Hyaluronan synthase 2–mediated hyaluronan production mediates Notch1 activation and liver fibrosis

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

Younossi, Z. M., Koenig, A. B., Abdelatif, D., Fazel, Y., Henry, L., & Wymer, M. (2016) · Hepatology · doi:10.1002/hep.28431 · Cited by 10,781

Neutrophil Emigration in the Skin, Lungs, and Peritoneum: Different Requirements for CD11/CD18 Revealed by CD18-deficient Mice

Mizgerd, J. P., Kubo, H., Kutkoski, G. J., Bhagwan, S. D., Scharffetter-Kochanek, K., Beaudet, A. L., & Doerschuk, C. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1357 · Cited by 7,332

Liver fibrosis

Bataller, R., & Brenner, D. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24282 · Cited by 4,958

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., & Akira, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.7.3749 · Cited by 3,374

Mechanisms of hepatic stellate cell activation

Tsuchida, T., & Friedman, S. L. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.38 · Cited by 2,909

TLR4 enhances TGF-β signaling and hepatic fibrosis

Seki, E., De Minicis, S., Österreicher, C. H., Kluwe, J., Osawa, Y., Brenner, D. A., & Schwabe, R. F. (2007) · Nature Medicine · doi:10.1038/nm1663 · Cited by 1,942

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

Mederacke, I., Hsu, C. C., Troeger, J. S., Huebener, P., Mu, X., Dapito, D. H., Pradere, J.-P., & Schwabe, R. F. (2013) · Nature Communications · doi:10.1038/ncomms3823 · Cited by 1,443

Regulation of lung injury and repair by Toll-like receptors and hyaluronan

Jiang, D., Liang, J., Fan, J., Yu, S., Chen, S., Luo, Y., Prestwich, G. D., Mascarenhas, M. M., Garg, H. G., Quinn, D. A., et al. (2005) · Nature Medicine · doi:10.1038/nm1315 · Cited by 1,401

Hyaluronan as an Immune Regulator in Human Diseases

Jiang, D., Liang, J., & Noble, P. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00052.2009 · Cited by 1,060

National Vital Statistics Reports NCHS.pdf

Hoyert, D. (2012) · Medical Entomology and Zoology · Cited by 982

Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments

Yuan, Z., Li, Y., Zhang, S., Wang, X., Dou, H., Yu, X., Zhang, Z., Yang, S., & Xiao, M. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01744-8 · Cited by 977

TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis—Updated 2019

Dewidar, B., Meyer, C., Dooley, S., & Meindl-Beinker, A. N. (2019) · Cells · doi:10.3390/cells8111419 · Cited by 837

Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations

Affo, S., Nair, A., Brundu, F., Ravichandra, A., Bhattacharjee, S., Matsuda, M., Chin, L., Filliol, A., Wen, W., Song, X., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.03.012 · Cited by 416

Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts

Bhattacharjee, S., Hamberger, F., Ravichandra, A., Miller, M., Nair, A., Affo, S., Filliol, A., Chin, L., Savage, T. M., Yin, D., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci146987 · Cited by 367

Liver fibrosis: Pathophysiology and clinical implications

Berumen, J. A., Baglieri, J., Kisseleva, T., & Mekeel, K. L. (2020) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1499 · Cited by 287

Hepatic Stellate Cell-Macrophage Crosstalk in Liver Fibrosis and Carcinogenesis

Matsuda, M., & Seki, E. (2020) · Seminars in Liver Disease · doi:10.1055/s-0040-1708876 · Cited by 189

Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment

Wang, Z., Kim, S. Y., Tu, W., Kim, J., Xu, A. M., Yang, Y. M., Matsuda, M., Reolizo, L., Tsuchiya, T., Billet, S., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.04.013 · Cited by 193

Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis

Kumar, V., Xin, X., Ma, J., Tan, C., Osna, N. A., & Mahato, R. I. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113888 · Cited by 165

Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)

Wang, S., & Friedman, S. L. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adi0759 · Cited by 158

Friend or foe? The elusive role of hepatic stellate cells in liver cancer

Cogliati, B., Yashaswini, C. N., Wang, S., Sia, D., & Friedman, S. L. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00821-z · Cited by 159

Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis

Yu, J., Zhu, C., Wang, X., Kim, K., Bartolome, A., Dongiovanni, P., Yates, K. P., Valenti, L., Carrer, M., Sadowski, T., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abe1692 · Cited by 132

A biological guide to glycosaminoglycans: current perspectives and pending questions

Ricard‐Blum, S., Vivès, R. R., Schaefer, L., Götte, M., Merline, R., Passi, A. G., Heldin, P., Magalhães, A., Reis, C. A., Skandalis, S. S., et al. (2024) · FEBS Journal · doi:10.1111/febs.17107 · Cited by 124

Maladaptive regeneration - the reawakening of developmental pathways in NASH and fibrosis

Zhu, C., Tabas, I., Schwabe, R. F., & Pajvani, U. B. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00365-6 · Cited by 112

Hepatic stellate cells: balancing homeostasis, hepatoprotection and fibrogenesis in health and disease

Schwabe, R. F., & Brenner, D. A. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01068-6 · Cited by 112

Tumor microenvironment remodeling-based penetration strategies to amplify nanodrug accessibility to tumor parenchyma

Liu, Y., Zhou, J., Li, Q., Li, L., Jia, Y., Geng, F., Zhou, J., & Yin, T. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.02.019 · Cited by 103

Extra- and Intra-Cellular Mechanisms of Hepatic Stellate Cell Activation

Yan, Y., Zeng, J., Xing, L., & Li, C. (2021) · Biomedicines · doi:10.3390/biomedicines9081014 · Cited by 103

Platelets in chronic liver disease, from bench to bedside

Ramadori, P., Klag, T., Malek, N. P., & Heikenwälder, M. F. (2019) · JHEP Reports · doi:10.1016/j.jhepr.2019.10.001 · Cited by 88

Inhibition of myostatin and related signaling pathways for the treatment of muscle atrophy in motor neuron diseases

Abati, E., Manini, A., Comi, G. P., & Corti, S. P. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04408-w · Cited by 85

TGF-β and RAS jointly unmask primed enhancers to drive metastasis

Lee, J. H., Rivera, F. J. S., He, L. Y., Basnet, H., Chen, F., Spina, E., Li, L., Torner, C., Chan, J. E., Yarlagadda, D. V. K., et al. (2024) · Cell · doi:10.1016/j.cell.2024.08.014 · Cited by 82

Function of TREM1 and TREM2 in Liver-Related Diseases

Sun, H., Feng, J., & Tang, L. (2020) · Cells · doi:10.3390/cells9122626 · Cited by 73

The liver fibrosis niche: Novel insights into the interplay between fibrosis-composing mesenchymal cells, immune cells, endothelial cells, and extracellular matrix

Matsuda, M., & Seki, E. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111556 · Cited by 65

Gα12/13 signaling in metabolic diseases

Yang, Y. M., Kuen, D., Chung, Y., Kurose, H., & Kim, S. G. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0454-5 · Cited by 57

Hyaluronan in liver fibrosis: basic mechanisms, clinical implications, and therapeutic targets

Kim, J., & Seki, E. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000083 · Cited by 57

Fibroblasts in liver cancer: functions and therapeutic translation

Affo, S., Filliol, A., Gores, G. J., & Schwabe, R. F. (2023) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(23)00111-5 · Cited by 49

Recent progress in molecular mechanisms of postoperative recurrence and metastasis of hepatocellular carcinoma

Niu, Z.-S., Wang, W., & Niu, X.-J. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i46.6433 · Cited by 47

Co-encapsulation of collagenase type I and silibinin in chondroitin sulfate coated multilayered nanoparticles for targeted treatment of liver fibrosis

Luo, J., Zhang, Z., Zeng, Y., Dong, Y., & Ma, L. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.117964 · Cited by 47

Gut Microbiota at the Crossroad of Hepatic Oxidative Stress and MASLD

Termite, F., Archilei, S., D’Ambrosio, F., Petrucci, L., Viceconti, N., Iaccarino, R., Liguori, A., Gasbarrini, A., & Miele, L. (2025) · Antioxidants · doi:10.3390/antiox14010056 · Cited by 50

