Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials

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TGFβ2 Regulates Human Trabecular Meshwork Cell Contractility via ERK and ROCK Pathways with Distinct Signaling Crosstalk Dependent on the Culture Substrate

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Geometric constraint-triggered collagen expression mediates bacterial-host adhesion

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The key role of matrix stiffness in colorectal cancer immunotherapy: mechanisms and therapeutic strategies

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Inhibition of CEMIP potentiates the effect of sorafenib on metastatic hepatocellular carcinoma by reducing the stiffness of lung metastases

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Strategic outline of interventions targeting extracellular matrix for promoting healthy longevity

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The effects of mechanical strain on mouse eye lens capsule and cellular microstructure

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Distinct Metalloproteinase Expression and Functions in Systemic Sclerosis and Fibrosis: What We Know and the Potential for Intervention

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Lipid-based nanoparticles for cancer immunotherapy

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Mechanobiology in oncology: basic concepts and clinical prospects

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Hyaluronidase overcomes the extracellular matrix barrier to enhance local drug delivery

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The role of extracellular matrix stiffness in regulating cytoskeletal remodeling via vinculin in synthetic smooth muscle cells

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Arterial stiffness and cardiac dysfunction in Hutchinson–Gilford Progeria Syndrome corrected by inhibition of lysyl oxidase

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Matrix stiffness induces an invasive-dormant subpopulation via cGAS-STING axis in oral cancer

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Impact of mechanical cues on key cell functions and cell-nanoparticle interactions

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Improving Tumor Targeting and Penetration for Nanoparticle‐Mediated Cancer Therapy

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Targeting the extracellular matrix for immunomodulation: applications in drug delivery and cell therapies

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Cell mediated remodeling of stiffness matched collagen and fibrin scaffolds

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The Stiffness‐Sensitive Transcriptome of Human Tendon Stromal Cells

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SWATH-MS Proteomic Analysis of Oxygen-Induced Retinopathy Reveals Novel Potential Therapeutic Targets

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How the mechanobiology orchestrates the iterative and reciprocal ECM-cell cross-talk that drives microtissue growth

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Mechano-active biomaterials for tissue repair and regeneration

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Emerging technologies provide insights on cancer extracellular matrix biology and therapeutics

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Human Adipocyte Conditioned Medium Promotes In Vitro Fibroblast Conversion to Myofibroblasts

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Expression Profiling of Extracellular Matrix Genes Reveals Global and Entity-Specific Characteristics in Adenoid Cystic, Mucoepidermoid and Salivary Duct Carcinomas

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Selective depletion of hepatic stellate cells‐specific LOXL1 alleviates liver fibrosis

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A novel method for sensor-based quantification of single/multicellular force dynamics and stiffening in 3D matrices

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Light-sheet photonic force optical coherence elastography for high-throughput quantitative 3D micromechanical imaging

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Applicability of atomic force microscopy to determine cancer-related changes in cells

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Collagen-Laponite Nanoclay Hydrogels for Tumor Spheroid Growth

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Targeting YAP/TAZ mechanosignaling to ameliorate stiffness-induced Schlemm’s canal cell pathobiology

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Mechanisms of aortic carboxypeptidase-like protein secretion and identification of an intracellularly retained variant associated with Ehlers–Danlos syndrome

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TGF-β-induced activation of conjunctival fibroblasts is modulated by FGF-2 and substratum stiffness

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The emerging promise of tumour mechanobiology in cancer treatment

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Exploiting Matrix Stiffness to Overcome Drug Resistance

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Changes in the Brain Extracellular Matrix Composition in schizophrenia: A Pathophysiological Dysregulation and a Potential Therapeutic Target

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Systems-Level Proteomics Evaluation of Microglia Response to Tumor-Supportive Anti-Inflammatory Cytokines

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Mass spectrometry methods for analysis of extracellular matrix components in neurological diseases

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Biophysical cues to improve the immunomodulatory capacity of mesenchymal stem cells: The progress and mechanisms

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Assessment of Electrospun Poly(ε-caprolactone) and Poly(lactic acid) Fiber Scaffolds to Generate 3D In Vitro Models of Colorectal Adenocarcinoma: A Preliminary Study

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Brillouin microscopy monitors rapid responses in subcellular compartments

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Synergic Interactions Between Hepatic Stellate Cells and Uveal Melanoma in Metastatic Growth

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Intercellular communication controls agonist-induced calcium oscillations independently of gap junctions in smooth muscle cells

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Myofibroblasts derived type V collagen promoting tissue mechanical stress and facilitating metastasis and therapy resistance of lung adenocarcinoma cells

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Modeling human hypertrophic scars with 3D preformed cellular aggregates bioprinting

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Leveraging cellular mechano-responsiveness for cancer therapy

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Contribution of mechanical homeostasis to epithelial-mesenchymal transition

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Piezo1 act as a potential oncogene in pancreatic cancer progression

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Effect of mechanical forces on cellular response to radiation

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Colorectal cancer liver metastasis: genomic evolution and crosstalk with the liver microenvironment

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Modulating tumor mechanics with nanomedicine for cancer therapy

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Coupling Microfluidic Platforms, Microfabrication, and Tissue Engineered Scaffolds to Investigate Tumor Cells Mechanobiology

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Caveolin1 Tyrosine-14 Phosphorylation: Role in Cellular Responsiveness to Mechanical Cues

Buwa, N., Mazumdar, D., & Balasubramanian, N. (2020) · The Journal of Membrane Biology · doi:10.1007/s00232-020-00143-0 · Cited by 23

The extracellular matrix phenome across species

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Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

