FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis

Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.

Sandri, M., Sandri, C., Gilbert, A., Skurk, C., Calabria, E., Picard, A., Walsh, K., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2004) · Cell · doi:10.1016/s0092-8674(04)00400-3 · Cited by 3,012

Osteoarthritis cartilage histopathology: grading and staging

Pritzker, K. P. H., Gay, S., Jiménez, S. A., Østergaard, K., Pelletier, J., Revell, P. A., Salter, D. M., & van den Berg, W. B. (2005) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2005.07.014 · Cited by 2,355

Epidemiology of Osteoarthritis

Zhang, Y., & Jordan, J. M. (2010) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2010.03.001 · Cited by 2,320

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

Kops, G. J. P. L., Dansen, T. B., Polderman, P. E., Saarloos, I., Wirtz, K. W. A., Coffer, P. J., Huang, T.-T., Bos, J. L., Medema, R. H., & Burgering, B. M. T. (2002) · Nature · doi:10.1038/nature01036 · Cited by 1,580

The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse

Glasson, S. S., Blanchet, T., & Morris, E. A. (2007) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2007.03.006 · Cited by 1,524

FOXOs: signalling integrators for homeostasis maintenance

Eijkelenboom, A., & Burgering, B. M. T. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3507 · Cited by 1,110

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

Paik, J.-H., Kollipara, R., Chu, G., Ji, H., Xiao, Y., Ding, Z., Miao, L., Tothova, Z., Horner, J. W., Carrasco, D. R., et al. (2007) · Cell · doi:10.1016/j.cell.2006.12.029 · Cited by 1,032

FOXO3A genotype is strongly associated with human longevity

Willcox, B. J., Donlon, T. A., He, Q., Chen, R., Grove, J. S., Yano, K., Masaki, K. H., Willcox, D. C., Rodriguez, B., & Curb, J. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801030105 · Cited by 983

Primary culture and phenotyping of murine chondrocytes

Gosset, M., Berenbaum, F., Thirion, S., & Jacques, C. (2008) · Nature Protocols · doi:10.1038/nprot.2008.95 · Cited by 735

The Role of Cytokines in Cartilage Matrix Degeneration in Osteoarthritis

Goldring, S. R., & Goldring, M. B. (2004) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000144854.66565.8f · Cited by 655

Punicalagin attenuates osteoarthritis progression via regulating Foxo1/Prg4/HIF3α axis

Liu, F., Yang, H., Li, D., Wu, X., & Han, Q. (2021) · Bone · doi:10.1016/j.bone.2021.116070 · Cited by 29

Autophagy in the pathogenesis and therapeutic potential of post-traumatic osteoarthritis

Gong, Y., Li, S., Wu, J., Zhang, T., Fang, S., Feng, D., Luo, X., Yuan, J., Wu, Y., Yan, X., et al. (2022) · Burns & Trauma · doi:10.1093/burnst/tkac060 · Cited by 28

Identification and validation of hub genes of synovial tissue for patients with osteoarthritis and rheumatoid arthritis

Ge, Y., Chen, Z., Fu, Y., Xiao, X., Xu, H., Shan, L., Tong, P., & Zhou, L. (2021) · Hereditas · doi:10.1186/s41065-021-00201-0 · Cited by 27

Ubiquitin-specific protease 3 attenuates interleukin-1β-mediated chondrocyte senescence by deacetylating forkhead box O-3 via sirtuin-3

Zhou, Q., Wang, W., Wu, J., Qiu, S., Yuan, S., Fu, P., Qian, Q., & Xu, Y. (2021) · Bioengineered · doi:10.1080/21655979.2021.2012552 · Cited by 27

Glycolytic enzyme PKM2 regulates cell senescence but not inflammation in the process of osteoarthritis

Liu, B., Wang, C., Weng, Z., Yang, Y., Zhao, H., Zhang, Y., Fei, Q., Shi, Y., & Zhang, C. (2023) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2023062 · Cited by 26

Therapeutic Potential of POU3F3, a Novel Long Non-coding RNA, Alleviates the Pathogenesis of Osteoarthritis by Regulating the miR-29a- 3p/FOXO3 Axis

Shi, M., Yan, S., Sun, M., Wang, C., Shen, Y. L., & Wang, Y. (2022) · Current Gene Therapy · doi:10.2174/1566523222666220309150722 · Cited by 26

Regulation of autophagy gene expression and its implications in cancer

Metur, S. P., Lei, Y., Zhang, Z., & Klionsky, D. J. (2023) · Journal of Cell Science · doi:10.1242/jcs.260631 · Cited by 28

Role of Forkhead Box O Transcription Factors in Oxidative Stress-Induced Chondrocyte Dysfunction: Possible Therapeutic Target for Osteoarthritis?

