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Hepatic Stellate Cells: Dictating Outcome in Nonalcoholic Fatty Liver Disease

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Hepatocytes demarcated by EphB2 contribute to the progression of nonalcoholic steatohepatitis

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The gut–liver axis in immune remodeling of hepatic cirrhosis

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The role and therapeutic targeting of the CCL2/CCR2 signaling axis in inflammatory and fibrotic diseases

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Molecular pathogenesis of subretinal fibrosis in neovascular AMD focusing on epithelial-mesenchymal transformation of retinal pigment epithelium

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Role of targeting TLR4 signaling axis in liver-related diseases

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Buddleoside alleviates nonalcoholic steatohepatitis by targeting the AMPK-TFEB signaling pathway

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Spatial genomics: mapping human steatotic liver disease

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Exploring the effect of Weifuchun capsule on the toll-like receptor pathway mediated HES6 and immune regulation against chronic atrophic gastritis

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Zonation in NASH – A key paradigm for understanding pathophysiology and clinical outcomes

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Intestinal Barrier Dysfunction and Gut Microbiota in Non-Alcoholic Fatty Liver Disease: Assessment, Mechanisms, and Therapeutic Considerations

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The Role of Notch Signaling Pathway in Non-Alcoholic Fatty Liver Disease

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Roles of immune dysregulation in MASLD

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Advances in the acting mechanism and treatment of gut microbiota in metabolic dysfunction-associated steatotic liver disease

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Regulatory role and translational potential of CCL11 in liver fibrosis

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Role of pattern recognition receptors in the development of MASLD and potential therapeutic applications

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The IGF2BP3/Notch/Jag1 pathway: A key regulator of hepatic stellate cell ferroptosis in liver fibrosis

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Neutrophil extracellular traps-triggered hepatocellular senescence exacerbates lipotoxicity in non-alcoholic steatohepatitis

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The Annexin A2-Notch regulatory loop in hepatocytes promotes liver fibrosis in NAFLD by increasing osteopontin expression

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GalNac-siRNA conjugate delivery technology promotes the treatment of typical chronic liver diseases

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Fibrogenic Pathways in Metabolic Dysfunction Associated Fatty Liver Disease (MAFLD)

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Myeloid-specific blockade of Notch signaling ameliorates nonalcoholic fatty liver disease in mice

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Crystalline Silica-Induced Proinflammatory Interstitial Macrophage Recruitment through Notch3 Signaling Promotes the Pathogenesis of Silicosis

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Gut-derived lipopolysaccharides and metabolic endotoxemia: a critical review

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Ongoing involvers and promising therapeutic targets of hepatic fibrosis: The hepatic immune microenvironment

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Inter-organ metabolic interaction networks in non-alcoholic fatty liver disease

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Gut Microbiome in the Progression of NAFLD, NASH and Cirrhosis, and Its Connection with Biotics: A Bibliometric Study Using Dimensions Scientific Research Database

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Hepatic adaptation to chronic metabolic stress primes tumorigenesis

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ADAM12 is an independent predictor of poor prognosis in liver cancer

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Notch Signaling Induced by Endoplasmic Reticulum Stress Regulates Cumulus-Oocyte Complex Expansion in Polycystic Ovary Syndrome

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Targeting lncRNA16 by GalNAc-siRNA conjugates facilitates chemotherapeutic sensibilization via the HBB/NDUFAF5/ROS pathway

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Jagged-mediated development and disease: Mechanistic insights and therapeutic implications for Alagille syndrome

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Hepatic NLRP3-Derived Hsp70 Binding to TLR4 Mediates MASLD to MASH Progression upon Inhibition of PP2A by Harmful Algal Bloom Toxin Microcystin, a Second Hit

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Regulation of SIRT1-TLR2/TLR4 pathway in cell communication from macrophages to hepatic stellate cells contribute to alleviates hepatic fibrosis by Luteoloside

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Antisense oligonucleotide is a promising intervention for liver diseases

