A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes

Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen

Shapiro, A. M. J., Lakey, J. R. T., Ryan, E. A., Korbutt, G. S., Toth, E., Warnock, G. L., Kneteman, N. M., & Rajotte, R. V. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007273430401 · Cited by 5,237

Hydrogels for biomedical applications

Hoffman, A. S. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00239-3 · Cited by 4,864

Hydrogels for biomedical applications

Hoffman, A. S. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.010 · Cited by 3,396

Generation of Functional Human Pancreatic β Cells In Vitro

Pagliuca, F. W., Millman, J. R., Gürtler, M., Segel, M., Van Dervort, A., Ryu, J. H., Peterson, Q. P., Greiner, D., & Melton, D. A. (2014) · Cell · doi:10.1016/j.cell.2014.09.040 · Cited by 2,025

International trial of the Edmonton protocol for islet transplantation

Shapiro, A. M. J., Ricordi, C., Hering, B. J., Auchincloss, H., Lindblad, R., Robertson, R. P., Secchi, A., Brendel, M. D., Berney, T., Brennan, D. C., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061267 · Cited by 1,942

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

Wen, L., Ley, R. E., Volchkov, P. Y., Stranges, P. B., Avanesyan, L., Stonebraker, A. C., Hu, C., Wong, F. S., Szot, G. L., Bluestone, J. A., et al. (2008) · Nature · doi:10.1038/nature07336 · Cited by 1,921

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

Rezania, A., Bruin, J. E., Arora, P., Rubin, A., Batushansky, I., Asadi, A., O'Dwyer, S., Quiskamp, N., Mojibian, M., Albrecht, T., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.3033 · Cited by 1,575

Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates

Veiseh, O., Doloff, J. C., Ma, M., Vegas, A. J., Tam, H. H., Bader, A. R., Li, J., Langan, E., Wyckoff, J., Loo, W. S., et al. (2015) · Nature Materials · doi:10.1038/nmat4290 · Cited by 897

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

Niu, D., Wei, H.-J., Lin, L., George, H., Wang, T., Lee, I.-H., Zhao, H.-Y., Wang, Y., Kan, Y., Shrock, E., et al. (2017) · Science · doi:10.1126/science.aan4187 · Cited by 717

Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice

Vegas, A. J., Veiseh, O., Gürtler, M., Millman, J. R., Pagliuca, F. W., Bader, A. R., Doloff, J. C., Li, J., Chen, M., Olejnik, K., et al. (2016) · Nature Medicine · doi:10.1038/nm.4030 · Cited by 710

Medical Applications of Porous Biomaterials: Features of Porosity and Tissue‐Specific Implications for Biocompatibility

Hernandez, J. L., & Woodrow, K. A. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202102087 · Cited by 278

Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes

Hogrebe, N. J., Ishahak, M., & Millman, J. R. (2023) · Cell Stem Cell · doi:10.1016/j.stem.2023.04.002 · Cited by 210

New Insights and Potential Therapeutic Interventions in Metabolic Diseases

Clemente‐Suárez, V. J., Martín-Rodríguez, A., Redondo-Flórez, L., López-Mora, C., Sepulveda, R. A. Y., & Tornero-Aguilera, J. F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310672 · Cited by 177

Solid implantable devices for sustained drug delivery

Magill, E., Demartis, S., Gavini, E., Permana, A. D., Thakur, R. R. S., Adrianto, M. F., Waite, D. T., Glover, K., Picco, C. J., Korelidou, A., et al. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114950 · Cited by 152

Advances in Pancreatic Islet Transplantation Sites for the Treatment of Diabetes

Cayabyab, F., Nih, L. R., & Yoshihara, E. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.732431 · Cited by 123

Partners in Crime: Beta-Cells and Autoimmune Responses Complicit in Type 1 Diabetes Pathogenesis

Toren, E., Burnette, K., Banerjee, R. R., Hunter, C. S., & Tse, H. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.756548 · Cited by 115

Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification

Augsornworawat, P., Hogrebe, N. J., Ishahak, M., Schmidt, M. D., Marquez, E., Maestas, M. M., Veronese-Paniagua, D., Gale, S. E., Miller, J. R., Velazco-Cruz, L., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01150-8 · Cited by 91

Advances in Encapsulation and Delivery Strategies for Islet Transplantation

Wu, S., Wang, L., Fang, Y., Huang, H. W., You, X., & Wu, J. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202100965 · Cited by 80

Stem Cell Transplantation in the Treatment of Type 1 Diabetes Mellitus: From Insulin Replacement to Beta-Cell Replacement

Wan, X.-X., Zhang, D.-Y., Khan, M. A., Zheng, S.-Y., Hu, X., Zhāng, Q., Yang, R., & Xiong, K. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.859638 · Cited by 72

Recent Advances in Alginate-Based Hydrogels for Cell Transplantation Applications

Kavand, A., Noverraz, F., & Gerber‐Lemaire, S. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16040469 · Cited by 64

Chemically engineering cells for precision medicine

Wang, Y., Li, Z., Mo, F., Chen‐Mayfield, T., Saini, A., LaMere, A. M., & Hu, Q. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00142j · Cited by 62

Engineered immunomodulatory accessory cells improve experimental allogeneic islet transplantation without immunosuppression

Wang, X., Wang, K., Yu, M., Velluto, D., Hong, X., Wang, B., Chiu, A., Melero-Martin, J. M., Tomei, A. A., & Ma, M. (2022) · Science Advances · doi:10.1126/sciadv.abn0071 · Cited by 62

Screening hydrogels for antifibrotic properties by implanting cellularly barcoded alginates in mice and a non-human primate

Mukherjee, S., Kim, B., Cheng, L. Y., Doerfert, M., Li, J., Hernández, A., Liang, L. R., Jarvis, M., Rios, P., Ghani, S., et al. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-023-01016-2 · Cited by 60

An adhesive and resilient hydrogel for the sealing and treatment of gastric perforation

Chen, J., Caserto, J. S., Ang, I., Shariati, K., Webb, J., Wang, B., Wang, X., Bouklas, N., & Ma, M. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.11.038 · Cited by 57

Pancreatic islet transplantation: current advances and challenges

Wang, Q., Huang, Y., Liu, L., Zhao, X., Sun, Y., Mao, X., & Li, S.-W. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1391504 · Cited by 63

Monolithic-to-focal evolving biointerfaces in tissue regeneration and bioelectronics

Shi, J., Lin, Y., Li, P., Mickel, P., Sun, C., Parekh, K., Ma, J., Kim, S., Ashwood, B., Meng, L., et al. (2024) · Nature Chemical Engineering · doi:10.1038/s44286-023-00008-y · Cited by 59

Differential Function and Maturation of Human Stem Cell-Derived Islets After Transplantation

Maxwell, K. G., Kim, M. H., Gale, S. E., & Millman, J. R. (2022) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szab013 · Cited by 54

Fluorescence‐Amplified Origami Microneedle Device for Quantitatively Monitoring Blood Glucose

Li, X., Xu, X., Wang, K., Chen, Y., Zhang, Y., Si, Q., Pan, Z., Jia, F., Cui, X., Wang, X., et al. (2023) · Advanced Materials · doi:10.1002/adma.202208820 · Cited by 52

Identification of unique cell type responses in pancreatic islets to stress

Maestas, M. M., Ishahak, M., Augsornworawat, P., Veronese-Paniagua, D., Maxwell, K. G., Velazco-Cruz, L., Marquez, E., Sun, J., Shunkarova, M., Gale, S. E., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49724-w · Cited by 53

Considerations and challenges of islet transplantation and future therapies on the horizon

Walker, S. L. M., Appari, M., & Forbes, S. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00310.2021 · Cited by 47

Emerging strategies for beta cell transplantation to treat diabetes

Paez‐Mayorga, J., Lukin, I., Emerich, D. F., de Vos, P., Orive, G., & Grattoni, A. (2021) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2021.11.007 · Cited by 43

