Cited by 551Cellular Mechanics and InteractionsTissue Engineering and Regenerative MedicineElasticity and Material Modeling

The DOI matches its Crossref record; 157 of the 159 references it cites were found in a registry or an index.

Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials

Lampi, Marsha C., Reinhart-King, Cynthia A.·2018·Science Translational Medicine

DOI 10.1126/scitranslmed.aao0475

Open this paper in CoChat — free account

Abstract

Tissues stiffen during aging and during the pathological progression of cancer, fibrosis, and cardiovascular disease. Extracellular matrix stiffness is emerging as a prominent mechanical cue that precedes disease and drives its progression by altering cellular behaviors. Targeting extracellular matrix mechanics, by preventing or reversing tissue stiffening or interrupting the cellular response, is a therapeutic approach with clinical potential. Major drivers of changes to the mechanical properties of the extracellular matrix include phenotypically converted myofibroblasts, transforming growth factor β (TGFβ), and matrix cross-linking. Potential pharmacological interventions to overcome extracellular matrix stiffening are emerging clinically. Aside from targeting stiffening directly, alternative approaches to mitigate the effects of increased matrix stiffness aim to identify and inhibit the downstream cellular response to matrix stiffness. Therapeutic interventions that target tissue stiffening are discussed in the context of their limitations, preclinical drug development efforts, and clinical trials.

Integrity signals

Registry

Crossref · 10.1126/scitranslmed.aao0475

Cites

157 of 157 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Tissue Cells Feel and Respond to the Stiffness of Their Substrate
Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science · doi:10.1126/science.1116995 · Cited by 6,382
Role of YAP/TAZ in mechanotransduction
Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979
The Nuclear Factor NF- B Pathway in InflammationPreprint
Lawrence, T. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001651 · Cited by 5,126
Remodelling the extracellular matrix in development and disease
Bonnans, C., Chou, J., & Werb, Z. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3904 · Cited by 4,367
The biology and function of fibroblasts in cancer
Kalluri, R. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.73 · Cited by 4,366
The extracellular matrix at a glance
Frantz, C., Stewart, K. M., & Weaver, V. M. (2010) · Journal of Cell Science · doi:10.1242/jcs.023820 · Cited by 4,334
Tensional homeostasis and the malignant phenotype
Paszek, M. J., Zahir, N., Johnson, K. R., Lakins, J. N., Rozenberg, G. I., Gefen, A., Reinhart-King, C. A., Margulies, S. S., Dembo, M., Boettiger, D., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.010 · Cited by 3,941
Self-citation
Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival
Özdemir, B. C., Pentcheva-Hoang, T., Carstens, J. L., Zheng, X., Wu, C.-C., Simpson, T. R., Laklai, H., Sugimoto, H., Kahlert, C., Novitskiy, S. V., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.005 · Cited by 2,681
Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion
Yeung, T., Georges, P. C., Flanagan, L. A., Marg, B., Ortiz, M., Funaki, M., Zahir, N., Ming, W., Weaver, V., & Janmey, P. A. (2005) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20041 · Cited by 2,325
Mechanotransduction and extracellular matrix homeostasis
Humphrey, J. D., Dufresne, E. R., & Schwartz, M. A. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3896 · Cited by 2,124

