Cited by 461Antifungal resistance and susceptibilityFungal and yeast genetics researchFungal Plant Pathogen Control

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Resistance Mechanisms in Clinical Isolates of Candida albicans

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White, Theodore C., Holleman, Scott, Dy, Francis, Mirels, Laurence F., Stevens, David A.·2002·Antimicrobial Agents and Chemotherapy

DOI 10.1128/aac.46.6.1704-1713.2002PMC PMC127245

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Abstract

Resistance to azole antifungals continues to be a significant problem in the common fungal pathogen Candida albicans . Many of the molecular mechanisms of resistance have been defined with matched sets of susceptible and resistant clinical isolates from the same strain. Mechanisms that have been identified include alterations in the gene encoding the target enzyme ERG11 or overexpression of efflux pump genes including CDR1 , CDR2 , and MDR1 . In the present study, a collection of unmatched clinical isolates of C. albicans was analyzed for the known molecular mechanisms of resistance by standard methods. The collection was assembled so that approximately half of the isolates were resistant to azole drugs. Extensive cross-resistance was observed for fluconazole, clotrimazole, itraconazole, and ketoconazole. Northern blotting analyses indicated that overexpression of CDR1 and CDR2 correlates with resistance, suggesting that the two genes may be coregulated. MDR1 overexpression was observed infrequently in some resistant isolates. Overexpression of FLU1 , an efflux pump gene related to MDR1 , did not correlate with resistance, nor did overexpression of ERG11 . Limited analysis of the ERG11 gene sequence identified several point mutations in resistant isolates; these mutations have been described previously. Two of the most common point mutations in ERG11 associated with resistance, D116E and E266D, were tested by restriction fragment length polymorphism analysis of the isolates from this collection. The results indicated that the two mutations occur frequently in different isolates of C. albicans and are not reliably associated with resistance. These analyses emphasize the diversity of mechanisms that result in a phenotype of azole resistance. They suggest that the resistance mechanisms identified in matched sets of susceptible and resistant isolates are not sufficient to explain resistance in a collection of unmatched clinical isolates and that additional mechanisms have yet to be discovered.

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Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
National Committee for Clinical Laboratory Standards
Bruck, E. (1980) · PEDIATRICS · doi:10.1542/peds.65.1.187 · Cited by 14,736
A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformaion of Escherichia coli
Hoffman, C. S., & Winston, F. (1987) · Gene · doi:10.1016/0378-1119(87)90131-4 · Cited by 2,492
Clinical, Cellular, and Molecular Factors That Contribute to Antifungal Drug Resistance
White, T. C., Marr, K. A., & Bowden, R. A. (1998) · Clinical Microbiology Reviews · doi:10.1128/cmr.11.2.382 · Cited by 1,353
Self-citation
Development of Interpretive Breakpoints for Antifungal Susceptibility Testing: Conceptual Framework and Analysis of In Vitro-In Vivo Correlation Data for Fluconazole, Itraconazole, and Candida Infections
Rex, J. H., Pfaller, M. A., Galgiani, J. N., Bartlett, M. S., Espinel-Ingroff, A., Ghannoum, M. A., Lancaster, M., Odds, F. C., Rinaldi, M. G., Walsh, T. J., et al. (1997) · Clinical Infectious Diseases · doi:10.1093/clinids/24.2.235 · Cited by 855
Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters
Sanglard, D., Kuchler, K., Ischer, F., Pagani, J. L., Monod, M., & Bille, J. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.11.2378 · Cited by 815
Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus
White, T. C. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.7.1482 · Cited by 612
Self-citation
Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene
Sanglard, D., Ischer, F., Monod, M., & Bille, J. (1997) · Microbiology · doi:10.1099/00221287-143-2-405 · Cited by 587
Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals
Prasad, R., De Wergifosse, P., Goffeau, A., & Balzi, E. (1995) · Current Genetics · doi:10.1007/bf00352101 · Cited by 486
Prevalence of Molecular Mechanisms of Resistance to Azole Antifungal Agents in Candida albicans Strains Displaying High-Level Fluconazole Resistance Isolated from Human Immunodeficiency Virus-Infected Patients
Perea, S., López-Ribot, J. L., Kirkpatrick, W. R., McAtee, R. K., Santillán, R. A., Martı́nez, M., Calabrese, D., Sanglard, D., & Patterson, T. F. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.10.2676-2684.2001 · Cited by 470

Show all 42 references

Research works printed but not linked: 2

Holmberg, K., and D. A. Stevens. 1999. Resistance to antifungal drugs: current status and clinical implications. Curr. Opin. Anti-Infective Investig. Drugs1:306-317.
Odds F. C. 1988. Candida and Candidosis: a review and bibliography. Bailliere Tindall London United Kingdom.