Immune Protection of Stem Cell-Derived Islet Cell Therapy for Treating Diabetes

Tahbaz, M., & Yoshihara, E. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.716625 · Cited by 43

Directed self-assembly of a xenogeneic vascularized endocrine pancreas for type 1 diabetes

Citro, A., Neroni, A., Pignatelli, C., Campo, F., Policardi, M., Monieri, M., Pellegrini, S., Dugnani, E., Manenti, F., Maffia, M. C., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36582-1 · Cited by 41

Macroencapsulation Devices for Cell Therapy

Liu, W., Wang, Y., Wang, J., Lanier, O. L., Wechsler, M. E., Peppas, N. A., & Gu, Z. (2022) · Engineering · doi:10.1016/j.eng.2021.10.021 · Cited by 38

Hydrogels: Definition, History, Classifications, Formation, Constitutive Characteristics, and Applications

Dodda, J. M., Deshmukh, K., Bezuidenhout, D., & Yeh, Y. (2023) · Royal Society of Chemistry eBooks · doi:10.1039/bk9781837670055-00001 · Cited by 44

A Century-long Journey From the Discovery of Insulin to the Implantation of Stem Cell–derived Islets

Ramzy, A., Belmonte, P. J., Braam, M. J. S., Ida, S., Wilts, E. M., Levings, M. K., Rezania, A., & Kieffer, T. J. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac021 · Cited by 37

Inflammation-induced subcutaneous neovascularization for the long-term survival of encapsulated islets without immunosuppression

Wang, L., Marfil‐Garza, B. A., Ernst, A. U., Pawlick, R. L., Pepper, A. R., Okada, K., Epel, B., Viswakarma, N., Kotecha, M., Flanders, J. A., et al. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-023-01145-8 · Cited by 38

Implantable Medical Devices, Biomaterials, and the Foreign Body Response: A Surgical Perspective

Kalashnikov, N., Barralet, J. E., & Vorstenbosch, J. (2025) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37983 · Cited by 39

Enhancing longevity of immunoisolated pancreatic islet grafts by modifying both the intracapsular and extracapsular environment

Qin, T., Smink, A. M., & de Vos, P. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.06.038 · Cited by 35

Microfluidic Production of Zwitterion Coating Microcapsules with Low Foreign Body Reactions for Improved Islet Transplantation

Xiao, Z., Wei, T., Ge, R., Li, Q., Лю, Б., Ji, Z., Chen, L., Zhu, J., Shen, J., Liu, Z., et al. (2022) · Small · doi:10.1002/smll.202202596 · Cited by 34

Immunocompatible elastomer with increased resistance to the foreign body response

Zhou, X., Lu, Z., Cao, W., Zhu, Z., Chen, Y., Ni, Y., Liu, Z., Jia, F., Yang, Y., Han, H., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52023-z · Cited by 35

Encapsulation and immune protection for type 1 diabetes cell therapy

Kioulaphides, S., & Garcı́a, A. J. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115205 · Cited by 37

An elastomer with in situ generated pure zwitterionic surfaces for fibrosis-resistant implants

Zhou, X., Cao, W., Chen, Y., Zhu, Z., Lai, Y., Liu, Z., Jia, F., Lu, Z., Han, H., Yao, K., et al. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.06.047 · Cited by 30

Immunomodulatory hydrogels for tissue repair and regeneration

Liu, X., Hu, Y., Ju, Y., Yang, P. S., Shen, N., Yang, A., Wu, R., Fang, B., & Liu, L. (2024) · APL Materials · doi:10.1063/5.0228692 · Cited by 32

Cell delivery systems: Toward the next generation of cell therapies for type 1 diabetes

Dang, H. P., Chen, H., Dargaville, T. R., & Tuch, B. E. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17499 · Cited by 29

Advancements in adoptive CAR immune cell immunotherapy synergistically combined with multimodal approaches for tumor treatment

Chang, Y., Chang, M., Bao, X., & Dong, C. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.08.046 · Cited by 28