Show all 159 references

Sorted by citations

Items 101–200 of 544

Scaling up single-cell mechanics to multicellular tissues – the role of the intermediate filament–desmosome network
Broussard, J. A., Jaiganesh, A., Zarkoob, H., Conway, D. E., Dunn, A. R., Espinosa, H. D., Janmey, P. A., & Green, K. J. (2020) · Journal of Cell Science · doi:10.1242/jcs.228031 · Cited by 64
Light-based fabrication and 4D customization of hydrogel biomaterials
Kopyeva, I., Brady, R., & DeForest, C. A. (2024) · Nature Reviews Bioengineering · doi:10.1038/s44222-024-00234-w · Cited by 61
Biofabrication Strategies and Engineered In Vitro Systems for Vascular Mechanobiology
Pradhan, S., Banda, O. A., Farino, C. J., Sperduto, J. L., Keller, K. A., Taitano, R. A., & Slater, J. H. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.201901255 · Cited by 63
Extracellular Matrix Stiffness and TGFβ2 Regulate YAP/TAZ Activity in Human Trabecular Meshwork Cells
Li, H., Raghunathan, V. K., Stamer, W. D., Ganapathy, P. S., & Herberg, S. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.844342 · Cited by 63
Pushing the Natural Frontier: Progress on the Integration of Biomaterial Cues toward Combinatorial Biofabrication and Tissue Engineering
Guimarães, C. F., Marques, A. P., & Reis, R. L. (2022) · Advanced Materials · doi:10.1002/adma.202105645 · Cited by 60
Exploration of Oxygen-Induced Retinopathy Model to Discover New Therapeutic Drug Targets in Retinopathies
Vähätupa, M., Järvinen, T. A. H., & Uusitalo‐Järvinen, H. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00873 · Cited by 61
Ultrasound-assisted tissue engineering
Melde, K., Athanassiadis, A. G., Missirlis, D., Shi, M., Seneca, S., & Fischer, P. (2024) · Nature Reviews Bioengineering · doi:10.1038/s44222-024-00166-5 · Cited by 59
Spatial mapping of the collagen distribution in human and mouse tissues by force volume atomic force microscopy
Calò, A., Romin, Y., Srouji, R. M., Zambirinis, C. P., Fan, N., Santella, A., Feng, E., Fujisawa, S., Turkekul, M., Huang, S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-72564-9 · Cited by 59
Structure, biochemistry, and gene expression patterns of the proline biosynthetic enzyme pyrroline-5-carboxylate reductase (PYCR), an emerging cancer therapy target
Bogner, A. N., Stiers, K. M., & Tanner, J. J. (2021) · Amino Acids · doi:10.1007/s00726-021-02999-5 · Cited by 60
The Extracellular Matrix Stiffening: A Trigger of Prostate Cancer Progression and Castration Resistance?
Luthold, C., Hallal, T., Labbé, D. P., & Bordeleau, F. (2022) · Cancers · doi:10.3390/cancers14122887 · Cited by 62
Predicting YAP/TAZ nuclear translocation in response to ECM mechanosensing
Cheng, B., Li, M., Wan, W., Guo, H., Genin, G. M., Lin, M., & Xu, F. (2022) · Biophysical Journal · doi:10.1016/j.bpj.2022.11.2943 · Cited by 61
Stiff Substrate Induces Nucleus Pulposus Cell Ferroptosis via YAP and N‐Cadherin Mediated Mechanotransduction
Ke, W., Liao, Z., Liang, H., Tong, B., Song, Y., Li, G., Ma, L., Wang, K., Feng, X., Li, S., et al. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300458 · Cited by 60
Identification of extracellular matrix proteins secreted by human dermal fibroblasts cultured in 3D electrospun scaffolds
Malakpour‐Permlid, A., Buzzi, I., Hegardt, C., Johansson, F., & Oredsson, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-85742-0 · Cited by 63
The mechanical phenotypic plasticity of melanoma cell: an emerging driver of therapy cross-resistance
Diazzi, S., Tartare‐Deckert, S., & Deckert, M. (2023) · Oncogenesis · doi:10.1038/s41389-023-00452-8 · Cited by 61
The role of matrix stiffness in cancer stromal cell fate and targeting therapeutic strategies
Wei, J., Yao, J., Yan, M., Xie, Y., Liu, P., Mao, Y., & Li, X. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.08.005 · Cited by 57
