A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes

Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen

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Hydrogels for biomedical applications

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Hydrogels for biomedical applications

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Generation of Functional Human Pancreatic β Cells In Vitro

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International trial of the Edmonton protocol for islet transplantation

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Innate immunity and intestinal microbiota in the development of Type 1 diabetes

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Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

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Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates

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Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

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Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice

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Phase 3 trial of transplantation of human islets in type 1 diabetes complicated by severe hypoglycemia

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Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates

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Teratoma formation by human embryonic stem cells: Evaluation of essential parameters for future safety studies

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Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells

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Macrophage functional polarization (M1/M2) in response to varying fiber and pore dimensions of electrospun scaffolds

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Advances in islet encapsulation technologies

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Markedly Decreased Oxygen Tension in Transplanted Rat Pancreatic Islets Irrespective of the Implantation Site

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Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells

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Generation of stem cell-derived β-cells from patients with type 1 diabetes

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A prevascularized subcutaneous device-less site for islet and cellular transplantation

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Insulin Secretion Depends on Intra-islet Glucagon Signaling

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An encapsulation system for the immunoisolation of pancreatic islets

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Immunological and Technical Considerations in Application of Alginate-Based Microencapsulation Systems

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Enrichment of human embryonic stem cell‐derived NKX6.1‐expressing pancreatic progenitor cells accelerates the maturation of insulin‐secreting cells in vivo

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Optimal implantation site for pancreatic islet transplantation

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Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes

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Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

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Zwitterionically modified alginates mitigate cellular overgrowth for cell encapsulation

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Designing a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes

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National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities

Ricordi, C., Goldstein, J., Balamurugan, A. N., Szot, G. L., Kin, T., Liu, C., Czarniecki, C. W., Barbaro, B., Bridges, N. D., Cano, J., et al. (2016) · Diabetes · doi:10.2337/db16-0234 · Cited by 200

PARACRINE INTERACTIONS WITHIN THE PANCREATIC ISLET DETERMINE THE GLYCEMIC SET POINT

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Gene-edited human stem cell–derived β cells from a patient with monogenic diabetes reverse preexisting diabetes in mice

Maxwell, K. G., Augsornworawat, P., Velazco-Cruz, L., Kim, M. H., Asada, R., Hogrebe, N. J., Morikawa, S., Urano, F., & Millman, J. R. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax9106 · Cited by 183

Vasculogenic hydrogel enhances islet survival, engraftment, and function in leading extrahepatic sites

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Prevention of Diabetes for up to 13 Years by Autoislet Transplantation After Pancreatectomy for Chronic Pancreatitis

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Hydrogels in Emerging Technologies for Type 1 Diabetes

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Local release of dexamethasone from macroporous scaffolds accelerates islet transplant engraftment by promotion of anti-inflammatory M2 macrophages

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Scientific and Political Impediments to Successful Islet Transplantation

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The TheraCyte™ Device Protects against Islet Allograft Rejection in Immunized Hosts

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Survival and Maturation of Microencapsulated Porcine Neonatal Pancreatic Cell Clusters Transplanted into Immunocompetent Diabetic Mice

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Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling

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Modular tissue engineering for the vascularization of subcutaneously transplanted pancreatic islets

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Alginate-microencapsulation of human stem cell–derived β cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression

Alagpulinsa, D. A., Cao, J. J. L., Driscoll, R. K., Sîrbulescu, R. F., Penson, M. F. E., Sremac, M., Engquist, E. N., Brauns, T. A., Markmann, J. F., Melton, D. A., et al. (2019) · American Journal of Transplantation · doi:10.1111/ajt.15308 · Cited by 130

Enhanced function of immuno-isolated islets in diabetes therapy by co-encapsulation with an anti-inflammatory drug

Dang, T. T., Thai, A. V., Cohen, J., Slosberg, J. E., Siniakowicz, K., Doloff, J. C., Ma, M., Hollister-Lock, J., Tang, K. M., Gu, Z., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.04.016 · Cited by 125

Navigating Two Roads to Glucose Normalization in Diabetes: Automated Insulin Delivery Devices and Cell Therapy

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Impact of Oxygen on Pancreatic Islet Survival

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Engineering the vasculature for islet transplantation

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Rapamycin Impairs In Vivo Proliferation of Islet Beta-Cells

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CD8 T-cell recognition of acquired alloantigen promotes acute allograft rejection

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Engineering transferrable microvascular meshes for subcutaneous islet transplantation