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Hepatocyte Kctd17 Inhibition Ameliorates Glucose Intolerance and Hepatic Steatosis Caused by Obesity-induced Chrebp Stabilization

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Dahuang zhechong pill ameliorates hepatic fibrosis by regulating gut microbiota and metabolites

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Integration of deep learning-based histopathology and transcriptomics reveals key genes associated with fibrogenesis in patients with advanced NASH

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Inflammatory liver diseases and susceptibility to sepsis

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A host enzyme reduces metabolic dysfunction-associated steatotic liver disease (MASLD) by inactivating intestinal lipopolysaccharide

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SFAs facilitates ceramide’s de novo synthesis via TLR4 and intensifies hepatocyte lipotoxicity

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Filamin A is overexpressed in non-alcoholic steatohepatitis and contributes to the progression of inflammation and fibrosis

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Hepatocyte CD36 protects mice from NASH diet-induced liver injury and fibrosis via blocking N1ICD production

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Emerging mechanisms of non-alcoholic steatohepatitis and novel drug therapies

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Alanyl-Glutamine Protects Mice against Methionine- and Choline-Deficient-Diet-Induced Steatohepatitis and Fibrosis by Modulating Oxidative Stress and Inflammation

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Mechanisms of hepatic steatosis in chickens: integrated analysis of the host genome, molecular phenomics and gut microbiome

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A read-through circular RNA RCRIN inhibits metabolic dysfunction-associated steatotic liver disease

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Regulatory Mechanisms of Phenolic Acids in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Review

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Multimodal Learning-based Prediction for Nonalcoholic Fatty Liver Disease

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Targeting the gut-liver axis with dietary polyphenols to ameliorate metabolic dysfunction-associated steatotic liver disease: advances in molecular mechanisms

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The beneficial effects of l ‐carnitine and infliximab in methotrexate‐induced hepatotoxicity: Emphasis on Notch1/Hes‐1 signaling

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Single-Cell and Spatial Multi-Omics Analysis Reveal That Targeting JAG1 in Epithelial Cells Reduces Periodontal Inflammation and Alveolar Bone Loss

Kuang, S., Yang, J., Shen, Z., Xia, J., & Lin, Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413255 · Cited by 11

Molecular Mechanisms and Mediators of Hepatotoxicity Resulting from an Excess of Lipids and Non-Alcoholic Fatty Liver Disease

Finelli, C. (2023) · Gastrointestinal Disorders · doi:10.3390/gidisord5020020 · Cited by 12

Inhibition of hepatic PCSK9 as a novel therapeutic target ameliorates metabolic steatohepatitis in mice

Mijiti, T., Chen, X., Ma, X., XiuMin, M., XiuMin, M., & Chen, B. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113621 · Cited by 10

Periostin-mediated NOTCH1 activation between tumor cells and HSCs crosstalk promotes liver metastasis of small cell lung cancer

Lou, L., Peng, K., Ouyang, S., Ding, W., Mo, J., Yan, J., Gong, X., Liu, G., Lu, J., Yue, P., et al. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03266-7 · Cited by 10

Alcohol‐Related Liver Disease and Metabolic Dysfunction‐Associated Steatotic Liver Disease: Molecular Pathogenesis and Therapeutic Interventions

Tan, Y., Hu, Y., Yang, Y., & Chu, H. (2025) · MedComm · doi:10.1002/mco2.70532 · Cited by 13

MFG-E8 Knockout Aggravated Nonalcoholic Steatohepatitis by Promoting the Activation of TLR4/NF-κB Signaling in Mice

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Unraveling the link between metabolic dysfunction-associated steatotic liver disease and osteoporosis: a bridging function of gut microbiota

Zhang, J., Sun, Z., Xu, L., Wang, Y., Wang, Y., & Dong, B. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1543003 · Cited by 9

Targeting NOTCH1-KEAP1 axis retards chronic liver injury and liver cancer progression via regulating stabilization of NRF2

Chang, C., Wang, M., Li, J., Qi, S., Yu, X., Xu, J., & Shi, S. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03488-3 · Cited by 9