Interleukin-17 Drives Interstitial Entrapment of Tissue Lipoproteins in Experimental Psoriasis
Huang, L., Zinselmeyer, B. H., Chang, C., Saunders, B. T., Elvington, A., Baba, O., Broekelmann, T. J., Qi, L., Rueve, J., Swartz, M. A., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.10.006 · Cited by 56
Dynamic Magneto-Softening of 3D Hydrogel Reverses Malignant Transformation of Cancer Cells and Enhances Drug Efficacy
Shou, Y., Teo, X. Y., Li, X., Le, Z., Liu, L., Sun, X., Jonhson, W., Ding, J., Lim, C. T., & Tay, A. K. P. (2023) · ACS Nano · doi:10.1021/acsnano.2c11278 · Cited by 53
Engineered Fibrous Networks To Investigate the Influence of Fiber Mechanics on Myofibroblast Differentiation
Davidson, M. D., Song, K. H., Lee, M., Llewellyn, J., Du, Y. M., Baker, B. M., Wells, R. G., & Burdick, J. A. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b01276 · Cited by 53
The Effects of Stiffness, Fluid Viscosity, and Geometry of Microenvironment in Homeostasis, Aging, and Diseases: A Brief Review
Park, S., Jung, W., Pittman, M., Chen, J., & Chen, Y. (2020) · Journal of Biomechanical Engineering · doi:10.1115/1.4048110 · Cited by 54
Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status
Murphy, K. J., Reed, D. A., Vennin, C., Conway, J. R. W., Nobis, M., Yin, J. X. M., Chambers, C. R., Pereira, B., Lee, V., Filipe, E. C., et al. (2021) · Science Advances · doi:10.1126/sciadv.abh0363 · Cited by 54
Matrix stiffness regulates epithelial-mesenchymal transition via cytoskeletal remodeling and MRTF-A translocation in osteosarcoma cells
Dai, J., Qin, L., Chen, Y., Wang, H., Lin, G., Li, X., Liao, H., & Fang, H. (2018) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2018.10.012 · Cited by 56
Hyperbaric oxygen regulates tumor mechanics and augments Abraxane and gemcitabine antitumor effects against pancreatic ductal adenocarcinoma by inhibiting cancer-associated fibroblasts
Wang, X., Ye, N., Chen, X., Xiao, C., Zhang, Z., Deng, Q., Li, S., Li, J., Li, Z., & Yang, X. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101458 · Cited by 51
Matrix stiffness drives drop like nuclear deformation and lamin A/C tension-dependent YAP nuclear localization
Wang, T., Abolghasemzade, S., McKee, B., Singh, I., Pendyala, K., Mohajeri, M., Patel, H., Shaji, A., Kersey, A. L., Harsh, K., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54577-4 · Cited by 53
Extracellular matrix and Hippo signaling as therapeutic targets of antifibrotic compounds for uterine fibroids
Islam, M. S., Afrin, S., Singh, B., Jayes, F. L., Brennan, J. T., Borahay, M. A., Leppert, P. C., & Segars, J. H. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.475 · Cited by 54
Endothelial inflammation and neutrophil transmigration are modulated by extracellular matrix composition in an inflammation-on-a-chip model
Riddle, R. B., Jennbacken, K., Hansson, K. M., & Harper, M. T. (2022) · Scientific Reports · doi:10.1038/s41598-022-10849-x · Cited by 51
Aged Breast Extracellular Matrix Drives Mammary Epithelial Cells to an Invasive and Cancer‐Like Phenotype
Bahçecioğlu, G., Yue, X. S., Howe, E. N., Guldner, I. H., Stack, M. S., Nakshatri, H., Zhang, S., & Zorlutuna, P. (2021) · Advanced Science · doi:10.1002/advs.202100128 · Cited by 52
Materials and extracellular matrix rigidity highlighted in tissue damages and diseases: Implication for biomaterials design and therapeutic targets
Park, J. H., Jo, S. B., Lee, J., Lee, H., Knowles, J. C., & Kim, H. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.06.003 · Cited by 49
Targeting STING-mediated pro-inflammatory and pro-fibrotic effects of alveolar macrophages and fibroblasts blunts silicosis caused by silica particles
