CoChat
Sign Up
Cited by 81Electrochemical Analysis and ApplicationsElectrochemical sensors and biosensorsAdvanced biosensing and bioanalysis techniques

Review—Electrochemistry's Potential to Reach the Ultimate Sensitivity in Measurement Science

Open access
Goines, Sondrica, Dick, Jeffrey E.·2020·Journal of The Electrochemical Society
DOI 10.1149/2.0052003jes
Open this paper in CoChat — free accountOpen PDF

Abstract

A holy grail in analytical chemistry is the specific quantification of a single entity, be that entity an atom, a molecule, a nanoparticle, a virus, or a circulating tumor cell. Analytical chemistry is entering an era where this sensitivity can be achieved. In these experiments, the limit of detection is 1, and the limit of quantitation is not only measured in units of concentration but units of time: the waiting time before positively identifying a single entity. Electrochemistry is front and center in single entity experiments with hundreds of publications per year detailing observations of various entities colliding with micro- and nano-electrodes. These types of experiments are referred to as 'stochastic electrochemistry' due to the stochastic nature of the collision of an entity with an electrode surface. If methods of detection can be made specific, simple, inexpensive, and robust, the techniques hold the promise of transforming diagnostics (i.e., the specific detection of a single cancerous cell in blood). This review will critically analyze the stochastic electrochemistry literature and focus on reports detailing methods to ensure the response at the electrode surface is specific to the colliding entity. The topic of specificity, and strategies to achieve it, are highlighted.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1149/2.0052003jes

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Lee et al. demonstrated a linear relationship between collision frequency f_exp and E. coli concentration C_bac, as expected by Equation 1.

    “The authors have demonstrated a linear relationship between the collision frequency f exp (number of step-shaped transients) and the E. coli concentration C bac , as expected by Equation 1 below (in conditions where the mass transport is controlled by diffusion) [10,16,32].”

    From Trends in single-impact electrochemistry for bacteria analysis (2023) · cites this paper as [10]

    In “Methods to Decrease Limit of Quantitation” (page unavailable), the review gives a diffusion-controlled equation in which collision frequency is proportional to the concentration of colliding entities. Its discussion of bacterial blocking experiments (page unavailable) reports detection of single E. coli collisions, but does not report that Lee et al. experimentally demonstrated a linear relationship between step-shaped transient frequency and E. coli concentration. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

No citation lists for this paper

No citation lists for this paper yet — checked again daily.

