The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Chi3l1 /YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis
Open accessAbstract
Chi3l1 /YKL-40 is regulated by BMAL1 in astrocytes and influences AD pathogenesis in both mouse models and humans.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Recently YKL-40 has been shown to have non-cell autonomous activity in the brain, affecting microglial function, circadian clock, and generally AD progression [75].”
From Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways (2022) · cites this paper as [75]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Choi, J. Y., Yeo, I. J., Kim, K. C., Choi, W. R., Jung, J., Han, S., & Hong, J. T. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1269-3 · Cited by 65
RetractedNeurotoxic reactive astrocytes are induced by activated microglia
Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971
Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875
Microglia Function in the Central Nervous System During Health and Neurodegeneration
Colonna, M., & Butovsky, O. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052358 · Cited by 2,894
Genomic analysis of reactive astrogliosis
Zamanian, J. L., Xu, L., Foo, L. C., Nouri, N., Zhou, L., Giffard, R. G., & Barres, B. A. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6221-11.2012 · Cited by 2,404
Zhang, Y., Sloan, S. A., Clarke, L. E., Caneda, C., Plaza, C. A., Blumenthal, P. D., Vogel, H., Steinberg, G. K., Edwards, M. S. B., Li, G., et al. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.013 · Cited by 2,295
Central and Peripheral Circadian Clocks in Mammals
Mohawk, J. A., Green, C. B., & Takahashi, J. S. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153128 · Cited by 2,265
Transcriptional architecture and chromatin landscape of the core circadian clock in mammals
Koike, N., Yoo, S.-H., Huang, H.-C., Kumar, V., Lee, C., Kim, T.-K., & Takahashi, J. S. (2012) · Science · doi:10.1126/science.1226339 · Cited by 1,464
Zhou, Y., Song, W. M., Andhey, P. S., Swain, A., Levy, T., Miller, K. R., Poliani, P. L., Cominelli, M., Grover, S., Gilfillan, S., et al. (2020) · Nature Medicine · doi:10.1038/s41591-019-0695-9 · Cited by 1,150
Aβ42‐driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
Radde, R., Bolmont, T., Kaeser, S. A., Coomaraswamy, J., Lindau, D., Stoltze, L., Calhoun, M. E., Jäggi, F., Wolburg, H., Gengler, S., et al. (2006) · The EMBO Reports · doi:10.1038/sj.embor.7400784 · Cited by 986
Morris, J. C., Weintraub, S., Chui, H. C., Cummings, J., DeCarli, C., Ferris, S., Foster, N. L., Galasko, D., Graff-Radford, N., Peskind, E. R., et al. (2006) · Alzheimer Disease & Associated Disorders · doi:10.1097/01.wad.0000213865.09806.92 · Cited by 950
Mechanisms linking circadian clocks, sleep, and neurodegeneration
Musiek, E. S., & Holtzman, D. M. (2016) · Science · doi:10.1126/science.aah4968 · Cited by 878
Self-citationCircadian Clock Proteins and Immunity
Curtis, A. M., Bellet, M. M., Sassone‐Corsi, P., & O'Neill, L. A. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.02.002 · Cited by 661
Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides
Koistinaho, M., Lin, S., Wu, X., Esterman, M., Koger, D., Hanson, J., Higgs, R., Liu, F., Malkani, S., Bales, K. R., et al. (2004) · Nature Medicine · doi:10.1038/nm1058 · Cited by 571
Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration
Musiek, E. S., Lim, M. M., Yang, G., Bauer, A. Q., Qi, L., Lee, Y., Roh, J. H., Ortiz-Gonzalez, X., Dearborn, J. T., Culver, J. P., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70317 · Cited by 524
Self-citationYKL-40: A Novel Prognostic Fluid Biomarker for Preclinical Alzheimer's Disease
Craig-Schapiro, R., Perrin, R. J., Roe, C. M., Xiong, C., Carter, D., Cairns, N. J., Mintun, M. A., Peskind, E. R., Li, G., Galasko, D. R., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.08.025 · Cited by 504
Circadian rest-activity pattern changes in aging and preclinical Alzheimer disease
Musiek, E. S., Bhimasani, M., Zangrilli, M. A., Morris, J. C., Holtzman, D. M., & Ju, Y.-E. S. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2017.4719 · Cited by 465
