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LMNA Reduced Acquired Resistance to Erlotinib in NSCLC by Reversing the Epithelial–Mesenchymal Transition via the FGFR/MAPK/c-fos Signaling Pathway

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Reduced PHLPP Expression Leads to EGFR-TKI Resistance in Lung Cancer by Activating PI3K-AKT and MAPK-ERK Dual Signaling

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AHSA1-HSP90AA1 complex stabilized IFI6 and TGFB1 promotes mitochondrial stability and EMT in EGFR-mutated lung adenocarcinoma under Osimertinib pressure

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Xiaoyaosan, a traditional Chinese medicine, inhibits the chronic restraint stress-induced liver metastasis of colon cancer in vivo

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A Holistic Perspective: Exosomes Shuttle between Nerves and Immune Cells in the Tumor Microenvironment

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Beta-Blocker Use and Lung Cancer Mortality in a Nationwide Cohort Study of Patients with Primary Non–Small Cell Lung Cancer

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IFITM3-MET interaction drives osimertinib resistance through AKT pathway activation in EGFR-mutant non–small cell lung cancer

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Increased Sympathetic Nervous System Impairs Prognosis in Lung Cancer Patients: A Scoping Review of Clinical Studies

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Neural regulation of drug resistance in cancer treatment

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The sympathetic nervous system shapes the tumor microenvironment to impair chemotherapy response

Manoleras, A. V., Sloan, E. K., & Chang, A. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1460493 · Cited by 15

GPCRs in head and neck squamous cell carcinoma

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Adrenergic microenvironment driven by cancer‐associated Schwann cells contributes to chemoresistance in patients with lung cancer

Otani, Y., Katayama, H., Zhu, Y., Huang, R., Shigehira, T., Shien, K., Suzawa, K., Yamamoto, H., Shien, T., Toyooka, S., et al. (2024) · Cancer Science · doi:10.1111/cas.16164 · Cited by 13

ß-Adrenoreceptors in Human Cancers

Krabóth, Z., & Kálmán, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043671 · Cited by 14

β2-AR inhibition enhances EGFR antibody efficacy hampering the oxidative stress response machinery

Vecchio, V. D., Mele, L. L., Panda, S. K., Sanchez-Pajares, I. R., Mosca, L., Tirino, V., Barbieri, M., Bruzzese, F., Luciano, A., Marino, F. Z., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06129-9 · Cited by 12

Comprehensive analysis of microRNA‐messenger RNA regulatory network in gemcitabine‐resistant bladder cancer cells

Zhang, S., Chang, Y., Gong, Y., Gao, Y., Guo, Q., Wang, Y., Zhao, Y., & Wang, Z. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27922 · Cited by 12

Stress-related hormone reduces autophagy through the regulation of phosphatidylethanolamine in breast cancer cells

Zhu, Z., Yu, R., Yang, C., Li, D., Wang, J., Yang, W., Ji, Y., Wang, L., Wang, Y., & Jiang, F. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-8176 · Cited by 12

Mechanisms underlying the effects of stress on tumorigenesis and metastasis (Review)

Zhang, Z., Wang, Y., & Li, Q. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4570 · Cited by 13

Beta1- and Beta2-Adrenoceptors Expression Patterns in Human Non-small Cell Lung Cancer: Relationship with Cancer Histology

Coelho, M., Imperatori, A. S., Chiaravalli, A. M., Franzi, F., Castiglioni, M., Rasini, E., Luini, A., Legnaro, M., Marino, F., Ribeiro, L. V. P. T., et al. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09879-6 · Cited by 11

Fear stress enhanced xenograft pancreatic tumor growth through activating epithelial-mesenchymal transition

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Kava and its Kavalactones Inhibit Norepinephrine-induced Intracellular Calcium Influx in Lung Cancer Cells

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Sympathetic β2-adrenergic receptor blockade overcomes docetaxel resistance in prostate cancer

Zhang, M., Chen, F., Sun, X., Huang, Y., Zeng, Y., Chen, J., Wu, S., & Chen, X. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.03.046 · Cited by 10

Beta-Adrenergic Blockade in Advanced Non-Small Cell Lung Cancer Patients Receiving Immunotherapy: A Multicentric Study

Mendes, A. D., Freitas, A. R., Vicente, R. S., Ferreira, R., Martins, T., Ramos, M. J., Baptista, C., Silva, B. M., Margarido, I., Vitorino, M. M., et al. (2024) · Cureus · doi:10.7759/cureus.52194 · Cited by 10

Opportunities and challenges of co‑targeting epidermal growth factor receptor and autophagy signaling in non‑small cell lung cancer (Review)

Wang, X., Li, W., Zhang, N., Zheng, X., & Zhao, J. (2019) · Oncology Letters · doi:10.3892/ol.2019.10372 · Cited by 9

Cx32 mediates norepinephrine‐promoted EGFR‐TKI resistance in a gap junction‐independent manner in non‐small‐cell lung cancer

Xie, J., Wang, X., Ge, H., Peng, F., Zheng, N., Wang, Q., & Tao, L. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28881 · Cited by 10