Genomic medicine in hepatology: mechanisms and liver treatment strategies

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Multidimensional landscape of non‐alcoholic fatty liver disease‐related disease spectrum uncovered by big omics data: Profiling evidence and new perspectives

Zhu, Z., Chen, Y., Qin, X., Liu, S., Wang, J., & Ren, H. (2023) · Smart Medicine · doi:10.1002/smmd.20220029 · Cited by 9

Toll Like Receptor 4: A Potential Link Between Obesity and Metabolic Diseases

Alhamar, G., Razafiarison, J., Alzaïd, F., Al‐Mulla, F., & Ahmad, R. (2026) · Obesity Reviews · doi:10.1111/obr.70107 · Cited by 8

Treatment Strategies and Mechanisms Associated with the Prevention of NASH-Associated HCC by a Toll-like Receptor 4 Inhibitor

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FTY‐720 alleviates diabetes‐induced liver injury by inhibiting oxidative stress and inflammation

Ye, H., Sun, M., Jin, Z., Yuan, Y., & Weng, H. (2023) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12897 · Cited by 8

Reactive Oxygen Species-Responsive Delivery of a Notch Inhibitor to Alleviate Nonalcoholic Steatohepatitis by Inhibiting Hepatic de Novo Lipogenesis and Inflammation

Chen, J.-H., Zhang, J., Xia, Y., Li, J., Jia, Q., Zhang, Z., Jing, X., Xu, Y., Zou, L., Wang, L., et al. (2024) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.4c00070 · Cited by 7

Biliary fibrosis is an important but neglected pathological feature in hepatobiliary disorders: from molecular mechanisms to clinical implications

Zhao, J., Yue, P., Mi, N., Li, M., Fu, W., Zhang, X., Gao, L., Bai, M., Tian, L., Jiang, N., et al. (2024) · Medical Review · doi:10.1515/mr-2024-0029 · Cited by 7

HMGB1 Accelerates Wound Healing by Promoting the Differentiation of Epidermal Stem Cells via the “HMGB1-TLR4-Wnt/Notch” Axis

Zhen, M., Zhu, Y., Wang, P., Liu, X., Zhu, J., Liu, H., Li, J., Zhao, J., & Shu, B. (2024) · Advances in Wound Care · doi:10.1089/wound.2023.0130 · Cited by 7

Dietary Inflammatory index and its association with fatty liver disease: a study in obese and non-obese populations

Fu, W., Zhao, J., Cheng, G., Xu, L.-B., Lyu, L., & Ding, Y. (2025) · BMC Gastroenterology · doi:10.1186/s12876-024-03585-1 · Cited by 7

Effects of the interaction of Notch and TLR4 pathways on inflammation and heart function in septic heart

Liu, Z., Li, W., Cao, Y., Zhang, X., Yang, K., Yin, F., Yang, M., & Peng, P. (2022) · Open Life Sciences · doi:10.1515/biol-2022-0076 · Cited by 7

Jagged-1/Notch Pathway and Key Transient Markers Involved in Biliary Fibrosis during Opisthorchis felineus Infection

Kovner, A. V., Zaparina, O. G., Kapushchak, Y. K., Minkova, G., Mordvinov, V. A., & Pakharukova, M. Y. (2022) · Tropical Medicine and Infectious Disease · doi:10.3390/tropicalmed7110364 · Cited by 7

Jag1 insufficiency alters liver fibrosis via T cell and hepatocyte differentiation defects

Mašek, J., Filipovic, I., Hul, N. V., Belicová, L., Jiroušková, M., Oliveira, D. V., Frontino, A. M., Hankeová, S., He, J., Turetti, F., et al. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00145-8 · Cited by 6

Notch Signaling Aggravates Helicobacter pylori–Induced Inflammation by Promoting Macrophage Activation and Proinflammatory Th1/Th17 Responses

He, Y., Xiao, D., Zhu, H., Chen, C., Liu, Q., Xie, J., Wei, L., Dai, Y., Ning, Y., & Li, Y. (2025) · American Journal Of Pathology · doi:10.1016/j.ajpath.2025.04.007 · Cited by 6

