The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Adaptive and Mutational Resistance: Role of Porins and Efflux Pumps in Drug Resistance
Open accessAbstract
SUMMARY: The substantial use of antibiotics in the clinic, combined with a dearth of new antibiotic classes, has led to a gradual increase in the resistance of bacterial pathogens to these compounds. Among the various mechanisms by which bacteria endure the action of antibiotics, those affecting influx and efflux are of particular importance, as they limit the interaction of the drug with its intracellular targets and, consequently, its deleterious effects on the cell. This review evaluates the impact of porins and efflux pumps on two major types of resistance, namely, mutational and adaptive types of resistance, both of which are regarded as key phenomena in the global rise of antibiotic resistance among pathogenic microorganisms. In particular, we explain how adaptive and mutational events can dramatically influence the outcome of antibiotic therapy by altering the mechanisms of influx and efflux of antibiotics. The identification of porins and pumps as major resistance markers has opened new possibilities for the development of novel therapeutic strategies directed specifically against these mechanisms.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Agents that increase the permeability of the outer membrane
Vaara, M. (1992) · Microbiological Reviews · doi:10.1128/mr.56.3.395-411.1992 · Cited by 1,879
Nikaido, H., Basina, M., Nguyen, V., & Rosenberg, E. Y. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.17.4686-4692.1998 · Cited by 224
Visalli, M. A., Murphy, E., Projan, S. J., & Bradford, P. A. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.2.665-669.2003 · Cited by 165
Cited by
Molecular mechanisms of antibiotic resistance
Blair, J. M. A., Webber, M. A., Baylay, A. J., Ogbolu, D. O., & Piddock, L. J. V. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3380 · Cited by 4,092
Molecular mechanisms of antibiotic resistance revisited
Darby, E. M., Trampari, E., Siasat, P., Gaya, M. S., Alav, I., Webber, M. A., & Blair, J. M. A. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00820-y · Cited by 1,398
Preparation and Characterization of Zinc Oxide Nanoparticles Using Leaf Extract of Sambucus ebulus
Alamdari, S., Sasani Ghamsari, M., Lee, C., Han, W., Park, H.-H., Tafreshi, M. J., Afarideh, H., & Ara, M. H. M. (2020) · Applied Sciences · doi:10.3390/app10103620 · Cited by 452
Borges, A., Abreu, A., Dias, C., Saavedra, M., Borges, F., & Simões, M. (2016) · Molecules · doi:10.3390/molecules21070877 · Cited by 308
Exploring phytochemicals for combating antibiotic resistance in microbial pathogens
Khare, T., Anand, U., Dey, A., Assaraf, Y. G., Chen, Z.-S., Liu, Z., & Kumar, V. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.720726 · Cited by 281
“…transporters are further sub-classed into four families, namely 1) major facilitator superfamily (MFS), 2) resistance-nodulation-cell division (RND), 3) multidrug and toxic compound extrusion (MATE), and 4) small-MDR (SMR) family (Putman et al., 2000; Fernández and Hancock, 2012; Sun et al., 2014).”
Background
Metadata
- Authors
- Fernández, L., & Hancock, R. E. W.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2012-10
- Volume
- 25
- Issue
- 4
- Pages
- 661-681
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- OpenAlex
- W2146639370
- Cited by
- 892
- References
- 3
- FWCI
- 12.73
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Adaptive and Mutational Resistance: Role of Porins and Efflux Pumps in Drug Resistance. https://app.cochat.ai/papers/10.1128/cmr.00043-12
- The paper
- Fernández, L., & Hancock, R. E. W. (2012). Adaptive and Mutational Resistance: Role of Porins and Efflux Pumps in Drug Resistance. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.00043-12
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
