Evaluation of Amphotericin B Interpretive Breakpoints for Candida Bloodstream Isolates by Correlation with Therapeutic Outcome

Park, Benjamin J.; Arthington-Skaggs, Beth A.; Hajjeh, Rana A.; Iqbal, Naureen; Ciblak, Meral A.; Lee-Yang, Wendy; Hairston, Mario D.; Phelan, Maureen; Plikaytis, Brian D.; Sofair, Andre N.; Harrison, Lee H.; Fridkin, Scott K.; Warnock, David W.

doi:10.1128/aac.50.4.1287-1292.2006

Cited by 113Antifungal resistance and susceptibilityBacterial Identification and Susceptibility TestingFungal Infections and Studies

Evaluation of Amphotericin B Interpretive Breakpoints for Candida Bloodstream Isolates by Correlation with Therapeutic Outcome

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Park, Benjamin J., Arthington-Skaggs, Beth A., Hajjeh, Rana A., Iqbal, Naureen, Ciblak, Meral A., Lee-Yang, Wendy, Hairston, Mario D., Phelan, Maureen +5 more·2006·Antimicrobial Agents and Chemotherapy

DOI 10.1128/aac.50.4.1287-1292.2006PMC PMC1426914

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Abstract

One hundred seven Candida bloodstream isolates (51 C. albicans, 24 C. glabrata, 13 C. parapsilosis, 13 C. tropicalis, 2 C. dubliniensis, 2 C. krusei, and 2 C. lusitaniae strains) from patients treated with amphotericin B alone underwent in vitro susceptibility testing against amphotericin B using five different methods. Fifty-four isolates were from patients who failed treatment, defined as death 7 to 14 days after the incident candidemia episode, having persistent fever of >or=5 days' duration after the date of the incident candidemia, or the recurrence of fever after two consecutive afebrile days while on antifungal treatment. MICs were determined by using the Clinical Laboratory Standards Institute (formally National Committee for Clinical Laboratory Standards) broth microdilution procedure with two media and by using Etest. Minimum fungicidal concentrations (MFCs) were also measured in two media. Broth microdilution tests with RPMI 1640 medium generated a restricted range of MICs (0.125 to 1 microg/ml); the corresponding MFC values ranged from 0.5 to 4 microg/ml. Broth microdilution tests with antibiotic medium 3 produced a broader distribution of MIC and MFC results (0.015 to 0.25 microg/ml and 0.06 to 2 microg/ml, respectively). Etest produced the widest distribution of MICs (0.094 to 2 microg/ml). However, none of the test formats studied generated results that significantly correlated with therapeutic success or failure.

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Correlation between amphotericin B MIC values and clinical response has not been consistently established.
“Correlation between amphotericin B MIC values and clinical response has not been consistently established [60,61].”
From Treatment of Invasive Candidiasis: A Narrative Review (2018) · cites this paper as [60]

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Authors: Park, B. J., Arthington-Skaggs, B. A., Hajjeh, R. A., Iqbal, N., Ciblak, M. A., Lee-Yang, W., Hairston, M. D., Phelan, M., Plikaytis, B. D., Sofair, A. N., Harrison, L. H., Fridkin, S. K., & Warnock, D. W.
Affiliations: Mycotic Diseases Branch
Centers for Disease Control and Prevention (US)
Yale University School of Medicine, New Haven, Connecticut
Johns Hopkins University (US)
Corresponding author: Park, Benjamin J.
ORCID: Hajjeh, Rana A.
Harrison, Lee H.
Fridkin, Scott K.
Venue: Antimicrobial Agents and Chemotherapy
Publisher: American Society for Microbiology
Published: 2006-04
Volume: 50
Issue: 4
Pages: 1287-1292
ISSN: 0066-4804 (ISSN-L)
1098-6596
DOI: 10.1128/aac.50.4.1287-1292.2006
PMC: PMC1426914
OpenAlex: W2137617742
Cited by: 113
References: 17
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2020: 7 · 2019: 2 · 2018: 6 · 2017: 10 · 2016: 4 · 2015: 6 · 2014: 11 · 2013: 5 · 2012: 6
FWCI: 6.40
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Antimicrobial Agents and Chemotherapy (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords: amphotericin B, interpretive breakpoints, candidemia, antifungal susceptibility testing, minimum inhibitory concentration, minimum fungicidal concentration, broth microdilution, E-test, treatment outcomes, Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, Candida dubliniensis, Candida krusei, Candida lusitaniae
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Amphotericin B, Antifungal Agents, Candida, Candidiasis, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Microbial Sensitivity Tests, Middle Aged, Fungemia, Treatment Failure

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Evaluation of Amphotericin B Interpretive Breakpoints for Candida Bloodstream Isolates by Correlation with Therapeutic Outcome

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