Distinct populations of highly potent TAU seed conformers in rapidly progressing Alzheimer’s disease
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Rapid replication in vitro implicates distinct populations of misfolded hippocampal 4R TAU protein in accelerated progression of Alzheimer’s disease.
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The observation that characteristics of soluble tau correlate with aggressiveness of clinical phenotype has been replicated in two other clinical populations.
“This observation—that the characteristics of soluble tau correlate with how aggressive the clinical phenotype is—has already been replicated in two other clinical populations (68, 69).”
From All the Tau We Cannot See (2023) · cites this paper as [68]
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A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer’s disease
Sepulveda-Falla, D., Chavez-Gutierrez, L., Portelius, E., Vélez, J. I., Dujardin, S., Barrera-Ocampo, A., Dinkel, F., Hagel, C., Puig, B., Mastronardi, C., et al. (2021) · Acta Neuropathologica · doi:10.1007/s00401-020-02249-0 · Cited by 54 · see citing works
Molecular pathogenesis of sporadic prion diseases in man
Safar, J. (2012) · Prion · doi:10.4161/pri.18666 · Cited by 53 · see citing works
Self-citationHaldiman, T., Kim, C., Cohen, Y., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.500108 · Cited by 53 · see citing works
Self-citationEvolutional Aspects of Alzheimer's Disease Pathogenesis
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Human prions and plasma lipoproteins
Safar, J., Wille, H., Geschwind, M. D., Deering, C., Latawiec, D., Serban, A. V., King, D. J., Legname, G., Weisgraber, K. H., Mahley, R. W., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604021103 · Cited by 49 · see citing works
Self-citationNoble, G. P., Wang, D. W., Walsh, D. J., et al. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005017 · Cited by 47 · see citing works
Ultrastructural Studies on Scrapie Prion Protein Crystals Obtained from Reverse Micellar Solutions
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Mays, C. E., van der Merwe, J., Kim, C., et al. (2015) · Journal of Virology · doi:10.1128/jvi.02142-15 · Cited by 44 · see citing works
Self-citationChapter 29 Molecular studies of prion diseases
Safar, J., & Prusiner, S. B. (1998) · Progress in brain research · doi:10.1016/s0079-6123(08)64030-3 · Cited by 43 · see citing works
Self-citationMinjarez, B. D., Rustarazo, M. L. V., del Pino, M. M. S., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121480 · Cited by 40 · see citing works
Artificial strain of human prions created in vitro
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Self-citationAlzheimer’s Disease: Genetic Polymorphisms and Rate of Decline
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Tatsuoka, C. M., Tseng, H., Jaeger, J., Váradi, F., Smith, M. A., Yamada, T., Smyth, K. A., Lerner, A. J., & Initiative, T. A. D. N. (2013) · Alzheimer s Research & Therapy · doi:10.1186/alzrt168 · Cited by 32 · see citing works
Self-citationRapidly Progressive Alzheimer’s Disease in Two Distinct Autopsy Cohorts
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Self-citationStructural attributes of mammalian prion infectivity: Insights from studies with synthetic prions
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Kang, S., Han, Z. Z., Daude, N., McNamara, E., Wohlgemuth, S. L., Molina‐Porcel, L., Safar, J., Mok, S., & Westaway, D. A. (2021) · BMC Biology · doi:10.1186/s12915-021-01132-y · Cited by 31 · see citing works
Self-citationDaude, N., Kim, C., Kang, S., Eskandari‐Sedighi, G., Haldiman, T., Yang, J., Fleck, S. C., Gomez‐Cardona, E., Han, Z. Z., Borrego‐Écija, S., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02148-4 · Cited by 29 · see citing works
Self-citationImplications of prion adaptation and evolution paradigm for human neurodegenerative diseases
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Self-citationCSF prion protein concentration and cognition in patients with Alzheimer disease
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Structurally distinct external solvent-exposed domains drive replication of major human prions
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Molecular and Genetic Basis of Prion Diseases
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Flagged first, then by citations
Research works printed but not linked: 4
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- [20]Prusiner SB, Legname G, DeArmond SJ, Cohen FE, Safar J, Riesner D, Kaneko K, in Prion Biology and Diseases, Prusiner SB, Ed. (Cold Spring Harbor Laboratory Press, 2004), pp. 857– 920.
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Cited by
Sorted by citations
Hyman, B. (2023) · Annual Review of Medicine · doi:10.1146/annurev-med-042921-023749 · Cited by 39 · see citing works
- Authors
- Kim, C., Haldiman, T., Kang, S.-G., Hromadkova, L., Han, Z. Z., Chen, W., Lissemore, F., Lerner, A., de Silva, R., Cohen, M. L., Westaway, D., & Safar, J. G.
- Affiliations
- Case Western Reserve University (US)
- University of Alberta (CA)
- Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
- Reta Lila Weston Institute of Neurological Studies and Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 1PJ, UK.
- Corresponding author
- Safar, Jiri G.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2022-01-05
- Volume
- 14
- Issue
- 626
- Pages
- eabg0253-eabg0253
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC9549419
- OpenAlex
- W4206156187
- Cited by
- 55
- References
- 113
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 10 · 2023: 13 · 2022: 11
- FWCI
- 7.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Parkinson's UK (K-1212)
- Canadian Institutes of Health Research (163048_1, PS148962)
- Medical Research Council (MR/M02492X/1)
- Biotechnology and Biological Sciences Research Council (1211442)
- National Institute on Aging (U01AG016976, RF1AG058267, RF1AG061797)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- Alzheimer's disease, tau protein, tau aggregation, four-repeat tau, protein misfolding, disease progression, cognitive decline, conformational heterogeneity, in vitro replication
- MeSH terms
- Alzheimer Disease, Humans, tau Proteins, Protein Isoforms
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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