The DOI matches its Crossref record; 65 of the 66 references it cites were found in a registry or an index.
Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with β-blockers
Open accessAbstract
-AR signaling by an LKB1/CREB (cyclic adenosine 3',5'-monophosphate response element-binding protein)/IL-6-dependent mechanism and suggest that combinations of β-blockers with EGFR TKIs merit further investigation as a strategy to abrogate resistance.
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“Stress hormone induced beta adrenergic pathway activation has recently been identified as a driver of resistance to first-generation TKIs and can be overcome by beta-adrenergic blockade[25]”
From Landscape of EGFR-Dependent and -Independent Resistance Mechanisms to Osimertinib and Continuation Therapy Beyond Progression in EGFR -Mutant NSCLC (2018) · cites this paper as [25]
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Metadata
- Authors
- Nilsson, M. B., Sun, H., Diao, L., Tong, P., Liu, D., Li, L., Fan, Y., Poteete, A., Lim, S.-O., Howells, K., Haddad, V., Gomez, D., Tran, H., Pena, G. A., Sequist, L. V., Yang, J. C., Wang, J., Kim, E. S., Herbst, R. S., Lee, J. J., Hong, W. K., Wistuba, I., Hung, M.-C., Sood, A. K., & Heymach, J. V.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- AstraZeneca, Melbourn, SG8 6EE, UK.
- Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- Massachusetts General Hospital (US)
- National Taiwan University (TW)
- Carolinas Healthcare System (US)
- Yale Cancer Center (US)
- Corresponding author
- Heymach, John V.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2017-11-08
- Volume
- 9
- Issue
- 415
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC5870120
- OpenAlex
- W2767479469
- Cited by
- 146
- References
- 66
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 9 · 2023: 17 · 2022: 17 · 2021: 15 · 2020: 29 · 2019: 18 · 2018: 13 · 2017: 1
- FWCI
- 13.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (award340275, Lung SPORE P50 CA070907, award340276, NIH CCSG(CA016672), award340277, 1R01 CA190628, award350130, CA109298)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- EGFR inhibitors, drug resistance, non-small cell lung cancer, beta-blockers, stress hormones, LKB1, CREB, IL-6 signaling, combination therapy, tyrosine kinase inhibitors
- MeSH terms
- Afatinib, AMP-Activated Protein Kinase Kinases, Adrenergic beta-Antagonists, Carcinoma, Non-Small-Cell Lung, Epinephrine, Humans, Lung Neoplasms, Mutation, Norepinephrine, Protein Kinase C, Quinazolines, Receptors, Adrenergic, beta, Signal Transduction, Interleukin-6, Protein Serine-Threonine Kinases, Cyclic AMP Response Element-Binding Protein, Drug Resistance, Neoplasm, Xenograft Model Antitumor Assays, Cell Line, Tumor, Protein Kinase Inhibitors, ErbB Receptors
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