Emerging local immunomodulatory strategies to circumvent systemic immunosuppression in cell transplantation

Campa‐Carranza, J. N., Paez‐Mayorga, J., Chua, C. Y. X., Nichols, J. E., & Grattoni, A. (2022) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2022.2076834 · Cited by 29

Stepwise differentiation of functional pancreatic β cells from human pluripotent stem cells

Jin, W., & Jiang, W. (2022) · Cell Regeneration · doi:10.1186/s13619-022-00125-8 · Cited by 35

Pancreatic islet cells in microfluidic-spun hydrogel microfibers for the treatment of diabetes

Huan, Z., Li, J., Guo, J., Yu, Y., & Li, L. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.08.047 · Cited by 24

A porcine islet-encapsulation device that enables long-term discordant xenotransplantation in immunocompetent diabetic mice

Ajima, K., Tsuda, N., Takaki, T., Furusako, S., Matsumoto, S., Shinohara, K., Yamashita, Y., Amano, S., Oyama, C., & Shimoda, M. (2022) · Cell Reports Methods · doi:10.1016/j.crmeth.2022.100370 · Cited by 22

Immunoprotection Strategies in β‐Cell Replacement Therapy: A Closer Look at Porcine Islet Xenotransplantation

Grimus, S., Sarangova, V., Welzel, P. B., Ludwig, B., Seißler, J., Kemter, E., Wolf, E., & Ali, A. (2024) · Advanced Science · doi:10.1002/advs.202401385 · Cited by 22

iPS cell therapy 2.0: Preparing for next‐generation regenerative medicine

Hui, K. K., & Yamanaka, S. (2024) · BioEssays · doi:10.1002/bies.202400072 · Cited by 23

Recent advances in biomaterial-assisted cell therapy

Chen, Y., Pal, S., & Hu, Q. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb00583b · Cited by 20

A 3D-printed microdevice encapsulates vascularized islets composed of iPSC-derived β-like cells and microvascular fragments for type 1 diabetes treatment

Chen, S., Wang, W., Shen, L., Liu, H., Luo, J. C., Ren, Y., Cui, S., Ye, Y., Shi, G., Cheng, F., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122947 · Cited by 19

3D Printing Mini-Capsule Device for Islet Delivery to Treat Type 1 Diabetes

Chen, S., Luo, J. C., Shen, L., Liu, X., Wang, W., Xu, J. M., Ren, Y., Ye, Y., Shi, G., Cheng, F., et al. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c02487 · Cited by 19

The progress of pluripotent stem cell-derived pancreatic β-cells regeneration for diabetic therapy

Wang, X., Gao, M., Wang, Y., & Zhang, Y. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.927324 · Cited by 20

Hydrogel-based approaches to target hypersensitivity mechanisms underlying autoimmune disease

Kim, K. M., D’Elia, A. M., & Rodell, C. B. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115395 · Cited by 20

Mouse models and human islet transplantation sites for intravital imaging

Wagner, L. E., Melnyk, O., Duffett, B. E., & Linnemann, A. K. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.992540 · Cited by 18

An injectable and retrievable bioartificial pancreas fabricated by time-sequentially assembling islets-laden microgels for minimally invasive treatment of type 1 diabetes

He, W., Li, H., Xu, X., Zhang, X., Chen, J., Lv, C., Yu, H., Feng, Q., & Dong, H. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.152261 · Cited by 15

Advancements and Challenges in Immune Protection Strategies for Islet Transplantation

Wang, X., Zeng, Z., Li, D., Wang, K., Zhang, W., Yu, Y., & Wang, X. (2025) · Journal of Diabetes · doi:10.1111/1753-0407.70048 · Cited by 18

Benefits and Hurdles of Pancreatic β-Cell Replacement

Bolla, A. M., Montefusco, L. B., Pastore, I., Lunati, M. E., Nasr, M. B., & Fiorina, P. (2022) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szac058 · Cited by 17