Ou, L., Zhāng, P., Huang, Z., Cheng, Y., Miao, Q., Niu, R., Hu, Y., & Chen, Y. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.131907 · Cited by 49
Tumor Microenvironment‐Activatable Nanoenzymes for Mechanical Remodeling of Extracellular Matrix and Enhanced Tumor Chemotherapy
Zhong, Y., Zhang, J., Zhang, J., Hou, Y. X., Chen, E., Huang, D., Chen, W., & Haag, R. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202007544 · Cited by 51
Matrix mechanics regulates epithelial defence against cancer by tuning dynamic localization of filamin
Pothapragada, S. P., Gupta, P., Mukherjee, S., & Das, T. (2022) · Nature Communications · doi:10.1038/s41467-021-27896-z · Cited by 47
Heterogeneous matrix stiffness regulates the cancer stem-like cell phenotype in hepatocellular carcinoma
Wei, J., Yao, J., Yang, C., Mao, Y., Zhu, D., Xie, Y., Liu, P., Yan, M., Ren, L., Lin, Y., et al. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03778-w · Cited by 48
Mechanobiology of portal hypertension
Felli, É., Selicean, S. E., Guixé‐Muntet, S., Wang, C., Bosch, J., Berzigotti, A., & Gracia‐Sancho, J. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100869 · Cited by 49
Self-Reporting and Splitting Nanopomegranates Potentiate Deep Tissue Cancer Radiotherapy via Elevated Diffusion and Transcytosis
Wang, L., Jiang, W., Liang, X., Li, H., Chen, Z., Liu, Y., Dou, J., Li, S., Wang, Q., Han, W., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c02674 · Cited by 48
Youthful and age-related matreotypes predict drugs promoting longevity
Statzer, C., Jongsma, E., Liu, S. X., Dakhovnik, A., Wandrey, F., Mozharovskyi, P., Zülli, F., & Ewald, C. Y. (2021) · Aging Cell · doi:10.1111/acel.13441 · Cited by 45
The circadian clock and extracellular matrix homeostasis in aging and age-related diseases
Dudek, M., Swift, J., & Meng, Q. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00122.2023 · Cited by 49
The epigenetics of keloids
Stevenson, A. W., Deng, Z., Allahham, A., Prêle, C. M., Wood, F. M., & Fear, M. W. (2021) · Experimental Dermatology · doi:10.1111/exd.14414 · Cited by 49
Tissue mechanics coevolves with fibrillar matrisomes in healthy and fibrotic tissues
Dooling, L. J., Saini, K., Anlaş, A. A., & Discher, D. E. (2022) · Matrix Biology · doi:10.1016/j.matbio.2022.06.006 · Cited by 46
Clinical doses of radiation reduce collagen matrix stiffness
Miller, J. P., Borde, B. H., Bordeleau, F., Zanotelli, M. R., LaValley, D. J., Parker, D. J., Bonassar, L. J., Pannullo, S. C., & Reinhart‐King, C. A. (2018) · APL Bioengineering · doi:10.1063/1.5018327 · Cited by 46
Self-citation
Addressing the tumour microenvironment in early drug discovery: a strategy to overcome drug resistance and identify novel targets for cancer therapy
Kaemmerer, E., Loessner, D., & Avery, V. M. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.11.030 · Cited by 48
Understanding the matrix: collagen modifications in tumors and their implications for immunotherapy
Borst, R., Meyaard, L., & Ramos, M. I. P. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05199-3 · Cited by 53
A tissue-engineered human trabecular meshwork hydrogel for advanced glaucoma disease modeling
Li, H., Bagué, T., Kirschner, A., Strat, A. N., Roberts, H., Weisenthal, R. W., Patteson, A. E., Annabi, N., Stamer, W. D., Ganapathy, P. S., et al. (2021) · Experimental Eye Research · doi:10.1016/j.exer.2021.108472 · Cited by 47
Targeted mechanical forces enhance the effects of tumor immunotherapy by regulating immune cells in the tumor microenvironment
Zhu, P., #x2019, #x2019, Lu, H., Wang, M., Chen, K., Chen, Z., & Yang, L. (2023) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2022.0491 · Cited by 44
The Role of Melanoma Cell-Stroma Interaction in Cell Motility, Invasion, and Metastasis