References 128 · Cited by 81

Research works printed but not linked: 101

  1. L. A. Baker, "Perspective and Prospectus on Single-Entity Electrochemistry." J. Am. Chem. Soc., 140(46), 15549 (2018). · DOI
  2. W. E. Moerner, R. M. Dickson, and D. J. Norris, "Single-molecule spectroscopy and quantum optics in solids." Advances in Atomic, Molecular, and Optical Physics, 38, 193 (1997). · DOI
  3. W. E. Moerner, "Polymer luminescence -Those blinking single molecules." Science, 277(5329), 1059 (1997). · DOI
  4. R. M. Dickson, A. B. Cubitt, R. Y. Tsien, and W. E. Moerner, "On/off blinking and switching behavior of single molecules of green fluorescent protein." Nature, 388(6640), 355 (1997). · DOI
  5. W. E. Moerner, "Nobel Lecture: Single-molecule spectroscopy, imaging, and photo- control: Foundations for super-resolution microscopy." Reviews of Modern Physics, 87(4), (2015). · DOI
  6. G. Q. Chen, N. M. Zou, B. Chen, J. B. Sambur, E. Choudhary, and P. Chen, "Bimetal- lic Effect of Single Nanocatalysts Visualized by Super-Resolution Catalysis Imag- ing." Acs Central Science, 3(11), 1189 (2017). · DOI
  7. P. Chen, X. C. Zhou, H. Shen, N. M. Andoy, E. Choudhary, K. S. Han, G. K. Liu, and W. L. Meng, "Single-molecule fluorescence imaging of nanocatalytic processes." Chemical Society Reviews, 39(12), 4560 (2010). · DOI
  8. K. S. Han, G. K. Liu, X. C. Zhou, R. E. Medina, and P. Chen, "How Does a Single Pt Nanocatalyst Behave in Two Different Reactions? A Single-Molecule Study." Nano Lett., 12(3), 1253 (2012). · DOI
  9. J. B. Sambur and P. Chen, "Distinguishing Direct and Indirect Photoelectrocatalytic Oxidation Mechanisms Using Quantitative Single-Molecule Reaction Imaging and Photocurrent Measurements." J. Phys. Chem. C, 120(37), 20668 (2016). · DOI
  10. J. B. Sambur, T. Y. Chen, E. Choudhary, G. Q. Chen, E. J. Nissen, E. M. Thomas, N. M. Zou, and P. Chen, "Sub-particle reaction and photocurrent mapping to opti- mize catalyst-modified photoanodes." Nature, 530(7588), 77-+ (2016). · DOI
  11. H. Shen, W. L. Xu, and P. Chen, "Single-molecule nanoscale electrocatalysis." Phys. Chem. Chem. Phys., 12(25), 6555 (2010). · DOI
  12. H. S. Ahn and A. J. Bard, "Single-Nanoparticle Collision Events: Tunneling Elec- tron Transfer on a Titanium Dioxide Passivated n-Silicon Electrode." Angew. Chem. Int. Ed., 54(46), 13753 (2015). · DOI
  13. T. M. Alligrant, M. J. Anderson, R. Dasari, K. J. Stevenson, and R. M. Crooks, "Single Nanoparticle Collisions at Microfluidic Microband Electrodes: The Effect of Electrode Material and Mass Transfer." Langmuir, 30(44), 13462 (2014). · DOI
  14. A. J. Bard, H. J. Zhou, and S. J. Kwon, "Electrochemistry of Single Nanoparticles via Electrocatalytic Amplification." Israel Journal of Chemistry, 50(3), 267 (2010). · DOI
  15. A. D. Castaneda, T. M. Alligrant, J. A. Loussaert, and R. M. Crooks, "Electrocat- alytic Amplification of Nanoparticle Collisions at Electrodes Modified with Poly- electrolyte Multi layer Films." Langmuir, 31(2), 876 (2015). · DOI
  16. J. T. Cox and B. Zhang, "Nanoelectrodes: Recent Advances and New Directions." In Annual Review of Analytical Chemistry, Vol 5, R. G. Cooks; E. S. Yeung, Eds. 2012; Vol. 5, pp 253.
  17. R. M. Crooks, "Concluding remarks: single entity electrochemistry one step at a time." Faraday Discussions, 193, 533 (2016). · DOI
  18. R. Dasari, D. A. Robinson, and K. J. Stevenson, "Ultrasensitive Electroanalyti- cal Tool for Detecting, Sizing, and Evaluating the Catalytic Activity of Platinum Nanoparticles." J. Am. Chem. Soc., 135(2), 570 (2013). · DOI
  19. B. Fu, C. Van Dyck, S. Zaleski, R. P. Van Duyne, and M. A. Ratner, "Single Molecule Electrochemistry: Impact of Surface Site Heterogeneity." J. Phys. Chem. C, 120(48), 27241 (2016). · DOI
  20. J. Kim, J. E. Dick, and A. J. Bard, "Advanced Electrochemistry of Individual Metal Clusters Electrodeposited Atom by Atom to Nanometer by Nanometer." Accounts of Chemical Research, 49(11), 2587 (2016). · DOI
