Cited by 139Antimicrobial Peptides and ActivitiesMicrobial Natural Products and BiosynthesisAntimicrobial agents and applications

Bacteriocins: Perspective for the development of novel anticancer drugs

Baindara, Piyush, Korpole, Suresh, Grover, Vishakha·2018·Applied Microbiology and Biotechnology

Abstract

Antimicrobial peptides (AMPs) from prokaryotic source also known as bacteriocins are ribosomally synthesized by bacteria belonging to different eubacterial taxonomic branches. Most of these AMPs are low molecular weight cationic membrane active peptides that disrupt membrane by forming pores in target cell membranes resulting in cell death. While these peptides known to exhibit broad-spectrum antimicrobial activity, including antibacterial and antifungal, they displayed minimal cytotoxicity to the host cells. Their antimicrobial efficacy has been demonstrated in vivo using diverse animal infection models. Therefore, we have discussed some of the promising peptides for their ability towards potential therapeutic applications. Further, some of these bacteriocins have also been reported to exhibit significant biological activity against various types of cancer cells in different experimental studies. In fact, differential cytotoxicity towards cancer cells as compared to normal cells by certain bacteriocins directs for a much focused research to utilize these compounds as novel therapeutic agents. In this review, bacteriocins that demonstrated antitumor activity against diverse cancer cell lines have been discussed emphasizing their biochemical features, selectivity against extra targets and molecular mechanisms of action.

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Crossref · 10.1007/s00253-018-9420-8

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213 of 213 references verified0 citation errors · 0 not checkable

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  • Some bacteriocins have been shown to exert selective effects on cancer cells, probably due to their unique membrane composition.

    “Some bacteriocins have been shown to exert selective effects on cancer cells, probably due to their unique membrane composition [249].”

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Authors
Baindara, P., Korpole, S., & Grover, V.
Affiliations
  • Institute of Microbial Technology (IN)
  • Panjab University (IN)
Corresponding author
Grover, Vishakha
Venue
Applied Microbiology and Biotechnology
Published
2018-10-18
Volume
102
Issue
24
Pages
10393-10408
ISSN
  • 0175-7598 (ISSN-L)
  • 1432-0614
OpenAlex
W2896326025
Cited by
139
References
213
Citations by year
2026: 10 · 2025: 14 · 2024: 25 · 2023: 18 · 2022: 17 · 2021: 24 · 2020: 22 · 2019: 8
FWCI
1.93
Type
journal article
Language
en
Open access
closed
Locations
  • Applied Microbiology and Biotechnology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
  • Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
  • Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
Keywords
bacteriocins, antimicrobial peptides, anticancer agents, anticancer activity, membrane-disrupting peptides, cationic peptides, selective cytotoxicity, cancer cell lines, mechanism of action, ribosomally synthesized peptides
MeSH terms
Pediocins, Antineoplastic Agents, Azurin, Bacteriocins, Cations, Cell Membrane, Humans, Nisin, Pyocins, Protein Engineering

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