Ju, R. J., Stehbens, S. J., & Haass, N. K. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00307 · Cited by 46
Impact of extracellular matrix stiffness on genomic heterogeneity in MYCN-amplified neuroblastoma cell line
López-Carrasco, A., Martín-Vañó, S., Burgos‐Panadero, R., Monferrer, E., Berbegall, A. P., Fernández-Blanco, B., Navarro, S., & Noguera, R. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01729-1 · Cited by 44
Stimuli‐Responsive Nanoradiosensitizers for Enhanced Cancer Radiotherapy
Xiao, W., Zhao, L., Sun, Y., Yang, X. P., & Fu, Q. (2023) · Small Methods · doi:10.1002/smtd.202301131 · Cited by 46
Amyloid aggregates accumulate in melanoma metastasis modulating YAP activity
Matafora, V., Farris, F., Restuccia, U., Tamburri, S., Martano, G., Bernardelli, C., Sofia, A., Pisati, F., Casagrande, F., Lazzari, L., et al. (2020) · The EMBO Reports · doi:10.15252/embr.202050446 · Cited by 44
Densification: Hyaluronan Aggregation in Different Human Organs
Stecco, A., Cowman, M. K., Pirri, N., Raghavan, P., & Pirri, C. (2022) · Bioengineering · doi:10.3390/bioengineering9040159 · Cited by 43
Framing cancer progression: influence of the organ‐ and tumour‐specific matrisome
Rafaeva, M., & Erler, J. T. (2020) · FEBS Journal · doi:10.1111/febs.15223 · Cited by 44
Actin cytoskeleton in mesenchymal-to-amoeboid transition of cancer cells
Alexandrova, A. Y., Chikina, A. S., & Svitkina, T. (2020) · International review of cytology · doi:10.1016/bs.ircmb.2020.06.002 · Cited by 44
3D bioprinting of engineered breast cancer constructs for personalized and targeted cancer therapy
Sharifi, M., Bai, Q., Babadaei, M. M. N., Chowdhury, F., Hassan, M., Taghizadeh, A., Derakhshankhah, H., Suliman, K., Hasan, A., & Falahati, M. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.03.026 · Cited by 42
Targeting Tissue Stiffness in Metastasis: Mechanomedicine Improves Cancer Therapy
Zhang, J., & Reinhart‐King, C. A. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.05.011 · Cited by 41
Self-citation
Multi-Step Extracellular Matrix Remodelling and Stiffening in the Development of Idiopathic Pulmonary Fibrosis
Júnior, C., Ulldemolins, A., Narciso, M., Almendros, I., Farré, R., Navajas, D., Alonso, J. L., Eroles, M., Rico, F., & Gavara, N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021708 · Cited by 40
Mechanobiomaterials: Harnessing mechanobiology principles for tissue repair and regeneration
Lin, X. Y., Yang, H. S., Xia, Y., Wu, K., Chu, F., Zhou, H., Gao, H., & Yang, L. (2024) · Mechanobiology in Medicine · doi:10.1016/j.mbm.2024.100079 · Cited by 41
Dynamic PEG–Peptide Hydrogels via Visible Light and FMN‐Induced Tyrosine Dimerization
Liu, H., Nguyen, H. D., & Lin, C. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800954 · Cited by 40
Substrate Stiffness Modulates Renal Progenitor Cell Properties via a ROCK-Mediated Mechanotransduction Mechanism
Melica, M. E., Regina, G. L., Parri, M., Peired, A. J., Romagnani, P., & Lasagni, L. (2019) · Cells · doi:10.3390/cells8121561 · Cited by 43
Nanofibrillar Hydrogel Recapitulates Changes Occurring in the Fibrotic Extracellular Matrix
Prince, E., Chen, Z., Khuu, N., & Kumacheva, E. (2021) · Biomacromolecules · doi:10.1021/acs.biomac.0c01714 · Cited by 41
Fiber Density and Matrix Stiffness Modulate Distinct Cell Migration Modes in a 3D Stroma Mimetic Composite HydrogelPreprint
Hiraki, H. L., Matera, D. L., Wang, W. Y., Prabhu, E. S., Zhang, Z., Midekssa, F. S., Argento, A. E., Buschhaus, J. M., Humphries, B. A., Luker, G. D., et al. (2021) · SSRN Electronic Journal · doi:10.1016/j.actbio.2022.09.043 · Cited by 40
Inhibition of matrix stiffness relating integrin β1 signaling pathway inhibits tumor growth in vitro and in hepatocellular cancer xenografts