Wang, R., Zhang, S., Previn, R., Chen, D., Jin, Y., & Zhou, G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123794 · Cited by 28

The role of FOXO1-mediated autophagy in the regulation of bone formation

Jiang, Y., Luo, W., Zhou, F., Gong, P., & Xiong, Y. (2022) · Cell Cycle · doi:10.1080/15384101.2022.2155443 · Cited by 24

Network-based modelling of mechano-inflammatory chondrocyte regulation in early osteoarthritis

Segarra-Queralt, M., Piella, G., & Noailly, J. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1006066 · Cited by 25

Enlightenment of Growth Plate Regeneration Based on Cartilage Repair Theory: A Review

Wang, X., Li, Z., Wang, C., Bai, H., Wang, Z., Liu, Y., Bao, Y., Ren, M., Liu, H., & Wang, J. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.654087 · Cited by 25

C10orf10/DEPP activates mitochondrial autophagy and maintains chondrocyte viability in the pathogenesis of osteoarthritis

Kuwahara, M., Akasaki, Y., Kurakazu, I., Sueishi, T., Toya, M., Uchida, T., Tsutsui, T., Hirose, R., Tsushima, H., Teramura, T., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202100896r · Cited by 25

The role of mechanobiology in bone and cartilage model systems in characterizing initiation and progression of osteoarthritis

Hodgkinson, T., Amado, I., O’Brien, F. J., & Kennedy, O. D. (2022) · APL Bioengineering · doi:10.1063/5.0068277 · Cited by 28

Microenvironment-responsive nanosystems for osteoarthritis therapy

Li, S., Xiong, Y., Zhu, H., Ma, T., Sun, X., & Xiao, J. (2023) · Engineered Regeneration · doi:10.1016/j.engreg.2023.12.002 · Cited by 27

Defective collagen proteostasis and matrix formation in the pathogenesis of lysosomal storage disorders

Settembre, C., Cinque, L., Bartolomeo, R., Malta, C. D., Leonibus, C. D., & Forrester, A. R. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.06.001 · Cited by 24

In vitro study of the role of FOXO transcription factors in regulating cigarette smoke extract-induced autophagy

Bagam, P., Kaur, G., Singh, D. P., & Batra, S. (2020) · Cell Biology and Toxicology · doi:10.1007/s10565-020-09556-y · Cited by 26

Inhibition of miR-130b-3p restores autophagy and attenuates intervertebral disc degeneration through mediating ATG14 and PRKAA1

Wu, T., Jia, X., Zhu, Z., Guo, K., Wang, Q., Gao, Z., Li, X., Huang, Y., & Wu, D. (2022) · APOPTOSIS · doi:10.1007/s10495-022-01725-0 · Cited by 26

Role of autophagy in the pathogenesis and regulation of pain

Zheng, G., Ren, J., Shang, L., & Bao, Y. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175859 · Cited by 24

Plumbagin alleviates temporomandibular joint osteoarthritis progression by inhibiting chondrocyte ferroptosis via the MAPK signaling pathways

Cui, T., Lan, Y., Yu, F., Lin, S., & Qiu, J. (2023) · Aging · doi:10.18632/aging.205253 · Cited by 23

The role of mitochondrial quality control mechanisms in chondrocyte senescence

Zhao, T., Niu, D., Chen, Y., & Fu, P. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112379 · Cited by 25

FoxO1a mediated cadmium‐induced annulus fibrosus cells apoptosis contributes to intervertebral disc degeneration in smoking

Jing, D., Wu, W., Deng, X., Peng, Y., Yang, W., Huang, D., Shao, Z., & Zheng, D. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29895 · Cited by 23

