Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with β-blockers

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

Edgar, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.207 · Cited by 13,288

EGFR Mutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib

Kobayashi, S., Boggon, T. J., Dayaram, T., Jänne, P. A., Kocher, O., Meyerson, M., Johnson, B. E., Eck, M. J., Tenen, D. G., & Halmos, B. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa044238 · Cited by 3,964

Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain

Pao, W., Miller, V. A., Politi, K. A., Riely, G. J., Somwar, R., Zakowski, M. F., Kris, M. G., & Varmus, H. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020073 · Cited by 3,527 · cited 1×

Phase III Study of Afatinib or Cisplatin Plus Pemetrexed in Patients With Metastatic Lung Adenocarcinoma With EGFR Mutations

Sequist, L. V., Yang, J. C.-H., Yamamoto, N., O'Byrne, K., Hirsh, V., Mok, T., Geater, S. L., Orlov, S., Tsai, C.-M., Boyer, M., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.44.2806 · Cited by 3,228

Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers

Shigematsu, H., Lin, L., Takahashi, T., Nomura, M., Suzuki, M., Wistuba, I. I., Fong, K. M., Lee, H., Toyooka, S., Shimizu, N., et al. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji055 · Cited by 2,377

AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer

Cross, D. A. E., Ashton, S. E., Ghiorghiu, S., Eberlein, C., Nebhan, C. A., Spitzler, P. J., Orme, J. P., Finlay, M. R. V., Ward, R. A., Mellor, M. J., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0337 · Cited by 2,246

AZD9291 in EGFR Inhibitor–Resistant Non–Small-Cell Lung Cancer

Jänne, P. A., Yang, J. C.-H., Kim, D.-W., Planchard, D., Ohe, Y., Ramalingam, S. S., Ahn, M.-J., Kim, S.-W., Su, W.-C., Horn, L., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1411817 · Cited by 2,116

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Shaw, R. J., Kosmatka, M., Bardeesy, N., Hurley, R. L., Witters, L. A., DePinho, R. A., & Cantley, L. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308061100 · Cited by 1,797

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

Prenzel, N., Zwick, E., Daub, H., Leserer, M., Abraham, R., Wallasch, C., & Ullrich, A. (1999) · Nature · doi:10.1038/47260 · Cited by 1,507

Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma

Thaker, P. H., Han, L. Y., Kamat, A. A., Arevalo, J. M., Takahashi, R., Lu, C., Jennings, N. B., Armaiz-Pena, G., Bankson, J. A., Ravoori, M., et al. (2006) · Nature Medicine · doi:10.1038/nm1447 · Cited by 1,320

Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A

Daaka, Y., Luttrell, L. M., & Lefkowitz, R. J. (1997) · Nature · doi:10.1038/36362 · Cited by 1,278

LKB1 modulates lung cancer differentiation and metastasis

Ji, H., Ramsey, M. R., Hayes, D. N., Fan, C., McNamara, K., Kozlowski, P., Torrice, C., Wu, M. C., Shimamura, T., Perera, S. A., et al. (2007) · Nature · doi:10.1038/nature06030 · Cited by 1,064

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression

Chen, L., Gibbons, D. L., Goswami, S., Cortez, M. A., Ahn, Y., Byers, L. A., Zhang, X., Yi, X., Dwyer, D. W., Lin, W., et al. (2014) · Nature Communications · doi:10.1038/ncomms6241 · Cited by 994

Protein Kinase C Contains a Pseudosubstrate Prototope in Its Regulatory Domain

House, C. M., & Kemp, B. E. (1987) · Science · doi:10.1126/science.3686012 · Cited by 989

The sympathetic nervous system induces a metastatic switch in primary breast cancer

Sloan, E. K., Priceman, S. J., Cox, B. F., Yu, S., Pimentel, M. A., Tangkanangnukul, V., Arevalo, J. M. G., Morizono, K., Karanikolas, B. D. W., Wu, L., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0522 · Cited by 930

The BATTLE Trial: Personalizing Therapy for Lung Cancer

Kim, E. S., Herbst, R. S., Wistuba, I. I., Lee, J. J., Blumenschein, G. R., Tsao, A. S., Stewart, D. J., Hicks, M. E., Erasmus, J. J., Gupta, S. K., et al. (2011) · Cancer Discovery · doi:10.1158/2159-8274.cd-10-0010 · Cited by 898

Mechanisms of Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non–Small Cell Lung Cancer

Engelman, J. A., & Janne, P. A. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-2248 · Cited by 706

