Cited by 55Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchAmyotrophic Lateral Sclerosis Research

Distinct populations of highly potent TAU seed conformers in rapidly progressing Alzheimer’s disease

Open access
Kim, Chae, Haldiman, Tracy, Kang, Sang-Gyun, Hromadkova, Lenka, Han, Zhuang Zhuang, Chen, Wei, Lissemore, Frances, Lerner, Alan +4 more·2022·Science Translational Medicine

Abstract

Rapid replication in vitro implicates distinct populations of misfolded hippocampal 4R TAU protein in accelerated progression of Alzheimer’s disease.

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Integrity signals

Registry

Crossref · 10.1126/scitranslmed.abg0253

Cites

113 of 113 references verified0 citation errors · 0 not checkable

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  • The observation that characteristics of soluble tau correlate with aggressiveness of clinical phenotype has been replicated in two other clinical populations.

    “This observation—that the characteristics of soluble tau correlate with how aggressive the clinical phenotype is—has already been replicated in two other clinical populations (68, 69).”

    From All the Tau We Cannot See (2023) · cites this paper as [68]

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Cites

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Research works printed but not linked: 4

  1. [19]Prusiner SB, in Principles of Molecular Medicine, Jameson JL, Ed. (Humana Press, 1998), pp. 927– 939.
  2. [20]Prusiner SB, Legname G, DeArmond SJ, Cohen FE, Safar J, Riesner D, Kaneko K, in Prion Biology and Diseases, Prusiner SB, Ed. (Cold Spring Harbor Laboratory Press, 2004), pp. 857– 920.
  3. [46]Safar JG, in Prions and Diseases, Zou W-Q, Gambetti P, Ed. (Springer Verlag, 2012), vol. 1.
  4. [109]Steensgaard J, Humphries S, Spragg SP, in Preparative Centrifugation: A Practical Approach, Rickwood D, Ed. (IRL Press, 1992), pp. 187– 232.

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Authors
Kim, C., Haldiman, T., Kang, S.-G., Hromadkova, L., Han, Z. Z., Chen, W., Lissemore, F., Lerner, A., de Silva, R., Cohen, M. L., Westaway, D., & Safar, J. G.
Affiliations
  • Case Western Reserve University (US)
  • University of Alberta (CA)
  • Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
  • Reta Lila Weston Institute of Neurological Studies and Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 1PJ, UK.
Corresponding author
Safar, Jiri G.
Venue
Science Translational Medicine
Published
2022-01-05
Volume
14
Issue
626
Pages
eabg0253-eabg0253
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W4206156187
Cited by
55
References
113
Citations by year
2026: 6 · 2025: 14 · 2024: 10 · 2023: 13 · 2022: 11
FWCI
7.43
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • Parkinson's UK (K-1212)
  • Canadian Institutes of Health Research (163048_1, PS148962)
  • Medical Research Council (MR/M02492X/1)
  • Biotechnology and Biological Sciences Research Council (1211442)
  • National Institute on Aging (U01AG016976, RF1AG058267, RF1AG061797)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
Keywords
Alzheimer's disease, tau protein, tau aggregation, four-repeat tau, protein misfolding, disease progression, cognitive decline, conformational heterogeneity, in vitro replication
MeSH terms
Alzheimer Disease, Humans, tau Proteins, Protein Isoforms

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