Wang, C., Jiang, X., Huang, B., Zhou, W., Cui, X., Zheng, C., Liu, F., Bi, J., Zhang, Y., Luo, H., et al. (2021) · BMC Cancer · doi:10.1186/s12885-021-08982-3 · Cited by 39
Pin1/ YAP pathway mediates matrix stiffness‐induced epithelial–mesenchymal transition driving cervical cancer metastasis via a non‐Hippo mechanism
Yang, L., Li, J., Zang, G., Song, S., Sun, Z., Li, X., Li, Y., Xie, Z., Zhang, G., Gui, N., et al. (2022) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10375 · Cited by 39
Cancer-Associated Fibroblast Heterogeneity and Its Influence on the Extracellular Matrix and the Tumor Microenvironment
Knipper, K., Lyu, S. I., Quaas, A., Bruns, C. J., & Schmidt, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713482 · Cited by 41
Carfilzomib Treatment Causes Molecular and Functional Alterations of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes
Forghani, P., Rashid, A., Sun, F., Liu, R., Li, D., Lee, M. R., Hwang, H., Maxwell, J. T., Mandawat, A., Wu, R., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.022247 · Cited by 40
The PCK2-glycolysis axis assists three-dimensional-stiffness maintaining stem cell osteogenesis
Li, Z., Yue, M., Liu, X., Liu, Y., Lv, L., Zhang, P., & Zhou, Y. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.03.036 · Cited by 39
Novel approaches to target fibroblast mechanotransduction in fibroproliferative diseases
Ezzo, M., & Hinz, B. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108528 · Cited by 39
Fiber stiffness, pore size and adhesion control migratory phenotype of MDA-MB-231 cells in collagen gels
Geiger, F., Rüdiger, D., Zahler, S., & Engelke, H. (2019) · PLoS ONE · doi:10.1371/journal.pone.0225215 · Cited by 38
The Extracellular Matrix-Derived Biomarkers for Diagnosis, Prognosis, and Personalized Therapy of Malignant Tumors
Petersen, E. V., Chudakova, D. A., Skorova, E., Anikin, V., Reshetov, I. V., & Mynbaev, O. A. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.575569 · Cited by 38
Fibrous stroma: Driver and passenger in cancer development
Sharma, V., Letson, J., & Furuta, S. (2022) · Science Signaling · doi:10.1126/scisignal.abg3449 · Cited by 38
An Inhibitor of Arginine‐Glycine‐Aspartate‐Binding Integrins Reverses Fibrosis in a Mouse Model of Nonalcoholic Steatohepatitis
Ulmasov, B., Noritake, H., Carmichael, P., Oshima, K., Griggs, D. W., & Neuschwander‐Tetri, B. A. (2018) · Hepatology Communications · doi:10.1002/hep4.1298 · Cited by 40
Molecular tension sensors: moving beyond force
Ham, T. R., Collins, K. L., & Hoffman, B. D. (2019) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2019.10.003 · Cited by 40
Single‐Cell Encapsulation via Click‐Chemistry Alters Production of Paracrine Factors from Neural Progenitor Cells
Oh, B., Swaminathan, V., Malkovskiy, A. V., Santhanam, S., McConnell, K. W., & George, P. M. (2020) · Advanced Science · doi:10.1002/advs.201902573 · Cited by 37
The Biological and Biomechanical Role of Transglutaminase-2 in the Tumour Microenvironment
Tempest, R., Guarnerio, S., Maani, R., Cooper, J., & Peake, N. (2021) · Cancers · doi:10.3390/cancers13112788 · Cited by 39
Engineered drug delivery nanosystems for tumor microenvironment normalization therapy
Yang, B., Meng, F., Zhang, J., Chen, K., Meng, S., Cai, K., Zhao, Y., & Dai, L. (2023) · Nano Today · doi:10.1016/j.nantod.2023.101766 · Cited by 37
Boosting antitumor efficacy of nanoparticles by modulating tumor mechanical microenvironment
Zhang, X., Zhang, X., Yong, T., Gan, L., & Yang, X. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105200 · Cited by 36
Extracellular matrix stiffness modulates host-bacteria interactions and antibiotic therapy of bacterial internalization
Liu, X., Zhu, K., Duan, X., Wang, P., Han, Y., Peng, W., & Huang, J. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121098 · Cited by 36