Novel Therapeutic Targets in Liver Fibrosis

Zhang, J., Liu, Q., He, J., & Li, Y. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.766855 · Cited by 48

Biochemical, biophysical, and immunological characterization of respiratory secretions in severe SARS-CoV-2 infections

Kratochvil, M. J., Kaber, G., Demirdjian, S., Cai, P. C., Burgener, E. B., Nagy, N., Barlow, G. L., Popescu, M. C., Nicolls, M. R., Ozawa, M. G., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.152629 · Cited by 46

Biomaterial-based cell delivery strategies to promote liver regeneration

Ali, M., & Payne, S. L. (2021) · Biomaterials Research · doi:10.1186/s40824-021-00206-w · Cited by 45

Cluster of Differentiation 44 Promotes Liver Fibrosis and Serves as a Biomarker in Congestive Hepatopathy

Osawa, Y., Kawai, H., Tsunoda, T., Komatsu, H., Okawara, M., Tsutsui, Y., Yoshida, Y., Yoshikawa, S., Mori, T., Yamazoe, T., et al. (2021) · Hepatology Communications · doi:10.1002/hep4.1721 · Cited by 44

Targeted Nutrient Modifications in Purified Diets Differentially Affect Nonalcoholic Fatty Liver Disease and Metabolic Disease Development in Rodent Models

Radhakrishnan, S., Ke, J., & Pellizzon, M. (2020) · Current Developments in Nutrition · doi:10.1093/cdn/nzaa078 · Cited by 40

Crosstalk between fibroblasts and immunocytes in fibrosis: From molecular mechanisms to clinical trials

Di, X., Chen, J., Li, Y., Wang, M., Wei, J., Li, T., Liao, B., & Luo, D. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1545 · Cited by 40

Exosomal microRNAs as diagnostic and therapeutic biomarkers in non-malignant liver diseases

Hwang, S., & Yang, Y. M. (2021) · Archives of Pharmacal Research · doi:10.1007/s12272-021-01338-2 · Cited by 38

Positive feedback loops between fibroblasts and the mechanical environment contribute to dermal fibrosis

Zhu, L., Liu, L., Wang, A., Liu, J., Huang, X., & Zan, T. (2023) · Matrix Biology · doi:10.1016/j.matbio.2023.05.001 · Cited by 36

Hepatic stellate cell single cell atlas reveals a highly similar activation process across liver disease aetiologies

Merens, V., Knetemann, E., Gürbüz, E., Smet, V. D., Messaoudi, N., Reynaert, H., Verhulst, S., & van Grunsven, L. A. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101223 · Cited by 36

HER2 drives lung fibrosis by activating a metastatic cancer signature in invasive lung fibroblasts

Liu, X., Geng, Y., Liang, J., Coelho, A. L., Yao, C., Deng, N., Wang, Y., Dai, K., Huang, G., Xie, T., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20220126 · Cited by 34

Regulatory role and translational potential of CCL11 in liver fibrosis

Kong, M., Dong, W., Kang, A., Kuai, Y., Xu, T., Fan, Z., Shi, L., Sun, D., Lu, Y., Li, Z., et al. (2023) · Hepatology · doi:10.1097/hep.0000000000000287 · Cited by 34

The IGF2BP3/Notch/Jag1 pathway: A key regulator of hepatic stellate cell ferroptosis in liver fibrosis

Li, X., Li, Y., Zhang, W., Jiang, F., Lin, L., Wang, Y., Wu, L., Zeng, H., & Zheng, J. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1793 · Cited by 33

Macrophage Notch1 inhibits TAK1 function and RIPK3-mediated hepatocyte necroptosis through activation of β-catenin signaling in liver ischemia and reperfusion injury

Xu, D., Qu, X., Tian, Y., Zhao, J., Xi, Z., Xue, F., Ma, X., Zhu, J., & Xia, Q. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00901-8 · Cited by 32

4-methylumbelliferone Prevents Liver Fibrosis by Affecting Hyaluronan Deposition, FSTL1 Expression and Cell Localization