PARP1 inhibition protects mice against Japanese encephalitis virus infection

Desingu, P. A., Mishra, S., Dindi, L., Srinivasan, S., Rajmani, R. S., Ravi, V., Tamta, A. K., Raghu, S., Murugasamy, K., Pandit, A. S., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113103 · Cited by 23

Transglutaminase-2 regulates Wnt and FoxO3a signaling to determine the severity of osteoarthritis

Han, M.-S., Jung, Y., Kim, G.-W., & Han, S. W. (2020) · Scientific Reports · doi:10.1038/s41598-020-70115-w · Cited by 22

The Role of Forkhead Box Family in Bone Metabolism and Diseases

Xu, J., Wang, K., Zhang, Z., Xue, D., Li, W., & Pan, Z. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.772237 · Cited by 21

Cartilaginous Organoids: Advances, Applications, and Perspectives

Yu, Y., Wang, J., Li, Y., Chen, Y., & Cui, W. (2022) · Advanced NanoBiomed Research · doi:10.1002/anbr.202200114 · Cited by 22

Adenosine A2A receptor activation reduces chondrocyte senescence

Friedman, B., Larranaga‐Vera, A., Castro, C. M., Corciulo, C., Rabbani, P. S., & Cronstein, B. N. (2023) · The FASEB Journal · doi:10.1096/fj.202201212rr · Cited by 23

Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate Enhances foxo1-Mediated Lipophagy to Remodel Lipid Metabolism in Zebrafish Liver

Zhou, Y., Li, F., Fu, K., Zhang, Y., Zheng, N., Tang, H., Xu, Z., Luo, L., Han, J. Z., Yang, L., et al. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.4c00421 · Cited by 22

Prg4 and Osteoarthritis: Functions, Regulatory Factors, and Treatment Strategies

Fu, P.-J., Zheng, S.-Y., Luo, Y., Ren, Z.-Q., Li, Z.-H., Wang, Y., & Lu, B. (2025) · Biomedicines · doi:10.3390/biomedicines13030693 · Cited by 21

Genetically inspired organoids prevent joint degeneration and alleviate chondrocyte senescence via Col11a1–HIF1α‐mediated glycolysis–OXPHOS metabolism shift

Sun, Y., You, Y., Wu, Q., Hu, R., & Kerong, D. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1574 · Cited by 20

MiR-490-3p inhibits osteogenic differentiation in thoracic ligamentum flavum cells by targeting FOXO1

Yang, X., Qu, X., Meng, X., Li, M., Fan, D., Fan, T., Huang, A. Y., Chen, Z., & Zhang, C. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.26686 · Cited by 21

Identification of key gene modules and transcription factors for human osteoarthritis by weighted gene co‑expression network analysis

Gao, X., Sun, Y. H., & Li, X. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7848 · Cited by 21

変形性関節症において、C10orf10/DEPPはミトコンドリアオートファジーを活性化し、軟骨細胞の生存を維持する

桑原, 正. (2022) · Kyushu University Institutional Repository (QIR) (Kyushu University) · Cited by 21

ESC-sEVs alleviate non-early-stage osteoarthritis progression by rejuvenating senescent chondrocytes via FOXO1A-autophagy axis but not inducing apoptosis

Feng, K., Ye, T., Xie, X., Liu, J., Gong, L., Chen, Z., Zhang, J., Li, H., Li, Q., & Wang, Y. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107474 · Cited by 20

P53: A Key Target in the Development of Osteoarthritis

Ma, W., Tan, X., Xie, Z., Jiang, Y., Li, P., Lin, X., Ouyang, S., Liu, Z., Hou, Q., Xie, N., et al. (2023) · Molecular Biotechnology · doi:10.1007/s12033-023-00736-9 · Cited by 20

Control of articular degeneration by extracellular vesicles from stem/stromal cells as a potential strategy for the treatment of osteoarthritis

Alcaraz, M. J. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116226 · Cited by 20

Bioactive Compounds and Their Chondroprotective Effects for Osteoarthritis Amelioration: A Focus on Nanotherapeutic Strategies, Epigenetic Modifications, and Gut Microbiota

Hridayanka, K. S. N., Duttaroy, A. K., & Basak, S. (2024) · Nutrients · doi:10.3390/nu16213587 · Cited by 21

Dynamic chromatin accessibility tuning by the long noncoding RNA ELDR accelerates chondrocyte senescence and osteoarthritis

