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Fecal Microbiota Composition and Frailty
Open accessAbstract
The relationship between fecal microbiota composition and frailty in the elderly was studied. Fecal samples from volunteers with high frailty scores showed a significant reduction in the number of lactobacilli (26-fold). At much higher population levels, both the Bacteroides/Prevotella(threefold) and the Faecalibacterium prausnitzii(fourfold) groups showed a significant reduction in percentage of total number of hybridizable bacteria in the elderly with high frailty scores. In contrast to this, the number of Enterobacteriaceae was significantly higher (sevenfold) in samples from very frail volunteers.
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Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics
Gibson, G. R., & Roberfroid, M. B. (1995) · Journal of Nutrition · doi:10.1093/jn/125.6.1401 · Cited by 7,659
Amann, R., Binder, B. J., Olson, R. J., Chisholm, S. W., Devereux, R., & Stahl, D. A. (1990) · Applied and Environmental Microbiology · doi:10.1128/aem.56.6.1919-1925.1990 · Cited by 4,049
Gut flora in health and disease
Guarner, F., & Malagelada, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12489-0 · Cited by 3,480
Suau, A., Bonnet, R., Sutren, M., Godon, J.-J., Gibson, G. R., Collins, M. D., & Doré, J. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.11.4799-4807.1999 · Cited by 1,490
Zoetendal, E. G., Akkermans, A. D. L., & de Vos, W. M. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.10.3854-3859.1998 · Cited by 1,360
Harmsen, H. J. M., Wildeboer-Veloo, A. C. M., Raangs, G. C., Wagendorp, A. A., Klijn, N., BINDELS, J. G., & Welling, G. W. (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200001000-00019 · Cited by 1,326
Self-citationManz, W., Amann, R., Ludwig, W., Vancanneyt, M., & SCHLEIFER, K. H. (1996) · Microbiology · doi:10.1099/13500872-142-5-1097 · Cited by 1,176
Franks, A. H., Harmsen, H. J. M., Raangs, G. C., Jansen, G. J., Schut, F., & Welling, G. W. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.9.3336-3345.1998 · Cited by 1,056
Self-citationLangendijk-Genevaux, P. S., Schut, F., Jansen, G. J., Raangs, G. C., Kamphuis, G. R., Wilkinson, M. H. F., & Welling, G. W. (1995) · Applied and Environmental Microbiology · doi:10.1128/aem.61.8.3069-3075.1995 · Cited by 974
Self-citationBartosch, S., Fite, A., Macfarlane, G. T., & McMurdo, M. E. T. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.6.3575-3581.2004 · Cited by 762 · cited 3×
“(3) characterized bacterial communities in feces from healthy elderly volunteers and hospitalized elderly patients by real-time PCR.”
Background
Research works printed but not linked: 2
- Mitsuoka, T. 1992. Intestinal flora and ageing. Nutr. Rev.50:438-446.
- Sullivan Å., R. Bennet, M. Viitanen, A.-C. Palmgren, and C. E. Nord. 2002. Influence of Lactobacillus F19 on intestinal microflora in children and elderly persons and impact on Helicobacter pylori infections. Microb. Ecol. Health Dis.3:17-21.
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BackgroundInfluentialProspective views for whey protein and/or resistance training against age-related sarcopenia
Liao, Y., Peng, Z., Chen, L., Zhang, Y., Cheng, Q., Nüssler, A. K., Bao, W., Liu, L., & Yang, W. (2019) · Aging and Disease · doi:10.14336/ad.2018.0325 · Cited by 68
“It has been reported that plenty of changes in gut microbiota take place in elder people aged over 65, such as changes in its diversity, composition and functional features [146-149].”
BackgroundKurakawa, T., Ogata, K., Matsuda, K., Tsuji, H., Kubota, H., Takada, T., Kado, Y., Asahara, T., Takahashi, T., & Nomoto, K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126226 · Cited by 74
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Cawthon, C. R., & Serre, C. B. D. L. (2018) · Brain Research · doi:10.1016/j.brainres.2018.01.012 · Cited by 69
Miller, L. E., Lehtoranta, L., & Lehtinen, M. J. (2017) · Nutrients · doi:10.3390/nu9030191 · Cited by 66
“For instance, lower bifidobacteria levels have been found to associate with increased risk of Clostridium difficile associated diarrhea [15], hospitalization [16], antibiotic treatment [17], and frailty [18].”