Emerging approaches for the development of artificial islets

Li, J., Sun, L., Bian, F., Pandol, S. J., & Li, L. (2024) · Smart Medicine · doi:10.1002/smmd.20230042 · Cited by 14

Recent progress in modeling and treating diabetes using stem cell-derived islets

Maestas, M. M., Bui, M. H., & Millman, J. R. (2024) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szae059 · Cited by 14

A continuously oxygenated macroencapsulation system enables high-density packing and delivery of insulin-secreting cells

Pham, T. T., Tran, P. L., Tempelman, L. A., Stone, S. G., Piccirillo, C., Li, A., Flanders, J. A., & Ma, M. (2025) · Nature Communications · doi:10.1038/s41467-025-62271-2 · Cited by 17

An electrospun macrodevice for durable encapsulation of human cells with consistent secretion of therapeutic antibodies

Imaichi, S., Kassab, R., Piersigilli, A., Robertson, R., Leonard, C., Long, N., Dean, B., Phaneuf, M. D., & Ling, V. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122123 · Cited by 13

An artificial LAMA2-GelMA hydrogel microenvironment for the development of pancreatic endocrine progenitors

Huang, Y. H., Xu, Y. Y., Zhu, J., Wan, J., Xiong, Y., Jiang, Z., Zhu, S., Guo, Q., Li, Y., Lu, Y., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121882 · Cited by 13

Progress in Biomaterials-Enhanced Vascularization by Modulating Physical Properties

Li, H., Li, D., Wang, X., Zeng, Z., Pahlavan, S., Zhang, W., Wang, X., & Wang, K. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c01106 · Cited by 12

Immune Evasion in Stem Cell-Based Diabetes Therapy—Current Strategies and Their Application in Clinical Trials

Mu-u-min, R., Diané, A., Allouch, A., & Al-Siddiqi, H. (2025) · Biomedicines · doi:10.3390/biomedicines13020383 · Cited by 14

Islet transplantation in immunomodulatory nanoparticle–remodeled spleens

Liu, M., Deng, H., Liu, C., Wang, L., Liao, Z., Li, D., Chen, Y., Li, J., Dong, J., Sun, X., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adj9615 · Cited by 12

Improving cellular fitness of human stem cell-derived islets under hypoxia

Wang, X., Brielle, S., Kenty, J. H.-R., Korover, N., Bavli, D., Pop, R., & Melton, D. A. (2025) · Nature Communications · doi:10.1038/s41467-025-59924-7 · Cited by 14

Engineering a Hierarchical Biphasic Gel for Subcutaneous Vascularization

Gao, D., Ernst, A. U., Wang, X., Wang, L., Liu, W. H., & Ma, M. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202200922 · Cited by 12

Hypoxia within subcutaneously implanted macroencapsulation devices limits the viability and functionality of densely loaded islets

Einstein, S. A., Steyn, L. V., Weegman, B. P., Suszynski, T. M., Sambanis, A., O’Brien, T. D., Avgoustiniatos, E. S., Firpo, M. T., Graham, M. L., Janecek, J. L., et al. (2023) · Frontiers in Transplantation · doi:10.3389/frtra.2023.1257029 · Cited by 12

New insights into β-cell failure, regeneration and replacement

Bakhti, M., & Lickert, H. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00611-0 · Cited by 11

Biomimetic cell encapsulations by microfluidics

Wang, J., Huang, D., Fang, Y., Ren, H., & Zhao, Y. (2024) · Science China Materials · doi:10.1007/s40843-024-2903-0 · Cited by 10

Therapeutic Effects of Insulin-Producing Human Umbilical Cord-Derived Mesenchymal Stem Cells in a Type 1 Diabetes Mouse Model

Park, Y. M., Yang, C. M., & Cho, H. Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23136877 · Cited by 10

Mechanically reinforced hydrogel vehicle delivering angiogenic factor for beta cell therapy

Toftdal, M. S., Christensen, N. P., Kadumudi, F. B., Dolatshahi‐Pirouz, A., Grunnet, L. G., & Chen, M. (2024) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2024.04.050 · Cited by 10

