Isolation and Characterization of Two Members of the Siderophore-Microcin Family, Microcins M and H47
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In this paper we provide the first biochemical evidence of the existence of a family of structure-related antimicrobial peptides, the siderophore-microcins, in the Enterobacteriaceae family. We isolated and characterized two novel siderophore-microcins, MccM and MccH47, previously characterized through genetic studies. MccM and MccH47 were expressed from several Escherichia coli strains containing the microcin gene clusters. The spectra of their bactericidal activities were found to be restricted to some species of the Enterobacteriaceae . MccM and MccH47 were unable to inhibit the growth of strains carrying mutations in the fepA , cir , and fiu genes, which showed the requirement of the iron-catecholate receptors for their recognition. The MccM and MccH47 peptide moieties contain 77 and 60 residues, respectively, and are derived from the microcin precursors McmA and MchB, respectively. In addition, both peptides carried a C-terminal posttranslational modification containing a salmochelin-like siderophore moiety also found in MccE492 (X. Thomas et al., J. Biol. Chem., 279:28233-28242, 2004). Interestingly, when MccM was isolated from E. coli Nissle 1917, which lacks the two genes necessary for modification biosynthesis, it was devoid of posttranslational modification. Those two genes could be complemented by their homologues from the MccH47 gene cluster, thereby showing their functional interchangeability between at least two members of the siderophore-microcin family. Finally, from the sequence analysis of the MccE492 gene cluster, we hypothesized the existence of an additional member of the siderophore-microcin family. Therefore, we propose that the siderophore-microcin family contains five representatives.
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E. coli Nissle 1917 has two plasmids pMUT1 and pMUT2 synthetizing microcins M and H47 active against Salmonella strains.
“having two plasmids (pMUT1 and pMUT2) synthetizing microcins M and H47 (active against Salmonella strains) [26, 31, 32]”
From Selection, Comparative Genomics, and Potential Probiotic Features of Escherichia coli 5C, a pks-Negative Strain Isolated from Healthy Infant Donor Feces (2026) · cites this paper as [31]
The Results report isolating both microcins M and H47 from E. coli Nissle 1917. They report that MccM was active against Salmonella, but MccH47 was inactive at the concentrations tested. The Materials and Methods identify different experimental plasmids and do not establish that pMUT1 and pMUT2 synthesize these microcins. (LLM, conf=0.88)
Experimental — accuracy not yet measuredNissle 1917 contains two microcins (M and H47), one colicin, and one bottromycin, with the colicin and bottromycin not phenotypically expressed.
“the strain Nissle 1917, besides the already described two microcins, known as M and H47 [31, 32], demonstrates the presence of one colicin and one bottromycin [116], both not phenotypically expressed.”
From Selection, Comparative Genomics, and Potential Probiotic Features of Escherichia coli 5C, a pks-Negative Strain Isolated from Healthy Infant Donor Feces (2026) · cites this paper as [31]
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“As regards to bacteriocin genes, the strain Nissle 1917, besides the already described two microcins, known as M and H47 [31, 32], demonstrates the presence of one colicin and one bottromycin [116], both not pheno-typically expressed.”
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- Authors
- Vassiliadis, G., Destoumieux-Garzón, D., Lombard, C., Rebuffat, S., & Peduzzi, J.
- Affiliations
- Molécules de Communication et Adaptation des Micro-organismes, FRE 3206 CNRS, Muséum National d'Histoire Naturelle, CP 54, 57 rue Cuvier, Paris 75005, France
- Centre National de la Recherche Scientifique (FR)
- ORCID
- Rebuffat, Sylvie
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2010-01
- Volume
- 54
- Issue
- 1
- Pages
- 288-297
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC2798501
- OpenAlex
- W2157624401
- Cited by
- 128
- References
- 30
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 15 · 2023: 6 · 2022: 13 · 2021: 14 · 2020: 8 · 2019: 8 · 2018: 7 · 2017: 10 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 7 · 2012: 4
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- antimicrobial peptides, Enterobacteriaceae, Escherichia coli, FepA, CIR, post-translational modification, salmochelin, gene complementation, siderophore biosynthesis
- MeSH terms
- Amino Acid Sequence, Anti-Bacterial Agents, Bacterial Outer Membrane Proteins, Colicins, Electrophoresis, Polyacrylamide Gel, Enterobacteriaceae, Escherichia coli, Hydrolysis, Klebsiella pneumoniae, Molecular Sequence Data, Peptides, Phylogeny, Plasmids, Protein Processing, Post-Translational, Receptors, Cell Surface, Trypsin, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Antimicrobial Cationic Peptides
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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