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Xu, Y., Chen, L., & Li, C. (2008) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkn015 · Cited by 104
Studies of the paradoxical effect of caspofungin at high drug concentrations
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Cools, H. J., Parker, J. E., Kelly, D. E., Lucas, J. A., FRAAIJE, B. A., & Kelly, S. L. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.02158-09 · Cited by 95
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Antifungal drug resistance: do molecular methods provide a way forward?
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Antifungal activity of thymol against clinical isolates of fluconazole-sensitive and -resistant Candida albicans
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Colonization of Candida species in denture wearers with emphasis on HIV infection: A literature review
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Self-citation
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Zhu, J., Krom, B. P., Sanglard, D., Intapa, C., Dawson, C. C., Peters, B. M., Shirtliff, M. E., & Jabra‐Rizk, M. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028830 · Cited by 83
Cyclic AMP Signaling Pathway Modulates Susceptibility of Candida Species and Saccharomyces cerevisiae to Antifungal Azoles and Other Sterol Biosynthesis Inhibitors
Jain, P., Akula, I., & Edlind, T. D. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.10.3195-3201.2003 · Cited by 82
Potent synergic effect between ibuprofen and azoles on Candida resulting from blockade of efflux pumps as determined by FUN-1 staining and flow cytometry
Pina‐Vaz, C., Rodrigues, A. G., Costa‐de‐Oliveira, S., Ricardo, E., & Mårdh, P. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki264 · Cited by 81
Fungicidal action of geraniol against Candida albicans is potentiated by abrogated CaCdr1p drug efflux and fluconazole synergism
Singh, S., Fatima, Z., Ahmad, K., & Hameed, S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0203079 · Cited by 82
Molecular mechanisms of acquired antifungal drug resistance in principal fungal pathogens and EUCAST guidance for their laboratory detection and clinical implications
Rogers, T. R., Verweij, P. E., Castanheira, M., Dannaoui, E., White, P. L., Arendrup, M. C., Subcommittee on Antifungal Susceptibility Testing (AFST) of the ESCMID European Committee for Antimicrobial Susceptibility Testing (EUCAST), Arendrup, M. C., Arikan-Akdagli, S., Barchiesi, F., et al. (2022) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkac161 · Cited by 82
Fluconazole resistant opportunistic oro-pharyngeal Candida and non-Candida yeast-like isolates from HIV infected patients attending ARV clinics in Lagos, Nigeria.
Enwuru, C. A., Ogunledun, A., Idika, N., Enwuru, N. V., Ogbonna, F., Aniedobe, M., & Adeiga, A. (2008) · PubMed Central · Cited by 78
UPC2 Is Universally Essential for Azole Antifungal Resistance in Candida albicans
Vasicek, E. M., Berkow, E. L., Flowers, S. A., Barker, K. S., & Rogers, P. D. (2014) · Eukaryotic Cell · doi:10.1128/ec.00221-13 · Cited by 71
Biogenic silver nanoparticles: efficient and effective antifungal agents
Netala, V. R., Kotakadi, V. S., Domdi, L., Gaddam, S. A., Bobbu, P., Venkata, S. K., Ghosh, S. B., & Tartte, V. (2015) · Applied Nanoscience · doi:10.1007/s13204-015-0463-1 · Cited by 78
Fluconazole Assists Berberine To Kill Fluconazole-Resistant Candida albicans
Li, D., Xu, Y., Zhang, D., Quan, H., Mylonakis, E. E., Hu, D., Li, M.-B., Zhao, L., Liang-hua, Z. H. U., Wang, Y., et al. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00499-13 · Cited by 80
A titanic drug resistance threat in Cryptococcus neoformans
Zafar, H., Altamirano, S., Ballou, E. R., & Nielsen, K. (2019) · Current Opinion in Microbiology · doi:10.1016/j.mib.2019.11.001 · Cited by 76

Authors: White, T. C., Holleman, S., Dy, F., Mirels, L. F., & Stevens, D. A.
Affiliations: Center for Infectious Disease Research (US)
Santa Clara Valley Medical Center (US)
Corresponding author: White, Theodore C.
ORCID: White, Theodore C.
Stevens, David A.
Venue: Antimicrobial Agents and Chemotherapy
Publisher: American Society for Microbiology
Published: 2002-06
Volume: 46
Issue: 6
Pages: 1704-1713
ISSN: 0066-4804 (ISSN-L)
1098-6596
DOI: 10.1128/aac.46.6.1704-1713.2002
PMC: PMC127245
OpenAlex: W2117461892
Cited by: 461
References: 42
Citations by year: 2026: 8 · 2025: 9 · 2024: 14 · 2023: 15 · 2022: 24 · 2021: 9 · 2020: 16 · 2019: 28 · 2018: 16 · 2017: 23 · 2016: 22 · 2015: 31 · 2014: 28 · 2013: 19 · 2012: 12
FWCI: 13.35
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Antimicrobial Agents and Chemotherapy (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Burroughs Wellcome Fund
M.J. Murdock Charitable Trust
National Institutes of Health
National Institute of Dental and Craniofacial Research (R01DE011367, R01 DE-11367)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Agricultural and Biological Sciences › Plant Science › Fungal Plant Pathogen Control
Keywords: Candida albicans, azole resistance, drug resistance mechanisms, ERG11 mutations, CDR1, CDR2, MDR1, efflux pump overexpression, cross-resistance, fluconazole, clotrimazole, itraconazole, ketoconazole, clinical isolates
MeSH terms: Antifungal Agents, Candida albicans, Candidiasis, DNA, Fungal, Drug Resistance, Microbial, Fungal Proteins, Microbial Sensitivity Tests, Phenotype, Polymorphism, Restriction Fragment Length, RNA, Fungal, Blotting, Southern, Blotting, Northern, DNA Probes, Gene Expression Regulation, Fungal, Drug Resistance, Multiple, ATP-Binding Cassette Transporters, Genes, MDR, Reverse Transcriptase Polymerase Chain Reaction

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Resistance Mechanisms in Clinical Isolates of Candida albicans

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