Emerging Strategies for Beta Cell Encapsulation for Type 1 Diabetes Therapy

Toftdal, M. S., Grunnet, L. G., & Chen, M. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400185 · Cited by 10

High‐Efficiency, Prevascularization‐Free Macroencapsulation System for Subcutaneous Transplantation of Pancreatic Islets for Enhanced Diabetes Treatment

Jeon, S., Heo, J., Myung, N., Shin, J. Y., Kim, M. K., & Kang, H. (2024) · Advanced Materials · doi:10.1002/adma.202408329 · Cited by 9

Integrating Additive Manufacturing Techniques to Improve Cell‐Based Implants for the Treatment of Type 1 Diabetes

Accolla, R. P., Simmons, A., & Stabler, C. L. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202200243 · Cited by 9

Unlocking Transplant Tolerance with Biomaterials

Pham, J. A., & Coronel, M. M. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400965 · Cited by 8

The future of islet transplantation beyond the BLA approval: challenges and opportunities

Wang, Y., McGarrigle, J. J., Cook, J., Rios, P., Monica, G. L., Chen, Y., Wei, W., & Oberholzer, J. (2025) · Frontiers in Transplantation · doi:10.3389/frtra.2025.1522409 · Cited by 9

Best practices in islet transplantation in mice.

Meier, R. P. H., Nasr, M. B., Fife, B., Finger, E. B., Fiorina, P., Luo, X., & Bromberg, J. (2025) · American Journal of Transplantation · doi:10.1016/j.ajt.2025.03.008 · Cited by 8

Gene editing strategies to address current challenges in stem cell-derived β cell therapy for type 1 Diabetes

Han, J., Lim, D., & Yang, K. (2025) · Journal of Tissue Engineering · doi:10.1177/20417314251373039 · Cited by 8

Overcoming barriers to delivery of biologics by novel approaches and advanced delivery systems

Ahator, S. D., Franzè, S., Obuobi, S. A. O., Anderluzzi, G., Flaten, G. E., & Škalko‐Basnet, N. (2026) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2026.115875 · Cited by 10

Human amniotic mesenchymal stem cell-islet organoids enhance the efficiency of islet engraftment in a mouse diabetes model

Zhou, J.-X., Jie-Zhou, Jin, W.-R., Li, J., Zhang, X.-C., Zhao, C.-Y., Lin, Y.-Y., Wang, X., Yan, L.-F., Kaiyan, et al. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122812 · Cited by 8

Advances in alginate encapsulation of pancreatic islets for immunoprotection in type 1 diabetes

Chaudhary, D., Nguyen, T. T., Yook, S., & Jeong, J. (2023) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-023-00627-w · Cited by 8

The efficiency of stem cell differentiation into functional beta cells for treating insulin-requiring diabetes: Recent advances and current challenges

Luo, Y., Yu, P., & Liu, J. (2024) · Endocrine · doi:10.1007/s12020-024-03855-8 · Cited by 7

Toward Systemic Lipofuscin Removal

Renteln, M. (2024) · Rejuvenation Research · doi:10.1089/rej.2024.0034 · Cited by 8

Developing a morphomics framework to optimize implant site-specific design parameters for islet macroencapsulation devices

McDermott, B., Robinson, S. T., Holcombe, S. A., Levey, R. E., Dockery, P., Johnson, P., Wang, S. C., Dolan, E. B., & Duffy, G. P. (2021) · Journal of The Royal Society Interface · doi:10.1098/rsif.2021.0673 · Cited by 7

Hydrogel-Bondable Asymmetric Planar Membranes with Hierarchical Pore Structures for Cell Scaffolding and Encapsulation

Wang, Y., Wang, K., Luo, Y., & Chen, H. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c01415 · Cited by 7

Biomimetic artificial islet model with vascularized microcapsule structures for durable glycemic control

Li, J., Fang, Y., Wu, Z.-H., Shang, L.-R., & Li, L. (2024) · Materials Futures · doi:10.1088/2752-5724/ad47ce · Cited by 6