STK11/LKB1 deficiency promotes neutrophil recruitment and proinflammatory cytokine production to suppress T-cell activity in the lung tumor microenvironment

Koyama, S., Akbay, E. A., Li, Y. Y., Aref, A. R., Skoulidis, F., Herter-Sprie, G. S., Buczkowski, K. A., Liu, Y., Awad, M. M., Denning, W. L., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-1439 · Cited by 640

Beta Blockers and Breast Cancer Mortality: A Population- Based Study

Barron, T. I., Connolly, R. M., Sharp, L., Bennett, K., & Visvanathan, K. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.33.5422 · Cited by 532

Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways

Arbiser, J. L., Moses, M. A., Fernández, C. A., Ghiso, N., Cao, Y., Klauber, N., Frank, D. A., Brownlee, M., Flynn, E. A., Parangi, S., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.3.861 · Cited by 469

A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1

Hara, M. R., Kovacs, J. J., Whalen, E. J., Rajagopal, S., Strachan, R. T., Grant, W., Towers, A. J., Williams, B., Lam, C. M., Xiao, K., et al. (2011) · Nature · doi:10.1038/nature10368 · Cited by 420

Phosphorylation Sites on Two Domains of the β2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization

Hausdorff, W. P., Bouvier, M., O’Dowd, B. F., Irons, G. P., Caron, M. G., & Lefkowitz, R. J. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63907-9 · Cited by 414

TGF-β IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer

Yao, Z., Fenoglio, S., Gao, D. C., Camiolo, M., Stiles, B., Lindsted, T., Schlederer, M., Johns, C., Altorki, N., Mittal, V., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009472107 · Cited by 389

Oncogenic B-RAF Negatively Regulates the Tumor Suppressor LKB1 to Promote Melanoma Cell Proliferation

Zheng, B., Jeong, J. H., Asara, J. M., Yuan, Y.-Y., Granter, S. R., Chin, L., & Cantley, L. C. (2009) · Molecular Cell · doi:10.1016/j.molcel.2008.12.026 · Cited by 364

Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination

Le, C. P., Nowell, C. J., Kim-Fuchs, C., Botteri, E., Hiller, J. G., Ismail, H., Pimentel, M. A., Chai, M. G., Karnezis, T., Rotmensz, N., et al. (2016) · Nature Communications · doi:10.1038/ncomms10634 · Cited by 354

Stress-related mediators stimulate vascular endothelial growth factor secretion by two ovarian cancer cell lines.

Lutgendorf, S. K., Cole, S. W., Costanzo, E. S., Bradley, S., Coffin, J. E., Jabbari, S., Rainwater, K. K., Ritchie, J. M., Yang, M., & Sood, A. K. (2003) · PubMed · Cited by 326

Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors.

Ercan, D., Xu, C., Yanagita, M., Monast, C. S., Pratilas, C. A., Montero, J., Butaney, M., Shimamura, T., Sholl, L., Ivanova, E. V., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0103 · Cited by 294

Phase III Trial of Vandetanib Compared With Erlotinib in Patients With Previously Treated Advanced Non–Small-Cell Lung Cancer

Natale, R. B., Thongprasert, S., Greco, F. A., Thomas, M., Tsai, C., Sunpaweravong, P., Ferry, D. R., Mulatero, C., Whorf, R. C., Thompson, J., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.28.5981 · Cited by 290

A 12-Gene Set Predicts Survival Benefits from Adjuvant Chemotherapy in Non–Small Cell Lung Cancer Patients

Tang, H., Xiao, G., Behrens, C., Schiller, J. H., Allen, J., Chow, C.-W. B., Suraokar, M. B., Corvalán, A. H., Mao, J., White, M. A., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-2321 · Cited by 284

Psychological distress and cancer mortality

Hamer, M., Chida, Y., & Molloy, G. J. (2009) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2008.11.002 · Cited by 282

Obesity Is a Positive Modulator of IL-6R and IL-6 Expression in the Subcutaneous Adipose Tissue: Significance for Metabolic Inflammation

Sindhu, S. T. A. K., Thomas, R., Kochumon, S., Devarajan, S., Behbehani, K., & Ahmad, R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133494 · Cited by 278

EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape

Lim, S., Li, C., Xia, W., Lee, H., Chang, S.-S., Shen, J., Hsu, J. L., Raftery, D., Djukovic, D., Gu, H., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2478 · Cited by 270

Computational identification of gene–social environment interaction at the human IL6 locus

