Cited by 201Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsCircadian rhythm and melatonin

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Chi3l1 /YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis

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Lananna, Brian V., McKee, Celia A., King, Melvin W., Del-Aguila, Jorge L., Dimitry, Julie M., Farias, Fabiana H. G., Nadarajah, Collin J., Xiong, David D., Guo, Chun, Cammack, Alexander J., Elias, Jack A., Zhang, Jinsong, Cruchaga, Carlos, Musiek, Erik S.·2020·Science Translational Medicine

DOI 10.1126/scitranslmed.aax3519PMC PMC7808313

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Abstract

Chi3l1 /YKL-40 is regulated by BMAL1 in astrocytes and influences AD pathogenesis in both mouse models and humans.

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K284-6111 prevents the amyloid beta-induced neuroinflammation and impairment of recognition memory through inhibition of NF-κB-mediated CHI3L1 expression
Choi, J. Y., Yeo, I. J., Kim, K. C., Choi, W. R., Jung, J., Han, S., & Hong, J. T. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1269-3 · Cited by 65
Retracted
Neurotoxic reactive astrocytes are induced by activated microglia
Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971
An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875
Microglia Function in the Central Nervous System During Health and Neurodegeneration
Colonna, M., & Butovsky, O. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052358 · Cited by 2,894
Genomic analysis of reactive astrogliosis
Zamanian, J. L., Xu, L., Foo, L. C., Nouri, N., Zhou, L., Giffard, R. G., & Barres, B. A. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6221-11.2012 · Cited by 2,404
Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse
Zhang, Y., Sloan, S. A., Clarke, L. E., Caneda, C., Plaza, C. A., Blumenthal, P. D., Vogel, H., Steinberg, G. K., Edwards, M. S. B., Li, G., et al. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.013 · Cited by 2,295
Central and Peripheral Circadian Clocks in Mammals
Mohawk, J. A., Green, C. B., & Takahashi, J. S. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153128 · Cited by 2,265
Transcriptional architecture and chromatin landscape of the core circadian clock in mammals
Koike, N., Yoo, S.-H., Huang, H.-C., Kumar, V., Lee, C., Kim, T.-K., & Takahashi, J. S. (2012) · Science · doi:10.1126/science.1226339 · Cited by 1,464
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease
Zhou, Y., Song, W. M., Andhey, P. S., Swain, A., Levy, T., Miller, K. R., Poliani, P. L., Cominelli, M., Grover, S., Gilfillan, S., et al. (2020) · Nature Medicine · doi:10.1038/s41591-019-0695-9 · Cited by 1,150
Aβ42‐driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
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Additional file 2 of Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers
Lane, R. M., Darreh-Shori, T., Junge, C., Li, D., Yang, Q., Edwards, A., Graham, D. L., Moore, K. M., & Mummery, C. J. (2024) · Figshare · doi:10.6084/m9.figshare.25572641
Additional file 5 of Single-cell transcriptome reveals Staphylococcus aureus modulating fibroblast differentiation in the bone-implant interface
Yu, J., Wang, B., Zhang, F., Ren, Z., Jiang, F., Hamushan, M., Li, M., Guo, G., & Shen, H. (2023) · Figshare · doi:10.6084/m9.figshare.22620074
Additional file 10 of Single-cell transcriptome reveals Staphylococcus aureus modulating fibroblast differentiation in the bone-implant interface
Yu, J., Wang, B., Zhang, F., Ren, Z., Jiang, F., Hamushan, M., Li, M., Guo, G., & Shen, H. (2023) · Figshare · doi:10.6084/m9.figshare.22620089
Additional file 1 of Single-cell transcriptome reveals Staphylococcus aureus modulating fibroblast differentiation in the bone-implant interface
Yu, J., Wang, B., Zhang, F., Ren, Z., Jiang, F., Hamushan, M., Li, M., Guo, G., & Shen, H. (2023) · Figshare · doi:10.6084/m9.figshare.22620062
Additional file 9 of Single-cell transcriptome reveals Staphylococcus aureus modulating fibroblast differentiation in the bone-implant interface
Yu, J., Wang, B., Zhang, F., Ren, Z., Jiang, F., Hamushan, M., Li, M., Guo, G., & Shen, H. (2023) · Figshare · doi:10.6084/m9.figshare.22620086
Additional file 1 of Longitudinal cerebrospinal fluid measurements show glial hypo- and hyperactivation in predementia Alzheimer’s disease
Nordengen, K., Kirsebom, B.-E., Richter, G., Pålhaugen, L., Gísladóttir, B., Siafarikas, N., Nakling, A. E., Rongve, A., Bråthen, G., Grøntvedt, G. R., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26653528
Additional file 3 of Single-cell transcriptome reveals Staphylococcus aureus modulating fibroblast differentiation in the bone-implant interface
Yu, J., Wang, B., Zhang, F., Ren, Z., Jiang, F., Hamushan, M., Li, M., Guo, G., & Shen, H. (2023) · Figshare · doi:10.6084/m9.figshare.22620068
Additional file 7 of Single-cell transcriptome reveals Staphylococcus aureus modulating fibroblast differentiation in the bone-implant interface
