The DOI matches its Crossref record; 51 of the 52 references it cites were found in a registry or an index.
Hyaluronan synthase 2–mediated hyaluronan production mediates Notch1 activation and liver fibrosis
Open accessAbstract
Hepatic stellate cells activated by hyaluronan synthase 2–mediated hyaluronan and Notch1 promote liver fibrosis, identifying a potential target.
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“Furthermore, HSCs synthesize hyaluronic acid through the expression of hyaluronic acid synthase 2, which promotes fibrogenicity in a NOTCH1-dependent manner by stimulating TLR4 and CD44 expressed on HSCs themselves (154).”
From Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH) (2023) · cites this paper as [154]
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Cites
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Mechanisms of hepatic stellate cell activation
Tsuchida, T., & Friedman, S. L. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.38 · Cited by 2,909
TLR4 enhances TGF-β signaling and hepatic fibrosis
Seki, E., De Minicis, S., Österreicher, C. H., Kluwe, J., Osawa, Y., Brenner, D. A., & Schwabe, R. F. (2007) · Nature Medicine · doi:10.1038/nm1663 · Cited by 1,942
Self-citationMederacke, I., Hsu, C. C., Troeger, J. S., Huebener, P., Mu, X., Dapito, D. H., Pradere, J.-P., & Schwabe, R. F. (2013) · Nature Communications · doi:10.1038/ncomms3823 · Cited by 1,443
Self-citationRegulation of lung injury and repair by Toll-like receptors and hyaluronan
Jiang, D., Liang, J., Fan, J., Yu, S., Chen, S., Luo, Y., Prestwich, G. D., Mascarenhas, M. M., Garg, H. G., Quinn, D. A., et al. (2005) · Nature Medicine · doi:10.1038/nm1315 · Cited by 1,401
Self-citationHyaluronan as an Immune Regulator in Human Diseases
Jiang, D., Liang, J., & Noble, P. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00052.2009 · Cited by 1,060
Self-citationNational Vital Statistics Reports NCHS.pdf
Hoyert, D. (2012) · Medical Entomology and Zoology · Cited by 982
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Yuan, Z., Li, Y., Zhang, S., Wang, X., Dou, H., Yu, X., Zhang, Z., Yang, S., & Xiao, M. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01744-8 · Cited by 977
TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis—Updated 2019
Dewidar, B., Meyer, C., Dooley, S., & Meindl-Beinker, A. N. (2019) · Cells · doi:10.3390/cells8111419 · Cited by 837
Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations
Affo, S., Nair, A., Brundu, F., Ravichandra, A., Bhattacharjee, S., Matsuda, M., Chin, L., Filliol, A., Wen, W., Song, X., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.03.012 · Cited by 416
Self-citationBhattacharjee, S., Hamberger, F., Ravichandra, A., Miller, M., Nair, A., Affo, S., Filliol, A., Chin, L., Savage, T. M., Yin, D., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci146987 · Cited by 367
Self-citationLiver fibrosis: Pathophysiology and clinical implications
Berumen, J. A., Baglieri, J., Kisseleva, T., & Mekeel, K. L. (2020) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1499 · Cited by 287
Metadata
- Authors
- Yang, Y. M., Noureddin, M., Liu, C., Ohashi, K., Kim, S. Y., Ramnath, D., Powell, E. E., Sweet, M. J., Roh, Y. S., Hsin, I.-F., Deng, N., Liu, Z., Liang, J., Mena, E., Shouhed, D., Schwabe, R. F., Jiang, D., Lu, S. C., Noble, P. W., & Seki, E.
- Affiliations
- Cedars-Sinai Medical Center (US)
- Shanghai University of Traditional Chinese Medicine (CN)
- The University of Queensland (AU)
- California Liver Research Institute (US)
- Columbia University (US)
- Corresponding author
- Noureddin, Mazen
- Liu, Cheng
- Seki, Ekihiro
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2019-06-12
- Volume
- 11
- Issue
- 496
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6589184
- OpenAlex
- W2952382623
- Cited by
- 166
- References
- 52
- Citations by year
- 2026: 13 · 2025: 32 · 2024: 28 · 2023: 30 · 2022: 19 · 2021: 25 · 2020: 14 · 2019: 5
- FWCI
- 10.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R21AA025841, R01 AA027036)
- National Heart, Lung, and Blood Institute (R01HL122068, 1T32HL134637-01, P01HL108793)
- National Institute of Allergy and Infectious Diseases (R01AI052201)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK085252, R01DK107288)
- American Liver Foundation (ALF Irwin M. Arias, MD Postdoctoral Research Fellowship, ALF Congressman John Joseph Moakley Postdoctoral Research Fellowship)
- American Association for the Study of Liver Diseases (AASLD The Leonard B. Seeff Award for Outstanding Research by Young Investigator)
- Cedars-Sinai Medical Center (Winnick Research award)
- Kangwon National University
- National Research Foundation of Korea (2014R1A6A3A01054056, 2017R1A5A2015541, 2017R1C1B2004423)
- Colleges and universities in Shanghai (A-U151902)
- National Natural Science Foundation of China (81673788)
- National Health and Medical Research Council of Australia (NHMRC Senior Research Fellowship, ID: 1107914)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Keywords
- hyaluronic acid, HAS2, liver fibrosis, Notch1, hepatic stellate cells, stellate cell activation, TGF-beta, Wilms tumor 1, CD44, TLR4, 4-methylumbelliferone, extracellular matrix, fibrosis treatment
- MeSH terms
- Hyaluronan Synthases, RNA-Seq, Enzyme-Linked Immunosorbent Assay, Humans, Hyaluronic Acid, Hymecromone, Liver Cirrhosis, Hyaluronan Receptors, Toll-Like Receptor 4, Hepatic Stellate Cells, HEK293 Cells
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