Self-citationLee, C. G., Hartl, D., Lee, G. R., Koller, B., Matsuura, H., Silva, C. A. D., Sohn, M. H., Cohn, L. E., Homer, R., Kozhich, A., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081271 · Cited by 433
Self-citationCSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease
Janelidze, S., Mattsson, N., Stomrud, E., Lindberg, O., Palmqvist, S., Zetterberg, H., Blennow, K., & Hansson, O. (2018) · Neurology · doi:10.1212/wnl.0000000000006082 · Cited by 359
Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model
Reichenbach, N., Delekate, A., Plescher, M., Schmitt, F., Krauss, S., Blank, N., Halle, A., & Petzold, G. C. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201809665 · Cited by 343
The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications
Arranz, A. M., & De Strooper, B. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30490-3 · Cited by 334
Chitinase 3-like 1 Regulates Cellular and Tissue Responses via IL-13 Receptor α2
He, C. H., Lee, C. G., Cruz, C. S. D., Lee, C.-M., Zhou, Y., Ahangari, F., Ma, B., Herzog, E. L., Rosenberg, S. A., Li, Y., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.07.032 · Cited by 331
Self-citationAttenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice
Kraft, A. W., Hu, X., Yoon, H., Yan, P., Xiao, Q., Wang, Y., Gil, S. C., Brown, J., Wilhelmsson, U., Restivo, J. L., et al. (2013) · The FASEB Journal · doi:10.1096/fj.12-208660 · Cited by 324
Sutphen, C. L., Jasielec, M. S., Shah, A. R., Macy, E. M., Xiong, C., Vlassenko, A. G., Benzinger, T. L. S., Stoops, E., Vanderstichele, H., Brix, B., et al. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.1285 · Cited by 301
Circadian Rhythm Generation and Entrainment in Astrocytes
Prolo, L. M., Takahashi, J. S., & Herzog, E. D. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4133-04.2005 · Cited by 294
Microglia inflammatory responses are controlled by an intrinsic circadian clock
Fonken, L. K., Frank, M. G., Kitt, M. M., Barrientos, R. M., Watkins, L. R., & Maier, S. F. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.11.009 · Cited by 291
Styren, S. D., Hamilton, R. L., Styren, G. C., & Klunk, W. E. (2000) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540004800906 · Cited by 279
YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias
Llorens, F., Thüne, K., Tahir, W., Kanata, E., Diaz-Lucena, D., Xanthopoulos, K., Kovatsi, E., Pleschka, C., Garcia-Esparcia, P., Schmitz, M., et al. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0226-4 · Cited by 249
Regulation of amyloid-β dynamics and pathology by the circadian clock
Kress, G. J., Liao, F., Dimitry, J. M., Cedeño, M. R., FitzGerald, G. A., Holtzman, D. M., & Musiek, E. S. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20172347 · Cited by 214
Self-citationA single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain
Del-Aguila, J. L., Li, Z., Dube, U., Mihindukulasuriya, K. A., Budde, J. P., Fernandez, M. V., Ibanez, L., Bradley, J., Wang, F., Bergmann, K., et al. (2019) · Alzheimer's Research & Therapy · doi:10.1186/s13195-019-0524-x · Cited by 183
Self-citationCell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1
Lananna, B. V., Nadarajah, C. J., Izumo, M., Cedeño, M. R., Xiong, D. D., Dimitry, J. M., Tso, C. F., McKee, C. A., Griffin, P. Y., Sheehan, P. W., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.015 · Cited by 173
Self-citationCruz, C. S. D., Liu, W., He, C. H., Jacoby, A., Gornitzky, A. L., Ma, B., Flavell, R. A., Lee, C. G., & Elias, J. A. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.05.017 · Cited by 166
Self-citationQuerol-Vilaseca, M., Colom-Cadena, M., Pegueroles, J., San Martín-Paniello, C., Clarimon, J., Belbin, O., Fortea, J., & Lleó, A. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0893-7 · Cited by 158
Lananna, B. V., & Musiek, E. S. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104832 · Cited by 147
Self-citationCSF sAPPβ, YKL-40, and neurofilament light in frontotemporal lobar degeneration
Alcolea, D., Vilaplana, E., Suárez-Calvet, M., Illán-Gala, I., Blesa, R., Clarimón, J., Lladó, A., Sánchez-Valle, R., Molinuevo, J. L., García-Ribas, G., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000004088 · Cited by 123
CSF sAPPβ, YKL-40, and NfL along the ALS-FTD spectrum
