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Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice
Open accessAbstract
Acid ceramidase inhibition promotes YAP/TAZ degradation to inactivate fibroblasts, decrease matrix stiffness, and reduce fibrosis in mice.
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Cites
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Metadata
- Authors
- Alsamman, S., Christenson, S. A., Yu, A., Ayad, N. M. E., Mooring, M. S., Segal, J. M., Hu, J. K.-H., Schaub, J. R., Ho, S. S., Rao, V., Marlow, M. M., Turner, S. M., Sedki, M., Pantano, L., Ghoshal, S., Ferreira, D. D. S., Ma, H.-Y., Duwaerts, C. C., Espanol-Suner, R., Wei, L., Newcomb, B., Mileva, I., Canals, D., Hannun, Y. A., Chung, R. T., Mattis, A. N., Fuchs, B. C., Tager, A. M., Yimlamai, D., Weaver, V. M., Mullen, A. C., Sheppard, D., & Chen, J. Y.
- Affiliations
- University of California, San Francisco (US)
- Yale University (US)
- University of California, Los Angeles (US)
- Pliant (United States) (US)
- Kaiser Permanente (US)
- Harvard University (US)
- Athinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
- Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA.
- Stony Brook University (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Tager, Andrew M.
- Sheppard, Dean
- Chen, Jennifer Y.
- ORCID
- Alsamman, Sarah
- Christenson, Stephanie A.
- Yu, Amy
- Ayad, Nadia M. E.
- Mooring, Meghan S.
- Segal, Joe M.
- Hu, Jimmy Kuang-Hsien
- Rao, Vikram
- Turner, Scott M.
- Sedki, Mai
- Pantano, Lorena
- Ferreira, Diego Dos Santos
- Ma, Hsiao-Yen
- Duwaerts, Caroline C.
- Wei, Lan
- Newcomb, Benjamin
- Canals, Daniel
- Hannun, Yusuf A.
- Chung, Raymond T.
- Mattis, Aras N.
- Fuchs, Bryan C.
- Tager, Andrew M.
- Yimlamai, Dean
- Weaver, Valerie M.
- Mullen, Alan C.
- Sheppard, Dean
- Chen, Jennifer Y.
- Venue
- Science Translational Medicine
- Published
- 2020-08-19
- Volume
- 12
- Issue
- 557
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC7976849
- OpenAlex
- W3073968329
- Cited by
- 122
- References
- 89
- Citations by year
- 2026: 13 · 2025: 23 · 2024: 19 · 2023: 21 · 2022: 24 · 2021: 20 · 2020: 2
- FWCI
- 9.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (K08DK114548, P30DK026743)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Keywords
- acid ceramidase, liver fibrosis, hepatic stellate cells, YAP/TAZ signaling, ceramide, tricyclic antidepressants, β-TrCP, proteasomal degradation, antifibrotic therapy, therapeutic target
- MeSH terms
- Animals, Fibrosis, Humans, Signal Transduction, Adaptor Proteins, Signal Transducing, Mice, Hepatic Stellate Cells, Acid Ceramidase
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