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Autologous Pluripotent Stem Cell–Derived β-Like Cells for Diabetes Cellular Therapy

Millman, J. R., & Pagliuca, F. W. (2017) · Diabetes · doi:10.2337/db16-1406 · Cited by 104

Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site

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Nanoporous Immunoprotective Device for Stem-Cell-Derived β-Cell Replacement Therapy

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Polycaprolactone Thin-Film Micro- and Nanoporous Cell-Encapsulation Devices

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Oxygenation strategies for encapsulated islet and beta cell transplants

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Cellular Plasticity of Inflammatory Myeloid Cells in the Peritoneal Foreign Body Response

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Three-Dimensional Objects Consisting of Hierarchically Assembled Nanofibers with Controlled Alignments for Regenerative Medicine

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Haemopoietic Origin of Myofibroblasts Formed in the Peritoneal Cavity in Response to a Foreign Body

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Functional Beta Cell Mass from Device-Encapsulated hESC-Derived Pancreatic Endoderm Achieving Metabolic Control

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Nanotechnology in cell replacement therapies for type 1 diabetes

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Overcoming foreign-body reaction through nanotopography: Biocompatibility and immunoisolation properties of a nanofibrous membrane

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A bilaminated decellularized scaffold for islet transplantation: Structure, properties and functions in diabetic mice

Wang, X., Wang, K., Zhang, W., Ming, Q., & Luo, Y. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.05.033 · Cited by 54

Islet encapsulation

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Cytotoxic effect of IFN-γ plus TNF-α on human islet cells

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Encapsulate this

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Diabetes: Encapsulating the problem

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Macroencapsulated Human iPSC-Derived Pancreatic Progenitors Protect against STZ-Induced Hyperglycemia in Mice

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Noninvasive evaluation of the vascular response to transplantation of alginate encapsulated islets using the dorsal skin-fold model

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Islet encapsulation therapy — racing towards the finish line?

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Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

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Assessment of Immune Isolation of Allogeneic Mouse Pancreatic Progenitor Cells by a Macroencapsulation Device

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Increase Functional β-Cell Mass in Subcutaneous Alginate Capsules With Porcine Prenatal Islet Cells but Loss With Human Adult Islet Cells

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Encapsulate this: the do's and don'ts

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Modified alginates provide a long-term disguise against the foreign body response

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Medical Applications of Porous Biomaterials: Features of Porosity and Tissue‐Specific Implications for Biocompatibility

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Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes

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New Insights and Potential Therapeutic Interventions in Metabolic Diseases

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Solid implantable devices for sustained drug delivery

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Advances in Pancreatic Islet Transplantation Sites for the Treatment of Diabetes

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A Safe, Fibrosis‐Mitigating, and Scalable Encapsulation Device Supports Long‐Term Function of Insulin‐Producing Cells

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Human β-cell Precursors Mature Into Functional Insulin-producing Cells in an Immunoisolation Device: Implications for Diabetes Cell Therapies

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A 3D-printed microdevice encapsulates vascularized islets composed of iPSC-derived β-like cells and microvascular fragments for type 1 diabetes treatment

Chen, S., Wang, W., Shen, L., Liu, H., Luo, J. C., Ren, Y., Cui, S., Ye, Y., Shi, G., Cheng, F., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122947 · Cited by 19

P-10: STRUCTURAL AND FUNCTIONAL PRELIMINARY ASSESSMENT OF AN ENCAPSULATION DEVICE FOR Β-CELLS SPHEROIDS USING A SEMIPERMEABLE MEMBRANE

Miceli, V., Castelbuono, S., Cuscino, N., Zito, G., Centi, C., Tinnirello, R., Cimino, M., Pinzani, M., Conaldi, P. G., & Mattina, A. (2025) · Transplantation · doi:10.1097/01.tp.0001123412.40447.5a

07-2: A PERFUSABLE ENCAPSULATION DEVICE SCALED FOR CLINICALLY RELEVANT THERAPEUTIC ISLET DOSES SHOWS RAPID INSULIN RESPONSE IN VITRO AND ACUTE SAFETY IN PIG TRANSPLANTATION MODEL

Vdovenko, D., Sidharthan, D. S., Brassard, J. A., Ruel, J., Bégin‐Drolet, A., Paraskevas, S., Gasparrini, M., Leask, R. L., Kieffer, T. J., & Hoesli, C. A. (2025) · Transplantation · doi:10.1097/01.tp.0001123064.83133.9a · Cited by 1