The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Metabolic Engineering of Clostridium cellulolyticum for Production of Isobutanol from Cellulose
Open accessAbstract
Producing biofuels directly from cellulose, known as consolidated bioprocessing, is believed to reduce costs substantially compared to a process in which cellulose degradation and fermentation to fuel are accomplished in separate steps. Here we present a metabolic engineering example for the development of a Clostridium cellulolyticum strain for isobutanol synthesis directly from cellulose. This strategy exploits the host's natural cellulolytic activity and the amino acid biosynthesis pathway and diverts its 2-keto acid intermediates toward alcohol synthesis. Specifically, we have demonstrated the first production of isobutanol to approximately 660 mg/liter from crystalline cellulose by using this microorganism.
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Cites
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Direct photosynthetic recycling of carbon dioxide to isobutyraldehyde
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Self-citationProgress and Challenges in Enzyme Development for Biomass Utilization
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Self-citation
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A metabolic pathway for bile acid dehydroxylation by the gut microbiome
Funabashi, M., Grove, T. L., Wang, M., Varma, Y., McFadden, M. E., Brown, L. C., Guo, C., Higginbottom, S., Almo, S. C., & Fischbach, M. A. (2020) · Nature · doi:10.1038/s41586-020-2396-4 · Cited by 590
Avalos, J. L., Fink, G. R., & Stephanopoulos, G. (2013) · Nature Biotechnology · doi:10.1038/nbt.2509 · Cited by 517
A review on commercial-scale high-value products that can be produced alongside cellulosic ethanol
Rosales-Calderon, O., & Arantes, V. (2019) · Biotechnology for Biofuels · doi:10.1186/s13068-019-1529-1 · Cited by 503
Transformation of Biomass into Commodity Chemicals Using Enzymes or Cells
Straathof, A. J. J. (2014) · Chemical Reviews · doi:10.1021/cr400309c · Cited by 459
Tracy, B. P., Jones, S. W., Fast, A. G., Indurthi, D. C., & Papoutsakis, E. T. (2012) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2011.10.008 · Cited by 408
Metadata
- Authors
- Higashide, W., Li, Y., Yang, Y., & Liao, J. C.
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2011-04-15
- Volume
- 77
- Issue
- 8
- Pages
- 2727-2733
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- OpenAlex
- W2157922642
- Cited by
- 316
- References
- 30
- FWCI
- 11.87
- Type
- journal article
- Language
- en
- Open access
- green
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- Higashide, W., Li, Y., Yang, Y., & Liao, J. C. (2011). Metabolic Engineering of Clostridium cellulolyticum for Production of Isobutanol from Cellulose. Applied and Environmental Microbiology. https://doi.org/10.1128/aem.02454-10
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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