adult locomotor muscle in Microhyla fissipes

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Prim-O-glucosylcimifugin alleviate osteoarthritis through regulates autophagy via IGF1R/JAK2/STAT3 axis

Yang, L., Feng, J., He, W., & Huang, Y. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158571

Metal ion-functionalized biomaterial scaffolds for promoting bone repair in osteonecrosis

Yao, L., Zhu, T., Huang, G., Liu, G., Yang, J., & Ding, J. (2026) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2026.218276

Histone deacetylase inhibition alters mRNA expression of cell cycle- and senescence-associated genes in primary equine chondrocytes

Ząbek, T., Szmatoła, T., Witarski, W., & Ropka‐Molik, K. (2026) · Research in Veterinary Science · doi:10.1016/j.rvsc.2026.106348

OIP5 ‐ AS1 Sponges miR ‐223‐3p to Upregulate FoxO3 and Ameliorate Temporomandibular Joint Osteoarthritis by Inhibiting Chondrocyte Apoptosis

Xu, X., & Qiao, S. (2026) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.71359

Lubricin (PRG4) in articular cartilage and intervertebral disc: Comparative biology and therapeutic potential

Zhang, Y., Zhang, C., Xie, X., Wang, X., Xie, C., Lv, C., & Pei, M. (2026) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2026.09.014

Dysregulated autophagy in osteoarthritis: Mechanisms, regulation by non-coding RNAs, and therapeutic implications

Liu, L., Wang, J., liu, L., Shi, W., Gao, H., & Liu, L. (2026) · Pathology - Research and Practice · doi:10.1016/j.prp.2026.156695

Cell-based and tissue engineering therapies for cartilage repair and osteoarthritis

Zelinka, A. A., Roelofs, A. J., Kandel, R. A., & Bari, C. D. (2026) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2026.09.016

Senotherapeutics for Age-Related Musculoskeletal Disorders: A Systematic Review of Preclinical Evidence

Falvino, A., Bonanni, R., Asaro, C., Cifelli, P., Tarantino, U., Gasbarra, E., Tancredi, V., & Cariati, I. (2026) · Calcified Tissue International · doi:10.1007/s00223-026-01626-3

FoxO1 is a crucial mediator of TGF-β/TAK1 signaling and protects against osteoarthritis by maintaining articular cartilage homeostasis

Wang, C., Shen, J., Ying, J., Xiao, D., & O’Keefe, R. J. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2017056117 · Cited by 104

FoxO1 Transcription Factor in Chondrocyte Regulation: A Review on Its Molecular Mechanisms, Pathological Roles, and Therapeutic Potential

Ting Chen, M. H. T. (2025) · Journal of Neonatal Surgery

The role of forkhead box o transcription factors in joint development, maturation and homeostasis

Matsuzaki, T., Olmer, M., Matsuzaki, O., & Lotz, M. (2016) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2016.01.286

An anti-arthritis signal

Ray, L. B. (2020) · Science · doi:10.1126/science.370.6523.1429-a

Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis

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