  21. S. J. Kwon, F. R. F. Fan, and A. J. Bard, "Observing Iridium Oxide (IrOx) Single Nanoparticle Collisions at Ultramicroelectrodes." J. Am. Chem. Soc., 132(38), 13165 (2010). · DOI
  22. S. J. Kwon, H. J. Zhou, F. R. F. Fan, V. Vorobyev, B. Zhang, and A. J. Bard, "Stochas- tic electrochemistry with electrocatalytic nanoparticles at inert ultramicroelectrodes- theory and experiments." Phys. Chem. Chem. Phys., 13(12), 5394 (2011). · DOI
  23. Y. X. Li, J. T. Cox, and B. Zhang, "Electrochemical Responses and Electrocatalysis at Single Au Nanoparticles." J. Am. Chem. Soc., 132(9), 3047 (2010). · DOI
  24. T. Sun, Y. Yu, B. J. Zacher, and M. V. Mirkin, "Scanning Electrochemical Mi- croscopy of Individual Catalytic Nanoparticles." Angew. Chem. Int. Ed., 53(51), 14120 (2014). · DOI
  25. J. E. Dick, "Electrochemical detection of single cancer and healthy cell collisions on a microelectrode." Chem. Commun., 52(72), 10906 (2016). · DOI
  26. J. J. Gooding, "Single Entity Electrochemistry Progresses to Cell Counting." Angew. Chem. Int. Ed., 55(42), 12956 (2016). · DOI
  27. M. M. Barchitta, "Andrea; Quattrochchi, Annalisa; Agrifoglio, Ottavia; Agodi, An- tonella, The Role of miRNAs as Biomarkers for Pregnancy Outcomes: A Compre- hensive Review." International Journal of Genomics (2017). · DOI
  28. E. E. R. Winger, L. Jane, Xuhuai Ji, and Kypros Nicolaides, "Peripheral blood cell microRNA quantification during the first trimester predicts preeclampsia: Proof of concept." PlosOne (2018). · DOI
  29. A. Nabers, L. Perna, J. Lange, U. Mons, J. Schartner, J. Guldenhaupt, K.-U. Saum, S. Janelidze, B. Holleczek, D. Rujescu, O. Hansson, K. Gerwert, and H. Brenner, "Amyloid Blood Biomarker Detects Alzheimer's Disease." EMBO Mol. Med., '0(5), e8763 (2019).
  30. M. W. Glasscott and J. E. Dick, "Direct Electrochemical Observation of Single Plat- inum Cluster Electrocatalysis on Ultramicroelectrodes." Anal. Chem., 90(13), 7804 (2018). · DOI
  31. M. Zhou, J. E. Dick, K. K. Hu, M. V. Mirkin, and A. J. Bard, "Ultrasensitive Elec- troanalysis: Femtomolar Determination of Lead, Cobalt, and Nickel." Anal. Chem., 90(2), 1142 (2018). · DOI
  32. M. Zhou, J. E. Dick, and A. J. Bard, "Electrodeposition of Isolated Platinum Atoms and Clusters on Bismuth-Characterization and Electrocatalysis." J. Am. Chem. Soc., 139(48), 17677 (2017). · DOI
  33. S. J. Percival, J. E. Dick, and A. J. Bard, "Cathodically Dissolved Platinum Resulting from the O-2 and H2O2 Reduction Reactions on Platinum Ultramicroelectrodes." Anal. Chem., 89(5), 3087 (2017). · DOI
  34. J. E. Dick and A. J. Bard, "Toward the Digital Electrochemical Recognition of Cobalt, Iridium, Nickel, and Iron Ion Collisions by Catalytic Amplification." J. Am. Chem. Soc., 138(27), 8446 (2016). · DOI
  35. J. E. Dick and A. J. Bard, "Recognizing Single Collisions of PtCl62-at Femtomolar Concentrations on Ultramicroelectrodes by Nucleating Electrocatalytic Clusters." J. Am. Chem. Soc., 137(43), 13752 (2015). · DOI
  36. F. R. F. Fan, J. Kwak, and A. J. Bard, "Single molecule electrochemistry." J. Am. Chem. Soc., 118(40), 9669 (1996). · DOI
  37. F. R. F. Fan and A. J. Bard, "Electrochemical Detection of Single Molecules." Sci- ence, 267(5199), 871 (1995). · DOI
  38. J. H. Park, H. J. Zhou, S. J. Percival, B. Zhang, F. R. F. Fan, and A. J. Bard, "Open Circuit (Mixed) Potential Changes Upon Contact Between Different Inert Electrodes-Size and Kinetic Effects." Anal. Chem., 85(2), 964 (2013). · DOI
  39. S. J. Percival and B. Zhang, "Fast-Scan Cyclic Voltammetry Allows Determination of Electron Transfer Kinetic Constants in Single Nanoparticle Collision." J. Phys. Chem. C, 120(37), 20536 (2016). · DOI