Antisense oligonucleotide-mediated upregulation of Jag1 ameliorates liver disease phenotypes in a mouse model of Alagille syndrome

Zhang, L., Niknejad, N., Li, J. J., Peng, L., Jain, S., Steiner, D., Thai, R., Yu, X. X., Wang, Y., & Liang, X. (2025) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2025.102694 · Cited by 6

The liver-specific long noncoding RNA FAM99B inhibits ribosome biogenesis and cancer progression through cleavage of dead-box Helicase 21

He, Y., Li, H., Shi, Q., Liu, Y., Pan, Q., & He, X. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07401-w · Cited by 6

Time-restricted feeding reduces inflammatory markers and downregulates JAG1 and NICD protein levels in the liver of aged mice

Macêdo, A. P. A., Neto, I. V. D. S., Antonio, G. C. F., Gaspar, R. C., de Lima, R. D., Dias, L. M., Vieira, R. F. L., Muñoz, V. R., Brunelli, D. T., da Silva, A. S. R., et al. (2025) · Nutrition · doi:10.1016/j.nut.2025.112691 · Cited by 5

Immune Microenvironment on the Molecular Mechanisms and Therapeutic Targets of MAFLD

Jiang, Z., Qian, B., Xu, T., Bai, J., & Fu, W. (2025) · ImmunoTargets and Therapy · doi:10.2147/itt.s530451 · Cited by 5

Elevated expression of Toll-like receptor 4 and cytokines in both serum and myometrium at term may serve as promising biomarkers for uterine activation preceding labor

Chen, Z., Li, J., Wenjuan, X., Wu, X., Xiang, F., Li, X., Zhang, M., Zheng, J., Kang, X., & Wu, R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1255925 · Cited by 5

Direct degradation and stabilization of proteins: New horizons in treatment of nonalcoholic steatohepatitis

Wang, Y., Zheng, J., Long, Y., Wu, W., & Zhu, Y. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115989 · Cited by 5

β-cell Jagged1 is sufficient but not necessary for islet Notch activity and insulin secretory defects in obese mice

Suda, N., Bartolomé, A., Liang, J., Son, J., Yagishita, Y., Siebel, C. W., Accili, D., Ding, H., & Pajvani, U. B. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.101894 · Cited by 5

Prediction of the mechanisms of action of Qutan Huoxue decoction in non-alcoholic steatohepatitis (NASH): a network pharmacology study and experimental validation

Wu, X., Zhang, Y., Ding, Z., Yin, Y., Peng, M., Wang, J., & Zhu, X. (2023) · Pharmaceutical Biology · doi:10.1080/13880209.2023.2182892 · Cited by 5

Hepatocyte KCTD17-mediated SERPINA3 inhibition determines liver fibrosis in metabolic dysfunction-associated steatohepatitis

Jeong, Y., Oh, A., Jung, Y. H., Jung, K. H., Lee, S., Carrer, M., Lee, S. B., Valenti, L. V. C., Pajvani, U. B., & Kim, K. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01499-w · Cited by 4

Maternal Vitamin D and Inulin Supplementation in Oxidized Oil Diet Improves Growth Performance and Hepatic Innate Immunity in Offspring Mice

Xie, G., Zhang, Q., Fang, Z., Che, L., Lin, Y., Xu, S., Zhuo, Y., Hua, L., Jiang, X., Li, J., et al. (2023) · Antioxidants · doi:10.3390/antiox12071355 · Cited by 4

Immune Features of Disparate Liver Transplant Outcomes in Female Hispanics With Nonalcoholic Steatohepatitis

Sosa, R. A., Terry, A. Q., Ito, T., Naini, B. V., Zheng, Y. Y., Pickering, H. C., Nevarez‐Mejia, J., Busuttil, R. W., Gjertson, D. W., Kupiec‐Weglinski, J. W., et al. (2023) · Transplantation Direct · doi:10.1097/txd.0000000000001550 · Cited by 3