Illán‐Gala, I., Alcolea, D. A., Montal, V., Dols‐Icardo, O., Muñoz, L., de Luna, N., Turón‐Sans, J., Cortés‐Vicente, E., Sánchez‐Saudinós, M. B., Subirana, A., et al. (2018) · Neurology · doi:10.1212/wnl.0000000000006383 · Cited by 86
The intrinsic microglial clock system regulates interleukin‐6 expression
Nakazato, R., Hotta, S., Yamada, D., Kou, M., Nakamura, S., Takahata, Y., Tei, H., Numano, R., Hida, A., Shimba, S., et al. (2016) · Glia · doi:10.1002/glia.23087 · Cited by 74
RelB/p50 Complexes Regulate Cytokine-Induced YKL-40 Expression
Bhardwaj, R., Yester, J., Singh, S. K., Biswas, D. D., Surace, M. J., Waters, M. R., Hauser, K. F., Yao, Z., Boyce, B. F., & Kordula, T. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1400874 · Cited by 69
CSF levels of YKL-40 are increased in MS and decrease with immunosuppressive treatment
Malmeström, C., Axelsson, M., Lycke, J., Zetterberg, H., Blennow, K., & Olsson, B. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.02.004 · Cited by 64
Assessment of the Genetic Architecture of Alzheimer’s Disease Risk in Rate of Memory Decline
Del-Aguila, J. L., Fernández, M. V., Schindler, S., Ibanez, L., Deming, Y., Ma, S., Saef, B., Black, K., Budde, J., Norton, J., et al. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-170834 · Cited by 60
Self-citationRole for mammalian chitinase 3‐like protein 1 in traumatic brain injury
Wiley, C. A., Bonneh‐Barkay, D., Dixon, C. E., Lesniak, A. J., Wang, G., Bissel, S. J., & Kochanek, P. M. (2014) · Neuropathology · doi:10.1111/neup.12158 · Cited by 45
Bonneh‐Barkay, D., Wang, G., LaFramboise, W. A., Wiley, C. A., & Bissel, S. J. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31826eaee7 · Cited by 35
Chitinase-3-like 1 protein (CHI3L1) locus influences cerebrospinal fluid levels of YKL-40
Deming, Y. K., Black, K., Carrell, D., Cai, Y., Del‐Aguila, J. L., Fernández, M. V., Budde, J., Ma, S., Saef, B. A., Howells, B., et al. (2016) · BMC Neurology · doi:10.1186/s12883-016-0742-9 · Cited by 18
Self-citation
Cited by
Sorted by citations
Oxidative stress: The core pathogenesis and mechanism of Alzheimer’s disease
Bai, R., Guo, J., Ye, X.-Y., Xie, Y., & Xie, T. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101619 · Cited by 813
Reactive astrogliosis: A friend or foe in the pathogenesis of Alzheimer’s disease
Kumar, A., Fontana, I. C., & Nordberg, A. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15565 · Cited by 150
Connolly, K., Lehoux, M., O’Rourke, R., Assetta, B., Erdemir, G. A., Elias, J. A., Lee, C. G., & Huang, Y. A. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12612 · Cited by 149
Self-citationAstrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease
Serrano-Pozo, A., Li, H., Li, Z., Muñoz-Castro, C., Jaisa-aad, M., Healey, M. A., Welikovitch, L. A., Jayakumar, R., Bryant, A. G., Noori, A., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01791-4 · Cited by 140
Molecular and metabolic heterogeneity of astrocytes and microglia
Hasel, P., Aisenberg, W. H., Bennett, F. C., & Liddelow, S. A. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.03.006 · Cited by 131
Metadata
- Authors
- Lananna, B. V., McKee, C. A., King, M. W., Del-Aguila, J. L., Dimitry, J. M., Farias, F. H. G., Nadarajah, C. J., Xiong, D. D., Guo, C., Cammack, A. J., Elias, J. A., Zhang, J., Cruchaga, C., & Musiek, E. S.
- Affiliations
- Washington University in St. Louis (US)
- Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
- Saint Louis University (US)
- Brown University (US)
- Corresponding author
- Musiek, Erik S.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2020-12-16
- Volume
- 12
- Issue
- 574
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC7808313
- OpenAlex
- W3111151889
- Cited by
- 201
- References
- 43
- Citations by year
- 2026: 29 · 2025: 35 · 2024: 44 · 2023: 46 · 2022: 30 · 2021: 16
- FWCI
- 8.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01AG054517, R01AG044546, P01AG003991, RF1AG053303, R01AG058501, U01AG058922, U01AG052411, R01AG05777)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- YKL-40, astrocytes, circadian clock, Bmal1, neuroinflammation, Alzheimer's disease
- MeSH terms
- Chitinase-3-Like Protein 1, Alzheimer Disease, Animals, Astrocytes, Humans, Mice, Transgenic, Amyloid beta-Peptides, Mice, Circadian Clocks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