  40. J. L. Zhang, J. Rector, J. Q. Lin, J. H. Young, M. Sans, N. Katta, N. Giese, W. D. Yu, C. Nagi, J. Suliburk, J. S. Liu, A. Bensussan, R. J. DeHoog, K. Y. Garza, B. Ludolph, A. G. Sorace, A. Syed, A. Zahedivash, T. E. Milner, and L. S. Eberlin, "Nondestruc- tive tissue analysis for ex vivo and in vivo cancer diagnosis using a handheld mass spectrometry system." Science Translational Medicine, 9(406), (2017). · DOI · Paper page
  41. Y. L. Ying, Z. F. Ding, D. P. Zhan, and Y. T. Long, "Advanced electroanalytical chemistry at nanoelectrodes." Chem. Sci., 8(5), 3338 (2017). · DOI
  42. L. H. Han, W. Wang, J. Nsabimana, J. W. Yan, B. Ren, and D. P. Zhan, "Single molecular catalysis of a redox enzyme on nanoelectrodes." Faraday Discussions, 193, 133 (2016). · DOI
  43. J. Velmurugan, J. M. Noel, and M. V. Mirkin, "Nucleation and growth of mercury on Pt nanoelectrodes at different overpotentials." Chem. Sci., 5(1), 189 (2014). · DOI
  44. J. Kim, B. K. Kim, S. K. Cho, and A. J. Bard, "Tunneling Ultramicroelectrode: Nanoelectrodes and Nanoparticle Collisions." J. Am. Chem. Soc., 136(23), 8173 (2014). · DOI
  45. J. H. Park, S. N. Thorgaard, B. Zhang, and A. J. Bard, "Single Particle Detection by Area Amplification: Single Wall Carbon Nanotube Attachment to a Nanoelectrode." J. Am. Chem. Soc., 135(14), 5258 (2013). · DOI
  46. S. G. Lemay, S. Kang, K. Mathwig, and P. S. Singh, "Single-Molecule Electro- chemistry: Present Status and Outlook." Accounts of Chemical Research, 46(2), 369 (2013). · DOI
  47. B. K. Jena, S. J. Percival, and B. Zhang, "Au Disk Nanoelectrode by Electrochemical Deposition in a Nanopore." Anal. Chem., 82(15), 6737 (2010). · DOI
  48. Y. X. Li, D. Bergman, and B. Zhang, "Preparation and Electrochemical Response of 1-3 nm Pt Disk Electrodes." Anal. Chem., 81(13), 5496 (2009). · DOI
  49. R. W. Murray, "Nanoelectrochemistry: Metal nanoparticles, nanoelectrodes, and nanopores." Chemical Reviews, 108(7), 2688 (2008). · DOI
  50. F. J. M. Hoeben, F. S. Meijer, C. Dekker, S. P. J. Albracht, H. A. Heering, and S. G. Lemay, "Toward Single-Enzyme Molecule Electrochemistry: NiFe - Hydrogenase Protein Film Voltammetry at Nanoelectrodes." ACS Nano, 2(12), 2497 (2008). · DOI
  51. A. Boika, S. N. Thorgaard, and A. J. Bard, "Monitoring the Electrophoretic Migra- tion and Adsorption of Single Insulating Nanoparticles at Ultramicroelectrodes." J. Phys. Chem. B, 117(16), 4371 (2013). · DOI · Paper page
  52. J. E. Dick, A. T. Hilterbrand, L. M. Strawsine, J. W. Upton, and A. J. Bard, "En- zymatically enhanced collisions on ultramicroelectrodes for specific and rapid detection of individual viruses." Proc. Nat'l. Acad. Sci. USA, 113(23), 6403 (2016). · DOI
  53. X. Deng, Frederica Galli, and Marc T. M. Koper, "In Situ Electrochemical AFM Imaging of a Pt Electrode in Sulfuric Acid under Potential Cycling Conditions." J. Am. Chem. Soc., 140(41), 13285 (2018). · DOI
  54. A. J. Bard, "Inner-Sphere Heterogeneous Electrode Reactions. Electrocatalysis and Photocatalysis: The Challenge." J. Am. Chem. Soc., 132(22), 7559 (2010). · DOI
  55. J. Bonezzi and A. Boika, "Deciphering the Magnitude of Current Steps in Electro- chemical Blocking Collision Experiments and Its Implications." Electrochim. Acta, 236, 252 (2017). · DOI
  56. A. J. B. A. L. R. Faulkner, Electrochemical Methods: Fundamentals and Applica- tions, 2 ed.; John Wiley & Sons: New York, New York, 2001.
  57. Z. Deng, R. Elattar, F. Maroun, and C. Renault, "In Situ Measurement of the Size Distribution and Concentration of Insulating Particles by Electrochemical Colli- sion on Hemispherical Ultramicroelectrodes." Analytical Chemistry, 90(21), 12923 (2018). · DOI · Paper page
  58. J. E. Dick, C. Renault, and A. J. Bard, "Observation of Single-Protein and DNA Macromolecule Collisions on Ultramicroelectrodes." J. Am. Chem. Soc., 137(26), 8376 (2015). · DOI · Paper page