Can nanotechnology overcome challenges facing stem cell therapy? A review

Zaghary, W. A., Elansary, M. M., Shouman, D. N., Abdelrahim, A. A., Abu‐Zied, K. M., & Sakr, T. M. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102883 · Cited by 8

A pluripotent road to immunoengineering

Chang, Y., Deng, Q., & Bao, X. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00056-2 · Cited by 6

A durable immuno-protective core-shell microgel for the enhanced pancreatic islet transplantation in diabetes therapy

Hu, Z., Luo, Y., Junaid, M., Xu, R., Chen, Y., Yao, J., Ni, R., Zhu, T., Zhang, H., Ding, H., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.169527 · Cited by 5

Stem cells as a therapeutic avenue for active and long-term complications of Necrotizing Enterocolitis

Mesfin, F. M., Manohar, K., Shelley, W. C., Brokaw, J. P., Liu, J., Ma, M., & Markel, T. A. (2023) · Seminars in Pediatric Surgery · doi:10.1016/j.sempedsurg.2023.151311 · Cited by 4

Designing next-generation islet-like cells from human pluripotent stem cells: Advances in overcoming allorejection and recurrent type 1 diabetes

Misra, P. S., & Nostro, M. C. (2022) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2022.100321 · Cited by 4

Tissue engineering approaches and generation of insulin-producing cells to treat type 1 diabetes

Khazaei, M., Khazaei, F., Niromand, E., & Ghanbari, E. (2022) · Journal of drug targeting · doi:10.1080/1061186x.2022.2107653 · Cited by 5

Transplantable cell-encapsulation device using a semipermeable ethylene-vinyl alcohol copolymer membrane in a mouse diabetic model

Kaneko, M., Moriguchi, H., Futatsubashi, R., Ayano, S., Kobayashi, G., & Itô, A. (2023) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2023.09.001 · Cited by 4

Silencing hsa_circ_0032449 inhibits the pancreatic differentiation of human embryonic stem cells via the hsa_miR-195-5p/CCND1/PI3K/AKT signaling pathway

Xu, Y., Xu, T., Huang, Y. H., Wan, J., & Jiang, Z. (2023) · Experimental Cell Research · doi:10.1016/j.yexcr.2023.113879 · Cited by 3

Next-gen therapeutics to spare and expand beta-cell mass

Bolla, A. M., Usuelli, V., Nasr, M. B., Frigerio, S., Loretelli, C., D’Addio, F., & Fiorina, P. (2021) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2021.09.001 · Cited by 3

Fabrication of nanofibrous mat surrounded hydrogel scaffold as an encapsulation device for encapsulating pancreas β cells

Seyyedi, M. S., Monfared, M., Mirzaei, E., & Azarpira, N. (2022) · Scientific Reports · doi:10.1038/s41598-022-25736-8 · Cited by 3

Hydrogel-Composited Laminate for Islet Immune-Isolation to Treat Type 1 Diabetes

Wang, Y., Wang, K., Wang, X., Luo, Y., & Chen, H. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c12359 · Cited by 3

Bio‐Inspired Pancreas With Microfluidic Multi‐Component Hydrogel Microfibers for Exploring Pancreatic Exocrine and Endocrine Interactions

Huan, Z., Luo, Z., Li, J., Yu, Y., & Li, L. (2025) · Aggregate · doi:10.1002/agt2.70210 · Cited by 2

Type 1 Diabetes and Islet Encapsulation: From Historical Milestones to Cutting-Edge Advances

Mukherjee, S., Mandal, S., Oberholzer, J., & Omid Veiseh, A. (2026) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-110824-024435 · Cited by 2

Advancing diabetes treatment: from human beta cell technology to bioartificial pancreas development

Sá, J., Sá, S. C., Leménager, H., Costa, R., Onteniente, B., Soares, R. A., Ribeiro, V. P., & de Oliveira, A. L. F. (2025) · Frontiers in Biomaterials Science · doi:10.3389/fbiom.2025.1524518 · Cited by 5

