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Progress and Problems in Understanding and Managing Primary Epstein-Barr Virus Infections
Open accessAbstract
SUMMARY: Epstein-Barr virus (EBV) is a gammaherpesvirus that infects a large fraction of the human population. Primary infection is often asymptomatic but results in lifelong infection, which is kept in check by the host immune system. In some cases, primary infection can result in infectious mononucleosis. Furthermore, when host-virus balance is not achieved, the virus can drive potentially lethal lymphoproliferation and lymphomagenesis. In this review, we describe the biology of EBV and the host immune response. We review the diagnosis of EBV infection and discuss the characteristics and pathogenesis of infectious mononucleosis. These topics are approached in the context of developing therapeutic and preventative strategies.
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Cites
Herpesvirus latency confers symbiotic protection from bacterial infection
Barton, E. S., White, D. W., Cathelyn, J. S., Brett-McClellan, K. A., Engle, M., Diamond, M. S., Miller, V. L., & Virgin, H. W. (2007) · Nature · doi:10.1038/nature05762 · Cited by 763
SAP-controlled T–B cell interactions underlie germinal centre formation
Qi, H., Cannons, J. L., Klauschen, F., Schwartzberg, P. L., & Germain, R. N. (2008) · Nature · doi:10.1038/nature07345 · Cited by 637
Cited by
Herpesviruses: latency and reactivation – viral strategies and host response
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Evolution of Cancer Vaccines—Challenges, Achievements, and Future Directions
Tay, B. Q., Wright, Q., Ladwa, R., Perry, C., Leggatt, G., Simpson, F., Wells, J. W., Panizza, B. J., Frazer, I. H., & Cruz, J. L. G. (2021) · Vaccines · doi:10.3390/vaccines9050535 · Cited by 76
Antiviral antibody profiling by high‐density protein arrays
Bian, X., Wiktor, P., Kahn, P., Brunner, A., Khela, A., Karthikeyan, K., Barker, K., Yu, X., Magee, M., Wasserfall, C. H., et al. (2015) · PROTEOMICS · doi:10.1002/pmic.201400612 · Cited by 31
Metadata
- Authors
- Odumade, O. A., Hogquist, K. A., & Balfour, H. H.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2011-01
- Volume
- 24
- Issue
- 1
- Pages
- 193-209
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- OpenAlex
- W2158114211
- Cited by
- 458
- References
- 2
- FWCI
- 10.75
- Type
- journal article
- Language
- en
- Open access
- green
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- Odumade, O. A., Hogquist, K. A., & Balfour, H. H. (2011). Progress and Problems in Understanding and Managing Primary Epstein-Barr Virus Infections. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.00044-10
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
