The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis
Open accessAbstract
Increased Jagged1 in pericentral hepatocytes causes liver fibrosis in response to hepatocyte TLR4–NF-κB pathway activation in NASH.
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In the citing paper
“All known human TLRs are expressed by HSCs, indicating the importance of their interaction with the gut microbiome.150,151”
From Understanding the cellular interactome of non-alcoholic fatty liver disease (2022) · cites this paper as [150]
Experimental — accuracy not yet measuredIn the citing paper
“Microbiota-associated molecular patterns such as bacterial lipopolysaccharide accumulate in the portal vein and have been shown to act as ligands for TLR2 and TLR4. These activate pro-inflammatory pathways leading to secretion of cytokines and chemokines from various cell types in the liver, including endothelia, myofibroblasts and hepatocytes.125,149,150”
From Understanding the cellular interactome of non-alcoholic fatty liver disease (2022) · cites this paper as [150]
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Cites
Eslam, M., Newsome, P. N., Sarin, S. K., Anstee, Q. M., Targher, G., Romero-Gomez, M., Zelber-Sagi, S., Wai-Sun Wong, V., Dufour, J.-F., Schattenberg, J. M., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.03.039 · Cited by 4,472
Self-citationThe Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
Kopan, R., & Ilagan, M. X. G. (2009) · Cell · doi:10.1016/j.cell.2009.03.045 · Cited by 3,764
Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis
Sanyal, A. J., Chalasani, N., Kowdley, K. V., McCullough, A., Diehl, A. M., Bass, N. M., Neuschwander-Tetri, B. A., Lavine, J. E., Tonascia, J., Unalp, A., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0907929 · Cited by 3,327
Self-citationMAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease
Eslam, M., Sanyal, A. J., George, J., Sanyal, A., Neuschwander-Tetri, B., Tiribelli, C., Kleiner, D. E., Brunt, E., Bugianesi, E., Yki-Järvinen, H., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.11.312 · Cited by 3,286
Self-citationActivating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
Weng, A. P., Ferrando, A. A., Lee, W., Morris, J. P., Silverman, L. B., Sanchez-Irizarry, C., Blacklow, S. C., Look, A. T., & Aster, J. C. (2004) · Science · doi:10.1126/science.1102160 · Cited by 2,706
Notch signalling: a simple pathway becomes complex
Bray, S. J. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2009 · Cited by 2,620
Resolving the fibrotic niche of human liver cirrhosis at single-cell level
Ramachandran, P., Dobie, R., Wilson-Kanamori, J. R., Dora, E. F., Henderson, B. E. P., Luu, N. T., Portman, J. R., Matchett, K. P., Brice, M., Marwick, J. A., et al. (2019) · Nature · doi:10.1038/s41586-019-1631-3 · Cited by 1,784
Fibrosis–a common pathway to organ injury and failure
Rockey, D. C., Bell, P. D., & Hill, J. A. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1300575 · Cited by 1,428
From NASH to HCC: current concepts and future challenges
Anstee, Q. M., Reeves, H. L., Kotsiliti, E., Govaere, O., & Heikenwalder, M. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0145-7 · Cited by 1,392
PROMO: detection of known transcription regulatory elements using species-tailored searches
Messeguer, X., Escudero, R., Farré, D., Núñez, Ó., Martı́nez, J., & Albà, M. M. (2002) · Bioinformatics · doi:10.1093/bioinformatics/18.2.333 · Cited by 1,371
Cited by
Sorted by citations
Notch signaling pathway: architecture, disease, and therapeutics
Zhou, B., Lin, W., Long, Y., Yang, Y., Zhang, H., Wu, K., & Chu, Q. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00934-y · Cited by 1,216
Understanding the cellular interactome of non-alcoholic fatty liver disease
Wallace, S. J., Tacke, F., Schwabe, R. F., & Henderson, N. C. (2022) · JHEP Reports · doi:10.1016/j.jhepr.2022.100524 · Cited by 116
Lau, H. C.-H., Zhang, X., & Yu, J. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01089-1 · Cited by 126
Self-citationPathophysiological underpinnings of metabolic dysfunction-associated steatotic liver disease
Kuchay, M. S., Choudhary, N. S., & Ramos‐Molina, B. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00951.2024 · Cited by 104
Metadata
- Authors
- Yu, J., Zhu, C., Wang, X., Kim, K., Bartolome, A., Dongiovanni, P., Yates, K. P., Valenti, L., Carrer, M., Sadowski, T., Qiang, L., Tabas, I., Lavine, J. E., & Pajvani, U. B.
- Affiliations
- Columbia University (US)
- Department of Medicine, Columbia University, New York, NY 10032, USA.
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Johns Hopkins University (US)
- University of Milan (IT)
- Ionis Pharmaceuticals (United States) (US)
- Sanofi (Germany) (DE)
- Corresponding author
- Pajvani, Utpal B.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2021-06-23
- Volume
- 13
- Issue
- 599
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC8792974
- OpenAlex
- W3173162204
- Cited by
- 132
- References
- 73
- Citations by year
- 2026: 21 · 2025: 39 · 2024: 21 · 2023: 28 · 2022: 20 · 2021: 3
- FWCI
- 10.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK103818, DK119767, DK116620)
- American Liver Foundation
- Stiftelsen för Kunskaps- och Kompetensutveckling (RF-2016-02364358, 777377)
- Russell Berrie Foundation
- MyFIRST AIRC GRANT (n.16888)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- Jagged1, Notch signaling, liver fibrosis, nonalcoholic steatohepatitis
- MeSH terms
- Jagged-1 Protein, Animals, Disease Models, Animal, Humans, Liver, Liver Cirrhosis, Mice, Inbred C57BL, Signal Transduction, Mice, Knockout, Hepatocytes, Toll-Like Receptor 4, Mice, Receptors, Notch, Non-alcoholic Fatty Liver Disease
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