Amniotic Membrane and Mesenchymal Stem Cell Coalescence for Islet Transplantation in Experimental Diabetes in Rats

Tiryaki, M., Atmaca, N., Pinarli, F., Böyük, G., Feyat, M. S., Mercan, S., Albayrak, A., & Atmaca, H. (2025) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1155/term/2645595 · Cited by 1

A stepwise funnel selection approach identifying natural polymer-derived hydrogels for long-term islet delivery, restoring normoglycemia in type-1 diabetes

Mandal, S., Yenurkar, D., Manna, S., Bhattacharjee, R., Nayak, M., Pradhan, L., & Mukherjee, S. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb02371h · Cited by 1

Whole-genome CRISPR screening identifies genetic modifiers of stem cell–derived islet transplantation

Maestas, M. M., Bradley, K., Shunkarova, M., Mukherjee, N., Ishahak, M., Lu, J., & Millman, J. R. (2026) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szag012 · Cited by 2

Tissue‐Material Characteristics Determine Fibrous Encapsulation Dynamics Across Common Polymeric Surgical Biomaterials in a Tissue‐Specific Mouse Foreign Body Response Model

Kalashnikov, N., Thareja, R., & Vorstenbosch, J. (2026) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.70096 · Cited by 1

Pancreatic tissue engineering: towards a vascularized bioengineered cure for diabetes

Park, J., Olawuyi, K., Jikaria, N. R., Dawes, J. S., Dabsha, I. E., Dick, A. A., & Ravnic, D. J. (2026) · Frontiers in Transplantation · doi:10.3389/frtra.2026.1768497 · Cited by 1

A Safe, Fibrosis‐Mitigating, and Scalable Encapsulation Device Supports Long‐Term Function of Insulin‐Producing Cells

Liu, W. H., Flanders, J. A., Wang, L., Liu, Q., Bowers, D. T., Wang, K., Chiu, A., Wang, X., Ernst, A. U., Shariati, K., et al. (2021) · Small · doi:10.1002/smll.202104899 · Cited by 54

Human β-cell Precursors Mature Into Functional Insulin-producing Cells in an Immunoisolation Device: Implications for Diabetes Cell Therapies

Lee, S., Hao, E., Savinov, A. Y., Geron, I., Strongin, A. Y., & Itkin‐Ansari, P. (2009) · Transplantation · doi:10.1097/tp.0b013e31819c86ea · Cited by 109

A 3D-printed microdevice encapsulates vascularized islets composed of iPSC-derived β-like cells and microvascular fragments for type 1 diabetes treatment

Chen, S., Wang, W., Shen, L., Liu, H., Luo, J. C., Ren, Y., Cui, S., Ye, Y., Shi, G., Cheng, F., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122947 · Cited by 19

P-10: STRUCTURAL AND FUNCTIONAL PRELIMINARY ASSESSMENT OF AN ENCAPSULATION DEVICE FOR Β-CELLS SPHEROIDS USING A SEMIPERMEABLE MEMBRANE

Miceli, V., Castelbuono, S., Cuscino, N., Zito, G., Centi, C., Tinnirello, R., Cimino, M., Pinzani, M., Conaldi, P. G., & Mattina, A. (2025) · Transplantation · doi:10.1097/01.tp.0001123412.40447.5a

07-2: A PERFUSABLE ENCAPSULATION DEVICE SCALED FOR CLINICALLY RELEVANT THERAPEUTIC ISLET DOSES SHOWS RAPID INSULIN RESPONSE IN VITRO AND ACUTE SAFETY IN PIG TRANSPLANTATION MODEL

Vdovenko, D., Sidharthan, D. S., Brassard, J. A., Ruel, J., Bégin‐Drolet, A., Paraskevas, S., Gasparrini, M., Leask, R. L., Kieffer, T. J., & Hoesli, C. A. (2025) · Transplantation · doi:10.1097/01.tp.0001123064.83133.9a · Cited by 1