Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials

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Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

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Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion

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Mechanotransduction and extracellular matrix homeostasis

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The Effect of Substrate Properties on Cellular Behavior and Nanoparticle Uptake in Human Fibroblasts and Epithelial Cells

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Matrix stiffening facilitates stemness of liver cancer stem cells by YAP activation and BMF inhibition

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Silencing of adipocyte enhancer-binding protein 1 (AEBP1) alleviates renal fibrosis in vivo and in vitro via inhibition of the β-catenin signaling pathway

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Extracellular Targets to Reduce Excessive Scarring in Response to Tissue Injury

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Combined application of biosponges and an antifibrotic agent for the treatment of volumetric muscle loss

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Synthetic mechanotransduction

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Engineering cryoelectrospun elastin-alginate scaffolds to serve as stromal extracellular matrices

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Mechanical Regulation of Epithelial Tissue Homeostasis

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Combining atomic force microscopy with complementary techniques for multidimensional single‐cell analysis

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Lysyl oxidase-responsive anchoring nanoparticles for modulation of the tumor immune microenvironment

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Analysis of friction in quantitative micro-elastography

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Tumor-stroma biomechanical crosstalk: a perspective on the role of caveolin-1 in tumor progression

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Biochemical signals from the extracellular matrix in inflammation and tumour immunology

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Enhanced stiffness in peri-cancerous tissue: a marker of poor prognosis in papillary thyroid carcinoma with lymph node metastasis

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Anthraquinones Extract from Morinda angustifolia Roxb. Root Alleviates Hepatic Injury Induced by Carbon Tetrachloride through Inhibition of Hepatic Oxidative Stress

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Intercellular Adhesion Stiffness Moderates Cell Decoupling as a Function of Substrate Stiffness

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Non-destructive vacuum-assisted measurement of lung elastic modulus

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Sensitive detection of cell-derived force and collagen matrix tension in microtissues undergoing large-scale densification

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Phloridzin Reveals New Treatment Strategies for Liver Fibrosis

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Liver stiffness correlates with serum osteopontin and TAZ expression in human liver cirrhosis

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A maladaptive feedback mechanism between the extracellular matrix and cytoskeleton contributes to hypertrophic cardiomyopathy pathophysiology

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Mechanical stiffness promotes skin fibrosis through FAPα-AKT signaling pathway

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The role of YAP/TAZ mechanosignaling in trabecular meshwork and Schlemm’s canal cell dysfunction

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Pulling the Rug Out from Under: Biomechanical Microenvironment Remodeling for Induction of Hepatic Stellate Cell Quiescence

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Coatings Releasing the Relaxin Peptide Analogue B7-33 Reduce Fibrotic Encapsulation

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Role of Changes in State of Bound Water and Tissue Stiffness in Development of Age-Related Diseases

Kerch, G. (2020) · Polymers · doi:10.3390/polym12061362 · Cited by 13

Targeting the cytoskeleton and extracellular matrix in cardiovascular disease drug discovery

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An extracellular matrix stiffness-induced breast cancer cell transcriptome resembles the transition from ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC)

Göransson, S., Chen, S., Olofsson, H., Larsson, O. S., & Strömblad, S. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.03.001 · Cited by 13

Regulation of AMPK activation by extracellular matrix stiffness in pancreatic cancer

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The role of Piezo1 in cardiovascular diseases: from molecular mechanisms to targeted therapeutic potential

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Increased cell stiffness contributes to complement‐mediated injury of choroidal endothelial cells in a monkey model of early age‐related macular degeneration

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In vivo shear wave elasticity imaging for assessment of diaphragm function in muscular dystrophy

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Mechanical characterization of native and sugar-modified decellularized kidneys

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Bioengineered models of cardiovascular diseases

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Off-the-Jaw Tactile Sensing System for Tissue Stiffness and Thickness Assessment in Minimally Invasive Surgery

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Matrix Stiffness and Biochemistry Govern Colorectal Cancer Cell Growth and Signaling in User-Programmable Synthetic Hydrogels

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Reciprocal Modulation of Tumour and Immune Cell Motility: Uncovering Dynamic Interplays and Therapeutic Approaches

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High extracellular matrix stiffness upregulates TNNT1 to awaken dormant tumor cells in liver metastatic niches of gastric cancer