BackgroundMicrobiota and healthy ageing: observational and nutritional intervention studies
Brüssow, H. (2013) · Microbial Biotechnology · doi:10.1111/1751-7915.12048 · Cited by 61
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Yassin, L. K., Nakhal, M. M., Alderei, A., Almehairbi, A., Mydeen, A. B., Akour, A. A., & Hamad, M. I. K. (2025) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2025.1504065 · Cited by 64
Payne, A. N., Chassard, C., Banz, Y., & Lacroix, C. (2012) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2012.01330.x · Cited by 64
“Comparably, little knowledge exists regarding gut microbial fermentation in starved populations with most studies directed at elderly and aging populations (Macfarlane et al., 2004; van Tongeren et al., 2005; Tiihonen et al., 2010).”
BackgroundApplication of Stool-PCR test for diagnosis of Helicobacter pylori infection in children
Falsafi, T., Favaedi, R., Mahjoub, F. E., & Najafil, M. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.484 · Cited by 60
Neto, J. V., de Melo, C., & Ribeiro, S. M. L. (2013) · Nutrients · doi:10.3390/nu5041276 · Cited by 59
The Impact of Long‐Term Intake of Phenolic Compounds‐Rich Grape Pomace on Rat Gut Microbiota
Chacar, S., Itani, T. M., Hajal, J., Saliba, Y., Louka, N., Faivre, J., Maroun, R. G., & Farès, N. (2017) · Journal of Food Science · doi:10.1111/1750-3841.14006 · Cited by 59
Goñi, I., & Hernández-Galiot, A. (2019) · Nutrients · doi:10.3390/nu11092165 · Cited by 59
“Numerous studies have shown that the elderly have increased oxidative stress and impaired antioxidant defense systems [1,2], which appears to be a contributory factor for neurological damage, dementia and depression and to be responsible for the onset and progression of chronic degenerative diseases [3] such as diabet…”
BackgroundImmunosenescence and Anti-Immunosenescence Therapies: The Case of Probiotics
Candore, G., Balistreri, C. R., Colonna‐Romano, G., Grimaldi, M. P., Lio, D., Listı̀, F., Scola, L., Vasto, S., & Caruso, C. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0662 · Cited by 55
“45,46 Thus, knowledge of age-related changes in the gastrointestinal tract flora might be important in the treatment and prophylaxis of diseases, and in maintenance of health among the elderly.”
Qi, Y., He, J., Zhang, Y., Ge, Q., Wang, Q., Chen, L., Xu, J., Wang, L., Chen, X., Jia, D., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41827-0 · Cited by 58
“Gradient dilutions of LPS (Sigma, USA) were used as positive controls for HEK-Blue-mTLR4 cells.”
InfluentialDevelopment ofFaecalibacterium16S rRNA gene marker for identification of human faeces
Zheng, G., Yampara-Iquise, H., Jones, J. E., & Carson, C. A. (2009) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2008.04037.x · Cited by 54
“Comparative content ranges from 1Æ0 · 104 to 2Æ6 · 108 for coliforms (Slanetz and Bartley 1957) and 2Æ9 · 109 to 7Æ7 · 109 for the BacteroidesPrevotella group (van Tongeren et al. 2005).”
BackgroundLim, S., Chang, D., Ahn, S., & Kim, B. C. (2016) · Gut Pathogens · doi:10.1186/s13099-016-0087-3 · Cited by 56
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Xu, Y., Liu, X., Liu, X., Chen, D., Wang, M., Jiang, X., & Xiong, Z. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.675414 · Cited by 60
“While the numbers of Enterobacteriaceae were higher (van Tongeren et al., 2005).”