Renin-angiotensin inhibitors were associated with improving outcomes of hepatocellular carcinoma with primary hypertension after hepatectomy

Feng, L.-H., Sun, H., Zhu, X., Zhang, S.-Z., Li, K., Li, X., Li, Y., & Tang, Z. (2019) · Annals of Translational Medicine · doi:10.21037/atm.2019.11.131 · Cited by 10

Impact of Tumoral β2-Adrenergic Receptor Expression on Chemotherapeutic Response and Prognosis in Patients with Advanced Colorectal Cancer

Komine, C., Sohda, M., Yokobori, T., Shioi, I., Ozawa, N., Shibasaki, Y., Nakazawa, N., Osone, K., Shiraishi, T., Okada, T., et al. (2024) · Annals of Surgical Oncology · doi:10.1245/s10434-024-16195-8 · Cited by 9

Chromosomal Instability Is Associated with cGAS–STING Activation in EGFR-TKI Refractory Non-Small-Cell Lung Cancer

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Cancer and neurotransmitter receptors

Wang, X., Shi, M., Tian, J., & Yu, W. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003656 · Cited by 10

The crosstalk between nerves and immunity: chronic stress as a driver of tumor progression

He, Y., Yu, H., Li, F., Liu, J., Chen, Z., Zhu, W., Yang, L., & Yan, T. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1758894 · Cited by 12

The Effects of Artificial Lake Space on Satisfaction and Restorativeness of the Overall Environment and Soundscape in Urban Parks

Qi, Y., Fang, X., Gao, T., & Qiu, L. (2021) · Frontiers in Built Environment · doi:10.3389/fbuil.2021.664442 · Cited by 10

Suppression of the innate cancer-killing activity in human granulocytes by stress reaction as a possible mechanism for affecting cancer development

Huang, X., Le, W., Chen, Q., Chen, J., Zhu, Y., Shi, D., Chen, B., & Cui, Z. (2019) · Stress · doi:10.1080/10253890.2019.1645112 · Cited by 8

Comprehensive network analysis of dysregulated genes revealed MNX1‐AS1 / hsa‐miR ‐4697‐3p/ HOXB13 axis in ovarian cancer chemotherapy response

Wu, A., Liu, J., Zhang, X., Niu, C., Shu, G., & Yin, G. (2022) · Cancer Science · doi:10.1111/cas.15447 · Cited by 8

The Nervous System as a Regulator of Cancer Hallmarks: Insights into Therapeutic Implications

Torres-Juárez, K. V., QUEIROGA, F. L., & Romero-Romero, L. P. (2022) · Cancers · doi:10.3390/cancers14184372 · Cited by 9

G Protein-coupled and Membrane Tyrosine Kinase Receptor Relationships Yield Therapeutic Opportunities

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A pomalidomide-based gefitinib PROTAC degrader effectively inhibits lung cancer progression in EGFR-TKIs-acquired resistant models by targeting EGFR degradation and ETFA-mediated ATP generation

Li, L., Li, Y., Ma, X., Li, P., Zeng, S., Jiang, F., & Zhang, G. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108864 · Cited by 7

The Activity of EGFR CAR NK and CAR T Cells against EGFR Inhibitor–Resistant NSCLC and Drug-Tolerant Persister Cells

Yang, Y., Nilsson, M. B., Yu, X., Poteete, A., Jiang, H., Huang, Q., He, J., Heeke, S., & Heymach, J. V. (2025) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-25-1693 · Cited by 7

Rational Combinations of PARP Inhibitors with HRD-Inducing Molecularly Targeted Agents

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Association Between Digoxin Use and Cancer Incidence: A Propensity Score-Matched Cohort Study With Competing Risk Analysis

Tai, C.-J., Yang, Y., Tseng, T., Chang, F., & Wang, H. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.564097 · Cited by 6

Abstract 4662: Beta blockers abrogate EGFR TKI resistance induced by adrenergic receptor-mediated upregulation of IL-6 and modulation of the LKB1/AMPK/mTOR axis

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Chronic Stress Hormones May Promote Resistance to EGFR Inhibitors

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The impact of ß-blockers in non–small cell lung cancer patients treated with Epidermal Growth Factor Receptor Kinase Inhibitors, Taiwan NHIRD database study.

Fan, G. W., & Lin, C. (2018) · Lung Cancer · doi:10.1183/13993003.congress-2018.pa2855

Blocking beta adrenergic signaling may be a target for overcoming EGFR TKI resistance.

Heo, E. Y., Lee, M., Lee, J., Kim, D. K., & Chung, H. S. (2018) · Lung Cancer · doi:10.1183/13993003.congress-2018.pa2854

2060eP Prognostic impact of concomitant beta-blocker use on survival in EGFR-mutant metastatic non-small cell lung cancer patients treated with erlotinib

Yıldız, O., Aykut, T., Kaya, B. E., Genç, Ö., Gürbüz, A. F., Eryılmaz, M. K., Araz, M., & Artaç, M. (2025) · Annals of Oncology · doi:10.1016/j.annonc.2025.08.2681