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Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain
Abstract
The poly(A) RNA binding proteins MSUT2 and PABPN1 regulate the accumulation of pathological tau in two mouse models of tauopathy.
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“In some contexts, removing the tau-interacting RBP ameliorates neurodegeneration and/or neurodegeneration-associated phenotypes 3,16,17 .”
From Tau is an m 6 A-associated RNA binding protein that causes RNA dysregulation in disease (2026) · cites this paper as [16]
In the citing paper
“RBPs constitute a large fraction of the tau interactome 11 , and pathogenic tau can have aberrant interactions with RBPs, leading to downstream consequences in cellular and RNA-related phenotypes 3,4,9,10,14-16 .”
From Tau is an m 6 A-associated RNA binding protein that causes RNA dysregulation in disease (2026) · cites this paper as [16]
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Self-citationSynapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
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Clavaguera, F., Bolmont, T., Crowther, R. A., Abramowski, D., Frank, S., Probst, A., Fraser, G., Stalder, A. K., Beibel, M., Staufenbiel, M., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1901 · Cited by 1,803
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Cited by
Hochmair, J., Exner, C., Franck, M., Dominguez‐Baquero, A., Diez, L., Brognaro, H., Kraushar, M. L., Mielke, T., Radbruch, H., Kaniyappan, S., et al. (2022) · The EMBO Journal · doi:10.15252/embj.2021108882 · Cited by 106
McMillan, P. J., Strovas, T. J., Baum, M., Mitchell, B. K., Eck, R. J., Hendricks, N., Wheeler, J. M., Latimer, C. S., Keene, C. D., & Kraemer, B. C. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01219-1 · Cited by 64
Self-citationTau is an m 6 A-associated RNA binding protein that causes RNA dysregulation in disease
Dixon, G., Keys, A., Rothamel, K., McKetney, J., Jiang, Y. X., Gordon, L. A., Page, M. L., Liu, C., Hou, K., Flanagan, K., et al. (2026) · doi:10.64898/2026.10.26.762095
Metadata
- Authors
- Wheeler, J. M., McMillan, P., Strovas, T. J., Liachko, N. F., Amlie-Wolf, A., Kow, R. L., Klein, R. L., Szot, P., Robinson, L., Guthrie, C., Saxton, A., Kanaan, N. M., Raskind, M., Peskind, E., Trojanowski, J. Q., Lee, V. M. Y., Wang, L.-S., Keene, C. D., Bird, T., Schellenberg, G. D., & Kraemer, B.
- Affiliations
- Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.
- Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA.
- Department of Translational Sciences and Molecular Medicine, College of Human Medicine, Michigan State University, Grand Rapids, MI 49503, USA.
- Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195, USA.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2019-12-18
- Volume
- 11
- Issue
- 523
- ISSN
- 1946-6234
- 1946-6242
- PMC
- PMC7311111
- Cited by
- 52
- References
- 14
- Language
- en
- Funders
- National Institute on Aging (RF1AG055474, AG05136, AG017856)
- National Institute of Neurological Disorders and Stroke (U544NS100693)
- U.S. Department of Veterans Affairs (BX002619, BX007080)
- NIA (AG017856)
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.