Cited by 314Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisPulmonary Hypertension Research and TreatmentsTransplantation: Methods and Outcomes

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Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis

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Ng, Benjamin, Dong, Jinrui, D’Agostino, Giuseppe, Viswanathan, Sivakumar, Widjaja, Anissa A., Lim, Wei-Wen, Ko, Nicole S. J., Tan, Jessie, Chothani, Sonia P., Huang, Benjamin, Xie, Chen, Pua, Chee Jian, Chacko, Ann-Marie, Guimarães-Camboa, Nuno, Evans, Sylvia M., Byrne, Adam J., Maher, Toby M., Liang, Jiurong, Jiang, Dianhua, Noble, Paul W., Schafer, Sebastian, Cook, Stuart A.·2019·Science Translational Medicine

DOI 10.1126/scitranslmed.aaw1237

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Abstract

Interleukin-11 is important for lung fibroblast activation in idiopathic pulmonary fibrosis, and its signaling represents a therapeutic target.

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See all 314

Authors: Ng, B., Dong, J., D’Agostino, G., Viswanathan, S., Widjaja, A. A., Lim, W.-W., Ko, N. S. J., Tan, J., Chothani, S. P., Huang, B., Xie, C., Pua, C. J., Chacko, A.-M., Guimarães-Camboa, N., Evans, S. M., Byrne, A. J., Maher, T. M., Liang, J., Jiang, D., Noble, P. W., Schafer, S., & Cook, S. A.
Affiliations: National University of Singapore (SG)
National Heart Centre Singapore (SG)
Institute for Cardiovascular Regeneration, Goethe University Frankfurt, Frankfurt 60590, Germany.
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Imperial College London (GB)
Royal Brompton Hospital (GB)
Cedars-Sinai Medical Center (US)
National Heart Centre Singapore, 169609 Singapore, Singapore.
Corresponding author: Ng, Benjamin
Dong, Jinrui
D’Agostino, Giuseppe
Cook, Stuart A.
ORCID: Ng, Benjamin
Dong, Jinrui
D’Agostino, Giuseppe
Viswanathan, Sivakumar
Widjaja, Anissa A.
Lim, Wei-Wen
Chothani, Sonia P.
Huang, Benjamin
Xie, Chen
Pua, Chee Jian
Chacko, Ann-Marie
Byrne, Adam J.
Maher, Toby M.
Liang, Jiurong
Jiang, Dianhua
Noble, Paul W.
Schafer, Sebastian
Cook, Stuart A.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2019-09-25
Volume: 11
Issue: 511
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.aaw1237
OpenAlex: W2975410560
Semantic Scholar: 707edf16b55c02f433b992ddc906064a1c8f30f7
Cited by: 314
References: 92
Citations by year: 2026: 41 · 2025: 42 · 2024: 51 · 2023: 45 · 2022: 45 · 2021: 55 · 2020: 29 · 2019: 6
FWCI: 24.67
Type: journal article
Language: en
Open access: green
doi.org
Licence: cc-by-nd
Locations: Science Translational Medicine (publishedVersion)
bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nd)
PubMed (publishedVersion)
Funders: National Medical Research Council (NMRC) Singapore (NMRC/OFYIRG/0053/2017)
NIHR Clinician Scientist Fellowship (HIHR Ref: CS-2013-13-017)
British Lung Foundation Chair in Respiratory Research (C17-3)
the National Medical Research Council (NMRC) Singapore STaR awards (NMRC/STaR/0011/2012)
National Medical Research Council (NMRC) Singapore STaR awards (NMRC/STaR/0029/2017)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
Keywords: interleukin-11, idiopathic pulmonary fibrosis, pulmonary fibrosis, lung fibroblast activation, myofibroblast activation, bleomycin-induced fibrosis, ERK signaling, Smad signaling, lung inflammation, therapeutic target
MeSH terms: Animals, Bleomycin, Fibroblasts, Humans, Lung, Severity of Illness Index, Signal Transduction, Up-Regulation, Interleukin-11, Mice, Knockout, Interleukin-11 Receptor alpha Subunit, Idiopathic Pulmonary Fibrosis, Antibodies, Neutralizing

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Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis

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