Yu, J., Wang, B., Zhang, F., Ren, Z., Jiang, F., Hamushan, M., Li, M., Guo, G., & Shen, H. (2023) · Figshare · doi:10.6084/m9.figshare.22620080
Additional file 8 of Single-cell transcriptome reveals Staphylococcus aureus modulating fibroblast differentiation in the bone-implant interface
Yu, J., Wang, B., Zhang, F., Ren, Z., Jiang, F., Hamushan, M., Li, M., Guo, G., & Shen, H. (2023) · Figshare · doi:10.6084/m9.figshare.22620083
Additional file 2 of Longitudinal cerebrospinal fluid measurements show glial hypo- and hyperactivation in predementia Alzheimer’s disease
Nordengen, K., Kirsebom, B.-E., Richter, G., Pålhaugen, L., Gísladóttir, B., Siafarikas, N., Nakling, A. E., Rongve, A., Bråthen, G., Grøntvedt, G. R., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26653531
Additional file 4 of Single-cell transcriptome reveals Staphylococcus aureus modulating fibroblast differentiation in the bone-implant interface
Yu, J., Wang, B., Zhang, F., Ren, Z., Jiang, F., Hamushan, M., Li, M., Guo, G., & Shen, H. (2023) · Figshare · doi:10.6084/m9.figshare.22620071
Additional file 1 of Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers
Lane, R. M., Darreh-Shori, T., Junge, C., Li, D., Yang, Q., Edwards, A., Graham, D. L., Moore, K. M., & Mummery, C. J. (2024) · Figshare · doi:10.6084/m9.figshare.25572515
Additional file 6 of Single-cell transcriptome reveals Staphylococcus aureus modulating fibroblast differentiation in the bone-implant interface
Yu, J., Wang, B., Zhang, F., Ren, Z., Jiang, F., Hamushan, M., Li, M., Guo, G., & Shen, H. (2023) · Figshare · doi:10.6084/m9.figshare.22620077
Additional file 3 of Longitudinal cerebrospinal fluid measurements show glial hypo- and hyperactivation in predementia Alzheimer’s disease
Nordengen, K., Kirsebom, B.-E., Richter, G., Pålhaugen, L., Gísladóttir, B., Siafarikas, N., Nakling, A. E., Rongve, A., Bråthen, G., Grøntvedt, G. R., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26653534
Additional file 2 of Single-cell transcriptome reveals Staphylococcus aureus modulating fibroblast differentiation in the bone-implant interface
Yu, J., Wang, B., Zhang, F., Ren, Z., Jiang, F., Hamushan, M., Li, M., Guo, G., & Shen, H. (2023) · Figshare · doi:10.6084/m9.figshare.22620065
Additional file 3 of Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers
Lane, R. M., Darreh-Shori, T., Junge, C., Li, D., Yang, Q., Edwards, A., Graham, D. L., Moore, K. M., & Mummery, C. J. (2024) · Figshare · doi:10.6084/m9.figshare.26703981
Additional file 1 of Astrocyte-specific knockout of YKL-40/Chi3l1 reduces Aβ burden and restores memory functions in 5xFAD mice
Zeng, X., Cheung, S. K. K., Shi, M., Or, P. M. Y., Li, Z., Liu, J. Y. H., Ho, W. L.-H., Liu, T., Lu, K., Rudd, J. A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26648808
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Li, J., Lian, T., Guo, P., Li, J., Qi, J., Luo, D., Meng, Y., He, M., Zheng, Z., Yue, H., et al. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261441465
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Sha, Y., Fu, H., Lu, K., Wang, G., & Wang, Y. (2026) · PeerJ · doi:10.7717/peerj.21361
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Mohamed, R. O. B., Elamin, A. M. M., Ahmed, S. S. A., Mahmuod, S. B. H., Hamid, H. A. M., Ahmed, R. A. A., & Aboaly, M. M. (2026) · Cureus · doi:10.7759/cureus.111423
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Authors: Lananna, B. V., McKee, C. A., King, M. W., Del-Aguila, J. L., Dimitry, J. M., Farias, F. H. G., Nadarajah, C. J., Xiong, D. D., Guo, C., Cammack, A. J., Elias, J. A., Zhang, J., Cruchaga, C., & Musiek, E. S.
Affiliations: Washington University in St. Louis (US)
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
Saint Louis University (US)
Brown University (US)
Corresponding author: Musiek, Erik S.
ORCID: Lananna, Brian V.
McKee, Celia A.
Del-Aguila, Jorge L.
Dimitry, Julie M.
Farias, Fabiana H. G.
Nadarajah, Collin J.
Xiong, David D.
Guo, Chun
Cammack, Alexander J.
Elias, Jack A.
Zhang, Jinsong
Cruchaga, Carlos
Musiek, Erik S.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2020-12-16
Volume: 12
Issue: 574
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.aax3519
PMC: PMC7808313
OpenAlex: W3111151889
Cited by: 201
References: 43
Citations by year: 2026: 29 · 2025: 35 · 2024: 44 · 2023: 46 · 2022: 30 · 2021: 16
FWCI: 8.75
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (R01AG054517, R01AG044546, P01AG003991, RF1AG053303, R01AG058501, U01AG058922, U01AG052411, R01AG05777)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: YKL-40, astrocytes, circadian clock, Bmal1, neuroinflammation, Alzheimer's disease
MeSH terms: Chitinase-3-Like Protein 1, Alzheimer Disease, Animals, Astrocytes, Humans, Mice, Transgenic, Amyloid beta-Peptides, Mice, Circadian Clocks

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Chi3l1 /YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis

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