BackgroundSabatino, A. D., Lenti, M. V., Cammalleri, L., Corazza, G. R., & Pilotto, A. (2018) · Digestive and Liver Disease · doi:10.1016/j.dld.2018.03.010 · Cited by 55
Hutchinson, A. N., Bergh, C., Krüger, K., Sűsserová, M., Allen, J., Améen, S., & Tingö, L. (2021) · Microorganisms · doi:10.3390/microorganisms9061344 · Cited by 59
Marcos-Pérez, D., Sánchez-Flores, M., Maseda, A., Lorenzo‐López, L., Millán-Calentí, J. C., Strasser, B., Gostner, J. M., Fuchs, D., Pásaro, E., Valdiglesias, V., et al. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.06.021 · Cited by 50
Guedj, A., Volman, Y., Geiger-Maor, A., Bolik, J., Schumacher, N., Künzel, S., Baines, J. F., Nevo, Y., Elgavish, S., Galun, E., et al. (2019) · Gut · doi:10.1136/gutjnl-2019-318491 · Cited by 51
Lee, S. M., Kim, N., Yoon, H., Nam, R. H., & Lee, D. H. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02236 · Cited by 48
Characterization of the gut microbiota in frail elderly patients
Zhang, L., Liao, J., Chen, Q., Chen, M., Kuang, Y., Chen, L., & Wen, H. (2019) · Aging Clinical and Experimental Research · doi:10.1007/s40520-019-01385-2 · Cited by 49
Lee, Y.-A., Song, S.-W., Jung, S. Y., Bae, J., Hwang, N., & Kim, H.-N. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111927 · Cited by 45
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O’Connor, E. M., O’Herlihy, E. A., & O’Toole, P. W. (2014) · Proceedings of The Nutrition Society · doi:10.1017/s0029665114000597 · Cited by 45
“Proportions of lactobacilli were significantly depleted (twenty-sixfold), while the abundance was also reduced for the Bacteroides/ Prevotella group (threefold) and the Faecalibacterium prausnitzii group (fourfold)((34)).”
BackgroundMicrobiome in Hidradenitis Suppurativa—What We Know and Where We Are Heading
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“, decreased microbial diversity is associated with increased weakness and decreased health parameters, as well as increased inflammatory markers, such as TNF-α, IL-6, IL-8, and C-reactive protein [36].”
BackgroundAlmeida, H. M., Sardeli, A. V., Conway, J., Duggal, N. A., & Cavaglieri, C. R. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101773 · Cited by 47
Gut Microbiota: Critical Controller and Intervention Target in Brain Aging and Cognitive Impairment
Li, H., Ni, J., & Qing, H. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.671142 · Cited by 44
Impact of Gut Microbiota in Brain Ageing: Polyphenols as Beneficial Modulators
Sarubbo, F., Moranta, D., Tejada, S., Jiménez-García, M., & Esteban, S. (2023) · Antioxidants · doi:10.3390/antiox12040812 · Cited by 44
Prevotella copri alleviates sarcopenia via attenuating muscle mass loss and function decline
Liu, X., Wu, J., Tang, J., Xu, Z., Zhou, B., Liu, Y., Hu, F., Zhang, G., Cheng, R., Xia, X., et al. (2023) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13313 · Cited by 44
“However, some studies found significant reductions in Prevotella have also been found in the feces of frail older adults.(37,38) These contradictory results may be due to the huge strain difference of P.”
ResultMikelsaar, M., Štšepetova, J., Hütt, P., Kolk, H., Sepp, E., Lõivukene, K., Zilmer, K., & Zilmer, M. (2010) · Anaerobe · doi:10.1016/j.anaerobe.2010.03.001 · Cited by 42
“In elderly, due to large inter-individual differences in physical fitness, the BMI have not been considered as full predictor of health status or adverse outcomes [35].”
BackgroundImproving healthspan via changes in gut microbiota and fermentation
Keenan, M. J., Marco, M. L., Ingram, D. K., & Martin, R. J. (2015) · AGE · doi:10.1007/s11357-015-9817-6 · Cited by 43
Gastrointestinal Microbiota and Their Contribution to Healthy Aging
Mello, A. M., Paroni, G., Daragjati, J., & Pilotto, A. (2016) · Digestive Diseases · doi:10.1159/000443350 · Cited by 40
Licht, T. R., Madsen, B., & Wilcks, A. (2007) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2007.00962.x · Cited by 40
Is there a link between aging and microbiome diversity in exceptional mammalian longevity?
Hughes, G. M., Leech, J., Puechmaille, S. J., Lopez, J. V., & Teeling, E. C. (2018) · PeerJ · doi:10.7717/peerj.4174 · Cited by 43
“In later life, a reduction of lactobacilli and an increase of potentially pathogenic Enterobacteriaceae have been observed in frail individuals ( Van Tongeren et al., 2005 ).”