Cole, S. W., Arevalo, J. M. G., Takahashi, R., Sloan, E. K., Lutgendorf, S. K., Sood, A. K., Sheridan, J. F., & Seeman, T. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911515107 · Cited by 256

Non-parametric quantification of protein lysate arrays

Hu, J., He, X., Baggerly, K., Coombes, K. R., Hennessy, B. T., & Mills, G. B. (2007) · Bioinformatics · doi:10.1093/bioinformatics/btm283 · Cited by 224

Combined EGFR/MEK Inhibition Prevents the Emergence of Resistance in EGFR -Mutant Lung Cancer

Tricker, E. M., Xu, C., Uddin, S., Capelletti, M., Ercan, D., Ogino, A., Pratilas, C. A., Rosen, N. X., Gray, N. S., Wong, K., et al. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0063 · Cited by 220

Improved survival outcomes with the incidental use of beta-blockers among patients with non-small-cell lung cancer treated with definitive radiation therapy

Wang, H. M., Liao, Z. X., Komaki, R. U., Welsh, J. W., OʼReilly, M., Chang, J. Y., Zhuang, Y., Levy, L. B., Lu, C., & Gomez, D. R. (2013) · Annals of Oncology · doi:10.1093/annonc/mds616 · Cited by 202

Epac and Phospholipase Cϵ Regulate Ca2+ Release in the Heart by Activation of Protein Kinase Cϵ and Calcium-Calmodulin Kinase II

Oestreich, E. A., Malik, S., Goonasekera, S. A., Blaxall, B. C., Kelley, G. G., Dirksen, R. T., & Smrcka, A. V. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806994200 · Cited by 200

The tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a beta-adrenergic agonist and stimulates DNA synthesis in lung adenocarcinoma via beta-adrenergic receptor-mediated release of arachidonic acid.

Schuller, H. M., Tithof, P. K., Williams, M., & Plummer, H. K. (1999) · PubMed · Cited by 189

Restraint stress differentially affects anti-viral cellular and humoral immune responses in mice

Sheridan, J. F., Feng, N., Bonneau, R. H., Allen, C. M., Huneycutt, B. S., & Glaser, R. (1991) · Journal of Neuroimmunology · doi:10.1016/0165-5728(91)90046-a · Cited by 173

Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients

Koivunen, J. P., Kim, J., Lee, J., Rogers, A. M., Park, J. O., Zhao, X., Naoki, K., Okamoto, I., Nakagawa, K., Yeap, B. Y., et al. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604469 · Cited by 168

IL ‐6 in diabetes and cardiovascular complications

Qu, D. C., Liu, J., Lau, C. W., & Huang, Y. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12713 · Cited by 166

Stress Hormones Regulate Interleukin-6 Expression by Human Ovarian Carcinoma Cells through a Src-dependent Mechanism

Nilsson, M. B., Armaiz-Peña, G. N., Takahashi, R., Lin, Y. G., Trevino, J. G., Li, Y., Jennings, N., Arevalo, J. M. G., Lutgendorf, S. K., Gallick, G. E., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611539200 · Cited by 158

β-Adrenergic receptors (β-AR) regulate VEGF and IL-6 production by divergent pathways in high β-AR-expressing breast cancer cell lines

Madden, K. S., Szpunar, M. J., & Brown, E. B. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1348-y · Cited by 156

Use of β‐blockers is associated with prostate cancer‐specific survival in prostate cancer patients on androgen deprivation therapy

Grytli, H. H., Fagerland, M. W., Fosså, S. D., Taskén, K. A., & Håheim, L. L. (2012) · The Prostate · doi:10.1002/pros.22564 · Cited by 144

Changes in sympathetic nerve activity of the mammalian ovary during a normal estrous cycle and in polycystic ovary syndrome: Studies on norepinephrine release

Lara, H. E., Dorfman, M. D., Venegas, M., Luza, S. M., Luna, S. L., Mayerhofer, A., Guimarães, M. A. D. B. V., Silva, A. A. M. R. E., & RAMIREZ, V. D. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10229 · Cited by 122

Reciprocal Regulation of c-Src and STAT3 in Non-Small Cell Lung Cancer

Byers, L. A., Sen, B., Saigal, B., Diao, L., Wang, J., Nanjundan, M., Cascone, T., Mills, G. B., Heymach, J. V., & Johnson, F. M. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0767 · Cited by 120

Epac- and Ca2+-controlled Activation of Ras and Extracellular Signal-regulated Kinases by Gs-coupled Receptors

