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Hyaluronan synthase 2–mediated hyaluronan production mediates Notch1 activation and liver fibrosis
Open accessAbstract
Hepatic stellate cells activated by hyaluronan synthase 2–mediated hyaluronan and Notch1 promote liver fibrosis, identifying a potential target.
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“Furthermore, HSCs synthesize hyaluronic acid through the expression of hyaluronic acid synthase 2, which promotes fibrogenicity in a NOTCH1-dependent manner by stimulating TLR4 and CD44 expressed on HSCs themselves (154).”
From Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH) (2023) · cites this paper as [154]
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Metadata
- Authors
- Yang, Y. M., Noureddin, M., Liu, C., Ohashi, K., Kim, S. Y., Ramnath, D., Powell, E. E., Sweet, M. J., Roh, Y. S., Hsin, I.-F., Deng, N., Liu, Z., Liang, J., Mena, E., Shouhed, D., Schwabe, R. F., Jiang, D., Lu, S. C., Noble, P. W., & Seki, E.
- Affiliations
- Cedars-Sinai Medical Center (US)
- Shanghai University of Traditional Chinese Medicine (CN)
- The University of Queensland (AU)
- California Liver Research Institute (US)
- Columbia University (US)
- Corresponding author
- Noureddin, Mazen
- Liu, Cheng
- Seki, Ekihiro
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2019-06-12
- Volume
- 11
- Issue
- 496
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6589184
- OpenAlex
- W2952382623
- Cited by
- 166
- References
- 52
- Citations by year
- 2026: 13 · 2025: 32 · 2024: 28 · 2023: 30 · 2022: 19 · 2021: 25 · 2020: 14 · 2019: 5
- FWCI
- 10.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R21AA025841, R01 AA027036)
- National Heart, Lung, and Blood Institute (R01HL122068, 1T32HL134637-01, P01HL108793)
- National Institute of Allergy and Infectious Diseases (R01AI052201)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK085252, R01DK107288)
- American Liver Foundation (ALF Irwin M. Arias, MD Postdoctoral Research Fellowship, ALF Congressman John Joseph Moakley Postdoctoral Research Fellowship)
- American Association for the Study of Liver Diseases (AASLD The Leonard B. Seeff Award for Outstanding Research by Young Investigator)
- Cedars-Sinai Medical Center (Winnick Research award)
- Kangwon National University
- National Research Foundation of Korea (2014R1A6A3A01054056, 2017R1A5A2015541, 2017R1C1B2004423)
- Colleges and universities in Shanghai (A-U151902)
- National Natural Science Foundation of China (81673788)
- National Health and Medical Research Council of Australia (NHMRC Senior Research Fellowship, ID: 1107914)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Keywords
- hyaluronic acid, HAS2, liver fibrosis, Notch1, hepatic stellate cells, stellate cell activation, TGF-beta, Wilms tumor 1, CD44, TLR4, 4-methylumbelliferone, extracellular matrix, fibrosis treatment
- MeSH terms
- Hyaluronan Synthases, RNA-Seq, Enzyme-Linked Immunosorbent Assay, Humans, Hyaluronic Acid, Hymecromone, Liver Cirrhosis, Hyaluronan Receptors, Toll-Like Receptor 4, Hepatic Stellate Cells, HEK293 Cells
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