Transforming medicine with the microbiome
Abstract
Advances in microbiome research are spurring the development of new therapeutics for a variety of diseases, but translational challenges remain.
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The microbial microenvironment is primarily comprised of intestinal and intra-tumoral microorganisms and their metabolites, which can facilitate or inhibit tumor progression and impact the effectiveness and toxicity of cancer treatments.
“The microbial microenvironment is primarily comprised of intestinal and intra-tumoral microorganisms and their metabolites, which possess the ability to either facilitate or inhibit tumor progression and impact the effectiveness and toxicity of cancer treatments.329–332”
From Drug repurposing for cancer therapy (2024) · cites this paper as [329]
Pre- and pro-biotics offer a route to manipulate the microbiome in prodromal PD.
“Alongside antibiotics, pre- and pro-biotics offer a route to manipulate the microbiome in prodromal PD [174–176], as assessed in Table 1.”
From The gut–brain axis in early Parkinson’s disease: from prodrome to prevention (2025) · cites this paper as [174]
Pre- and pro-biotic interventions are shown to reverse PD pathology and symptoms in animal models.
“These interventions are shown to reverse PD pathology and symptoms in animal models, but these findings have not been reliably replicated in human studies, particularly for motor symptoms.”
From The gut–brain axis in early Parkinson’s disease: from prodrome to prevention (2025) · cites this paper as [174]
Cites
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241 · see citing works
The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice
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Zmora, N., Zilberman-Schapira, G., Suez, J., Mor, U., Dori-Bachash, M., Bashiardes, S., Kotler, E., Zur, M., Regev-Lehavi, D., Brik, R. B.-Z., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.041 · Cited by 1,695 · see citing works
Self-citationDisease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease
Norman, J. M., Handley, S. A., Baldridge, M. T., Droit, L., Liu, C. Y., Keller, B. C., Kambal, A., Monaco, C. L., Zhao, G., Fleshner, P., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.002 · Cited by 1,285 · see citing works
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Hallmarks of aging: An expanding universe
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023) · Cell · doi:10.1016/j.cell.2022.11.001 · Cited by 6,549 · see citing works
Microbiome definition re-visited: old concepts and new challenges
Berg, G., Rybakova, D., Fischer, D., Cernava, T., Vergès, M.-C. C., Charles, T., Chen, X., Cocolin, L., Eversole, K., Corral, G. H., et al. (2020) · Microbiome · doi:10.1186/s40168-020-00875-0 · Cited by 2,275 · see citing works
Environmental factors shaping the gut microbiome in a Dutch population
Gacesa, R., Kurilshikov, A., Vich Vila, A., Sinha, T., Klaassen, M. A. Y., Bolte, L. A., Andreu-Sánchez, S., Chen, L., Collij, V., Hu, S., et al. (2022) · Nature · doi:10.1038/s41586-022-04567-7 · Cited by 735 · see citing works
Shaping the Future of Probiotics and Prebiotics
Cunningham, M., Azcarate-Peril, M. A., Barnard, A., Benoit, V., Grimaldi, R., Guyonnet, D., Holscher, H. D., Hunter, K., Manurung, S., Obis, D., et al. (2021) · Trends in Microbiology · doi:10.1016/j.tim.2021.01.003 · Cited by 637 · see citing works
Drug repurposing for cancer therapy
Xia, Y., Sun, M., Huang, H., & Jin, W.-L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01808-1 · Cited by 443 · see citing works
The microbiome–gut–brain axis in Parkinson disease — from basic research to the clinic
Tan, A. H., Lim, S. Y., & Lang, A. E. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00681-2 · Cited by 392 · see citing works
Probiotics and the microbiota-gut-brain axis: Focus on psychiatry
Mörkl, S., Butler, M. I., Holl, A., Cryan, J. F., & Dinan, T. G. (2020) · Current Nutrition Reports · doi:10.1007/s13668-020-00313-5 · Cited by 337 · see citing works
An ecological framework to understand the efficacy of fecal microbiota transplantation
Xiao, Y., Angulo, M. T., Lao, S., Weiss, S. T., & Liu, Y.-Y. (2020) · Nature Communications · doi:10.1038/s41467-020-17180-x · Cited by 89 · see citing works
The gut–brain axis in early Parkinson’s disease: from prodrome to prevention
Oliver, P. J., Civitelli, L., & Hu, M. T. (2025) · Journal of Neurology · doi:10.1007/s00415-025-13138-5 · Cited by 42 · see citing works
“Alongside antibiotics, pre-and pro-biotics offer a route to manipulate the microbiome in prodromal PD [174–176], as assessed in Table 1.”
Gödel, C., Kunkel, B., Kashani, A., Lassmann, H., Arumugam, M., & Krishnamoorthy, G. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01766-9 · Cited by 28 · see citing works
- Authors
- Zmora, N., Soffer, E., & Elinav, E.
- Affiliations
- Tel Aviv Sourasky Medical Center (IL)
- Weizmann Institute of Science (IL)
- Corresponding author
- Zmora, Niv
- Soffer, Eliran
- Elinav, Eran
- Venue
- Science Translational Medicine
- Published
- 2019-01-30
- Volume
- 11
- Issue
- 477
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2914251418
- Cited by
- 92
- References
- 4
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 16 · 2023: 14 · 2022: 11 · 2021: 9 · 2020: 13 · 2019: 6
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- microbiome, microbiota-based therapy, translational challenges, disease treatment
- MeSH terms
- Fecal Microbiota Transplantation, Animals, Diet, Humans, Probiotics, Gastrointestinal Tract, Precision Medicine, Microbiota
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