Keiper, M., Stope, M. B., Szatkowski, D., Böhm, A., Tysack, K., Dorp, F. V., Saur, O., Weernink, P. A. O., Evellin, S., Jakobs, K. H., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403604200 · Cited by 106

NNK activates ERK1/2 and CREB/ATF‐1 via β‐1‐AR and EGFR signaling in human lung adenocarcinoma and small airway epithelial cells

Laag, E. M., Majidi, M., Cekanova, M., Masi, T. J., Takahashi, T., & Schuller, H. M. (2006) · International Journal of Cancer · doi:10.1002/ijc.21987 · Cited by 90

LKB1 Loss Induces Characteristic Patterns of Gene Expression in Human Tumors Associated with NRF2 Activation and Attenuation of PI3K-AKT

Kaufman, J. M., Amann, J. M., Park, K., Arasada, R. R., Li, H., Shyr, Y., & Carbone, D. P. (2014) · Journal of Thoracic Oncology · doi:10.1097/jto.0000000000000173 · Cited by 87

Smoking Status Effect on Inflammatory Markers in a Randomized Trial of Current and Former Heavy Smokers

Aldaham, S. A., Foote, J. A., Chow, H. ‐. S., & Hakim, I. A. (2015) · International Journal of Inflammation · doi:10.1155/2015/439396 · Cited by 86

Effects of adrenaline in human colon adenocarcinoma HT-29 cells

Wong, H. P. S., Ho, J. W. C., Koo, M. W. L., Yu, L., Wu, W. K. K., Lam, E. K. Y., Tai, E. K. K., Ko, J. K.-S., Shin, V. Y., Chu, K., et al. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.04.007 · Cited by 77

Norepinephrine Stimulates Pancreatic Cancer Cell Proliferation, Migration and Invasion Via ß-Adrenergic Receptor-Dependent Activation of P38/MAPK Pathway

Huang, X., Wang, H., Zhou, Y. M., Huang, J. J., & Zheng, Q. (2011) · Hepatogastroenterology · doi:10.5754/hge11476 · Cited by 74

β-adrenergic mitogenic signal transduction in peripheral lung adenocarcinoma: Implications for individuals with preexisting chronic lung disease

Park, P. G. (1995) · Lung Cancer · doi:10.1016/0169-5002(96)84221-8 · Cited by 74

Direct Demonstration of Impaired Functionality of a Purified Desensitized β-Adrenergic Receptor in a Reconstituted System

Strulovici, B., Cerione, R. A., Kilpatrick, B. F., Caron, M. G., & Lefkowitz, R. J. (1984) · Science · doi:10.1126/science.6089331 · Cited by 71

Proteomic Profiling Identifies Pathways Dysregulated in Non-small Cell Lung Cancer and an Inverse Association of AMPK and Adhesion Pathways with Recurrence

Nanjundan, M., Byers, L. A., Carey, M. S., Siwak, D. R., Raso, M. G., Diao, L., Wang, J., Coombes, K. R., Roth, J. A., Mills, G. B., et al. (2010) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e3181f2a266 · Cited by 68

Social Stress Promotes and γ-Aminobutyric Acid Inhibits Tumor Growth in Mouse Models of Non–Small Cell Lung Cancer

Al-Wadei, H. A. N., Plummer, H. K., Ullah, M. F., Unger, B. L., Brody, J. R., & Schuller, H. M. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0177 · Cited by 67

GPCRs and EGFR – Cross-talk of membrane receptors in cancer

Köse, M. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.07.002 · Cited by 64

Ligand-independent and EGF receptor-supported transactivation: Lessons from β2-adrenergic receptor signalling

Drube, S., Stirnweiss, J., Valkova, C., & Liebmann, C. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.01.003 · Cited by 61

Release of Norepinephrine from Human Ovary: Coupling to Steroidogenic Response

Lara, H. E., Arnaldo Porcile, J., Espinoza, J., Romero, C., Luza, S. M., Fuhrer, J., Miranda, C., & Roblero, L. S. (2001) · Endocrine · doi:10.1385/endo:15:2:187 · Cited by 49

Beta-endorphin and catecholamine concentrations during chronic and acute stress in intensive care patients.