  59. J. E. Dick, A. T. Hilterbrand, A. Boika, J. W. Upton, and A. J. Bard, "Electrochemi- cal detection of a single cytomegalovirus at an ultramicroelectrode and its antibody anchoring." Proc. Nat'l. Acad. Sci. USA, 112(17), 5303 (2015). · DOI · Paper page
  60. J. Y. Lee, Byung-Kwon Kim, Mijeong Kang, and Jun Hui Park, "Label-Free De- tection of Single Living Bacteria via Electrochemical Collision Event." Scientific Reports, 6 (2016). · DOI · Paper page
  61. G. Gao, Denchao Wang, Ricardo Brocenschi, Jinfang Zhi, and Michael V. Mirkin, "Toward the Detection and Identification of Single Bacteria by Electrochemical Collision Technique." Anal. Chem., 90(20), 12123 (2018). · DOI · Paper page
  62. H. Ren, S. R. German, M. A. Edwards, Q. J. Chen, and H. S. White, "Electrochemi- cal Generation of Individual O-2 Nanobubbles via H2O2 Oxidation." J. Phys. Chem. Lett., 8(11), 2450 (2017). · DOI
  63. Y. W. Liu, M. A. Edwards, S. R. German, Q. J. Chen, and H. S. White, "The Dy- namic Steady State of an Electrochemically Generated Nanobubble." Langmuir, 33(8), 1845 (2017). · DOI
  64. S. R. German, M. A. Edwards, Q. J. Chen, Y. W. Liu, L. Luo, and H. S. White, "Electrochemistry of single nanobubbles. Estimating the critical size of bubble- forming nuclei for gas-evolving electrode reactions." Faraday Discussions, 193, 223 (2016). · DOI
  65. S. R. German, Q. J. Chen, M. A. Edwards, and H. S. White, "Electrochemical Mea- surement of Hydrogen and Nitrogen Nanobubble Lifetimes at Pt Nanoelectrodes." J. Electrochem. Soc., 163(4), H3160 (2016). · DOI
  66. Q. J. Chen, H. S. Wiedenroth, S. R. German, and H. S. White, "Electrochemical Nucleation of Stable N-2 Nanobubbles at Pt Nanoelectrodes." J. Am. Chem. Soc., 137(37), 12064 (2015). · DOI
  67. Q. J. Chen, L. Luo, H. Faraji, S. W. Feldberg, and H. S. White, "Electrochemical Measurements of Single H-2 Nanobubble Nucleation and Stability at Pt Nanoelec- trodes." J. Phys. Chem. Lett., 5(20), 3539 (2014). · DOI
  68. L. Luo and H. S. White, "Electrogeneration of Single Nanobubbles at Sub-50-nm- Radius Platinum Nanodisk Electrodes." Langmuir, 29(35), 11169 (2013). · DOI
  69. Z. P. Xiang, H. Deng, P. Peljo, Z. Y. Fu, S. L. Wang, D. Mandler, G. Q. Sun, and Z. X. Liang, "Electrochemical Dynamics of a Single Platinum Nanoparticle Colli- sion Event for the Hydrogen Evolution Reaction." Angew. Chem. Int. Ed., 57(13), 3464 (2018). · DOI
  70. A. D. Castaneda, N. J. Brenes, A. Kondajji, and R. M. Crooks, "Detection of mi- croRNA by Electrocatalytic Amplification: A General Approach for Single-Particle Biosensing." J. Am. Chem. Soc., 139(22), 7657 (2017). · DOI
  71. A. D. Castaneda, D. A. Robinson, K. J. Stevenson, and R. M. Crooks, "Electrocat- alytic amplification of DNA-modified nanoparticle collisions via enzymatic diges- tion." Chem. Sci., 7(10), 6450 (2016). · DOI
  72. T. M. Alligrant, E. G. Nettleton, and R. M. Crooks, "Electrochemical detection of individual DNA hybridization events." Lab on a Chip, 13(3), 349 (2013). · DOI
  73. T. M. Alligrant, R. Dasari, K. J. Stevenson, and R. M. Crooks, "Electrocatalytic Amplification of Single Nanoparticle Collisions Using DNA-Modified Surfaces." Langmuir, 31(42), 11724 (2015). · DOI
  74. J. E. Dick, "Studies in the Electrochemistry of Single Atoms, Molecules, and Nanoparticles." Dissertation, The University of Texas at Austin (2017). · DOI
  75. Y. Zhang, Jinpeng Mao, Wenliang Ji, Taotao Feng, Zixuan Fu, Meining Zhang, and Lanqun Mao, "Collision of Aptamer/Pt Nanoparticles Enables Label-Free Amper- ometric Detection of Protein in Rat Brain." Anal. Chem., 91(9), 5654 (2019). · DOI
  76. B. Haddou, N. V. Rees, and R. G. Compton, "Nanoparticle-electrode impacts: the oxidation of copper nanoparticles has slow kinetics." Phys. Chem. Chem. Phys., 14(39), 13612 (2012). · DOI
  77. Y. G. Zhou, N. V. Rees, and R. G. Compton, "Electrode-nanoparticle collisions: The measurement of the sticking coefficient of silver nanoparticles on a glassy carbon electrode." Chemical Physics Letters, 514(4-6), 291 (2011). · DOI
