The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Clinical and Pathophysiological Overview of Acinetobacter Infections: a Century of Challenges
Open accessAbstract
SUMMARY: Acinetobacter is a complex genus, and historically, there has been confusion about the existence of multiple species. The species commonly cause nosocomial infections, predominantly aspiration pneumonia and catheter-associated bacteremia, but can also cause soft tissue and urinary tract infections. Community-acquired infections by Acinetobacter spp. are increasingly reported. Transmission of Acinetobacter and subsequent disease is facilitated by the organism's environmental tenacity, resistance to desiccation, and evasion of host immunity. The virulence properties demonstrated by Acinetobacter spp. primarily stem from evasion of rapid clearance by the innate immune system, effectively enabling high bacterial density that triggers lipopolysaccharide (LPS)–Toll-like receptor 4 (TLR4)-mediated sepsis. Capsular polysaccharide is a critical virulence factor that enables immune evasion, while LPS triggers septic shock. However, the primary driver of clinical outcome is antibiotic resistance. Administration of initially effective therapy is key to improving survival, reducing 30-day mortality threefold. Regrettably, due to the high frequency of this organism having an extreme drug resistance (XDR) phenotype, early initiation of effective therapy is a major clinical challenge. Given its high rate of antibiotic resistance and abysmal outcomes (up to 70% mortality rate from infections caused by XDR strains in some case series), new preventative and therapeutic options for Acinetobacter spp. are desperately needed.
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Hidron, A. I., Edwards, J. R., Patel, J., Horan, T. C., Sievert, D. M., Pollock, D. A., Fridkin, S. K., & National Healthcare Safety Network Team and Participating National Healthcare Safety Network Facilities (2008) · Infection Control & Hospital Epidemiology · doi:10.1086/591861 · Cited by 3,724
The Battle for Iron between Bacterial Pathogens and Their Vertebrate Hosts
Skaar, E. P. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000949 · Cited by 796
Genome-wide identification of Acinetobacter baumannii genes necessary for persistence in the lung
Wang, N., Ozer, E. A., Mandel, M. J., & Hauser, A. R. (2014) · mBio · doi:10.1128/mbio.01163-14 · Cited by 234
The Response of Acinetobacter baumannii to Zinc Starvation
Nairn, B. L., Lonergan, Z. R., Wang, J., Braymer, J. J., Zhang, Y., Calcutt, M. W., Lisher, J. P., Gilston, B. A., Chazin, W. J., de Crécy-Lagard, V., et al. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.05.007 · Cited by 148
Luke, N. R., Sauberan, S. L., Russo, T. A., Beanan, J. M., Olson, R., Loehfelm, T. W., Cox, A. D., St. Michael, F., Vinogradov, E. V., & Campagnari, A. A. (2010) · Infection and Immunity · doi:10.1128/iai.00016-10 · Cited by 114
Mortensen, B. L., & Skaar, E. P. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00095 · Cited by 99
Transferrin iron starvation therapy for lethal bacterial and fungal infections
Lin, L., Pantapalangkoor, P., Tan, B., Bruhn, K. W., Ho, T., Nielsen, T., Skaar, E. P., Zhang, Y., Bai, R., Wang, A., et al. (2014) · Journal of Infectious Diseases · doi:10.1093/infdis/jiu049 · Cited by 68
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Sheldon, J. R., & Skaar, E. P. (2020) · PLOS Pathogens · doi:10.1371/journal.ppat.1008995 · Cited by 177
Klebba, P. E., Newton, S. M. C., Six, D. A., Kumar, A., Yang, T., Nairn, B. L., Munger, C., & Chakravorty, S. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01005 · Cited by 150
Acinetobacter baumannii OxyR Regulates the Transcriptional Response to Hydrogen Peroxide
Juttukonda, L. J., Green, E. R., Lonergan, Z. R., Heffern, M. C., Chang, C. J., & Skaar, E. P. (2019) · Infection and Immunity · doi:10.1128/iai.00413-18 · Cited by 75
Changes in mouse gut bacterial community in response to different types of drinking water
Dias, M. F., Reis, M. P., Acurcio, L. B., Carmo, A. O., Diamantino, C. F., Motta, A. M., Kalapothakis, E., Nicoli, J. R., & Nascimento, A. M. A. (2018) · Water Research · doi:10.1016/j.watres.2017.12.052 · Cited by 43
Metadata
- Authors
- Wong, D., Nielsen, T. B., Bonomo, R. A., Pantapalangkoor, P., Luna, B., & Spellberg, B.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2017-01
- Volume
- 30
- Issue
- 1
- Pages
- 409-447
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- OpenAlex
- W2578361705
- Cited by
- 1,170
- References
- 7
- FWCI
- 30.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wong, D., Nielsen, T. B., Bonomo, R. A., Pantapalangkoor, P., Luna, B., & Spellberg, B. (2017). Clinical and Pathophysiological Overview of Acinetobacter Infections: a Century of Challenges. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.00058-16
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