Schmidt, C., & Kraft, K. (1996) · PubMed · Cited by 48

Regulation of nonsmall‐cell lung cancer stem cell like cells by neurotransmitters and opioid peptides

Banerjee, J., John, A. M. P., & Schuller, H. M. (2015) · International Journal of Cancer · doi:10.1002/ijc.29646 · Cited by 45

LKB1 and Mammalian Target of Rapamycin As Predictive Factors for the Anticancer Efficacy of Metformin

Memmott, R. M., & Dennis, P. A. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.25.3963 · Cited by 44

Further data on beta-blockers and cancer risk: observational study and meta-analysis of randomized clinical trials

Monami, M., Filippi, L., Ungar, A., Sgrilli, F., Antenore, A., Dicembrini, I., Bagnoli, P., Marchionni, N., Rotella, C. M., & Mannucci, E. (2013) · Current Medical Research and Opinion · doi:10.1185/03007995.2013.772505 · Cited by 41

Adrenaline induces chemoresistance in HT-29 colon adenocarcinoma cells

Yao, H., Duan, Z., Wang, M., Awonuga, A. O., Rappolee, D. A., & Xie, Y. (2009) · Cancer Genetics and Cytogenetics · doi:10.1016/j.cancergencyto.2008.12.009 · Cited by 37

5′-AMP-activated protein kinase is inactivated by adrenergic signalling in adult cardiac myocytes

Tsuchiya, Y., Denison, F. C., Heath, R. B., Carling, D., & Saggerson, D. (2011) · Bioscience Reports · doi:10.1042/bsr20110076 · Cited by 11

Mechanisms and clinical activity of an EGFR and HER2 exon 20–selective kinase inhibitor in non–small cell lung cancer

Robichaux, J. P., Elamin, Y. Y., Tan, Z., Carter, B. W., Zhang, S., Liu, S., Li, S., Chen, T., Poteete, A., Estrada-Bernal, A., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0007-9 · Cited by 468

Landscape of EGFR-Dependent and -Independent Resistance Mechanisms to Osimertinib and Continuation Therapy Beyond Progression in EGFR -Mutant NSCLC

Le, X., Puri, S., Negrao, M. V., Nilsson, M. B., Robichaux, J., Boyle, T., Hicks, J. K., Lovinger, K. L., Roarty, E., Rinsurongkawong, W., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-1542 · Cited by 387

Neurotransmitters: emerging targets in cancer

Jiang, S., Hu, L.-P., Wang, X., Li, J., & Zhang, Z. (2019) · Oncogene · doi:10.1038/s41388-019-1006-0 · Cited by 239

Illuminating the Onco-GPCRome: Novel G protein–coupled receptor-driven oncocrine networks and targets for cancer immunotherapy

Wu, V. H., Yeerna, H., Nohata, N., Chiou, J., Harismendy, O., Raimondi, F., Inoue, A., Russell, R. B., Tamayo, P., & Gutkind, J. S. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.005601 · Cited by 185

A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components

Nilsson, M. B., Sun, H., Robichaux, J., Pfeifer, M., McDermott, U., Travers, J., Diao, L., Xi, Y., Tong, P., Shen, L., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz4589 · Cited by 177

Abstract 4662: Beta blockers abrogate EGFR TKI resistance induced by adrenergic receptor-mediated upregulation of IL-6 and modulation of the LKB1/AMPK/mTOR axis

Nilsson, M. B., Sun, H., Diao, L., Tong, P., Fan, Y.-H., Tran, H. T., Liu, D., Armaiz-Peña, G. N., Wang, J., Rowe, P. J., et al. (2016) · Cancer Research · doi:10.1158/1538-7445.am2016-4662

Chronic Stress Hormones May Promote Resistance to EGFR Inhibitors

(2017) · Oncology Times · doi:10.1097/01.cot.0000527904.90180.2e

The impact of ß-blockers in non–small cell lung cancer patients treated with Epidermal Growth Factor Receptor Kinase Inhibitors, Taiwan NHIRD database study.

Fan, G. W., & Lin, C. (2018) · Lung Cancer · doi:10.1183/13993003.congress-2018.pa2855

Blocking beta adrenergic signaling may be a target for overcoming EGFR TKI resistance.

Heo, E. Y., Lee, M., Lee, J., Kim, D. K., & Chung, H. S. (2018) · Lung Cancer · doi:10.1183/13993003.congress-2018.pa2854

2060eP Prognostic impact of concomitant beta-blocker use on survival in EGFR-mutant metastatic non-small cell lung cancer patients treated with erlotinib

Yıldız, O., Aykut, T., Kaya, B. E., Genç, Ö., Gürbüz, A. F., Eryılmaz, M. K., Araz, M., & Artaç, M. (2025) · Annals of Oncology · doi:10.1016/j.annonc.2025.08.2681