Cited by 201Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsCircadian rhythm and melatonin

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Chi3l1 /YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis

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Lananna, Brian V., McKee, Celia A., King, Melvin W., Del-Aguila, Jorge L., Dimitry, Julie M., Farias, Fabiana H. G., Nadarajah, Collin J., Xiong, David D., Guo, Chun, Cammack, Alexander J., Elias, Jack A., Zhang, Jinsong, Cruchaga, Carlos, Musiek, Erik S.·2020·Science Translational Medicine

DOI 10.1126/scitranslmed.aax3519PMC PMC7808313

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Abstract

Chi3l1 /YKL-40 is regulated by BMAL1 in astrocytes and influences AD pathogenesis in both mouse models and humans.

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Authors: Lananna, B. V., McKee, C. A., King, M. W., Del-Aguila, J. L., Dimitry, J. M., Farias, F. H. G., Nadarajah, C. J., Xiong, D. D., Guo, C., Cammack, A. J., Elias, J. A., Zhang, J., Cruchaga, C., & Musiek, E. S.
Affiliations: Washington University in St. Louis (US)
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
Saint Louis University (US)
Brown University (US)
Corresponding author: Musiek, Erik S.
ORCID: Lananna, Brian V.
McKee, Celia A.
Del-Aguila, Jorge L.
Dimitry, Julie M.
Farias, Fabiana H. G.
Nadarajah, Collin J.
Xiong, David D.
Guo, Chun
Cammack, Alexander J.
Elias, Jack A.
Zhang, Jinsong
Cruchaga, Carlos
Musiek, Erik S.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2020-12-16
Volume: 12
Issue: 574
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.aax3519
PMC: PMC7808313
OpenAlex: W3111151889
Cited by: 201
References: 43
Citations by year: 2026: 29 · 2025: 35 · 2024: 44 · 2023: 46 · 2022: 30 · 2021: 16
FWCI: 8.75
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (R01AG054517, R01AG044546, P01AG003991, RF1AG053303, R01AG058501, U01AG058922, U01AG052411, R01AG05777)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: YKL-40, astrocytes, circadian clock, Bmal1, neuroinflammation, Alzheimer's disease
MeSH terms: Chitinase-3-Like Protein 1, Alzheimer Disease, Animals, Astrocytes, Humans, Mice, Transgenic, Amyloid beta-Peptides, Mice, Circadian Clocks

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Chi3l1 /YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis

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