Multiscale insights into cornusideʼs effects on NAFLD: A cross-disciplinary integrating bioinformatics, computational chemistry, and machine learning

Gao, G., Zhang, X., Wang, Z., Xu, J., Wang, J., Liu, T., & Xie, Z. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156809 · Cited by 3

Notch signaling in metabolic diseases: A key regulator and potential target

Xi, Z., Zhang, J., & Bao, M. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152492 · Cited by 3

Paeoniflorin Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease by SYK/SH3BP2 Signaling Pathway

Liu, Y. Y., Tao, J., Tan, D., Zheng, F., Su, Z., Yuan, J., Zhu, C., Zheng, Z., Zhou, X., & Luo, D. (2026) · Research · doi:10.34133/research.1100 · Cited by 3

Molecular mechanisms and pathogenesis of MASH

Gallage, S., Govaere, O., Anstee, Q. M., Shulman, G. I., Tacke, F., & Heikenwälder, M. F. (2026) · Nature · doi:10.1038/s41586-026-10529-0 · Cited by 3

RAGE is a key regulator of ductular reaction-mediated fibrosis during cholestasis

Lam, W.-L. M., Gabernet, G., Poth, T., Sator‐Schmitt, M., Oquendo, M. B., Kast, B., Lohr, S., Ponti, A. D., Weiß, L., Schneider, M., et al. (2025) · EMBO Reports · doi:10.1038/s44319-024-00356-7 · Cited by 3

The hepatic transcriptome is differentially regulated by a standardized meal in healthy individuals compared to patients with fatty liver disease

Grandt, J., Johansen, C. D., Jensen, A. H., Werge, M. P., Rashu, E. B., Møller, A., Junker, A. E., Hobolth, L., Mortensen, C., Vyberg, M., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0307345 · Cited by 3

Gene expression inhibitors for the treatment of liver fibrosis: drugs under preclinical and early clinical investigation

Ocker, M., & Neureiter, D. (2023) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2023.2288075 · Cited by 3

Physiological accumulation of lipid droplets in the newborn liver during breastfeeding is driven by TLR4 ligands

Júnior, W. F. D. S., Costa, K. M. D. O., Oliveira, H. M. D. C., Antunes, M. M., Mafra, K., Nakagaki, B. N., da Silva, P. S. C., Megale, J. D., de Sales, S. C., Caixeta, D. C., et al. (2025) · Journal of Lipid Research · doi:10.1016/j.jlr.2025.100744 · Cited by 3

Notch signaling in liver diseases: mechanistic insights and therapeutic implications

Shi, Q., Lou, N., Huang, D., & Fu, L. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1770031 · Cited by 2

Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis

Zhu, C., Kim, K., Wang, X., Bartolome, A., Salomao, M., Dongiovanni, P., Meroni, M., Graham, M. J., Yates, K. P., Diehl, A. M., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat0344 · Cited by 250

Hepatocyte-targeted siTAZ therapy lowers liver fibrosis in NASH diet-fed chimeric mice with hepatocyte-humanized livers

Wang, X., Moore, M. P., Shi, H., Miyata, Y., Donnelly, S. K., Radiloff, D. R., & Tabas, I. (2023) · Molecular Therapy Methods & Clinical Development · doi:10.1016/j.omtm.2023.101165 · Cited by 21

Notch and Nonalcoholic Fatty Liver and Fibrosis

Romeo, S. (2019) · New England Journal of Medicine · doi:10.1056/nejmcibr1815636 · Cited by 49

Hepatocyte Notch in non-alcoholic steatohepatitis (NASH)-associated liver fibrosis and cancer

Zhu, C. (2019) · doi:10.7916/d8-877b-v389

Jagged-1 signalling is required in liver fibrogensis

Weng, H., Liu, Y., Ilkavets, I., Shen, H., Zimmer, V., Lammert, F., Mueller, A. J., Herweck, F., Stump, C., Mertens, P., et al. (2011) · Zeitschrift für Gastroenterologie · doi:10.1055/s-0030-1269508