Cited by 146Cellular transport and secretionLipid metabolism and biosynthesisProtein Kinase Regulation and GTPase Signaling

Acyl-coenzyme A binding domain containing 3 (ACBD3; PAP7; GCP60): An emerging signaling molecule

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Fan, Jinjiang, Liu, Jun, Culty, Martine, Papadopoulos, Vassilios·2010·Progress in Lipid Research

Abstract

Golgi body-mediated signaling has been linked to its fragmentation and regeneration during the mitotic cycle of the cell. During this process, Golgi-resident proteins are released to the cytosol and interact with other signaling molecules to regulate various cellular processes. Acyl-coenzyme A binding domain containing 3 protein (ACBD3) is a Golgi protein involved in several signaling events. ACBD3 protein was previously known as peripheral-type benzodiazepine receptor and cAMP-dependent protein kinase associated protein 7 (PAP7), Golgi complex-associated protein of 60kDa (GCP60), Golgi complex-associated protein 1 (GOCAP1), and Golgi phosphoprotein 1 (GOLPH1). In this review, we present the gene ontology of ACBD3, its relations to other Acyl-coenzyme A binding domain containing (ACBD) proteins, and its biological function in steroidogenesis, apoptosis, neurogenesis, and embryogenesis. We also discuss the role of ACBD3 in asymmetric cell division and cancer. New findings about ACBD3 may help understand this newly characterized signaling molecule and stimulate further research into its role in molecular endocrinology, neurology, and stem cell biology.

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Authors
Fan, J., Liu, J., Culty, M., & Papadopoulos, V.
Affiliations
  • McGill University Health Centre (CA)
  • Georgetown University Medical Center (US)
Corresponding author
Papadopoulos, Vassilios
Venue
Progress in Lipid Research
Publisher
Elsevier BV
Published
2010-07
Volume
49
Issue
3
Pages
218-234
ISSN
0163-7827 (ISSN-L)
OpenAlex
W2054877611
Cited by
142
References
110
Citations by year
2026: 1 · 2025: 2 · 2024: 9 · 2023: 1 · 2022: 9 · 2021: 19 · 2020: 12 · 2019: 9 · 2018: 7 · 2017: 7 · 2016: 10 · 2015: 21 · 2014: 8 · 2013: 5 · 2012: 11
FWCI
3.64
Type
journal article
Language
en
Open access
Locations
  • Progress in Lipid Research (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD37031, R01HD037031)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords
ACBD3, Golgi apparatus, steroidogenesis, apoptosis, neurogenesis, embryonic development, asymmetric cell division, cancer, molecular endocrinology, neurology, stem cell biology
MeSH terms
Golgi Apparatus, Humans, Membrane Proteins, Signal Transduction, Apoptosis, Protein Structure, Tertiary, Embryonic Development, Adaptor Proteins, Signal Transducing, Neurogenesis

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