  78. N. V. Rees, Y. G. Zhou, and R. G. Compton, "The Aggregation of Silver Nanoparticles in Aqueous Solution Investigated via Anodic Particle Coulometry." Chemphyschem, 12(9), 1645 (2011). · DOI · Paper page
  79. Y. G. Zhou, N. V. Rees, and R. G. Compton, "The Electrochemical Detection and Characterization of Silver Nanoparticles in Aqueous Solution." Angew. Chem. Int. Ed., 50(18), 4219 (2011). · DOI
  80. A. N. Sekretaryova, M. Y. Vagin, A. P. F. Turner, and M. Eriksson, "Electrocatalytic Currents from Single Enzyme Molecules (vol 138, pg 2504, 2016)." J. Am. Chem. Soc., 139(3), 1344 (2017). · DOI
  81. A. N. Sekretaryova, M. Y. Vagin, A. P. F. Turner, and M. Eriksson, "Correspondence on "Can Nanoimpacts Detect Single-Enzyme Activity? Theoretical Considerations and an Experimental Study of Catalase Impacts"." Acs Catalysis, 7(5), 3591 (2017). · DOI
  82. A. N. Sekretaryova, M. Y. Vagin, A. P. F. Turner, and M. Eriksson, "Electrocatalytic Currents from Single Enzyme Molecules." J. Am. Chem. Soc., 138(8), 2504 (2016). · DOI
  83. E. Katelhon, L. Sepunaru, A. A. Karyakin, and R. G. Compton, "Reply to Comment on "Can Nanoimpacts Detect Single-Enzyme Activity? Theoretical Considerations and an Experimental Study of Catalase Impacts"." Acs Catalysis, 7(5), 3594 (2017). · DOI
  84. C. Chan, L. Sepunaru, S. V. Sokolov, E. Katelhon, N. P. Young, and R. G. Compton, "Catalytic activity of catalase-silica nanoparticle hybrids: from ensemble to individ- ual entity activity." Chem. Sci., 8(3), 2303 (2017). · DOI
  85. E. Katelhon, L. Sepunaru, A. A. Karyakin, and R. G. Compton, "Can Nanoimpacts Detect Single-Enzyme Activity? Theoretical Considerations and an Experimental Study of Catalase Impacts." Acs Catalysis, 6(12), 8313 (2016). · DOI
  86. C. Bourdillon, C. Demaille, J. Moiroux, and J. M. Saveant, "Analyzing product in- hibition and pH gradients in immobilized enzyme films as illustrated experimentally by immunologically bound glucose oxidase electrode coatings." J. Phys. Chem. B, 103(40), 8532 (1999). · DOI
  87. K. Scida, "Microfluidics for bioanalytical research: transitioning into point-of-care diagnostics." Dissertation, The University of Texas at Austin (2014).
  88. H. Q. Deng, J. E. Dick, S. Kummer, U. Kragl, S. H. Strauss, and A. J. Bard, "Probing Ion Transfer across Liquid-Liquid Interfaces by Monitoring Collisions of Single Femtoliter Oil Droplets on Ultramicroelectrodes." Anal. Chem., 88(15), 7754 (2016). · DOI
  89. J. E. Dick, E. Lebegue, L. M. Strawsine, and A. J. Bard, "Millisecond Coulome- try via Zeptoliter Droplet Collisions on an Ultramicroelectrode." Electroanalysis, 28(10), 2320 (2016). · DOI · Paper page
  90. Y. Li, H. Q. Deng, J. E. Dick, and A. J. Bard, "Analyzing Benzene and Cyclohexane Emulsion Droplet Collisions on Ultramicroelectrodes." Anal. Chem., 87(21), 11013 (2015). · DOI
  91. J. E. Dick, A. Poirel, R. Ziessel, and A. J. Bard, "Electrochemistry, Electrogenerated Chemiluminescence, and Electropolymerization of Oligothienyl-BODIPY Deriva- tives." Electrochim. Acta, 178, 234 (2015). · DOI
  92. B. K. Kim, A. Boika, J. Kim, J. E. Dick, and A. J. Bard, "Characterizing Emulsions by Observation of Single Droplet Collisions-Attoliter Electrochemical Reactors." J. Am. Chem. Soc., 136(13), 4849 (2014). · DOI
  93. J. E. Dick, C. Renault, B. K. Kim, and A. J. Bard, "Electrogenerated Chemilumi- nescence of Common Organic Luminophores in Water Using an Emulsion System." J. Am. Chem. Soc., 136(39), 13546 (2014). · DOI
  94. J. E. Dick, C. Renault, B. K. Kim, and A. J. Bard, "Simultaneous Detection of Single Attoliter Droplet Collisions by Electrochemical and Electrogenerated Chemilumi- nescent Responses." Angew. Chem. Int. Ed., 53(44), 11859 (2014). · DOI
