The metabolic basis of Candida albicans morphogenesis and quorum sensing.

Han, Ting-Li; Cannon, Richard D.; Villas-Bôas, Silas G.

doi:10.1016/j.fgb.2011.04.002

Cited by 173Fungal and yeast genetics researchAntifungal resistance and susceptibilityFungal Infections and Studies

The metabolic basis of Candida albicans morphogenesis and quorum sensing.

Han, Ting-Li, Cannon, Richard D., Villas-Bôas, Silas G.·2011·Fungal Genetics and Biology

DOI 10.1016/j.fgb.2011.04.002

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Abstract

Candida albicans is a polymorphic fungus that has the ability to rapidly switch between yeast and filamentous forms. The morphological transition appears to be a critical virulence factor of this fungus. Recent studies have elucidated the signal transduction pathways and quorum sensing molecules that affect the morphological transition of C. albicans. The metabolic mechanisms that recognize, and respond to, such signaling molecules and promote the morphological changes at a system level, however, remain unknown. Here we review the metabolic basis of C. albicans morphogenesis and we discuss the role of primary metabolic pathways and quorum sensing molecules in the morphogenetic process. We have reconstructed, in silico, the central carbon metabolism and sterol biosynthesis of C. albicans based on its genome sequence, highlighting the metabolic pathways associated with the dimorphic transition and virulence as well as pathways involved in the biosynthesis of important quorum sensing molecules.

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Data obtained with mutant strains in these pathways using mouse models of systemic candidiasis showed that the glyoxylate cycle is required for virulence, while β-oxidation is not.
“Additionally, data obtained with mutant strains in these pathways using mouse models of systemic candidiasis showed that the glyoxylate cycle is required for virulence (Lorenz and Fink, 2001, 2002; Barelle et al., 2006; Han et al., 2011), while β-oxidation is not (Piekarska et al., 2006).”
From Candida glabrata susceptibility to antifungals and phagocytosis is modulated by acetate (2015) · cites this paper as Han et al., 2011
Adaptation to the host environment is essential for Candida spp. to infect and survive in various anatomical sites of the human host, some of which are clearly glucose-limited.
“Adaptation to the host environment is essential for Candida spp. to infect and survive in various anatomical sites of the human host, some of which are clearly glucose-limited (Han et al., 2011).”
From Candida glabrata susceptibility to antifungals and phagocytosis is modulated by acetate (2015) · cites this paper as Han et al., 2011

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Authors: Han, T.-L., Cannon, R. D., & Villas-Bôas, S. G.
Affiliations: University of Auckland (NZ)
University of Otago (NZ)
Corresponding author: Villas-Bôas, Silas G.
ORCID: Han, Ting-Li
Cannon, Richard D.
Villas-Bôas, Silas G.
Venue: Fungal Genetics and Biology
Publisher: Elsevier BV
Published: 2011-08
Volume: 48
Issue: 8
Pages: 747-763
ISSN: 1087-1845 (ISSN-L)
DOI: 10.1016/j.fgb.2011.04.002
OpenAlex: W2157594666
Cited by: 173
References: 250
Citations by year: 2026: 11 · 2025: 3 · 2024: 7 · 2023: 14 · 2022: 7 · 2021: 15 · 2020: 17 · 2019: 15 · 2018: 14 · 2017: 17 · 2016: 13 · 2015: 6 · 2014: 11 · 2013: 10 · 2012: 11
FWCI: 0.99
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Fungal Genetics and Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords: Candida albicans, morphogenesis, quorum sensing, dimorphic transition, yeast-to-hypha transition, virulence, signal transduction, primary metabolism, central carbon metabolism, sterol biosynthesis, fungal metabolism
MeSH terms: Candida albicans, Carbon, Fungal Proteins, Morphogenesis, Sterols, Signal Transduction, Gene Expression Regulation, Fungal, Quorum Sensing

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The metabolic basis of Candida albicans morphogenesis and quorum sensing.

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