Ji, M.-L., Li, Z., Hu, X. Y., Zhang, W. T., Zhang, H. X., & Lu, J. (2023) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2023.02.011 · Cited by 19

Advances in epigenetic research of adolescent idiopathic scoliosis and congenital scoliosis

Sun, D., Ding, Z., Hai, Y., & Cheng, Y. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1211376 · Cited by 19

Evaluation and Application of Silk Fibroin Based Biomaterials to Promote Cartilage Regeneration in Osteoarthritis Therapy

Su, X., Li, W., Xu, Z., Qin, L., Yang, J., Zou, Y., Zhao, C., Chen, L., & Hu, N. (2023) · Biomedicines · doi:10.3390/biomedicines11082244 · Cited by 22

Human adipose and synovial-derived MSCs synergistically attenuate osteoarthritis by promoting chondrocyte autophagy through FoxO1 signaling

Wu, J., Huang, S., Yu, Y., Lian, Q., Liu, Y., Dai, W., Liu, Q., Pan, Y., Liu, G.-A., Li, K., et al. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03870-6 · Cited by 21

Glutathione: A Key Regulator of Extracellular Matrix and Cell Death in Intervertebral Disc Degeneration

Li, F., Li, S., Shi, Y., Lin, F., Rui, L., Shi, J., & Sun, K. (2024) · Mediators of Inflammation · doi:10.1155/2024/4482642 · Cited by 19

A matter of time: Circadian clocks in osteoarthritis and the potential of chronotherapy

Dernie, F., & Adeyoju, D. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111163 · Cited by 19

Methyl gallate prevents oxidative stress induced apoptosis and ECM degradation in chondrocytes via restoring Sirt3 mediated autophagy and ameliorates osteoarthritis progression

Li, Y., Shen, B., Lv, C., Zhu, X., Naren, Q., Xu, D., Chen, H., & Wu, F. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109489 · Cited by 18

The Roles of Forkhead Box O3a (FOXO3a) in Bone and Cartilage Diseases – A Narrative Review

Wu, Z., Wang, Z., Wu, L., Yu, L., Xie, X., Yu, F., Kong, W., Bi, S., Liu, S., Yin, G., et al. (2025) · Drug Design Development and Therapy · doi:10.2147/dddt.s494841 · Cited by 16

Epigenetic modification and exosome effects on autophagy in osteoarthritis

Cheng, C., Wu, Y., Huang, Y., Xue, Q., Wang, Y., Liao, F., Wang, X., & Miao, C. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115930 · Cited by 16

Transient anabolic effects of synovium in early post-traumatic osteoarthritis: a novel ex vivo joint tissue co-culture system for investigating synovium-chondrocyte interactions

Lai-Zhao, Y., Pitchers, K. K., & Appleton, C. T. (2021) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2021.03.010 · Cited by 16

Characterization and miRNA Profiling of Extracellular Vesicles from Human Osteoarthritic Subchondral Bone Multipotential Stromal Cells (MSCs)

Sanjurjo‐Rodríguez, C., Crossland, R. E., Reis, M., Pandit, H. G., Wang, X., & Jones, E. (2021) · Stem Cells International · doi:10.1155/2021/7232773 · Cited by 17

T‐2 toxin‐induced femur lesion is accompanied by autophagy and apoptosis associated with Wnt/β‐catenin signaling in mice

Zhang, J., Song, M., Cui, Y., Shao, B., Zhang, X., Cao, Z., & Li, Y. (2022) · Environmental Toxicology · doi:10.1002/tox.23514 · Cited by 16

Dnmt3a-mediated hypermethylation of FoxO3 promotes redox imbalance during osteoclastogenesis

Zhang, W., Li, W., Du, J., Chen, Y., Yu, L., Yang, P., Zhang, H., Wu, Z., Ge, G., Yang, H., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2418023122 · Cited by 17

Identification of key biomarkers related to fibrocartilage chondrocytes for osteoarthritis based on bulk, single-cell transcriptomic data

Pan, B., Yao, P., Ma, J., Lin, X., Zhou, L., Lin, C., Zhang, Y., Lin, B., & Lin, C. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1482361 · Cited by 15