Andreichenko, I. N., Tsitrina, A. A., Fokin, A. V., Gabdulkhakova, A. I., Maltsev, D. I., Perelman, G., Bulgakova, E. V., Куликов, А. М., Mikaelyan, A. S., & Kotelevtsev, Y. V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246301 · Cited by 31

Hyaluronan synthase 2, a target of miR-200c, promotes carbon tetrachloride-induced acute and chronic liver inflammation via regulation of CCL3 and CCL4

Kim, S. M., Song, G. Y., Shim, A., Lee, J. H., Eom, C. B., Liu, C., Yang, Y. M., & Seki, E. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00781-5 · Cited by 29

‘Two-faces’ of hyaluronan, a dynamic barometer of disease progression in tumor microenvironment

Liu, Y., Li, L., Wang, L., Lu, L., Li, Y., Huang, G., & Song, J. (2023) · Discover Oncology · doi:10.1007/s12672-023-00618-1 · Cited by 31

Noncellular components in the liver cancer stem cell niche: Biology and potential clinical implications

Lam, K.-H., & Ma, S. (2022) · Hepatology · doi:10.1002/hep.32629 · Cited by 28

Photochemically Activated Notch Signaling Hydrogel Preferentially Differentiates Human Derived Hepatoblasts to Cholangiocytes

Rizwan, M., Fokina, A., Kivijärvi, T., Ogawa, M., Kufleitner, M., Laselva, O., Smith, L. J., Bear, C. E., Ogawa, S., Keller, G. M., et al. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202006116 · Cited by 27

Metastatic tumor growth in steatotic liver is promoted by HAS2-mediated fibrotic tumor microenvironment

Yang, Y. M., Kim, J., Wang, Z., Kim, J., Kim, S. Y., Cho, G. J., Lee, J. H., Kim, S. M., Tsuchiya, T., Matsuda, M., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci180802 · Cited by 26

Modulation of hyaluronan signaling as a therapeutic target in human disease

Garantziotis, S. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107993 · Cited by 26

Hyaluronan in the pathogenesis of acute and post-acute COVID-19 infection

Barnes, H. W., Demirdjian, S., Haddock, N. L., Kaber, G., Martinez, H. A., Nagy, N., Karmouty‐Quintana, H., & Bollyky, P. L. (2023) · Matrix Biology · doi:10.1016/j.matbio.2023.02.001 · Cited by 26

Supramolecular Nanoarchitectonics Based on Antagonist Peptide Self‐Assembly for Treatment of Liver Fibrosis

Li, B., Huang, Y., Bao, J., Xu, Z., Yan, X., & Zou, Q. (2023) · Small · doi:10.1002/smll.202304675 · Cited by 24

Cancer-associated fibroblasts in intrahepatic cholangiocarcinoma progression and therapeutic resistance

Ravichandra, A., Bhattacharjee, S., & Affò, S. (2022) · Advances in cancer research · doi:10.1016/bs.acr.2022.01.009 · Cited by 23

The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge

Zhu, L., Luo, S., Zhu, Y., Tang, S., Li, C., Jin, X., Wu, F.-L., Jiang, H., Wu, L., & Xu, Y. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s385977 · Cited by 21

Excessive DNA damage mediates ECM degradation via the RBBP8/NOTCH1 pathway in sporadic aortic dissection

Zhou, Z., Liu, Y., Gao, S., Zhou, M., Qi, F., Ding, N., Zhang, J., Li, R., Wang, J., Shi, J., et al. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166303 · Cited by 21

Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis

Mukherjee, S. K., Chakraborty, M., Ulmasov, B., McCommis, K. S., Zhang, J., Carpenter, D. H., Msengi, E. N., Haubner, J., Guo, C. H., Pike, D. P., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101364 · Cited by 20

4-Methylumbelliferone Targets Revealed by Public Data Analysis and Liver Transcriptome Sequencing

Tsitrina, A. A., Halimani, N., Andreichenko, I. N., Sabirov, M. S., Nesterchuk, M. V., Dashenkova, N. O., Romanov, R. A., Bulgakova, E. V., Mikaelyan, A. S., & Kotelevtsev, Y. V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032129 · Cited by 20