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Technological perspectives on laser speckle micro-rheology for cancer mechanobiology research

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Increased liver stiffness promotes hepatitis B progression by impairing innate immunity in CCl4-induced fibrotic HBV+ transgenic mice

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Mechanical compressive forces increase PI3K output signaling in breast and pancreatic cancer cells

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Increased matrix stiffness suppresses ATP-induced sustained Ca2+ influx in MDA-MB-231 breast cancer cells

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Mechanisms Underlying the Rarity of Skeletal Muscle Cancers

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Breaking Bruch's: How changes in Bruch's membrane influence retinal homeostasis

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Corneal Collagen Cross-Linking Pretreatment Mitigates Injury-Induced Inflammation, Hemangiogenesis and Lymphangiogenesis In Vivo

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Impact of Collagen Crosslinking on Dislocated Human Shoulder Capsules—Effect on Structural and Mechanical Properties

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A biomechanical model for fibril recruitment: Evaluation in tendons and arteries

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The Physical Microenvironment of Tumors: Characterization and Clinical Impact

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The Human Extracellular Matrix Diseasome Reveals Genotype–Phenotype Associations with Clinical Implications for Age-Related Diseases

Statzer, C., Luthria, K. D., Sharma, A., Kann, M. G., & Ewald, C. Y. (2023) · Biomedicines · doi:10.3390/biomedicines11041212 · Cited by 10

The Matrisome during Aging and Longevity: A Systems-Level Approach towards Defining Matreotypes Promoting Healthy AgingPreprint

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Confinement by Liquid‐Liquid Interface Replicates In Vivo Neutrophil Deformations and Elicits Bleb‐Based Migration

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Polyacrylamide Hydrogels with Reversibly Photocontrolled Stiffness for 2D Mechanobiology

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Basement membrane structure and function: Relating biology to mechanics

Page, A. W., & Ferrell, N. J. (2025) · Matrix Biology · doi:10.1016/j.matbio.2025.08.004 · Cited by 9

Transformative biomechanics and mechanobiology breakthroughs shaping the future of health and medicine

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Matrix stiffness primes cells for future oxidative stress

Taufalele, P., & Reinhart‐King, C. A. (2021) · Trends in cancer · doi:10.1016/j.trecan.2021.08.003 · Cited by 9

Flexibly Deformable Collagen Hydrogel Tube Reproducing Immunological Tissue Deformation of Blood Vessels as a Pharmacokinetic Testing Model

Itai, S., & Onoe, H. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101509 · Cited by 9

Developing biomaterials to mediate the spatial distribution of integrins

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Rho activation drives luminal collapse and eversion in epithelial acini

Narayanan, V., Purkayastha, P., Yu, B., Pendyala, K., Chukkapalli, S. S., Cabe, J. I., Dickinson, R. B., Conway, D. E., & Lele, T. P. (2023) · Biophysical Journal · doi:10.1016/j.bpj.2023.01.005 · Cited by 11

Matrix obstructions cause multiscale disruption in collective epithelial migration by suppressing leader cell function

Lee, Y. L., Mathur, J., Walter, C., Zmuda, H. M., & Pathak, A. (2023) · Molecular Biology of the Cell · doi:10.1091/mbc.e22-06-0226 · Cited by 9

Biomaterials meet organ-on-chips – a perspective on tumor modeling

Monteiro, C. F., Deus, I. A., Custódio, C. A., & Mano, J. F. (2024) · International Materials Reviews · doi:10.1177/09506608241303436 · Cited by 9

Matrix Stiffness Affects Spheroid Invasion, Collagen Remodeling, and Effective Reach of Stress into ECM

Beslmüller, K., de Mercado, R. R., Koenderink, G. H., Danen, E. H. J., & Schmidt, T. (2025) · Organoids · doi:10.3390/organoids4020011 · Cited by 8

Engineered basement membrane mimetic hydrogels to study mammary epithelial morphogenesis and invasion

Baude, J. A., Li, M., Jackson, S. M., Sharma, A., Walter, D. I., & Stowers, R. S. (2025) · Science Advances · doi:10.1126/sciadv.adx2110 · Cited by 8

Hepatic Fibrosis and Liver Cancer

Anton, A., Friedman, S. L., & Cogliati, B. (2025) · Seminars in Liver Disease · doi:10.1055/a-2779-4937 · Cited by 10