The gut microbiome and frailty
Piggott, D. A., & Tuddenham, S. (2020) · Translational research · doi:10.1016/j.trsl.2020.03.012 · Cited by 43
Evidence for the Contribution of Gut Microbiota to Age-Related Anabolic Resistance
Watson, M. D., Cross, B. L., & Grosicki, G. J. (2021) · Nutrients · doi:10.3390/nu13020706 · Cited by 41
Hong, S. J., & Katz, S. (2021) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848211023399 · Cited by 40
Augmented temperature fluctuation aggravates muscular atrophy through the gut microbiota
Liu, Y., Guo, Y., Liu, Z., Xu, F., Zhou, R., He, Y., Zhou, H., Peng, H., & Huang, Y. (2023) · Nature Communications · doi:10.1038/s41467-023-39171-4 · Cited by 40
“Van Tongeren et al. have reported that the increased level of Enterobacteriacae , and the decreased level of Lactobacilli , Bacterioides/ Prevotella , and Faecalibacterium prausnitzii in elder people were related with high frailty scores 35 decreased bacteria in FT group.”
Chen, S., Zhang, P., Duan, H., Wang, J., Qiu, Y., Cui, Z., Yin, Y., Wan, D., & Xie, L. (2023) · The Innovation · doi:10.1016/j.xinn.2023.100479 · Cited by 40
Frailty syndrome: A target for functional nutrients?
Davinelli, S., Corbi, G., & Scapagnini, G. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111441 · Cited by 38
The Microbiome and Osteosarcopenic Obesity in Older Individuals in Long-Term Care Facilities
Inglis, J. E., & Ilich, J. Z. (2015) · Current Osteoporosis Reports · doi:10.1007/s11914-015-0287-7 · Cited by 36
Therapeutic Delivery of Ang(1–7) via Genetically Modified Probiotic: A Dosing Study
Carter, C. S., Morgan, D., Verma, A., Lobaton, G. O., Aquino, V. P., Sumners, E., Raizada, M. K., Li, Q., & Buford, T. W. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz222 · Cited by 36
“Moreover, gut dysbiosis is tightly linked with the development of cognitive impairment (21,22), physical frailty (23,24), and Alzheimer’s disease (25).”
BackgroundA Multifactorial Approach for Sarcopenia Assessment: A Literature Review
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“[59] were the first researchers who reported for the first time that frailty is associated with microbiota composition in the gut.”
BackgroundGlycan profiling of the gut microbiota by Glycan-seq
Oinam, L., Minoshima, F., & Tateno, H. (2022) · ISME Communications · doi:10.1038/s43705-021-00084-2 · Cited by 35
“The composition of the gut microbiota of adults is unique, and the α-diversity of this microbiota increases with age, suggesting a correlation between the composition of the gut microbiota and physiological aging [39].”
BackgroundThe gut microbial metabolome: modulation of cancer risk in obese individuals
Russell, W. R., Duncan, S. H., & Flint, H. J. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112002881 · Cited by 35
“prausnitzii abundance is diminished in Crohn’s sufferers((17,18)) and in the elderly((19)).”
BackgroundAmong older adults, age-related changes in the stool microbiome differ by HIV-1 serostatus
Liu, J., Johnson, R. L., Dillon, S. M., Kroehl, M., Frank, D. N., Tunçil, Y. E., Zhang, X., Ir, D., Robertson, C. E., Seifert, S. M., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.01.033 · Cited by 37
“For example, Escherichia belongs to the family Enterobacteriaceae, facultative anaerobes that are commonly increased in abundance in inflammatory bowel disease (IBD) and colorectal cancer [86–88].”
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Zhang, S., Paul, S., & Kundu, P. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.874940 · Cited by 40
Lactic Acid Bacteria in Health and Disease
Xiao, J., Zhang, Y., & Yang, Z. (2014) · Springer eBooks · doi:10.1007/978-94-017-8841-0_5 · Cited by 38
Diet-Microbiota-Health Interactions in Older Subjects: Implications for Healthy Aging
Lynch, D. B., Jeffery, I. B., Cusack, S., O’Connor, E. M., & O’Toole, P. W. (2014) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/000364976 · Cited by 35
Faecal Microbiota of Cats with Insulin-Treated Diabetes Mellitus
Bell, E. T., Suchodolski, J. S., Isaiah, A., Fleeman, L. M., Cook, A. K., Steiner, J. M., & Mansfield, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108729 · Cited by 34
“have also been reported in elderly humans [44,45].”