Deletion of FOXO1 in chondrocytes rescues the effect of diabetes on mechanical strength in fracture healing

Lu, Y., Alharbi, M., Zhang, C., O’Connor, J. P., & Graves, D. T. (2019) · Bone · doi:10.1016/j.bone.2019.03.026 · Cited by 14

FoxO3a cooperates with RUNX1 to promote chondrogenesis and terminal hypertrophic of the chondrogenic progenitor cells

Yuan, S., Zhang, L., Ji, L., Zhong, S., Jiang, L., Wan, Y., Song, Y., Zhang, C., & Wang, R. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.12.008 · Cited by 14

M6A Demethyltransferase FTO Attenuates Meniscus Degeneration and Osteoarthritis via Orchestrating Autophagy and Energetic Metabolism

Jiang, Z., Zhang, C., Liu, R., Zhu, Z., Long, D., Wen, X., Yang, Z., Jiang, D., Mao, G., Liao, W., et al. (2025) · Advanced Science · doi:10.1002/advs.202412379 · Cited by 13

LncRNA‐SULT1C2A regulates Foxo4 in congenital scoliosis by targeting rno‐miR‐466c‐5p through PI3K‐ATK signalling

Chen, C., Tan, H., Bi, J., Li, L., Rong, T., Lin, Y., Sun, P., Liang, J., Jiao, Y., Li, Z., et al. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14355 · Cited by 13

MicroRNA-486-5p suppresses inflammatory response by targeting FOXO1 in MSU-treated macrophages

Hu, J., Jin, C. Z., Fang, L., Lu, Y., Wu, Y., Xu, X., & Sun, S. (2022) · Autoimmunity · doi:10.1080/08916934.2022.2128780 · Cited by 13

Increased hydrostatic pressure induces nuclear translocation of DAF-16/FOXO in C. elegans

Watanabe, N., Morimatsu, M., Fujita, A., Teranishi, M., Sudevan, S., Watanabe, M., Iwasa, H., Hata, Y., Kagi, H., Nishiyama, M., et al. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.01.047 · Cited by 13

NFIA regulates articular chondrocyte fatty acid metabolism and joint homeostasis

Wang, C., Fang, L., Shi, M., Niu, X., Li, T., Li, X., Cho, K., He, Y., Liu, S., Lu, A., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adm9488 · Cited by 14

The Added Value of the “Co” in Co-Culture Systems in Research on Osteoarthritis Pathology and Treatment Development

Muenzebrock, K. A., Kersten, V., Alblas, J., Garcia, J. P., & Creemers, L. B. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.843056 · Cited by 12

DL‐3‐N‐Butylphthalide Promotes Cartilage Extracellular Matrix Synthesis and Inhibits Osteoarthritis Development by Regulating FoxO3a

Zhang, Y., Dai, J., Yan, L., Lin, Q., Miao, H., Wang, X., Wang, J., & Sun, Y. L. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9468040 · Cited by 11

Hypoxia dissociates HDAC6/FOXO1 complex and aggregates them into nucleus to regulate autophagy and osteogenic differentiation

Xu, Y., Wang, Y., Xiao, H., & Li, Y. (2023) · Journal of Periodontal Research · doi:10.1111/jre.13180 · Cited by 12

Dysfunction of Akt/FoxO3a/Atg7 regulatory loop magnifies obesity-regulated muscular mass decline

Yu, Y., Yang, J., Zheng, L., Su, H., Cao, S., Jiang, X., Liu, X., Liu, W., Wang, Z., Meng, F., et al. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.101892 · Cited by 11

Punicalin alleviates TNF‐α‐ and IL‐1β‐induced chondrocyte dysfunction and cartilage metabolism via mediating FOXO3 signaling axis

Yang, L., Fan, C., Shu, T., & Wang, S. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13755 · Cited by 11

Novel molecule BBC0901 inhibits BRD4 and acts as a catabolic regulator in the pathogenesis of osteoarthritis

Lee, H., Nam, J., Jang, H., Park, Y., Son, M., Lee, I., Eyun, S., Jeon, J., & Yang, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115426 · Cited by 10

Biodegradable Poly(D-L-lactide-co-glycolide) (PLGA)-Infiltrated Bioactive Glass (CAR12N) Scaffolds Maintain Mesenchymal Stem Cell Chondrogenesis for Cartilage Tissue Engineering