  95. M. W. Glasscott, A. D. Pendergast, S. Goines, A. R. Bishop, A. H. Hoang, C. R. Renault, and J. E. Dick, "Electrosynthesis of high-entropy metallic glass nanoparticles for designer, multi-functional electrocatalysis." Nature Communica- tions (2019). · DOI
  96. M. W. Glasscott, A. D. Pendergast, M. H. Choudhury, and J. E. Dick, "Advanced Characterization Techniques for Evaluating Porosity, Nanopore Tortuosity, and Elec- trical Connectivity at the Single-Nanoparticle Level." ACS Applied Nano Materials, 2(2), 819 (2019). 100. · DOI
  97. M. W. Glasscott and J. E. Dick, "Fine-Tuning Porosity and Time-Resolved Obser- vation of the Nucleation and Growth of Single Platinum Nanoparticles." ACS Nano, 13(4), 4572 (2019). 101. · DOI
  98. M. W. Glasscott and J. E. Dick, "Direct Electrochemical Observation of Single Platinum Cluster Electrocatalysis on Ultramicroelectrodes." Anal. Chem., 90, 7804 (2018). 102. M. W. Glasscott, A. D. Pendergast, and J. E. Dick, "A Universal Platform for the Electrodeposition of Ligand-Free Metal Nanoparticles from a Water-in-Oil Emul- sion System." ACS Applied Nano Materials, 1(10), 5702 (2018). 103. Y. E. Jeun, Bongkwan Baek, Myoung Won Lee, and Hyun S. Ahn, "Surfactant- free electrochemical synthesis of metallic nanoparticles via stochastic collisions of aqueous nanodroplet reactors." Chem. Commun., 54(72), 10052 (2018). 104. M. V. Evers, Miguel Bernal, Beatriz Roldan Cuenya, and Kristina Tschulik, "Piece by Piece-Electrochemical Synthesis of Individual Nanoparticles and their Perfor- mance in ORR Electrocatalysis." Angew. Chem. Int. Ed., 58(24), 8221 (2019). 105. M. W. Glasscott, A. D. Pendergast, S. Goines, A. R. Bishop, A. T. Hoang, C. Renault, and J. E. Dick, "Electrosynthesis of high-entropy metallic glass nanopar- ticles for designer, multi-functional electrocatalysis." Nature Communications, 10, (2019). 106. E. Lebegue, C. M. Anderson, J. E. Dick, L. J. Webb, and A. J. Bard, "Electrochemi- cal Detection of Single Phospholipid Vesicle Collisions at a Pt Ultramicroelectrode." Langmuir, 31(42), 11734 (2015). 107. · DOI · Paper page
  99. H. S. Toh and R. G. Compton, "Electrochemical detection of single micelles through 'nano-impacts'." Chem. Sci., 6, 5053 (2015). 108. B. K. Kim, J. Kim, and A. J. Bard, "Electrochemistry of a Single Attoliter Emulsion Droplet in Collisions." J. Am. Chem. Soc., 137(6), 2343 (2015). 109. D. A. Robinson and H. S. White, "Electrochemical Synthesis of Individual Core@Shell and Hollow Ag/Ag2S Nanoparticles." Nano Lett., 19(8), 5612 (2019). 110. D. A. Robinson, M. A. Edwards, H. Ren, and H. S. White, "Effects of Instrumental Filters on Electrochemical Measurement of Single-Nanoparticle Collision Dynam- ics." Chemelectrochem, 5(20), 3059 (2018). 111. K. McKelvey, D. A. Robinson, N. J. Vitti, M. A. Edwards, and H. S. White, "Single Ag nanoparticle collisions within a dual-electrode micro-gap cell." Faraday Discus- sions, 210, 189 (2018). 112. D. A. Robinson, Y. W. Liu, M. A. Edwards, N. J. Vitti, S. M. Oja, B. Zhang, and H. S. White, "Collision Dynamics during the Electrooxidation of Individual Silver Nanoparticles." J. Am. Chem. Soc., 139(46), 16923 (2017). 113. S. M. Oja, D. A. Robinson, N. J. Vitti, M. A. Edwards, Y. W. Liu, H. S. White, and B. Zhang, "Observation of Multipeak Collision Behavior during the Electro- Oxidation of Single Ag Nanoparticles." J. Am. Chem. Soc., 139(2), 708 (2017). · DOI