Glisson’s capsule matrix structure and function is altered in patients with cirrhosis irrespective of aetiology

Llewellyn, J., Fede, C., Loneker, A. E., Friday, C. S., Hast, M. W., Theise, N. D., Furth, E. E., Guido, M., Stecco, C., & Wells, R. G. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100760 · Cited by 20

Dual Oxygen‐Supply Immunosuppression‐Inhibiting Nanomedicine to Avoid the Intratumoral Recruitment of Myeloid‐Derived Suppressor Cells

Yang, Z., Zuo, H., Hou, Y., Zhou, S., Zhang, Y., Yang, W., He, J., Shen, X., & Peng, Q. (2024) · Small · doi:10.1002/smll.202406860 · Cited by 19

Increased SPHK1 and HAS2 Expressions Correlate to Poor Prognosis in Pancreatic Cancer

Yu, M., Zhang, K., Wang, S., Li, X., Chen, Z., Ning, F., Ning, C., Wang, L., Li, J., Zhang, B., et al. (2021) · BioMed Research International · doi:10.1155/2021/8861766 · Cited by 19

S1PR1 serves as a viable drug target against pulmonary fibrosis by increasing the integrity of the endothelial barrier of the lung

Hao, M., Fu, R., Tai, J., Tian, Z., Yuan, X., Chen, Y., Wang, M., Jiang, H., Ji, M., Lai, F., et al. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.10.006 · Cited by 18

Combined Amphiphilic Silybin Meglumine Nanosuspension Effective Against Hepatic Fibrosis in Mice Model

Yang, Q., Tan, T., He, Q., Guo, C., Chen, D., Tan, Y., Feng, J., Song, X., Gong, T., & Li, J. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s407762 · Cited by 17

Emerging targets and potential therapeutic agents in non-alcoholic fatty liver disease treatment

Yang, Y., Zhao, Y., Li, W., Wu, Y., Wang, X., Wang, Y., Liu, T.-M., Ye, T., Xie, Y., Cheng, Z., et al. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112311 · Cited by 17

The Pro-fibrotic Response of Mesenchymal Leader Cells to Lens Wounding Involves Hyaluronic Acid, Its Receptor RHAMM, and Vimentin

Menko, A. S., Romisher, A., & Walker, J. L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.862423 · Cited by 17

Hyaluronan synthesis inhibition impairs antigen presentation and delays transplantation rejection

Marshall, P. L., Nagy, N., Kaber, G., Barlow, G. L., Ramesh, A., Xie, B. J., Linde, M. H., Haddock, N. L., Lester, C. A., Tran, Q., et al. (2020) · Matrix Biology · doi:10.1016/j.matbio.2020.12.001 · Cited by 15

Non-invasive diagnosis of liver fibrosis via MRI using targeted gadolinium-based nanoparticles

Wu, S., Xu, T., Gao, J., Zhang, Q., Huang, Y., Liu, Z., Hao, X., Yao, Z., Hao, X., Wu, P., et al. (2024) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-024-06894-5 · Cited by 15

GNA14 stimulation of KLF7 promotes malignant growth of endometrial cancer through upregulation of HAS2

Wang, J., Teng, F., Chai, H., Zhang, C., Liang, X., & Yang, Y. (2021) · BMC Cancer · doi:10.1186/s12885-021-08202-y · Cited by 15

Inhibition of hyaluronan synthesis by 4-methylumbelliferone ameliorates non-alcoholic steatohepatitis in choline-deficient l-amino acid-defined diet-induced murine model

Yang, Y. M., Wang, Z., Matsuda, M., & Seki, E. (2021) · Archives of Pharmacal Research · doi:10.1007/s12272-021-01309-7 · Cited by 15

Loss of ERdj5 exacerbates oxidative stress in mice with alcoholic liver disease via suppressing Nrf2

Hong, D.-G., Song, G. Y., Eom, C. B., Ahn, J.-H., Kim, S. M., Shim, A., Han, Y., Roh, Y., Han, C. Y., Bae, E. J., et al. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.03.027 · Cited by 15