BackgroundAge-related diseases, therapies and gut microbiome: A new frontier for healthy aging
Barone, M., D’Amico, F., Rampelli, S., Brigidi, P., & Turroni, S. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111711 · Cited by 34
Association of dietary live microbe intake with frailty in US adults: evidence from NHANES
Huo, X., Jia, S., Sun, L., Yao, Y., Liao, H., & Chen, X. (2024) · The journal of nutrition health & aging · doi:10.1016/j.jnha.2024.100171 · Cited by 33
Origination, change, and modulation of geriatric disease-related gut microbiota during life
Rajoka, M. S. R., Zhao, H., Li, N., Lu, Y. P., Lian, Z., Shao, D., Jin, M., Li, Q., Zhao, L., & Shi, J. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-9264-2 · Cited by 32
The Many Ages of Microbiome–Gut–Brain Axis
Ratto, D., Roda, E., Romeo, M., Venuti, M. T., Desiderio, A., Lupo, G., Capelli, E., Sandionigi, A., & Rossi, P. (2022) · Nutrients · doi:10.3390/nu14142937 · Cited by 32
Wen, N.-N., Sun, L., Qian, G., & Zheng, G.-H. (2024) · World Journal of Clinical Cases · doi:10.12998/wjcc.v12.i35.6815 · Cited by 37
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Xu, Y., Mao, T., Wang, Y., Qi, X., Zhao, W.-J., Chen, H., Zhang, C., & Li, X. (2024) · The Journals of Gerontology Series A · doi:10.1093/gerona/glae044 · Cited by 31
Muthyala, S. D. V., Shankar, S., Klemashevich, C. L., Blazier, J. C., Hillhouse, A., & Wu, C. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.108999 · Cited by 33
Probiotic Bacteria and Enteric Infections
Paton, A., Morona, R., & Paton, J. (2011) · Springer eBooks · doi:10.1007/978-94-007-0386-5 · Cited by 30
Human Microbiome: age-related changes and functions
Kaybysheva, V. O., Zharova, M. E., Filimendikova, K. Y., & Nikonov, E. L. (2020) · Russian Journal of Evidence-Based Gastroenterology · doi:10.17116/dokgastro2020902142 · Cited by 31
Effects of 12 weeks of resistance training on rat gut microbiota composition
de Castro, A. P., Silva, K. K. S., Medeiros, C. S. D. A., Alves, F. D. C. G., Araújo, R. C., & de Almeida, J. A. (2021) · Journal of Experimental Biology · doi:10.1242/jeb.242543 · Cited by 28
Du, Y., Li, L., Gong, C., Li, T., & Xia, Y. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1054685 · Cited by 29
“observed a decreased relative abundance of Faecalibacterium in frail and elderly patients (51).”
BackgroundExercise, the Gut Microbiome, and Frailty
Shin, H. E., Kwak, S. E., Lee, J., Zhang, D., Bae, J. H., & Song, W. J. (2019) · Annals of Geriatric Medicine and Research · doi:10.4235/agmr.19.0014 · Cited by 28
Wang, Y., Jin, T., Zhang, N., Li, J., Wang, Y., Kulyar, M. F., Han, Z., & Li, Y. (2021) · Microbial Cell Factories · doi:10.1186/s12934-021-01707-y · Cited by 28
“Furthermore, longitudinal studies of gut content samples of different ages revealed a connection between various changes in gut microbial composition and diversity [26, 27].”
BackgroundSugimura, Y., Kanda, A., Sawada, K., Wai, K. M., Tanabu, A., Ozato, N., Midorikawa, T., Hisada, T., Nakaji, S., & Ihara, K. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19127464 · Cited by 28
“Among the residents of welfare facilities for older adults, those who were frailer had a lower relative abundance of the major gut microbiota [9].”