Targeting extracellular matrix glycation to attenuate fibroblast activation
Jang, M., Oh, S. W., Lee, Y., Kim, J. Y., Ji, E. S., & Kim, P. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.01.040 · Cited by 37
Biophysics Role and Biomimetic Culture Systems of ECM Stiffness in Cancer EMT
Tian, H., Shi, H., Yu, J., Ge, S., & Ruan, J. (2022) · Global Challenges · doi:10.1002/gch2.202100094 · Cited by 36
Immune‐mediated ECM depletion improves tumour perfusion and payload delivery
Yeow, Y. L., Kotamraju, V. R., Wang, X., Chopra, M., Azme, N., Wu, J., Schoep, T. D., Delaney, D. S., Feindel, K. W., Li, J., et al. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201910923 · Cited by 35
The plasticity of fibroblasts: A forgotten player in the aging process
Salminen, A. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101995 · Cited by 36
Atomic Force Microscopy in Probing Tumor Physics for Nanomedicine
Li, M., Xi, N., Wang, Y., & Liu, L. (2018) · IEEE Transactions on Nanotechnology · doi:10.1109/tnano.2018.2882383 · Cited by 34
Influence of limb position on assessment of nerve mechanical properties by using shear wave ultrasound elastography
Rugel, C. L., Franz, C. K., & Lee, S. S. M. (2020) · Muscle & Nerve · doi:10.1002/mus.26842 · Cited by 34
A story of fibers and stress: Matrix‐embedded signals for fibroblast activation in the skin
Sawant, M., Hinz, B., Schönborn, K., Zeinert, I., Eckes, B., Krieg, T., & Schuster, R. (2021) · Wound Repair and Regeneration · doi:10.1111/wrr.12950 · Cited by 36
Towards an integrative understanding of cancer mechanobiology: calcium, YAP, and microRNA under biophysical forces
Liang, C., Huang, M. L., Li, T., Li, L., Sussman, H., Dai, Y., Siemann, D. W., Xie, M., & Tang, X. (2022) · Soft Matter · doi:10.1039/d1sm01618k · Cited by 34
Combination Therapy of Lox Inhibitor and Stimuli‐Responsive Drug for Mechanochemically Synergistic Breast Cancer Treatment
Zhu, S., Zhang, T., Gao, H., Jin, G., Yang, J., He, X., Guo, H., & Xu, F. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300103 · Cited by 33
Dose-dependent pro- or anti-fibrotic responses of endometriotic stromal cells to interleukin-1β and tumor necrosis factor α
Matsuzaki, S., Pouly, J. L., & Canis, M. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-66298-x · Cited by 34
Substrate stiffness regulates the proliferation and inflammation of chondrocytes and macrophages through exosomes
Lai, Q., Li, B., Chen, L., Zhou, Y., Bao, H., & Li, H. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.12.021 · Cited by 32
Engineering biomimetic and instructive materials for wound healing and regeneration
Chantre, C. O., Hoerstrup, S. P., & Parker, K. K. (2019) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2019.04.004 · Cited by 32
Mechanosensing of Mechanical Confinement by Mesenchymal-Like Cells
Doolin, M. T., Moriarty, R. A., & Stroka, K. M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00365 · Cited by 33
Eyeing the Extracellular Matrix in Vascular Development and Microvascular Diseases and Bridging the Divide between Vascular Mechanics and Function
Chaqour, B., & Karrasch, C. C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103487 · Cited by 32
Modeling the mechanical stiffness of pancreatic ductal adenocarcinoma
Kpeglo, D., Hughes, M. D. G., Dougan, L., Haddrick, M., Knowles, M. A., Evans, S. D., & Peyman, S. A. (2022) · Matrix Biology Plus · doi:10.1016/j.mbplus.2022.100109 · Cited by 33
Mechanical Forces Govern Interactions of Host Cells with Intracellular Bacterial Pathogens
Bastounis, E. E., Radhakrishnan, P., Prinz, C. K., & Theriot, J. A. (2022) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00094-20 · Cited by 31
Tumor microenvironment reprogramming by nanomedicine to enhance the effect of tumor immunotherapy