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The interplay of signaling pathway in endothelial cells—matrix stiffness dependency with targeted-therapeutic drugs

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LncRNA miR205HG hinders HNRNPA0 translation: anti‐oncogenic effects in esophageal carcinoma

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Macrophage uptake of oxidized and acetylated low-density lipoproteins and generation of reactive oxygen species are regulated by linear stiffness of the growth surface

Gruber, E. J., Aygun, A. Y., & Leifer, C. A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0260756 · Cited by 21

Lung fibrosis is a novel therapeutic target to suppress lung metastasis of osteosarcoma

Yui, Y., Kumai, J., Watanabe, K., Wakamatsu, T., & Sasagawa, S. (2022) · International Journal of Cancer · doi:10.1002/ijc.34008 · Cited by 23

Mechanoregulation of Metastasis beyond the Matrix

Er, E. E., Tello‐Lafoz, M., & Huse, M. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-0419 · Cited by 22

Deep Learning Image Recognition-Assisted Atomic Force Microscopy for Single-Cell Efficient Mechanics in Co-culture Environments

Yang, X., Yang, Y., Zhang, Z., & Li, M. (2023) · Langmuir · doi:10.1021/acs.langmuir.3c03046 · Cited by 21

Laser speckle rheological microscopy reveals wideband viscoelastic spectra of biological tissues

Leartprapun, N., Zeng, Z., Hajjarian, Z., Bossuyt, V., & Nadkarni, S. K. (2024) · Science Advances · doi:10.1126/sciadv.adl1586 · Cited by 21

The receptor tyrosine kinase HIR-1 coordinates HIF-independent responses to hypoxia and extracellular matrix injury

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The consequences of ageing, progeroid syndromes and cellular senescence on mechanotransduction and the nucleus

Gilbert, H. T. J., & Swift, J. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.03.002 · Cited by 22

In-situ clickable prodrug nanoplatform locally activates T lymphocytes to potentiate cancer immunotherapy

Hou, B., Ye, J., Li, J., Xu, Z., & Yu, H. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101661 · Cited by 21

Targeting tumor extracellular matrix with nanoparticles to circumvent therapeutic resistance

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Piezo1/ ITGB1 Synergizes With Ca 2+ / YAP Signaling to Propel Bladder Carcinoma Progression via a Stiffness‐Dependent Positive Feedback Loop

Ma, M., Li, J., Li, X., Jing, M., Wang, L., Jiang, Y., Yang, Z., He, J., Wang, M., Liu, H., et al. (2025) · Cancer Medicine · doi:10.1002/cam4.71059 · Cited by 20

Tumour Initiation: a Discussion on Evidence for a “Load-Trigger” Mechanism

Evans, J. J., Alkaisi, M. M., & Sykes, P. H. (2019) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-019-00888-z · Cited by 20

Short-term angiotensin II treatment regulates cardiac nanomechanics via microtubule modifications

Swiatlowska, P., Sanchez‐Alonso, J. L., Mansfield, C. A., Scaini, D., Korchev, Y. E., Novák, P., & Gorelik, J. (2020) · Nanoscale · doi:10.1039/d0nr02474k · Cited by 20

Interplay of Fluid Mechanics and Matrix Stiffness in Tuning the Mechanical Behaviors of Single Cells Probed by Atomic Force Microscopy

Wei, J., & Li, M. (2023) · Langmuir · doi:10.1021/acs.langmuir.2c03137 · Cited by 20

Matrix stiffening promotes perinuclear clustering of mitochondria

Daga, P., Thurakkal, B., Rawal, S., & Das, T. (2024) · Molecular Biology of the Cell · doi:10.1091/mbc.e23-04-0139 · Cited by 20

Synergistic Anticancer Strategy Targeting ECM Stiffness: Integration of Matrix Softening and Mechanical Signal Transduction Blockade in Primary Liver Cancers

Shen, Z., Tao, L., Wang, Y., Zhu, Y., Pan, H., Li, Y., Shi, J., Zheng, J., Cai, J., Liu, Y., et al. (2024) · Advanced Science · doi:10.1002/advs.202403040 · Cited by 21

Microfabrication-Based Three-Dimensional (3-D) Extracellular Matrix Microenvironments for Cancer and Other Diseases

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The Art of Engineering Biomimetic Cellular Microenvironments

Bretherton, R. C., & DeForest, C. A. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c01549 · Cited by 20

From organ-on-chip to body-on-chip: The next generation of microfluidics platforms for in vitro drug efficacy and toxicity testing

Lacombe, J., Soldevila, M., & Zenhausern, F. (2022) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2021.07.019 · Cited by 20

Stromal Characteristics and Impact on New Therapies for Metastatic Triple-Negative Breast Cancer

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Focal adhesion kinase priming in pancreatic cancer, altering biomechanics to improve chemotherapy

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Simvastatin Attenuates Glucocorticoid-Induced Human Trabecular Meshwork Cell Dysfunction via YAP/TAZ Inactivation

Yoo, H., Singh, A., Li, H., Strat, A. N., Bagué, T., Ganapathy, P. S., & Herberg, S. (2023) · Current Eye Research · doi:10.1080/02713683.2023.2206067 · Cited by 19

Modelling and breaking down the biophysical barriers to drug delivery in pancreatic cancer

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TENSCell: Imaging of Stretch-Activated Cells Reveals Divergent Nuclear Behavior and Tension

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Implications of enigmatic transglutaminase 2 (TG2) in cardiac diseases and therapeutic developments

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Proteolytic and mechanical remodeling of the extracellular matrix by invadopodia in cancer

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