Dynamic crosstalk between HSCs and liver microenvironment: multicellular interactions in the regulation of liver fibrosis

Wang, L., Huang, Y., Chen, J., Gao, J., Chen, S., Zhao, M., Lin, J., Zhou, S., Shen, Y., & Cheng, Y. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1635763 · Cited by 15

Hyaluronic Acid in Liver Fibrosis: Role in Inflammation, Tissue Remodeling, and Disease Progression

Rojano-Alfonso, C., López‐Vicario, C., Romero-Grimaldo, B., Contreras, B. J., Clària, J., & Titos, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262010139 · Cited by 14

Identification and functional validation of miR-190b-5p and miR-296-3p as novel therapeutic attenuators of liver fibrosis

Markovic, J., Li, R., Khanal, R., Peng, Q., Möbus, S., Yuan, Q., Engel, B., Taubert, R., Vondran, F. W. R., Bantel, H., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.08.014 · Cited by 14

Activated cardiac fibroblasts are a primary source of high-molecular-weight hyaluronan production

Little, D. T., Howard, C. M., Pendergraft, E., Brittian, K. R., Audam, T. N., Lukudu, E. W., Smith, J. L., Nguyen, D. C., Nishida, Y., Yamaguchi, Y., et al. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00786.2024 · Cited by 14

Bioengineering liver microtissues for modeling non-alcoholic fatty liver disease

Aasadollahei, N., Rezaei, N., Golroo, R., Agarwal, T., Vosough, M., & Piryaei, A. (2023) · EXCLI journal · doi:10.17179/excli2022-5892 · Cited by 14

Targeted platelet with hydrogen peroxide responsive behavior for non-alcoholic steatohepatitis detection

Liu, J., Liu, X., Shan, Y., Ting, H. J., Yu, X., Wang, J., & Liu, B. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122506 · Cited by 13

LncRNA CCAT2, involving miR-34a/TGF-β1/Smad4 signaling, regulate hepatic stellate cells proliferation

Gao, H., Wang, X., Ma, H., Lin, S., Zhang, D., Wu, W., Liao, Z., Chen, M., Ye, H., Li, Q., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-25738-6 · Cited by 15

Regulatory Functions and Mechanisms of Circular RNAs in Hepatic Stellate Cell Activation and Liver Fibrosis

Nokkeaw, A., Thamjamrassri, P., Tangkijvanich, P., & Ariyachet, C. (2023) · Cells · doi:10.3390/cells12030378 · Cited by 13

Targeting of Secretory Proteins as a Therapeutic Strategy for Treatment of Nonalcoholic Steatohepatitis (NASH)

Kim, K., & Kim, K. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072296 · Cited by 13

Jiawei Taohe Chengqi decoction inhibition of the notch signal pathway affects macrophage reprogramming to inhibit HSCs activation for the treatment of hepatic fibrosis

Shao, C., Xu, H., Sun, X., Pan, Y., Liang, X., Huang, J., He, Y., Guo, W., Ye, L., & Zhang, J. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117486 · Cited by 12

Interactions between hepatic stellate cells and immune cells: Implications for liver fibrosis

Xie, D., Huang, Y., Yu, Y., Jin, W., Zhang, X., & Yu, F. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.168062 · Cited by 12

Knockdown of Hyaluronan synthase 2 suppresses liver fibrosis in mice via induction of transcriptomic changes similar to 4MU treatment

Halimani, N., Nesterchuk, M. V., Tsitrina, A. A., Sabirov, M. S., Andreichenko, I. N., Dashenkova, N. O., Petrova, E., Куликов, А. М., Zatsepin, T. S., Romanov, R. A., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-53089-x · Cited by 12

Cancer-Associated Fibroblasts in Intrahepatic Cholangiocarcinoma

Affò, S., Sererols-Viñas, L., Garcia‐Vicién, G., Cadamuro, M., Chakraborty, S., & Sirica, A. E. (2024) · American Journal Of Pathology · doi:10.1016/j.ajpath.2024.07.009 · Cited by 12