Gögele, C., Müller, S., Belov, S., Pradel, A., Wiltzsch, S., Lenhart, A., Hornfeck, M., Kerling, V., Rübling, A., Kühl, H., et al. (2022) · Cells · doi:10.3390/cells11091577 · Cited by 11

Luteolin regulating synthesis and catabolism of osteoarthritis chondrocytes via activating autophagy

Li, Y., Liu, F., Li, S., Huang, W., Zhou, S., Han, Y., Liu, L., Li, Y., & Yin, Z. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e31028 · Cited by 10

Targeting of hyperlipid-producing senescent synovial fibroblasts to ameliorate cartilage degeneration

Hu, J., Yu, D., Wang, J., Guo, P., Chen, M., Wu, D., Cai, Y., Wang, Y., Ji, J., Yao, X., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2417708122 · Cited by 11

DNA methylation and FoxO3a regulate PHLPP1 expression in chondrocytes

Becerra, C. M. C., Mattson, A. M., Molstad, D. H. H., Lorang, I. M., Westendorf, J. J., & Bradley, E. W. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27056 · Cited by 10

The Implications of Brain-Derived Neurotrophic Factor in the Biological Activities of Platelet-Rich Plasma

Malange, K. F., de Souza, D. M., Lemes, J. B. P., Fagundes, C. C., Oliveira, A. L. L., Pagliusi, M., Carvalho, N. S., Nishijima, C. M., da Silva, C. R. R., Consonni, S. R., et al. (2024) · Inflammation · doi:10.1007/s10753-024-02072-9 · Cited by 10

FOXO1 expression in chondrocytes modulates cartilage production and removal in fracture healing

Ding, Z., Qiu, M. R., Alharbi, M., Huang, T., Pei, X., Milovanova, T. N., Jiao, H., Lu, C., Liu, M., Qin, L., et al. (2021) · Bone · doi:10.1016/j.bone.2021.115905 · Cited by 10

YY1-induced lncRNA XIST inhibits cartilage differentiation of BMSCs by binding with TAF15 to stabilizing FUT1 expression

He, J.-Y., Cheng, M., Ye, J.-L., Peng, C.-H., Chen, J., Luo, B., Zhang, X., & Fu, Q. (2022) · Regenerative Therapy · doi:10.1016/j.reth.2022.02.002 · Cited by 10

Adenosine A2A receptor null chondrocyte transcriptome resembles that of human osteoarthritic chondrocytes

Castro, C. M., Corciulo, C., Friedman, B., Li, Z., Jacob, S. T., Fenyö, D., & Cronstein, B. N. (2021) · Purinergic Signalling · doi:10.1007/s11302-021-09788-5 · Cited by 9

Molecular Mechanisms Involved in the Progression and Protection of Osteoarthritis

Takahata, Y., Murakami, T., Hata, K., & Nishimura, R. (2020) · Current Molecular Pharmacology · doi:10.2174/1874467213666200417122933 · Cited by 9

Systemic transplantation of adult multipotent stem cells prevents articular cartilage degeneration in a mouse model of accelerated ageing

Thompson, S. D., Pichika, R., Lieber, R. L., & Lavasani, M. (2021) · Immunity & Ageing · doi:10.1186/s12979-021-00239-8 · Cited by 9

Quadruped Gait and Regulation of Apoptotic Factors in Tibiofemoral Joints following Intra-Articular rhPRG4 Injection in Prg4 Null Mice

Yang, D. S., Dickerson, E. E., Zhang, L. X., Richendrfer, H. A., Karamchedu, N. P., Badger, G. J., Schmidt, T. A., Fredericks, A. M., Elsaid, K. A., & Jay, G. D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084245 · Cited by 9

Baicalin Maintains Articular Cartilage Homeostasis and Alleviates Osteoarthritis by Activating FOXO1

Wei, Q., Yu, Z., Yang, P., & Chen, X. (2024) · Journal of Medicinal Food · doi:10.1089/jmf.2023.k.0206 · Cited by 8

Characterization of clinical data for patient stratification in moderate osteoarthritis with support vector machines, regulatory network models, and verification against osteoarthritis Initiative data