Salivary Gland Bioengineering

Rose, S. C., Larsen, M., Xie, Y., & Sharfstein, S. T. (2023) · Bioengineering · doi:10.3390/bioengineering11010028 · Cited by 8

Patient-Derived Xenografts as an Innovative Surrogate Tumor Model for the Investigation of Health Disparities in Triple Negative Breast Cancer

Matossian, M. D., Giardina, A. A., Wright, M. K., Elliott, S. G., Loch, M. M., Nguyen, K., Zea, A. H., Lau, F. H., Moroz, K., Riker, A. I., et al. (2020) · Women s Health Reports · doi:10.1089/whr.2020.0037 · Cited by 9

A roadmap for developing and engineering in vitro pulmonary fibrosis models

Dabaghi, M., Carpio, M. B., Saraei, N., Moran-Mirabal, J. M., Kolb, M. R. J., & Hirota, J. A. (2023) · Biophysics Reviews · doi:10.1063/5.0134177 · Cited by 7

A high throughput cell stretch device for investigating mechanobiology in vitro

Pratt, S. J. P., Plunkett, C. M., Kuzu, G., Trinh, T., Barbara, J., Choconta, P., Quackenbush, D., Huynh, T., Smith, A. J., Barnes, S. W., et al. (2024) · APL Bioengineering · doi:10.1063/5.0206852 · Cited by 7

Beyond classical collagen: basement membrane collagen IV in age-associated lung diseases

El-Merhie, N., Staab-Weijnitz, C. A., Burgess, J. K., & Kwapiszewska, G. (2025) · European Respiratory Review · doi:10.1183/16000617.0192-2024 · Cited by 8

Tissue Engineering Approaches to Uncover Therapeutic Targets for Endothelial Dysfunction in Pathological Microenvironments

Ntekoumes, D., & Gerecht, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137416 · Cited by 7

Transcriptome analysis of the epididymis from Plag1 deficient mice suggests dysregulation of sperm maturation and extracellular matrix genes

Wong, J., Damdimopoulos, A. E., Damdimopoulou, P., Gasperoni, J. G., Tran, S. C., Grommen, S. V. H., Groef, B. D., & Dworkin, S. (2020) · Developmental Dynamics · doi:10.1002/dvdy.254 · Cited by 7

Atomic force microscopy-based indentation of cells: modelling the effect of a pericellular coat

Argatov, I., Jin, X., & Mishuris, G. (2023) · Journal of The Royal Society Interface · doi:10.1098/rsif.2022.0857 · Cited by 7

Scar formation in the presence of mitomycin C and the anti-fibrotic antibody in a rabbit model of glaucoma microsurgery: A pilot study

Shukla, A. G., Milman, T., Fertala, J., Steplewski, A., & Fertala, A. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e15368 · Cited by 7

The heterogeneity of fibroblasts in laryngotracheal stenosis and skin hypertrophic scar in pediatric patients

Hu, B., Wang, J., Chen, J., Zhao, L., & Li, X. (2021) · International Journal of Pediatric Otorhinolaryngology · doi:10.1016/j.ijporl.2021.110709 · Cited by 8

Pilot study quantifying muscle glycosaminoglycan using bi-exponential T1ρ mapping in patients with muscle stiffness after stroke

Menon, R. G., Raghavan, P., & Regatte, R. R. (2021) · Scientific Reports · doi:10.1038/s41598-021-93304-7 · Cited by 7

Intra-Nuclear Tensile Strain Mediates Reorganization of Epigenetically Marked Chromatin During Cardiac Development and DiseasePreprint

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Matrix Stiffness-Mediated DNA Methylation in Endothelial Cells

Taufalele, P., Kirkham, H. K., & Reinhart‐King, C. A. (2025) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-024-00836-9 · Cited by 6

The FOXO1-SIRT1 axis in ankylosing spondylitis: A cross-platform regulator linking immunometabolism, oxidative stress, and bone remodeling

Zhang, X., Jia, L., Lin, X., & Zhou, L. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103878 · Cited by 6

Pancreatic Cancer Progression Involves Increased Lysyl Oxidase-Mediated Collagen Cross-Links as Part of the Desmoplastic Reaction