Hyaluronic acid promotes hepatocellular carcinoma proliferation by upregulating CD44 expression and enhancing glucose metabolism flux

Zhang, X., Zhong, Y., Miao, Z., & Yang, Q. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114035 · Cited by 12

A thioacetamide-induced liver fibrosis model for pre-clinical studies in microminipig

Nishi, K., Yagi, H., Ohtomo, M., Nagata, S., Udagawa, D., Tsuchida, T., Morisaku, T., & Kitagawa, Y. (2023) · Scientific Reports · doi:10.1038/s41598-023-42144-8 · Cited by 12

Atractylodes Lancea and Its Constituent, Atractylodin, Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease via AMPK Activation

Song, G. Y., Kim, S. M., Back, S. H., Yang, S.-B., & Yang, Y. M. (2024) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2024.083 · Cited by 11

Dual‐Integrin‐Targeted Supramolecular Peptide Nanoarchitectonics for Enhanced Hepatic Delivery and Antifibrotic Therapy

Li, B., Bao, J., Huang, Y., Liu, J., Yan, X., & Zou, Q. (2024) · Small · doi:10.1002/smll.202409038 · Cited by 11

Intercellular communication interference through energy metabolism-related exosome secretion inhibition for liver fibrosis treatment

Zhang, M., Jing, H., Liu, X., Milichko, V. A., Dou, Y., Ren, Y., Qiu, Z., Li, W., Liu, W., Wang, X., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.07.008 · Cited by 11

Cardiomyocyte-restricted high-mobility group box 1 (HMGB1) deletion leads to small heart and glycolipid metabolic disorder through GR/PGC-1α signalling

Yu, P., Liu, M., Zhang, B., Yu, Y., Su, E., Xie, S., Zhang, L., Yang, X., Jiang, H., Chen, R., et al. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-00340-9 · Cited by 11

Inhibition of hyaluronan secretion by novel coumarin compounds and chitin synthesis inhibitors

Tsitrina, A. A., Krasylov, I. V., Maltsev, D. I., Andreichenko, I. N., Москвина, В. С., Ivankov, D. N., Bulgakova, E. V., Nesterchuk, M. V., Shashkovskaya, V. S., Dashenkova, N. O., et al. (2021) · Glycobiology · doi:10.1093/glycob/cwab038 · Cited by 11

Endogenously-Produced Hyaluronan and Its Potential to Regulate the Development of Peritoneal Adhesions

Kocurková, A., Nešporová, K., Sandanusova, M., Kerberova, M., Lehká, K., Velebný, V., Kubala, L., & Ambrožová, G. (2021) · Biomolecules · doi:10.3390/biom12010045 · Cited by 11

Tumor necrosis factor-inducible gene 6 protein and its derived peptide ameliorate liver fibrosis by repressing CD44 activation in mice with alcohol-related liver disease

Han, J., Lee, C., Jeong, H., Jeon, S.-H., Lee, M., Lee, H., Choi, Y. H., & Jung, Y. (2024) · Journal of Biomedical Science · doi:10.1186/s12929-024-01042-5 · Cited by 11

Identification of a novel role for TL1A/DR3 deficiency in acute respiratory distress syndrome that exacerbates alveolar epithelial disruption

Zhang, D., Zhang, J., Zhang, J., Ji, X., Qi, Q., Xu, J., Pan, Y., Liu, X., Sun, F., Zeng, R., et al. (2023) · Respiratory Research · doi:10.1186/s12931-023-02488-1 · Cited by 10

Didymin ameliorates ulcerative colitis-associated secondary liver damage by facilitating Notch1 degradation

Lv, Q., Wang, J., Yang, H., Chen, X., Zhang, Y., Ji, G.-Y., Hu, L., & Zhang, Y. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155561 · Cited by 10

Radix rehmanniae praeparata extracts ameliorate hepatic ischemia-reperfusion injury by reversing LRP1-NOTCH1-C/EBPβ axis-mediated senescence fate of LSECs

Zhang, Y., Qu, J., Luo, R., Jia, K., Fan, G., Li, F., Wu, R., Li, J., & Li, X. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155923 · Cited by 10