BackgroundAroniadis, O. C., Drossman, D. A., & Simrén, M. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000431 · Cited by 25
Improving the bowel habits of elderly residents in a nursing home using probiotic fermented milk
van den Nieuwboer, M., Klomp-Hogeterp, A., Verdoorn, S., Metsemakers-Brameijer, L., Vriend, T., Claassen, E., & Larsen, O. F. A. (2015) · Beneficial Microbes · doi:10.3920/bm2014.0113 · Cited by 25
Yu, J., Fu, Y., Deng, Z., Fan, Y., & Li, H. (2020) · Food & Function · doi:10.1039/d0fo01093f · Cited by 25
Jia, T., Zhao, S., Knott, K. K., Li, X., Liu, Y., Li, Y., Chen, Y., Yang, M., Lu, Y., Wu, J., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-21117-2 · Cited by 24
Chenhuichen, C., Cabello-Olmo, M., Barajas, M., Izquierdo, M., Ramírez‐Vélez, R., Zambom-Ferraresi, F., & Martínez‐Velilla, N. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111809 · Cited by 26
Research progress of gut microbiota and frailty syndrome
Wang, X. Q., & Wu, M. (2021) · Open Medicine · doi:10.1515/med-2021-0364 · Cited by 23
“The study discovered that Lactobacilli is decreased in frail people compared with non-frail ones, and the same thing happens in Faecalibacterium prausnitzii (with anti-inflammatory and immunoregulation effects); while Enterobacteriaceae, which could increase opportunistic infections [32], was found to be higher in fra…”
Ray, S., Narayanan, A., Vesterbacka, J., Blennow, O., Chen, P., Gao, Y., Gabarrini, G., Ljunggren, H., Buggert, M., Manoharan, L., et al. (2023) · npj Biofilms and Microbiomes · doi:10.1038/s41522-023-00461-w · Cited by 23
“…our analyses also detected in this group an abundance of certain members of the Ruminococcaceae family, Butyricimonas , Chris-tensenellaceae R_7 group, Akkermansia , members of Erysipelo-trichaceae and a reduction of Faecalibacterium , a pattern which has been linked to in fl ammatory disorders 69 .”
Exploring the Relationship Between Gut Microbiota and Sarcopenia Based on Gut–Muscle Axis
Li, W., Sheng, R., Cao, M., & Rui, Y. (2024) · Food Science & Nutrition · doi:10.1002/fsn3.4550 · Cited by 31
Culture ofHelicobacter pylorifrom stool samples in children
Falsafi, T., Valizadeh, N., Najafi, M., Ehsani, A., Khani, A., Landarani, Z., & Falahi, Z. (2007) · Canadian Journal of Microbiology · doi:10.1139/w06-144 · Cited by 22
Farsijani, S., Cauley, J. A., Peddada, S., Langsetmo, L., Shikany, J. M., ORWOLL, E. S., Ensrud, K. E., Cawthon, P. M., & Newman, A. B. (2022) · Journal of Nutrition · doi:10.1093/jn/nxac231 · Cited by 21
Bio-ecological control of chronic liver disease and encephalopathy
Bengmark, S. (2008) · Metabolic Brain Disease · doi:10.1007/s11011-008-9128-z · Cited by 21
“The deranged intestinal microbionta represents an important source of continuous antigenic stimulation and contribute to development of chronic diseases and to immunosenescence ( van Tongeren et al. 2005; Pancer and Cooper 2006).”
BackgroundMaukonen, J., Mättö, J., Kajander, K., Mattila, T., & Saarela, M. (2007) · International Dairy Journal · doi:10.1016/j.idairyj.2007.10.003 · Cited by 21
What is the collective effect of aging and HIV on the gut microbiome?
Dillon, S. M., & Wilson, C. C. (2019) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000611 · Cited by 21
Guo, Y. P., Zhu, G., Wang, F., Zhang, H., Chen, X., Mao, Y., Lv, Y., Xia, F., Jin, Y., Ding, G.-X., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.827174 · Cited by 22
“(32) reported that Faecalibacterium prausnitzii significantly reduced in frail people, and the similar result was confirmed in a study conducted by Jackson et al.”
ResultLi, C., Li, Y., Wang, N., Ge, Z., Shi, Z., Wang, J., Ding, B., Bi, Y., Wang, Y., & Hong, Z. (2022) · Healthcare · doi:10.3390/healthcare10061100 · Cited by 22
“In an observation study including 23 of the oldest people, who ranged from 70 to 100 years, a significant reduction in Bacteroides/Prevotella was observed in the older adults with high frailty scores [35].”