Segarra-Queralt, M., Galofré, M., Tío, L., Monfort, J., Monllau, J. C., Piella, G., & Noailly, J. (2024) · Scientific Reports · doi:10.1038/s41598-024-62212-x · Cited by 8

FOXO1-mTOR pathway in vascular pericyte regulates the formation of type H vessels to control bone metabolism

Cheng, C., Deng, M., Cheng, C., Wu, H., Wang, Y., Lu, M., Yao, Z., Li, K., Zhang, X., & Yu, B. (2024) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2024.08.010 · Cited by 8

Stem and progenitor cells in the synovial joint as targets for regenerative therapy

Roelofs, A. J., McClure, J. J., Hay, E. A., & Bari, C. D. (2025) · Nature Reviews Rheumatology · doi:10.1038/s41584-025-01222-z · Cited by 9

Forkhead box O proteins in chondrocyte aging and diseases

He, Y., Zhu, W., Alexander, P. G., Hines, S. E., Bartholomew, O., Zhao, C., Liu, Q., & Lin, H. (2025) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2025.07.011 · Cited by 8

Histamine H1 receptor inverse agonists improve structure and pain in an osteoarthritis mouse model

Kurakazu, I., Olmer, M., Swahn, H., Myers, K., Kenvisay, C., Akasaki, Y., Nakashima, Y., & Lotz, M. (2025) · Journal of Clinical Investigation · doi:10.1172/jci183588 · Cited by 9

Increased expression of cyclooxygenase‑2 in synovium tissues and synovial fluid from patients with knee osteoarthritis is associated with downregulated microRNA‑758‑3p expression

Liu, Z., Sun, J., Liang, T., & Huang, X. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10433 · Cited by 8

Do Pomegranate Hydrolyzable Tannins and Their Derived Metabolites Provide Relief in Osteoarthritis? Findings from a Scoping Review

Govoni, M., & Danesi, F. (2022) · Molecules · doi:10.3390/molecules27031033 · Cited by 8

Protein phosphatase SCP4 regulates cartilage development and endochondral osteogenesis via FoxO3a dephosphorylation

Wang, P., Zou, K., Cao, J., Zhang, Z., Yuan, W., Chen, J., Xu, J., Zou, Z., Chen, D., Ruan, H., et al. (2024) · Cell Proliferation · doi:10.1111/cpr.13691 · Cited by 8

Articular Cartilage: Homeostasis, Aging and Degeneration

Pritzker, K. P. H., & Gahunia, H. K. (2020) · Springer eBooks · doi:10.1007/978-1-4939-7587-7_3 · Cited by 10

TGFB1, FOXO1, and COMP Genes Expression in Blood of Patients with Osteoarthritis after SARS-CoV2 Infection

Huet, A., Тугаров, Ю. Р., Dvorshchenko, K., Grebinyk, D. M., Savchuk, О., Korotkyi, O., & Остапченко, Л. І. (2023) · Cytology and Genetics · doi:10.3103/s009545272302010x · Cited by 8

Hypoxia activates autophagy by Akt/FoxO1 pathway in fish cells

Chen, K., Shi, L., Liu, H., & Wang, H. (2023) · Aquaculture and Fisheries · doi:10.1016/j.aaf.2023.05.001 · Cited by 9

Interleukin‑Iβ promotes cartilage degeneration by regulating forkhead box protein O4 and type Ⅱ collagen

Wu, J., Zhang, H., Deng, R., Xing, L., Hu, M., & Fu, X. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12453 · Cited by 8

A high throughput cell stretch device for investigating mechanobiology in vitro

Pratt, S. J. P., Plunkett, C. M., Kuzu, G., Trinh, T., Barbara, J., Choconta, P., Quackenbush, D., Huynh, T., Smith, A. J., Barnes, S. W., et al. (2024) · APL Bioengineering · doi:10.1063/5.0206852 · Cited by 7

Glabridin mitigates osteoarthritis progression through modulation of the PI3K/AKT/FOXO3A autophagy axis

Lou, L., Zhu, Z., Xu, L., Wu, Z., Wang, X., Yuan, L., Miao, H., Xia, C., & Dai, J. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157359 · Cited by 7

Decreased FoxO1 expression contributes to facet joint osteoarthritis pathogenesis by impairing chondrocyte migration and extracellular matrix synthesis

