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Mobile Genetic Elements Associated with Antimicrobial Resistance
Open accessAbstract
Strains of bacteria resistant to antibiotics, particularly those that are multiresistant, are an increasing major health care problem around the world. It is now abundantly clear that both Gram-negative and Gram-positive bacteria are able to meet the evolutionary challenge of combating antimicrobial chemotherapy, often by acquiring preexisting resistance determinants from the bacterial gene pool.
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“Some determinants reflect intrinsic or species-associated background resistance, whereas others are acquired, horizontally transferable and clinically relevant.”
From Integrated Phenotypic and Sequencing-Based Resistome Assessment of Antimicrobial Resistance Determinants in a Sample of Commercial Farm-Animal Probiotic Products (2026) · cites this paper as [11]
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“the mere presence of an AMR-associated database hit does not necessarily imply public-health risk.”
From Integrated Phenotypic and Sequencing-Based Resistome Assessment of Antimicrobial Resistance Determinants in a Sample of Commercial Farm-Animal Probiotic Products (2026) · cites this paper as [11]
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“Intrinsic determinants in Enterococcus faecium, for example, must be interpreted differently from mobile glycopeptide, oxazolidinone, colistin, extended-spectrum β-lactamase (ESBL) or carbapenemase genes [11,12,13,14].”
From Integrated Phenotypic and Sequencing-Based Resistome Assessment of Antimicrobial Resistance Determinants in a Sample of Commercial Farm-Animal Probiotic Products (2026) · cites this paper as [11]
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“This framework is consistent with the broader horizontal gene transfer (HGT) literature, which emphasizes that mobility, ecological opportunity and recipient compatibility determine whether an ARG becomes a clinically relevant hazard [11,12,16,17].”
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“The ESKAPEE species E. hormaechei 107 was detected in 77 food samples with rel. ab. = 0.02% (Figure 6C)”
From Unexplored microbial diversity from 2,500 food metagenomes and links with the human microbiome. (2024) · cites this paper as [107]
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Metadata
- Authors
- Partridge, S. R., Kwong, S. M., Firth, N., & Jensen, S. O.
- Affiliations
- The University of Sydney (AU)
- Ingham Institute (AU)
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2018-10
- Volume
- 31
- Issue
- 4
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- PMC
- PMC6148190
- OpenAlex
- W2885680427
- Cited by
- 2,751
- References
- 527
- Citations by year
- 2026: 579 · 2025: 452 · 2024: 367 · 2023: 374 · 2022: 352 · 2021: 296 · 2020: 197 · 2019: 116 · 2018: 15
- FWCI
- 13.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Microbiology Reviews (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- mobile genetic elements, antimicrobial resistance, antibiotic resistance, multidrug resistance, horizontal gene transfer, resistance determinants, Gram-negative bacteria, Gram-positive bacteria, bacterial evolution
- MeSH terms
- Anti-Bacterial Agents, Bacteria, Bacterial Infections, DNA Transposable Elements, Biological Evolution, Gene Transfer, Horizontal, Drug Resistance, Bacterial
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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