The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
Salivary Biomarkers: Toward Future Clinical and Diagnostic Utilities
Open accessAbstract
SUMMARY: The pursuit of timely, cost-effective, accurate, and noninvasive diagnostic methodologies is an endeavor of urgency among clinicians and scientists alike. Detecting pathologies at their earliest stages can significantly affect patient discomfort, prognosis, therapeutic intervention, survival rates, and recurrence. Diagnosis and monitoring often require painful invasive procedures such as biopsies and repeated blood draws, adding undue stress to an already unpleasant experience. The discovery of saliva-based microbial, immunologic, and molecular biomarkers offers unique opportunities to bypass these measures by utilizing oral fluids to evaluate the condition of both healthy and diseased individuals. Here we discuss saliva and its significance as a source of indicators for local, systemic, and infectious disorders. We highlight contemporary innovations and explore recent discoveries that deem saliva a mediator of the body's physiological condition. Additionally, we examine the current state of salivary diagnostics and its associated technologies, future aspirations, and potential as the preferred route of disease detection, monitoring, and prognosis.
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Cites
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Self-citationA review of saliva: Normal composition, flow, and function
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The NIH Human Microbiome Project
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Wearable chemical sensors for biomarker discovery in the omics era
Sempionatto, J. R., Lasalde-Ramírez, J. A., Mahato, K., Wang, J., & Gao, W. (2022) · Nature Reviews Chemistry · doi:10.1038/s41570-022-00439-w · Cited by 613
Abranches, J., Zeng, L., Kajfasz, J. K., Palmer, S. R., Chakraborty, B., Wen, Z. T., Richards, V. P., Brady, L. J., & Lemos, J. A. (2018) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0042-2018 · Cited by 502
Ahmad, A., Imran, M., & Ahsan, H. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061630 · Cited by 386
The Era of Digital Health: A Review of Portable and Wearable Affinity Biosensors
Tu, J., Torrente‐Rodríguez, R. M., Wang, M., & Gao, W. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201906713 · Cited by 357
Bacterial diversity in saliva and oral health-related conditions: the Hisayama Study
Takeshita, T., Kageyama, S., Furuta, M., Tsuboi, H., Takeuchi, K., Shibata, Y., Shimazaki, Y., Akifusa, S., Ninomiya, T., Kiyohara, Y., et al. (2016) · Scientific Reports · doi:10.1038/srep22164 · Cited by 284
Metadata
- Authors
- Yoshizawa, J. M., Schafer, C. A., Schafer, J. J., Farrell, J. J., Paster, B. J., & Wong, D. T. W.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2013-10
- Volume
- 26
- Issue
- 4
- Pages
- 781-791
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- OpenAlex
- W2106479432
- Cited by
- 656
- References
- 109
- FWCI
- 13.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yoshizawa, J. M., Schafer, C. A., Schafer, J. J., Farrell, J. J., Paster, B. J., & Wong, D. T. W. (2013). Salivary Biomarkers: Toward Future Clinical and Diagnostic Utilities. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.00021-13
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