BackgroundUrinary isoflavonoid excretion and soy consumption in three generations of Japanese women in Hawaii
Maskarinec, G., Yamakawa, R., Hebshi, S. M., & Franke, A. A. (2006) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602511 · Cited by 20
“Other explanations include older age because it is known that the composition of the gut flora changes with age (Saunier and Dore 2002; van Tongeren et al., 2005) or environmental factors that influence equol-producing gut bacteria (Lampe et al., 1999).”
BackgroundGut microbiota influence frailty syndrome in older adults: mechanisms and therapeutic strategies
Wang, X., Fan, L., Meng, C., Wang, Y., Deng, L.-E., Yuan, Z., Zhang, J., Li, Y., & Lv, S. (2023) · Biogerontology · doi:10.1007/s10522-023-10082-7 · Cited by 20
“…fresh fecal samples from 23 older volunteers (the range of age is from 70 to 100 years old), it was found that older adults with high Groningen frailty indicator (GFI) scores differed significantly from those who got low GFI scores in their bacterial composition of feces (van Tongeren et al. 2005).”
Meehan, C. J., Langille, M. G. I., & Beiko, R. G. (2015) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/000381162 · Cited by 19
Pekkala, S., Lensu, S., Nokia, M., Vanhatalo, S., Koch, L. G., Britton, S. L., & Kainulainen, H. (2017) · Physiological Genomics · doi:10.1152/physiolgenomics.00081.2017 · Cited by 16
“For instance, an age-associated decrease in Lactobacillus and an increase in Ruminococcus, also detected also in this study, have been reported to associate with high frailty in the elderly (45).”
BackgroundRamos, C., Magistro, D., Walton, G., Whitham, A., Camp, N., Poveda, C. G., Gibson, G. R., Hough, J., Kinnear, W., & Hunter, K. A. (2025) · GeroScience · doi:10.1007/s11357-025-01605-w · Cited by 21
“Interestingly, Enterobacteriaceae abundance was found to be seven-fold higher in very frail older adults [62].”
The gut microbiota and nervous system: Age-defined and age-defying
Madison, A. A., & Kiecolt‐Glaser, J. K. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.12.009 · Cited by 19
Cutuli, D., Giacovazzo, G., Decandia, D., & Coccurello, R. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1010169 · Cited by 19
Ye, H., Ghosh, T. S., Hueston, C. M., Vlčková, K., Golubeva, A. V., Hyland, N. P., & O’Toole, P. W. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2282796 · Cited by 19
Immunoprotective Effects of Probiotics in the Elderly
Marx, T. K. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-418680-4.00035-x · Cited by 18
Yao, J., & Xia, S. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1541373 · Cited by 21
Exploratory studies of oral and fecal microbiome in healthy human aging
Zhou, X., Wang, B., Demkowicz, P. C., Johnson, J. S., Chen, Y., Spakowicz, D. J., Zhou, Y., Dorsett, Y., Chen, L., Sodergren, E. J., et al. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.1002405 · Cited by 18
Metadata
- Authors
- van Tongeren, S. P., Slaets, J. P. J., Harmsen, H. J. M., & Welling, G. W.
- Affiliations
- Department of Medical Microbiology
- University Medical Center Groningen (NL)
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2005-10
- Volume
- 71
- Issue
- 10
- Pages
- 6438-6442
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- PMC
- PMC1265947
- OpenAlex
- W2129130754
- Cited by
- 333
- References
- 37
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 21 · 2023: 15 · 2022: 28 · 2021: 39 · 2020: 24 · 2019: 26 · 2018: 28 · 2017: 22 · 2016: 18 · 2015: 15 · 2014: 16 · 2013: 9 · 2012: 6
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Applied and Environmental Microbiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- fecal microbiota, frailty, older adults, lactobacilli, Bacteroides-Prevotella, Faecalibacterium prausnitzii, Enterobacteriaceae, gut microbiota, microbial diversity
- MeSH terms
- Aged, Aged, 80 and over, Bifidobacterium, Enterobacteriaceae, Feces, Humans, Lactobacillus, Colony Count, Microbial, Frail Elderly, Prevotella
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