Barrett, A., Maslanka, M. D., Darula, Z., McCabe, M. C., Saviola, A. J., Schmitt, L. R., Weaver, V. M., Pitts, T. M., Messersmith, W. A., & Hansen, K. C. (2025) · Biochemistry · doi:10.1021/acs.biochem.5c00125 · Cited by 6

Matrix Stiffness Directs Early Injury and Ketogenesis Programs to Prime Kidney Repair

Gui, Y., Wang, Y., Li, W., Liu, J.-J., Zheng, K., Li, J., Schaffer, H. W., Jones, C., Mallari, S. M., Yu, Y., et al. (2025) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000000967 · Cited by 6

TGF-β1 requires IL-13 to sustain collagen accumulation and increasing tissue strength and stiffness

Hopkins, C. M., Wilks, B. T., & Morgan, J. R. (2025) · Connective Tissue Research · doi:10.1080/03008207.2025.2469575 · Cited by 6

Cascade‐Responsive Nanoprodrug Disrupts Immune‐Fibroblast Communications for Potentiated Cancer Mechanoimmunotherapy

Guan, X., Shen, Y., Zhao, C., Li, X., Li, X., Lü, D., Wang, L., Liu, L., Wu, S., Huang, B., et al. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202500176 · Cited by 6

Recent advances in acid sensing by G protein coupled receptors

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Prolonged exposure to dexamethasone alters the proteome and cellular phenotype of human testicular peritubular cells

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Cell sources and methods for producing organotypic in vitro human tissue models

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The texture of collagen in the microenvironments of Merkel cell carcinoma

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High type I collagen density fails to increase breast cancer stem cell phenotype

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The Stiff Side of Cancer: How Matrix Mechanics Rewrites Non-Coding RNA Expression Programs

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Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

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Preclinical Three-Dimensional Vibrational Shear Wave Elastography for Mapping of Tumour Biomechanical Properties In Vivo

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Desmoplastic tumor priming using clinical-stage corticosteroid liposomes

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Air-pressure-driven Separable Microdevice to Control the Anisotropic Curvature of Cell Culture Surface

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The effect of mechanical force in genitourinary malignancies

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Extracellular matrix–dependent mechanosensing and mechanotransduction

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Stiffness-dependent dynamic effect of inflammation on keratocyte phenotype and differentiation

Chen, J., Mo, Q., Sheng, R., Long, Q., Chen, Z., Liu, C., Zhang, A., Luo, Y., Liu, J., & Zhang, W. (2023) · Biomedical Materials · doi:10.1088/1748-605x/accda9 · Cited by 5

Shwachman-Bodian-Diamond syndrome protein desensitizes breast cancer cells to apoptosis in stiff matrices by repressing the caspase 8-mediated pathway

Lee, J., Ko, P., You, E., Jeong, J., Keum, S., Kim, J., Rahman, M., Lee, D. H., & Rhee, S. (2019) · Animal Cells and Systems · doi:10.1080/19768354.2019.1666030 · Cited by 5

Manipulating the mechanics of extracellular matrix to study effects on the nucleus and its structure

Xia, Y., Cho, S., Vashisth, M., Ivanovska, I. L., Dingal, P. C. D. P., & Discher, D. E. (2018) · Methods · doi:10.1016/j.ymeth.2018.12.009 · Cited by 5

Explicating the publication paradigm by bibliometric approaches: A case of interplay between nanoscience and ferroptosis

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The appropriate remodeling of extracellular matrix is the key molecular signature in subcutaneous adipose tissue following Roux-en-Y gastric bypass

Chen, X., Gong, L., Li, Q., Hu, J., Liu, X., Wang, Y., Bai, J., Ran, X., Wu, J., Ge, Q., et al. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.12.051 · Cited by 5

Tissue Integrity and COVID-19

Kerch, G. (2021) · Encyclopedia · doi:10.3390/encyclopedia1010020 · Cited by 5

Functional nucleic acid-based fluorescence imaging for tumor microenvironment monitoring: A review

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Matrix stiffness-driven cancer progression and the targeted therapeutic strategy

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ECM-Targeted and cell-based therapies in musculoskeletal and aging-related disorders: A review

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The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship

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Extracellular Matrix Stiffness in Lung Health and Disease

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Extracellular Matrix Stiffness Exists in a Feedback Loop that Drives Tumor Progression

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