Chen, C., Xu, G., Chen, J., Wu, C., Zhang, J., Jiang, J., Hong, H., & Cui, Z. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110942 · Cited by 7

microRNAs are differentially expressed in equine plasma of horses with osteoarthritis and osteochondritis dissecans versus control horses

Antunes, J., Salcedo-Jiménez, R., Lively, S. S., Potla, P., Coté, N., Dubois, M., Koenig, J. B., Kapoor, M., LaMarre, J., & Koch, T. G. (2024) · PLoS ONE · doi:10.1371/journal.pone.0297303 · Cited by 7

Composite Hydrogel Containing Collagen‐Modified Polylactic Acid‐Hydroxylactic Acid Copolymer Microspheres Loaded with Tetramethylpyrazine Promotes Articular Cartilage Repair

Pan, Y., Li, B., Sun, X., Tu, P., Guo, Y., Zhao, Z., Wu, M., Wang, Y., Wang, Z., & Ma, Y. (2024) · Macromolecular Bioscience · doi:10.1002/mabi.202400003 · Cited by 7

Selective inhibition of progesterone receptor in osteochondral progenitor cells, but not in mature chondrocytes, modulated subchondral bone structures

Dai, C., Jia, J., Kot, A., Liu, X., Liu, L., Jiang, M., Lane, N. E., Wise, B. L., & Yao, W. (2019) · Bone · doi:10.1016/j.bone.2019.115196 · Cited by 7

Identification of Key Genes and Pathways in Osteoarthritis via Bioinformatic Tools: An Updated Analysis

Zhang, Y., Zhu, T., He, F., Chen, A. C., Yang, H., & Zhu, X. (2021) · Cartilage · doi:10.1177/19476035211008975 · Cited by 7

Autophagy Behavior in Endothelial Cell Regeneration

Marzoog, B. A. (2023) · Current Aging Science · doi:10.2174/0118746098260689231002044435 · Cited by 7

Recent Developments in Osteoarthritis Research: Innovative Therapeutic Approaches and the Role of Polyphenols and Nanotechnology

Vélez-Slimani, H., Hernández‐Montelongo, J., & Salazar, L. A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26188925 · Cited by 7

Salidroside ameliorates lipopolysaccharide‑induced ferroptosis in chondrocytes via regulation of the sirt1/foxo1 axis

Zhang, X. D., Huang, L., Feng, W., Xu, D., & Zeng, Y. (2025) · Molecular Medicine Reports · doi:10.3892/mmr.2025.13502 · Cited by 7

Transcriptional regulation of autophagy in aging

Moreno, T. M., Lange, C. M., & Kumsta, C. (2022) · Current Opinion in Physiology · doi:10.1016/j.cophys.2022.100591 · Cited by 5

FOXO 1 deletion in chondrocytes rescues diabetes-impaired fracture healing by restoring angiogenesis and reducing apoptosis

Alharbi, M., & Graves, D. T. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1136117 · Cited by 6

Exploring molecular mechanisms underlying the pathophysiological association between knee osteoarthritis and sarcopenia

Yang, J., Jiang, T., Xu, G., Wang, S., & Liu, W. (2023) · Osteoporosis and Sarcopenia · doi:10.1016/j.afos.2023.08.005 · Cited by 6

FoxO1 is a crucial mediator of TGF-β/TAK1 signaling and protects against osteoarthritis by maintaining articular cartilage homeostasis

Wang, C., Shen, J., Ying, J., Xiao, D., & O’Keefe, R. J. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2017056117 · Cited by 104

FoxO1 Transcription Factor in Chondrocyte Regulation: A Review on Its Molecular Mechanisms, Pathological Roles, and Therapeutic Potential

Ting Chen, M. H. T. (2025) · Journal of Neonatal Surgery

The role of forkhead box o transcription factors in joint development, maturation and homeostasis

Matsuzaki, T., Olmer, M., Matsuzaki, O., & Lotz, M. (2016) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2016.01.286

An anti-arthritis signal

Ray, L. B. (2020) · Science · doi:10.1126/science.370.6523.1429-a

Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis

Akasaki, Y., Hasegawa, A., Saito, M., Asahara, H., Iwamoto, Y., & Lotz, M. (2013) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2013.11.004 · Cited by 141