  100. A. Einstein, "Über die von der molekularkinetischen Theorie der Wärme geforderte Bewegung von in ruhenden Flüssigkeiten suspendierten Teilchen." Annalen der Physik, 322(8), 549 (1905). 115. A. Boika and A. J. Bard, "Time of First Arrival in Electrochemical Collision Ex- periments as a Measure of Ultra low Concentrations of Analytes in Solution." Anal. Chem., 87(8), 4341 (2015). 116. A. Boika and A. J. Bard, "Electrophoretic Migration and Particle Collisions in Scan- ning Electrochemical Microscopy." Anal. Chem., 86(23), 11666 (2014). 117. J. H. Park, A. Boika, H. S. Park, H. C. Lee, and A. J. Bard, "Single Collision Events of Conductive Nanoparticles Driven by Migration." J. Phys. Chem. C, 117(13), 6651 (2013). 118. K. J. Freedman, L. M. Otto, A. P. Ivanov, A. Barik, S. H. Oh, and J. B. Edel, "Nanopore sensing at ultra-low concentrations using single-molecule dielec- trophoretic trapping." Nature Communications, 7, 9 (2016). 119. F. R. Madiyar, L. U. Syed, C. T. Culbertson, and J. Li, "Manipulation of bac- teriophages with dielectrophoresis on carbon nanofiber nanoelectrode arrays." Electrophoresis, 34(7), 1123 (2013). 120. B. P. Nadappuram, P. Cadinu, A. Barik, A. Ainscough, M. J. Devine, M. Kang, J. Gonzalez-Garcia, J. T. Kittler, K. R. Willison, R. Vilar, P. Actis, B. Wojciak-Stothard, S. H. Oh, A. P. Ivanov, and J. B. Edel, "Nanoscale tweezers for single-cell biopsies." Nature Nano., 14(1), 80-+ (2019). 121. D. A. Robinson, J. J. Yoo, A. D. Castaneda, B. Gu, R. Dasari, R. M. Crooks, and K. J. Stevenson, "Increasing the Collision Rate of Particle Impact Electroanalysis with Magnetically Guided Pt-Decorated Iron Oxide Nanoparticles." ACS Nano, 9(7), 7583 (2015). 122. J. J. Yoo, J. Kim, and R. M. Crooks, "Direct electrochemical detection of individual collisions between magnetic microbead/silver nanoparticle conjugates and a mag- netized ultramicroelectrode." Chem. Sci., 6(11), 6665 (2015). 123. J. Bonezzi, Tulashi Luitel, and Aliaksei Boika, "Electrokinetic Manipulation of Silver and Platinum Nanoparticles and Their Stochastic Electrochemical Detection." Anal. Chem., 89(17), 8614 (2017). 124. K. J. Stevenson and K. Tschulik, "A materials driven approach for understanding single entity nano impact electrochemistry." Current Opinion in Electrochemistry, 6(1), 38 (2017). 125. R. Dasari, K. Tai, D. A. Robinson, and K. J. Stevenson, "Electrochemical Monitor- ing of Single Nanoparticle Collisions at Mercury-Modified Platinum Ultramicro- electrodes." ACS Nano, 8(5), 4539 (2014). 126. V. Tsakova and R. Seeber, "Conducting polymers in electrochemical sensing: factors influencing the electroanalytical signal." Analytical and Bioanalytical Chemistry, 408(26), 7231 (2016). 127. M. Scampicchio, A. Bulbarello, A. Arecchi, M. S. Cosio, S. Benedetti, and S. Mannino, "Electrospun Nonwoven Nanofibrous Membranes for Sensors and Biosensors." Electroanalysis, 24(4), 719 (2012). 128. · DOI
  101. X. H. Niu, L. B. Shi, H. L. Zhao, and M. B. Lan, "Advanced strategies for improv- ing the analytical performance of Pt-based nonenzymatic electrochemical glucose sensors: a minireview." Analytical Methods, 8(8), 1755 (2016). 129. D. A. Robinson, A. M. Kondajji, A. D. Castaneda, R. Dasari, R. M. Crooks, and K. J. Stevenson, "Addressing Colloidal Stability for Unambiguous Electroanalysis of Single Nanoparticle Impacts." J. Phys. Chem. Lett., 7(13), 2512 (2016). · DOI

Authors
Goines, S., & Dick, J. E.
Affiliations
University of North Carolina at Chapel Hill (US)
ORCID
Venue
Journal of The Electrochemical Society
Publisher
The Electrochemical Society
Published
2019-11-20
Volume
167
Issue
3
Pages
037505
ISSN
  • 0013-4651 (ISSN-L)
  • 1945-7111
DOI
10.1149/2.0052003jes
OpenAlex
W2990758229
Cited by
81
References
128
Citations by year
2026: 5 · 2025: 5 · 2024: 14 · 2023: 16 · 2022: 12 · 2021: 10 · 2020: 19
FWCI
4.61
Type
journal article
Language
en
Open access
Licence
Locations
Journal of The Electrochemical Society (publishedVersion, cc-by)
Funders
The University of North Carolina at Chapel Hill (Start-Up)
Topics
  • Physical Sciences › Chemistry › Electrochemistry › Electrochemical Analysis and Applications
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
Keywords
single-molecule detection, single-cell detection, detection limit, detection specificity, nanoelectrodes, microelectrodes, cancer cell detection, point-of-care testing, single-atom detection

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review