Understanding Fascial Tissue on the Molecular Level—How Its Unique Properties Enable Adaptation or Dysfunction

Kirkness, K. B., & Scarlata, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010160 · Cited by 9

CD44 expression in the bile duct epithelium is related to hepatic fibrosis in nonalcoholic steatohepatitis rats induced by a choline-deficient, methionine-lowered, L-amino acid diet

Uno, K., Miyajima, K., Toma, M., Suzuki‐Kemuriyama, N., & Nakae, D. (2021) · Journal of Toxicologic Pathology · doi:10.1293/tox.2021-0069 · Cited by 9

Macrophage heterogeneity in liver fibrosis

Wang, W., Li, S., Liu, Y., Ding, X., Yang, Y., Chen, S., Cao, J., Tacke, F., Dong, W., & Lan, T. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1639455 · Cited by 8

Increased HA/CD44/TGFβ signaling implicates in renal fibrosis of a Col4a5 mutant Alport mice

Bao, Y., Wu, W., Lin, J., Yang, Y., Lin, S. K., Su, J., Qin, Y., Wang, B., & Duan, S. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01146-0 · Cited by 8

Inhibition of circular RNA ASPH reduces the proliferation and promotes the apoptosis of hepatic stellate cells in hepatic fibrosis

Meng, H., Jiang, L., Jia, P., Niu, R., Bu, F., Zhu, Y. Y., Pan, X., Li, J., Liu, J., Zhang, Y., et al. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115451 · Cited by 8

Upregulation of HAS2 promotes glioma cell proliferation and chemoresistance via c-myc

Wang, J., Ruan, S., Yu, T., Meng, X., Ran, J., Cen, C., Kong, C., Bao, X., Li, Z., Wang, Y., et al. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111218 · Cited by 7

A novel 11β-HSD1 inhibitor ameliorates liver fibrosis by inhibiting the notch signaling pathway and increasing NK cell population

Kim, J. E., Kim, Y., Bae, J., Yoon, E. L., Kim, H. S., Lee, S. R., Yoon, T. H., & Jun, D. W. (2025) · Archives of Pharmacal Research · doi:10.1007/s12272-025-01534-4 · Cited by 7

Cirrhosis Promotes Cardiac Fibrosis Development by Inhibiting Notch1 in Cardiac Fibroblasts

Sun, H., Song, K., Zhou, Z.-Y., Tu, B., Zhou, Y., Lin, L.-C., Liu, Z., Liu, Z., Sha, J.-M., Shi, Y. X., et al. (2025) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2024.11.015 · Cited by 7

Inflammation-Associated Cytotoxic Agents in Tumorigenesis

Arnhold, J. (2023) · Cancers · doi:10.3390/cancers16010081 · Cited by 7

HAstening the development of liver fibrosis

Ray, K. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0184-0 · Cited by 5

Hyaluronan synthase 2, a target of miR-200c, promotes carbon tetrachloride-induced acute and chronic liver inflammation via regulation of CCL3 and CCL4

Kim, S. M., Song, G. Y., Shim, A., Lee, J. H., Eom, C. B., Liu, C., Yang, Y. M., & Seki, E. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00781-5 · Cited by 29

Hyaluronan in liver fibrosis: basic mechanisms, clinical implications, and therapeutic targets

Kim, J., & Seki, E. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000083 · Cited by 57

Knockdown of Hyaluronan synthase 2 suppresses liver fibrosis in mice via induction of transcriptomic changes similar to 4MU treatment

Halimani, N., Nesterchuk, M. V., Tsitrina, A. A., Sabirov, M. S., Andreichenko, I. N., Dashenkova, N. O., Petrova, E., Куликов, А. М., Zatsepin, T. S., Romanov, R. A., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-53089-x · Cited by 12

MASP1‑METTL3‑HAS2 axis aggravates liver fibrosis through HMW‑HA‑mediated senescence inhibition and LMW‑HA‑induced activation of hepatic stellate cells

Liu, X., Wang, P., Zeng, W., Liu, H., Lin, J., Gan, W., Yu, M., Zheng, Y., Luo, Q., Zhang, M., et al. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-09158-2