Huang, Y., Fan, H., & Ti, H. (2024) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2024.100902 · Cited by 33
A comprehensive review on different approaches for tumor targeting using nanocarriers and recent developments with special focus on multifunctional approaches
Sahu, B. P., Baishya, R., Hatiboruah, J. L., Laloo, D., & Biswas, N. (2022) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-022-00583-x · Cited by 31
Extracellular matrix in skin diseases: The road to new therapies
Malta, M. D., Cerqueira, M. T., & Marques, A. P. (2022) · Journal of Advanced Research · doi:10.1016/j.jare.2022.11.008 · Cited by 35
Engineered systems to study the synergistic signaling between integrin-mediated mechanotransduction and growth factors (Review)
Isabela Monteiro, A., Kollmetz, T., & Malmström, J. (2018) · Biointerphases · doi:10.1116/1.5045231 · Cited by 33
Emerging strategies to disrupt the central TGF-β axis in kidney fibrosis
Rauchman, M. I., & Griggs, D. W. (2019) · Translational research · doi:10.1016/j.trsl.2019.04.003 · Cited by 31
Biological Hyperthermia-Inducing Nanoparticles for Specific Remodeling of the Extracellular Matrix Microenvironment Enhance Pro-Apoptotic Therapy in Fibrosis
Zhang, J., Ji, K., Ning, Y., Sun, L., Fan, M., Shu, C., Zhang, Z., Tu, T., Cao, J., Gao, F., et al. (2023) · ACS Nano · doi:10.1021/acsnano.2c12831 · Cited by 30
Quantifying muscle glycosaminoglycan levels in patients with post-stroke muscle stiffness using T1ρ MRI
Menon, R. G., Raghavan, P., & Regatte, R. R. (2019) · Scientific Reports · doi:10.1038/s41598-019-50715-x · Cited by 30
Cell-Based Strain Remodeling of a Nonfibrous Matrix as an Organizing Principle for Vasculogenesis
Rüdiger, D., Kick, K., Goychuk, A., Vollmar, A. M., Frey, E., & Zahler, S. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108015 · Cited by 30
Long non‐coding RNAs: Promising new targets in pulmonary fibrosis
Zhang, S., Chen, H., Yue, D., Blackwell, T. S., Lv, C., & Song, X. (2021) · The Journal of Gene Medicine · doi:10.1002/jgm.3318 · Cited by 30
Stiffness-responsive feedback autoregulation of DDR1 expression is mediated by a DDR1-YAP/TAZ axis
Ngai, D., Mohabeer, A. L., Mao, A., Lino, M., & Bendeck, M. P. (2022) · Matrix Biology · doi:10.1016/j.matbio.2022.05.004 · Cited by 30
Extracellular-matrix mechanics regulate cellular metabolism: A ninja warrior behind mechano-chemo signaling crosstalk
Liao, X., Li, X., & Liu, R. R. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09768-z · Cited by 31

Authors: Lampi, M. C., & Reinhart-King, C. A.
Affiliations: Cornell University (US)
Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37212, USA.
ORCID: Lampi, Marsha C.
Reinhart-King, Cynthia A.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2018-01-03
Volume: 10
Issue: 422
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.aao0475
OpenAlex: W2781877987
Cited by: 551
References: 159
Citations by year: 2026: 50 · 2025: 68 · 2024: 57 · 2023: 77 · 2022: 81 · 2021: 69 · 2020: 72 · 2019: 43 · 2018: 32
FWCI: 6.09
Type: journal article
Language: en
Open access: closed
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation (award333523, 1435755, award333525, 2013155462)
Ford Foundation (award333526)
National Heart, Lung, and Blood Institute (award333524, HL127499)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
Keywords: extracellular matrix stiffness, tissue stiffening, mechanotransduction, myofibroblasts, TGF-beta, tumor progression, fibrosis, cardiovascular disease, aging, pharmacological interventions, drug development, clinical trials
MeSH terms: Animals, Cell Differentiation, Extracellular Matrix, Fibrosis, Humans, Transforming Growth Factor beta, Myofibroblasts

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks